KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 1995.04

  -

  1997.03

  慶應義塾大学医学部, 病理学教室, 慶應義塾大学医学部助手（病理学）

• 1997.04

  -

  2007.03

  慶應義塾大学医学部, 病理学教室, 慶應義塾大学助手（医学部病理学）

• 2007.04

  -

  2013.11

  慶應義塾大学医学部, 病理学教室, 慶應義塾大学助教（医学部病理学）

• 2013.12

  -

  Present

  慶應義塾大学医学部, 病理学教室, 慶應義塾大学専任講師（医学部病理学）

Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1989.04

  -

  1995.03

  Keio University, School of Meicine

  University, Graduated

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士（医学）, Keio University, Dissertation, 2010.11

  Using immunofluorescent digital slide technology to quantify protein expression in archival paraffin-embedded tissue sections

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Human pathology

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• Digital Pathology

• Renal Pathology

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Detection of the Highest-Grade Lesion in Multifocal Discordant Prostate Cancer by Multiparametric Magnetic Resonance Imaging.

  Kazuhiro Matsumoto, Hirotaka Akita, Akinori Hashiguchi, Toshikazu Takeda, Takeo Kosaka, Keishiro Fukumoto, Yota Yasumizu, Nobuyuki Tanaka, Shinya Morita, Ryuichi Mizuno, Hiroshi Asanuma, Mototsugu Oya, Masahiro Jinzaki

  Clinical genitourinary cancer （Clinical Genitourinary Cancer)  22 （ 3 ） 102084 - 102084 2024.06

  Joint Work,  ISSN  15587673

  　View Summary

  PURPOSE: Prostate cancer generally occurs multifocally. The lesions of the largest size and highest-grade are often concordant, and defined as an index tumor. However, these factors sometimes do not coincide within one lesion. In such discordant cases, not the largest size lesion but the highest-grade lesion is known to determine the prognosis. We focused on the multiparametric magnetic resonance imaging (mpMRI) detectability of the highest-grade tumors in discordant cases. MATERIALS AND METHODS: We investigated the detectability of the highest-grade tumor using preoperative mpMRI in 50 discordant patients who underwent radical prostatectomy. The radiologist was informed of the tumor location on the pathological tumor map, and mpMRI interpretation for each tumor was performed. RESULTS: Prostate Imaging-Reporting and Data System (PI-RADS) scores of 1, 2, 3, 4, and 5 on preoperative mpMRI were assigned to 13, 1, 9, 16, and 11 of the largest tumors, respectively. On the other hand, scores of 1, 2, 3, 4, and 5 were assigned to 23, 0, 7, 19, and 1 of the highest-grade tumors, respectively. The difference between them was statistically significant (p=0.007). We also found that the largest anterior tumor frequently hid the ipsilateral posterior highest-grade tumor; the detection rate of the highest-grade tumor in this pattern was 42.1% (8 of 19 cases) CONCLUSION: We found that mpMRI detectability of the highest-grade tumor in discordant cases was inferior to that of the largest tumor with low malignant potential. Our results suggest that the risk of high-grade tumors which determine patient prognosis being overlooked.

  • Access to Document (DOI)

• Establishment of artificial intelligence model for precise histological subtyping of lung adenocarcinoma and its application to quantitative and spatial analysis.

  Miura E, Emoto K, Abe T, Hashiguchi A, Hishida T, Asakura K, Sakamoto M

  Japanese journal of clinical oncology  2024.05

  Joint Work,  ISSN  0368-2811

  • Access to Document (DOI)

• Renal sinus fat is associated with intrarenal hemodynamic abnormalities independent of visceral fat in patients with chronic kidney disease.

