Hashiguchi, Akinori

写真a

Affiliation

School of Medicine, Department of Pathology (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor

External Links
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Career 【 Display / hide 】

  • 1995.04
    -
    1997.03

    慶應義塾大学医学部, 病理学教室, 慶應義塾大学医学部助手（病理学）

  • 1997.04
    -
    2007.03

    慶應義塾大学医学部, 病理学教室, 慶應義塾大学助手（医学部病理学）

  • 2007.04
    -
    2013.11

    慶應義塾大学医学部, 病理学教室, 慶應義塾大学助教（医学部病理学）

  • 2013.12
    -
    Present

    慶應義塾大学医学部, 病理学教室, 慶應義塾大学専任講師（医学部病理学）

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Academic Background 【 Display / hide 】

  • 1989.04
    -
    1995.03

    Keio University, School of Meicine

    University, Graduated

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Academic Degrees 【 Display / hide 】

  • 博士（医学）, Keio University, Dissertation, 2010.11

    Using immunofluorescent digital slide technology to quantify protein expression in archival paraffin-embedded tissue sections

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Research Areas 【 Display / hide 】

  • Life Science / Human pathology

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Research Keywords 【 Display / hide 】

  • Digital Pathology

  • Renal Pathology

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Papers 【 Display / hide 】

  • Urinary biomarkers associated with pathogenic pathways reflecting histological findings in lupus nephritis.

    Kazuoto Hiramoto, Shuntaro Saito, Hironari Hanaoka, Jun Kikuchi, Hiroyuki Fukui, Akinori Hashiguchi, Katsuya Suzuki, Tsutomu Takeuchi, Yuko Kaneko

    Arthritis & rheumatology (Hoboken, N.J.) 77 ( 3 ) 298 - 310 2025.03

    Joint Work,  ISSN  23265191

    　View Summary

    OBJECTIVE: There is a pressing need to understand the pathogenesis of histological findings and identify the biomarkers for predicting the histological severity in lupus nephritis (LN). This study aimed to identify the pathogenic signal pathway and elucidate urinary biomarkers for predicting the presence or severity of histological findings in LN. METHODS: Urine samples from patients with biopsy-proven active LN were screened for 1305 proteins using an aptamer-based proteomic assay. The diversity and expansion of individual renal histological features in LN were quantified to identify the urinary proteins associated with the histological findings found in each score. Candidate urinary proteins were validated in a validation cohort. Immunohistochemical staining of the renal tissues was performed to clarify the localisation of the candidate proteins. RESULTS: Cluster analysis extracted five histological subgroups according to their correlations with each histological finding in LN. Protein groups which correlated with each histological subgroup revealed a distinct pathogenesis in LN using pathway analyses. Enzyme-linked immunosorbent assay validation revealed that urinary calgranulin B (S100A9), MCP-1, and IGFBP-5 levels could specifically predict the presence and severity of active glomerular lesions, interstitial inflammation, and interstitial fibrosis, respectively. Immunohistochemical staining revealed the localisation of these proteins in each lesion. CONCLUSIONS: Renal histological findings may reflect the different pathogeneses involved in each lesion, and estimating the urinary calgranulin B, MCP-1, and IGFBP-5 levels may be useful in predicting the presence and severity of histological findings in LN.

  • A Case of Membranous Nephropathy Associated with Syphilis: Correlative Light and Electron Microscopy Revealing the Localization of Neuron-derived Neurotrophic Factor within Subepithelial Electron Dense Deposits.

    Minezaki C, Azegami T, Hashiguchi A, Yoshifuji A, Yoshimoto N, Hagiwara A, Hishikawa A, Hayashi K

    Internal medicine (Tokyo, Japan)  2024.12

    Joint Work,  ISSN  0918-2918

  • The proteinuria selectivity index value predicts the remission of IgA nephropathy: a retrospective cohort study.

    Mitsuno R, Nakayama T, Ito W, Maruki T, Nakamichi R, Adachi K, Yoshimoto N, Hishikawa A, Hagiwara A, Yamaguchi S, Monkawa T, Yoshino J, Hashiguchi A, Azegami T, Hayashi K

    Renal failure 46 ( 2 ) 2423839 2024.12

    Joint Work,  ISSN  0886-022X

  • Clinical relevance of proteinuria selectivity index and fractional excretion of sodium in patients with nephrotic syndrome.

    Nakayama T, Azegami T, Yamaguchi S, Hirano K, Komatsu M, Fujii K, Futatsugi K, Urai H, Kawaguchi T, Itoh T, Yoshimoto N, Hagiwara A, Hishikawa A, Matsuda H, Ando T, Yamaji Y, Murakami M, Hashiguchi A, Kaneko Y, Yokoo T, Hayashi K

    Scientific reports 14 ( 1 ) 23755 2024.10

    Joint Work

  • Primary breast lymphoma mimicking triple-negative breast cancer: a case report with clinical and pathological implications.

    Sawano T, Wada M, Ozaki A, Hashiguchi A, Hirooka S, Tanimoto T

    Surgical case reports 10 ( 1 ) 234 2024.10

    Joint Work,  ISSN  2198-7793

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • Erratum: DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation (Cell Reports (2023) 42(4), (S2211124723003133), (10.1016/j.celrep.2023.112302))

    Nakamichi R., Hishikawa A., Chikuma S., Yoshimura A., Sasaki T., Hashiguchi A., Abe T., Tokuhara T., Yoshimoto N., Nishimura E.S., Hama E.Y., Azegami T., Nakayama T., Hayashi K., Itoh H.

