Hashiguchi, Akinori



School of Medicine, Electron Microscope Laboratory (Shinanomachi)


Assistant Professor/Senior Assistant Professor

External Links

Career 【 Display / hide

  • 1995.04

    慶應義塾大学医学部, 病理学教室, 慶應義塾大学医学部助手(病理学)

  • 1997.04

    慶應義塾大学医学部, 病理学教室, 慶應義塾大学助手(医学部病理学)

  • 2007.04

    慶應義塾大学医学部, 病理学教室, 慶應義塾大学助教(医学部病理学)

  • 2013.12

    慶應義塾大学医学部, 病理学教室, 慶應義塾大学専任講師(医学部病理学)

Academic Background 【 Display / hide

  • 1989.04

    Keio University, School of Meicine

    Japan, University, Graduated

Academic Degrees 【 Display / hide

  • 博士(医学), Keio University, Dissertation, 2010.11

    Using immunofluorescent digital slide technology to quantify protein expression in archival paraffin-embedded tissue sections


Research Areas 【 Display / hide

  • Human pathology

Research Keywords 【 Display / hide

  • Digital Pathology

  • Renal Pathology


Papers 【 Display / hide

  • Diabetic condition induces hypertrophy and vacuolization in glomerular parietal epithelial cells

    Kawaguchi T., Hasegawa K., Yasuda I., Muraoka H., Umino H., Tokuyama H., Hashiguchi A., Wakino S., Itoh H.

    Scientific Reports (Scientific Reports)  11 ( 1 )  2021.12

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    Diabetic nephropathy (DN) is accompanied by characteristic changes in the glomerulus, but little is known about the effect of diabetes on parietal epithelial cells (PECs). In this study, a descriptive analysis of PECs was undertaken in diabetic db/db mice and in diabetic patients. PEC hypertrophy was significantly more prominent in diabetic mice than in nondiabetic mice, and this was evident even at the early stage. Additionally, the number of vacuoles in PECs was markedly increased in diabetic mice, suggesting the presence of cellular injury in PECs in DN. Although rare, binuclear cells were observed in mice with early diabetes. In cultured PECs, a high glucose condition, compared with normal glucose condition, induced cellular hypertrophy and apoptosis. Flow cytometry showed that some PECs in the G0 phase reentered the cell cycle but got arrested in the S phase. Finally, in human diabetic subjects, hypertrophy and vacuolization were observed in the PECs. Our data showed that PECs undergo substantial changes in DN and may participate in rearrangement for differentiation into podocytes.

  • A girl with a mutation of the ciliary gene CC2D2A presenting with FSGS and nephronophthisis.

    Awazu M, Yamada M, Asada N, Hashiguchi A, Kosaki K, Matsumura K

    CEN case reports  2021.08

    Research paper (scientific journal), Joint Work, Accepted

  • Grading of Multifocal Prostate Cancer Cases in which the Largest Volume and the Highest Grade Do Not Coincide within One Lesion

    Matsumoto K., Omura M., Takeda T., Kosaka T., Hashiguchi A., Takamatsu K., Yasumizu Y., Tanaka N., Morita S., Mizuno R., Asanuma H., Oya M.

    The Journal of urology (The Journal of urology)  206 ( 2 ) 338 - 345 2021.08

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0022-5347

     View Summary

    PURPOSE: In general, the index lesion of prostate cancer has the largest tumor volume, the highest Grade Group (GG), and the highest stage (concordant cases). However, these factors sometimes do not coincide within one lesion (discordant cases). In such discordant cases, the largest tumor may not be of biological significance and the secondary tumor may more greatly impact the prognosis. MATERIALS AND METHODS: We retrospectively reviewed the medical records of patients who underwent radical prostatectomy, and we identified 580 (85.3%) concordant cases and 100 (14.7%) discordant cases. The end point of this study was biochemical recurrence, and median followup was 4.2 years. RESULTS: Among discordant cases in which GGs of the largest tumor and the highest GG tumor differed, the majority (67 patients) had the largest tumor of GG 2, and we set them as the study cohort. On the other hand, we regarded 212 concordant cases with an index tumor of GG 2 as the control cohort. The study cohort comprised 48 (71.6%) patients with a secondary tumor of GG 3 and 19 (28.4%) with a secondary tumor of GG 4/5. Kaplan-Meier curves revealed that the 5-year biochemical recurrence-free survival rates were 76%, and 67%, respectively. The 5-year biochemical recurrence-free survival rate of the control cohort was 91%, which was significantly better than that of the study cohort (p=0.013 and p=0.014, respectively). CONCLUSIONS: Our study suggests that the prognosis of discordant cases is better determined by the secondary cancer lesion with the highest GG instead of the largest lesion.