  Kenji Kaneko, Ryunosuke Mitsuno, Daiki Kojima, Tatsuhiko Azegami, Shotaro Kosugi, Toshifumi Nakamura, Akinori Hashiguchi, Yoshitake Yamada, Masahiro Jinzaki, Shintaro Yamaguchi, Hiroshi Itoh, Jun Yoshino, Kaori Hayashi

  Obesity research & clinical practice （Obesity Research and Clinical Practice)  18 （ 2 ） 118 - 123 2024.03

  Joint Work,  ISSN  1871403X

  　View Summary

  OBJECTIVE: Obesity is a risk factor of chronic kidney disease (CKD), contributing to the rising incidence of cardiometabolic diseases. Renal sinus fat (RSF) is an ectopic fat depot located at the renal cavity that could impair renal function and hemodynamic through compression of renal structures. The major purpose of this study was to explore the relationship between RSF accumulation and renal dysfunction in CKD patients. METHODS: We evaluated the associations between computed tomography measured RSF volume and key clinical and histologic parameters involved in renal function and hemodynamics in 132 well-characterized CKD patients who underwent renal biopsy (median age: 62 years; 63.6% men). RESULTS: RSF volume normalized by renal volume (RSF%) positively correlated with obesity-related traits such body mass index and visceral fat volume (VFV) (all P < 0.001) whereas it negatively correlated with estimated glomerular filtration rate (eGFR) (ρ = -0.42, P < 0.001) and 24-h urinary creatinine clearance (CCr) (ρ = -0.34, P < 0.001). Notably, we found robust positive correlations between RSF% and renal resistive index (RRI) measured by the Doppler ultrasound (ρ = 0.40, P < 0.001), and the histological severity of global glomerular sclerosis (ρ = 0.48, P < 0.001) and interstitial fibrosis and tubular atrophy (IFTA) (ρ = 0.35, P < 0.001). In the multivariate linear regression models, after accounting for potential confounders including VFV, RSF% remained significantly associated with CCr (β = -0.26, P < 0.001), RRI (β = 0.17, P = 0.022), global glomerular sclerosis (β = 0.21, P = 0.002), and IFTA (β = 0.17, P = 0.012). CONCLUSION: RSF accumulation is associated with renal dysfunction and hemodynamic abnormalities independent of visceral adiposity. Our results suggest that RSF may have a potential unique role in the pathogenesis of CKD.

  • Access to Document (DOI)

• Morphological and etiological analyses of C3 and non-C3 glomerulonephritis in primary membranoproliferative glomerulonephritis using periodic acid-methenamine silver stain electron microscopy: a retrospective multicentered study.

  Shiko Honma, Naomi Sato, Ryoko Sakaguchi, Akinori Hashiguchi, Noriko Uesugi, Yasuhiro Nakamura, Hironobu Sasano, Kensuke Joh

  Medical molecular morphology （Medical Molecular Morphology)  57 （ 1 ） 23 - 34 2024.03

  Joint Work,  ISSN  18601480

  　View Summary

  This study elucidated the etiology of C3 glomerulonephritis (C3GN) and non-C3GN with primary membranoproliferative glomerulonephritis (MPGN) using transmission electron microscopy (TEM) and periodic acid-methenamine silver stain (PAM-EM). Thirty-one primary MPGN cases were analyzed by TEM and PAM-EM to distinguish among MPGN I, MPGN II, MPGN III Burkholder subtype (MPGN IIIB), and Anders and Strife subtype (MPGN IIIA/S). Each case was also classified into C3GN or non-C3GN according to the standard C3GN definition using immunostaining. Four cases of MPGN II met C3 glomerulopathy; whereas, four cases of MPGN IIIB did not meet C3 glomerulopathy. Seven of 11 cases (64%) of MPGN I without GBM disruption and 7 of 12 cases (58%) of MPGN IIIA/S with GBM disruption met the non-C3GN criteria with significant immunoglobulins' deposition. Regardless of the C3GN or non-C3GN diagnosis, the deposits in primary MPGN I and MPGN IIIA/S exhibited ill-defined, amorphous, and foggy characteristics similar to those found in postinfectious GN but were different from immune complex (IC) deposits seen in MPGN IIIB. Not only C3GN but also non-C3GN was due to mechanisms other than IC deposition as found in postinfectious GN. Consequently, GBM disruption of MPGN IIIA/S was not due to IC deposition.