    Cell Reports (Cell Reports)  42 ( 5 )  2023.05

    Joint Work

    　View Summary

    (Cell Reports 42, 112302; April 25, 2023) In the originally published version of this article, Figure 4 was accidentally constructed with a duplicate of panel (D) in place of the intended panel (E). The figure has been corrected online. The authors regret this error. [Formula presented] [Formula presented]

  • Minimal Change Disease Associated With Durvalumab

    Toda M.G., Fujii K., Kato A., Yoshifuji A., Komatsu M., Amino Y., Kitazono S., Hashiguchi A., Ryuzaki M.

    Kidney International Reports (Kidney International Reports)  6 ( 10 ) 2733 - 2734 2021.10

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work,  ISSN  24680249

  • IgA腎症のOxford分類と日本分類(組織学的重症度分類)の腎機能予後予測に関する比較

    城 謙輔, 中里 毅, 橋口 明典, 清水 章, 久野 敏, 片渕 律子, 川村 哲也

    日本腎臓学会誌 ((一社)日本腎臓学会)  61 ( 3 ) 394 - 394 2019.05

    Other, Joint Work,  ISSN  0385-2385

  • IgA腎症の生検時の臨床データと病理所見の関連性

    鎌野 千佐子, 清水 章, 城 謙輔, 橋口 明典, 久野 敏, 片渕 律子, 川村 哲也

    日本腎臓学会誌 ((一社)日本腎臓学会)  61 ( 3 ) 395 - 395 2019.05

    Other, Joint Work,  ISSN  0385-2385

  • 前立腺癌の腫瘍局在が診断・治療・予後に及ぼす影響

    松本 一宏, 高松 公晴, 武田 利和, 小坂 威雄, 田中 伸之, 森田 伸也, 水野 隆一, 篠島 利明, 菊地 栄次, 浅沼 宏, 橋口 明典, 陣崎 雅弘, 大家 基嗣

    日本泌尿器科学会総会 ((一社)日本泌尿器科学会総会事務局)  107回   PP1 - 075 2019.04

    Other, Joint Work

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Presentations 【 Display / hide 】

  • 胸腺腫に合併した巣状分節性糸球体硬化症に対してステロイド/シクロスポリンの併用療法で完全寛解を得た1例

    圓谷 泰章, 大島 洋一, 伊崎 慶史郎, 橋元 麻里子, 中村 彰良, 杉原 晋之介, 加藤 亜唯, 橋口 明典, 小松 素明

    日本腎臓学会誌, 

    2024.09
    , 

    (一社)日本腎臓学会

  • 紅麹コレステヘルプ服用中に発症した完全型Fanconi症候群を伴う急性腎障害の一例

    星 健太, 村上 円人, 船木 裕規, 佐藤 芳紀, 杉浦 康平, 橋口 明典

    日本腎臓学会誌, 

    2024.09
    , 

    (一社)日本腎臓学会

  • 濾胞性リンパ腫の治療後に糸球体endotheliosisを認め,アシクロビルの関与が疑われた急性腎障害の一例

    三守 賢, 吉本 憲史, 菱川 彰人, 萩原 あいか, 畔上 達彦, 橋口 明典, 林 香

    日本腎臓学会誌, 

    2024.09
    , 

    (一社)日本腎臓学会

  • 光・電子相関顕微鏡法にて上皮下高電子密度沈着物内でのNDNFの局在を明確にした梅毒関連膜性腎症の1例

    峯崎 千智, 吉本 憲史, 萩原 あいか, 菱川 彰人, 橋口 明典, 畔上 達彦, 林 香

    日本腎臓学会誌, 

    2024.09
    , 

    (一社)日本腎臓学会

  • 他臓器障害なく原因不明の腎不全を呈した若年成人にミトコンドリア遺伝子上の病的バリアントを認めた一例

    川口 隆久, 橋口 明典, 畔上 達彦, 今澤 俊之, 村山 圭, 岡崎 康司, 安藤 孝

    日本腎臓学会誌, 

    2024.09
    , 

    (一社)日本腎臓学会

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Courses Taught 【 Display / hide 】

  • GENERAL PATHOLOGY

    2025

  • DISEASES OF ORGAN SYSTEMS

    2025

  • GENERAL PATHOLOGY

    2024

  • DISEASES OF ORGAN SYSTEMS

    2024

  • GENERAL PATHOLOGY

    2023

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Courses Previously Taught 【 Display / hide 】

  • 臨床実習（病理診断部）

    Keio University

    2017.04
    -
    2018.03
    , 

    Laboratory work/practical work/exercise

  • 病理学各論（実習）

    Keio University

    2017.04
    -
    2018.03
    , 

    Laboratory work/practical work/exercise

  • 病理学総論（実習）

    Keio University

    2017.04
    -
    2018.03
    , 

    Laboratory work/practical work/exercise

  • 病理学各論（講義）

    Keio University

    2017.04
    -
    2018.03
    , 

    Lecture

  • 病理学各論（講義）

    Keio University

    2016.04
    -
    2017.03
    , 

    Lecture

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Memberships in Academic Societies 【 Display / hide 】

  • The Japanese Society of Pathology

    　

  • Japanese Society of Nephrology

    　

  • The Japanese Society of Digital Pathology

    　
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