KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 1995.04

  -

  1997.03

  慶應義塾大学医学部, 病理学教室, 慶應義塾大学医学部助手（病理学）

• 1997.04

  -

  2007.03

  慶應義塾大学医学部, 病理学教室, 慶應義塾大学助手（医学部病理学）

• 2007.04

  -

  2013.11

  慶應義塾大学医学部, 病理学教室, 慶應義塾大学助教（医学部病理学）

• 2013.12

  -

  Present

  慶應義塾大学医学部, 病理学教室, 慶應義塾大学専任講師（医学部病理学）

Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1989.04

  -

  1995.03

  Keio University, School of Meicine

  University, Graduated

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士（医学）, Keio University, Dissertation, 2010.11

  Using immunofluorescent digital slide technology to quantify protein expression in archival paraffin-embedded tissue sections

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Human pathology

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• Digital Pathology

• Renal Pathology

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Granulomatous interstitial nephritis with CTLA-4 haploinsufficiency: a case report

  Kohatsu K., Suzuki T., Takimoto M., Matsui K., Hashiguchi A., Koike J., Shirai S.

  BMC Nephrology （BMC Nephrology)  23 （ 1 ） 367 2022.12

  Joint Work

  　View Summary

  Background: Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential inhibitory regulator of immune activation. CTLA-4 haploinsufficiency is known to be associated with dysregulation of FOXP3+ regulatory T cells, hyperactivation of effector T cells, and lymphocytic infiltration of multiple organs. However, there have only been a few reports of renal involvement with CTLA-4. Herein, we present a case of acute granulomatous tubulointerstitial nephritis (TIN) in a patient with CTLA-4 haploinsufficiency. Case presentation: A 44-year-old man presented with a 3-week history of fever and malaise, and subsequently developed acute kidney injury (AKI) a few days after treatment with levofloxacin (LVFX). A kidney biopsy and immunohistochemical staining revealed granulomatous TIN with dominantly infiltrating CD4+ T cells. General symptoms and renal impairment showed improvement after discontinuation of LVFX and initiation of oral steroids. However, they worsened following steroid tapering. Further, a colon biopsy analysis showed similar findings to the renal tissue analysis. We suspected that granulomatous TIN was possibly associated with CTLA-4 haploinsufficiency. Therefore, the patient was transferred to another hospital for further treatment of CTLA-4 haploinsufficiency using immunosuppressive agents. Conclusions: There have been few reports regarding renal involvement of CTLA-4 haploinsufficiency. In the present case, granulomatous TIN could have arisen due to instability of immune regulatory functions, such as CTLA-4 haploinsufficiency, and treatment with LVFX could have triggered immunologic activation and severe inflammation as well as renal dysfunction.

  • Access to Document (DOI)

• A girl with membranous nephropathy associated with ventriculoperitoneal shunt infection.

  Awazu M, Miyahara M, Chiga M, Hashiguchi A, Takahashi H

  CEN case reports  2022.09

  Joint Work

  • Access to Document (DOI)

• Structural modeling for Oxford histological classifications of immunoglobulin A nephropathy

  Kensuke Joh, Takashi Nakazato, Akinori Hashiguchi, Akira Shimizu, Ritsuko Katafuchi, Hideo Okonogi, Kentaro Koike, Keita Hirano, Nobuo Tsuboi, Tetsuya Kawamura, Takashi Yokoo, Ichiei Narita, Yusuke Suzuki