  • Access to Document (DOI)

• Clinicopathological prognostic stratification for proteinuria and kidney survival in IgA nephropathy: a Japanese prospective cohort study

  Kentaro Koike, Tetsuya Kawamura, Keita Hirano, Masako Nishikawa, Akira Shimizu, Kensuke Joh, Ritsuko Katafuchi, Akinori Hashiguchi, Yuichiro Yano, Keiichi Matsuzaki, Masato Matsushima, Nobuo Tsuboi, Shoichi Maruyama, Ichiei Narita, Yokoo Takashi, Yusuke Suzuki

  Clinical Kidney Journal （Clinical Kidney Journal)  17 （ 1 ） sfad294 2024.01

  Joint Work,  ISSN  20488505

  　View Summary

  Background. We require a clinicopathological risk stratification method for immunoglobulin A nephropathy (IgAN) to predict kidney outcomes. We examined a renal failure risk group (RF-RG) classification system created following a prior multicentre, retrospective study to determine if RF-RG could predict kidney outcomes. Methods. We collected data from Japanese patients with IgAN registered between 1 April 2005 and 31 August 2015. The primary outcome was a composite 50% increase in serum creatinine from baseline or dialysis induction. The secondary outcomes were times to proteinuria remission (ProR) and haematuria remission (HemR). Results. The enrolled 991 patients from 44 facilities were followed for a median of 5.5 years (interquartile range 2.5-7.5), during which 87 composite events (8.8%) occurred. RF-RG was significantly associated with the primary outcome {hazard ratio [HR] II 2.78 [95% confidence interval (CI) 1.12-6.93], III 7.15 (2.90-17.6), IV 33.4 (14.1-79.0), I as a reference, P < .001}. The discrimination performance was good [C-statistic 0.81 (95% CI 0.76-0.86)] and the time-dependent C-statistics exceeded 0.8 over 10 years. Among the 764 patients with proteinuria and 879 patients with haematuria at baseline, 515 and 645 patients showed ProR and HemR, respectively. ProR was significantly less frequent in patients with advanced disease [subdistribution HR: II 0.79 (95% CI 0.67-0.94), III 0.53 (0.41-0.66), IV 0.15 (0.09-0.23), I as a reference, P < .001]. We also observed an association between HemR and RF-RG. Conclusions. RF-RG demonstrated good predictive ability for kidney outcomes.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• The results of renal biopsies performed within the past thirty five years at Keio University Hospital, with an analysis in detail of the cases with membranous nephropathy.

  Hashiguchi, Akinori

  Journal of the Keio Medical Society （慶應医学会)  82 （ 3 ） 143 - 155 2005.09

  ISSN  03685179

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• Erratum: DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation (Cell Reports (2023) 42(4), (S2211124723003133), (10.1016/j.celrep.2023.112302))

  Nakamichi R., Hishikawa A., Chikuma S., Yoshimura A., Sasaki T., Hashiguchi A., Abe T., Tokuhara T., Yoshimoto N., Nishimura E.S., Hama E.Y., Azegami T., Nakayama T., Hayashi K., Itoh H.

  Cell Reports (Cell Reports)  42 ( 5 )  2023.05

  Joint Work

  　View Summary

  (Cell Reports 42, 112302; April 25, 2023) In the originally published version of this article, Figure 4 was accidentally constructed with a duplicate of panel (D) in place of the intended panel (E). The figure has been corrected online. The authors regret this error. [Formula presented] [Formula presented]

  • Access to Document (DOI)

• Minimal Change Disease Associated With Durvalumab

  Toda M.G., Fujii K., Kato A., Yoshifuji A., Komatsu M., Amino Y., Kitazono S., Hashiguchi A., Ryuzaki M.