  • Development of nephropathy in an adult patient after Fontan palliation for cyanotic congenital heart disease

    Hayashi K., Hashiguchi A., Ikemiyagi M., Tokuyama H., Wakino S., Itoh H.

    CEN case reports (CEN case reports)  10 ( 3 ) 354 - 358 2021.08

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    Cyanotic congenital heart disease is occasionally associated with kidney dysfunction, which is known as cyanotic nephropathy or cyanotic glomerulopathy. The clinical presentation of cyanotic nephropathy includes proteinuria, decreased estimated glomerular filtration rate, hyperuricemia, thrombocytopenia, or polycythemia. Although advances in surgical procedures have improved the prognosis of cyanotic congenital heart diseases, adult cases of cyanotic nephropathy are still rare, and there are few reports of kidney biopsy in adults with cyanotic nephropathy. Here, we present the case of a 41-year-old patient with Fontan palliation who developed nephrotic range proteinuria and had a kidney biopsy, which showed glomerular hypertrophy with segmental glomerulosclerosis around vascular poles, suggesting adaptive focal segmental glomerulosclerosis. This case provides further understanding of kidney dysfunction due to cyanotic congenital heart disease and shows the need for attention in the management for prevention of progression to end-stage renal disease and in the selection of renal replacement therapy.

  • Malignancy-associated membranous nephropathy with PLA2R double-positive for glomeruli and carcinoma

    Yasuda I., Tokuyama H., Hashiguchi A., Hasegawa K., Uchiyama K., Ryuzaki M., Yasuda M., Mizuno R., Ishidoya S., Wakino S., Itoh H.

    CEN case reports (CEN case reports)  10 ( 2 ) 281 - 286 2021.05

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    Phospholipase A2 receptor (PLA2R) is the most common primary target antigen of idiopathic membranous nephropathy (MN) although PLA2R antibodies are also reported to be present in malignancy-associated MN. However, a case of PLA2R-positive MN secondary to PLA2R-positive carcinoma has not been reported. A 26-year-old Japanese woman presented with general fatigue, fever, and nonproductive cough. Computed tomography demonstrated a left kidney mass with pathologic diagnosis of Xp11.2 translocation renal cell carcinoma (RCC). After the second time of administration with Sunitinib, the patients exhibited significant proteinuria and hypoalbuminemia. Renal biopsy revealed a diagnosis of diffuse MN secondary to RCC. Immunofluorescence staining showed granular patterns positive for immunoglobulin (Ig) G, IgA, and C3c. PLA2R and IgG1-3 were positive, while IgG4 was negative. For the treatment of severe nephrotic syndrome, we attempted steroid therapy without any clinical improvement. Open nephrectomy was performed and surprisingly, RCC was stained for PLA2R with polarity for the basal side. At outpatient follow-up, 4 months after the operation, urinary protein had still persisted, although serum albumin was slightly increased. We report a case of PLA2R-positive MN secondary to PLA2R-positive RCC.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • IgA腎症のOxford分類と日本分類(組織学的重症度分類)の腎機能予後予測に関する比較

    城 謙輔, 中里 毅, 橋口 明典, 清水 章, 久野 敏, 片渕 律子, 川村 哲也

    日本腎臓学会誌 ((一社)日本腎臓学会)  61 ( 3 ) 394 - 394 2019.05

    Other article, Joint Work,  ISSN  0385-2385

  • IgA腎症の生検時の臨床データと病理所見の関連性

    鎌野 千佐子, 清水 章, 城 謙輔, 橋口 明典, 久野 敏, 片渕 律子, 川村 哲也

    日本腎臓学会誌 ((一社)日本腎臓学会)  61 ( 3 ) 395 - 395 2019.05

    Other article, Joint Work,  ISSN  0385-2385

  • 前立腺癌の腫瘍局在が診断・治療・予後に及ぼす影響

    松本 一宏, 高松 公晴, 武田 利和, 小坂 威雄, 田中 伸之, 森田 伸也, 水野 隆一, 篠島 利明, 菊地 栄次, 浅沼 宏, 橋口 明典, 陣崎 雅弘, 大家 基嗣