  PLoS ONE （PLoS ONE)  17 （ 9 September ） e0268731 2022.09

  Joint Work

  　View Summary

  In immunoglobulin A nephropathy (IgAN), Cox regression analysis can select independent prognostic variables for renal functional decline (RFD). However, the correlation of the selected histological variables with clinical and/or treatment variables is unknown, thereby making histology-based treatment decisions unreliable. We prospectively followed 946 Japanese patients with IgAN for a median of 66 mo. and applied structural equation modeling (SEM) to identify direct and indirect effects of histological variables on RFD as a regression line of estimated glomerular filtration rate (eGFR) via clinical variables including amount of proteinuria, eGFR, mean arterial pressure (MAP) at biopsy, and treatment variables such as steroid therapy with/without tonsillectomy (ST) and renin-angiotensin system blocker (RASB). Multi-layered correlations between the variables and RFD were identified by multivariate linear regression analysis and the model's goodness of fit was confirmed. Only tubular atrophy/interstitial fibrosis (T) had an accelerative direct effect on RFD, while endocapillary hypercellularity and active crescent (C) had an attenuating indirect effect via ST. Segmental sclerosis (S) had an attenuating indirect effect via eGFR and mesangial hypercellularity (M) had accelerative indirect effect for RFD via proteinuria. Moreover, M and C had accelerative indirect effect via proteinuria, which can be controlled by ST. However, both T and S had additional indirect accelerative effects via eGFR or MAP at biopsy, which cannot be controlled by ST. SEM identified a systemic path links between histological variables and RFD via dependent clinical and/or treatment variables. These findings lead to clinically applicable novel methodologies that can contribute to predict treatment outcomes using the Oxford classifications.

  • Access to Document (DOI)

• Diagnosis of monoclonal immunotactoid glomerulopathy with positive λ chain by immunoelectron microscopy.

  Sugita E, Sonoda H, Ryuzaki M, Hashiguchi A, Tokuyama H, Wakino S, Kanda T, Itoh H

  CEN case reports （Springer Science and Business Media LLC)   2022.06

  Joint Work

  • Access to Document (DOI)

• MPO-ANCA、抗GBM抗体共陽性かつ膜性腎症を合併した急速進行性糸球体腎炎に対して選択的血漿交換(SePE)を行った一例

  星 健太, 浦井 秀徳, 渡部 統, 中村 彰良, 橋口 明典, 村上 円人

  日本急性血液浄化学会雑誌 （(NPO)日本急性血液浄化学会)  13 （ 1 ） 48 - 51 2022.06

  Joint Work,  ISSN  2185-1085

  　View Summary

  当院において、半月体形成性糸球体腎炎を呈したMPO-ANCA、抗糸球体基底膜(glomerular basement membrane:GBM)抗体共陽性かつ膜性腎症を合併した急速進行性糸球体腎炎(rapidly progressive glomerulonephritis:RPGN)を経験した。血清Crの上昇がみられた早期に副腎皮質ステロイド、静注シクロホスファミドパルス療法(intravenous cyclophosphamide:IVCY)に加え選択的血漿交換(selective plasma exchange:SePE)を行ったところ、2抗体の陰性化を得られ肺障害を生じることなく腎機能障害も改善した。発症早期に、免疫抑制療法に加えて凝固因子補充不要なSePEを行うことが新規抗体産生抑制および抗体除去に有用であると考えられた。(著者抄録)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• The results of renal biopsies performed within the past thirty five years at Keio University Hospital, with an analysis in detail of the cases with membranous nephropathy.

  Hashiguchi, Akinori

  Journal of the Keio Medical Society （慶應医学会)  82 （ 3 ） 143 - 155 2005.09

  ISSN  03685179

Reviews, Commentaries, etc. 【 Display / hide 】

Reviews, Commentaries, etc. 【 Display / hide 】

• Minimal Change Disease Associated With Durvalumab

  Toda M.G., Fujii K., Kato A., Yoshifuji A., Komatsu M., Amino Y., Kitazono S., Hashiguchi A., Ryuzaki M.

  Kidney International Reports (Kidney International Reports)  6 ( 10 ) 2733 - 2734 2021.10

  Article, review, commentary, editorial, etc. (scientific journal), Joint Work,  ISSN  24680249

  • Access to Document (DOI)