  Kidney International Reports (Kidney International Reports)  6 ( 10 ) 2733 - 2734 2021.10

  Article, review, commentary, editorial, etc. (scientific journal), Joint Work,  ISSN  24680249

  • Access to Document (DOI)

• IgA腎症のOxford分類と日本分類(組織学的重症度分類)の腎機能予後予測に関する比較

  城 謙輔, 中里 毅, 橋口 明典, 清水 章, 久野 敏, 片渕 律子, 川村 哲也

  日本腎臓学会誌 ((一社)日本腎臓学会)  61 ( 3 ) 394 - 394 2019.05

  Other, Joint Work,  ISSN  0385-2385

• IgA腎症の生検時の臨床データと病理所見の関連性

  鎌野 千佐子, 清水 章, 城 謙輔, 橋口 明典, 久野 敏, 片渕 律子, 川村 哲也

  日本腎臓学会誌 ((一社)日本腎臓学会)  61 ( 3 ) 395 - 395 2019.05

  Other, Joint Work,  ISSN  0385-2385

• 前立腺癌の腫瘍局在が診断・治療・予後に及ぼす影響

  松本 一宏, 高松 公晴, 武田 利和, 小坂 威雄, 田中 伸之, 森田 伸也, 水野 隆一, 篠島 利明, 菊地 栄次, 浅沼 宏, 橋口 明典, 陣崎 雅弘, 大家 基嗣

  日本泌尿器科学会総会 ((一社)日本泌尿器科学会総会事務局)  107回   PP1 - 075 2019.04

  Other, Joint Work

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• 免疫チェックポイント阻害薬投与後に抗GBM抗体型糸球体腎炎と尿細管間質性腎炎を併発した1例

  杉浦 康平, 大島 洋一, 中村 彰良, 堤 遼太郎, 圓谷 泰章, 杉原 晋之介, 加藤 亜唯, 緒方 大, 橋口 明典, 小松 素明

  日本腎臓学会誌, 

  2023.09

  , 

  (一社)日本腎臓学会

• IgA血管炎と鑑別を要した本態性クリオグロブリン血症性糸球体腎炎の一例

  堤 遼太郎, 大島 洋一, 中村 彰良, 杉浦 康平, 圓谷 泰章, 杉原 晋之介, 加藤 亜唯, 橋口 明典, 小松 素明

  日本腎臓学会誌, 

  2023.09

  , 

  (一社)日本腎臓学会

• SARS-CoV-2ワクチン接種後に発熱,蛋白尿,血尿を認め,腎生検でC3腎症と診断した1例

  中村 共生, 井田 真規子, 黄田 宗明, 重原 理宏, 神戸 香織, 荒木 崇志, 森永 正二郎, 橋口 明典

  日本腎臓学会誌, 

  2023.09

  , 

  (一社)日本腎臓学会

• ステロイドが著効したイムノタクトイド腎症の2例

  殿村 駿, 吉本 憲史, 満野 竜ノ介, 橋口 明典, 山口 慎太郎, 林 香

  日本腎臓学会誌, 

  2023.09

  , 

  (一社)日本腎臓学会

• ステロイド治療が有効であったFSGS型C3腎症の一例

  菊地 隆之, 深澤 佑介, 山中 真理子, 大久保 泰宏, 橋口 明典

  日本腎臓学会誌, 

  2023.09

  , 

  (一社)日本腎臓学会

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Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• GENERAL PATHOLOGY

  2024

• DISEASES OF ORGAN SYSTEMS

  2024

• GENERAL PATHOLOGY

  2023

• DISEASES OF ORGAN SYSTEMS

  2023

• GENERAL PATHOLOGY

  2022

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Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• 病理学各論（講義）

  Keio University

  2017.04

  -

  2018.03

  , 

  Lecture

• 臨床実習（病理診断部）

  Keio University

  2017.04

  -

  2018.03

  , 

  Laboratory work/practical work/exercise

• 病理学各論（実習）

  Keio University

  2017.04

  -

  2018.03

  , 

  Laboratory work/practical work/exercise

• 病理学総論（実習）

  Keio University

  2017.04

  -

  2018.03

  , 

  Laboratory work/practical work/exercise

• 病理学各論（講義）

  Keio University

  2016.04

  -

  2017.03

  , 

  Lecture

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Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• The Japanese Society of Pathology

  　

• Japanese Society of Nephrology

  　

• The Japanese Society of Digital Pathology