    日本泌尿器科学会総会 ((一社)日本泌尿器科学会総会事務局)  107回   PP1 - 075 2019.04

    Other article, Joint Work

  • ステロイドパルス療法が有効であった腎移植後IgA腎症の1例

    森田 伸也, 高橋 遼平, 環 聡, 篠田 和伸, 香野 日高, 浅沼 宏, 橋口 明典, 脇野 修, 中川 健, 大家 基嗣

    日本臨床腎移植学会プログラム・抄録集 ((一社)日本臨床腎移植学会)  52回   264 - 264 2019.02

    Other article, Joint Work

  • C3腎症の視点から膜性増殖性糸球体腎炎(MPGN)の再検討 MPGN I型とIII型-2nd formは同一疾患か?

    佐藤 直実, 城 謙輔, 中村 保宏, 谷内 真司, 橋口 明典, 高木 孝士, 笹野 公伸

    日本病理学会会誌 ((一社)日本病理学会)  107 ( 1 ) 448 - 448 2018.04

    Other article, Joint Work,  ISSN  0300-9181

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Presentations 【 Display / hide

  • 同時性かつ同一乳房内に全く異なった治療法を必要とする原発性乳癌と乳房内原発悪性リンパ腫を認めた一例

    和田 真弘, 橋口 明典

    日本乳癌学会総会プログラム抄録集, 2021.07, Oral Presentation(general), (一社)日本乳癌学会

  • DNA修復因子KAT5を介した尿細管糸球体フィードバック制御

    菱川 彰人, 林 香, 久保 亜紀子, 宮下 和季, 橋口 明典, 吉本 憲史, 中道 蘭, 杉田 絵里那, 赤塩 理起, 門川 俊明, 末松 誠, 伊藤 裕

    日本腎臓学会誌, 2021.06, Oral Presentation(general), (一社)日本腎臓学会

  • C3腎症を基準とした一次性MPGNの再分類:電顕PAMを用いたType 3 Anders-Strife型の鑑別のもとに

    本間 志功, 佐藤 直実, 橋口 明典, 上杉 憲子, 中村 保宏, 城 謙輔

    日本腎臓学会誌, 2021.06, Oral Presentation(general), (一社)日本腎臓学会

  • デジタル画像解析を用いたIgA腎症糸球体病変定量化

    橋口 明典, 石川 雅浩, 城 謙輔, 坂本 直樹, 山内 暁, 大塚 武, 福西 宗憲, 清水 章, 片渕 律子, 川村 哲也

    日本病理学会会誌, 2021.03, Oral Presentation(general), (一社)日本病理学会

  • 【腎非腫瘍性疾患の病理診断の実践-腎生検病理診断から剖検診断まで-】自己免疫疾患に伴う腎障害 ループス腎炎を中心に

    橋口 明典

    病理と臨床, 2021.02, Oral Presentation(general), (株)文光堂

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Courses Taught 【 Display / hide











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Courses Previously Taught 【 Display / hide

  • 臨床実習(病理診断部)

    Keio University, 2017, Major subject, Laboratory work/practical work/exercise

  • 病理学各論(実習)

    Keio University, 2017, Major subject, Laboratory work/practical work/exercise

  • 病理学総論(実習)

    Keio University, 2017, Major subject, Laboratory work/practical work/exercise

  • 病理学各論(講義)

    Keio University, 2017, Major subject, Lecture

  • 臨床実習(病理診断部)

    Keio University, 2016, Major subject, Laboratory work/practical work/exercise

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Memberships in Academic Societies 【 Display / hide

  • The Japanese Society of Pathology

  • Japanese Society of Nephrology

  • The Japanese Society of Digital Pathology