• IgA腎症のOxford分類と日本分類(組織学的重症度分類)の腎機能予後予測に関する比較

  城 謙輔, 中里 毅, 橋口 明典, 清水 章, 久野 敏, 片渕 律子, 川村 哲也

  日本腎臓学会誌 ((一社)日本腎臓学会)  61 ( 3 ) 394 - 394 2019.05

  Other, Joint Work,  ISSN  0385-2385

• IgA腎症の生検時の臨床データと病理所見の関連性

  鎌野 千佐子, 清水 章, 城 謙輔, 橋口 明典, 久野 敏, 片渕 律子, 川村 哲也

  日本腎臓学会誌 ((一社)日本腎臓学会)  61 ( 3 ) 395 - 395 2019.05

  Other, Joint Work,  ISSN  0385-2385

• 前立腺癌の腫瘍局在が診断・治療・予後に及ぼす影響

  松本 一宏, 高松 公晴, 武田 利和, 小坂 威雄, 田中 伸之, 森田 伸也, 水野 隆一, 篠島 利明, 菊地 栄次, 浅沼 宏, 橋口 明典, 陣崎 雅弘, 大家 基嗣

  日本泌尿器科学会総会 ((一社)日本泌尿器科学会総会事務局)  107回   PP1 - 075 2019.04

  Other, Joint Work

• ステロイドパルス療法が有効であった腎移植後IgA腎症の1例

  森田 伸也, 高橋 遼平, 環 聡, 篠田 和伸, 香野 日高, 浅沼 宏, 橋口 明典, 脇野 修, 中川 健, 大家 基嗣

  日本臨床腎移植学会プログラム・抄録集 ((一社)日本臨床腎移植学会)  52回   264 - 264 2019.02

  Other, Joint Work

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Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• 妊娠末期に発症した膜性腎症の1例

  伊藤 智章, 中村 健吾, 篠塚 圭祐, 二木 功治, 緒方 謙太郎, 橋口 明典

  日本腎臓学会誌, 

  2022.10

  , 

  (一社)日本腎臓学会

• 間質にIgM-λ陽性の沈着物を認めたprimary renal lymphomaの一例

  川口 隆久, 唐澤 隆明, 橋口 明典, 大嶋 洋佑, 渡辺 雄祐, 熊谷 聡佑, 有馬 功一郎, 安藤 孝

  日本腎臓学会誌, 

  2022.10

  , 

  (一社)日本腎臓学会

• 膜性腎症とMPO-ANCA関連血管炎を合併した高齢男性の1例

  野間 悠太朗, 竜崎 正毅, 田島 敬也, 伊藤 亘, 松本 朋美, 坂口 知広, 森田 洋平, 貫井 紀宏, 池上 良, 橋口 明典, 久保田 英司

  日本腎臓学会誌, 

  2022.10

  , 

  (一社)日本腎臓学会

• 尿細管・間質病変主体のANCA関連血管炎の一例

  西岡 謙, 山口 慎太郎, 安田 格, 吉本 憲史, 田島 敬也, 林 香, 吉野 純, 橋口 明典, 神田 武志, 伊藤 裕

  日本腎臓学会誌, 

  2022.10

  , 

  (一社)日本腎臓学会

• キャッスルマン病で治療中に壊死性筋膜炎及び急性腎障害を呈した2型糖尿病患者の1例

  山口 慎太郎, 安達 京華, 吉本 憲史, 安田 格, 内山 清貴, 田島 敬也, 吉野 純, 橋口 明典, 神田 武志, 目黒 周, 伊藤 裕

  糖尿病, 

  2022.07

  , 

  (一社)日本糖尿病学会

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Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• GENERAL PATHOLOGY

  2022

• DISEASES OF ORGAN SYSTEMS

  2022

• GENERAL PATHOLOGY

  2021

• DISEASES OF ORGAN SYSTEMS

  2021

• GENERAL PATHOLOGY

  2020

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Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• 病理学各論（講義）

  Keio University

  2017.04

  -

  2018.03

  , 

  Lecture

• 臨床実習（病理診断部）

  Keio University

  2017.04

  -

  2018.03

  , 

  Laboratory work/practical work/exercise

• 病理学各論（実習）

  Keio University

  2017.04

  -

  2018.03

  , 

  Laboratory work/practical work/exercise

• 病理学総論（実習）

  Keio University

  2017.04

  -

  2018.03

  , 

  Laboratory work/practical work/exercise

• 病理学各論（講義）

  Keio University

  2016.04

  -

  2017.03

  , 

  Lecture

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Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• The Japanese Society of Pathology

  　

• Japanese Society of Nephrology

  　

• The Japanese Society of Digital Pathology