論文 - 金井　弥栄

Somatic mutations in IFN-γ-Signal molecules in human uterine leiomyosarcoma

T Hayashi, T Ichimura, M Kasai, K Sano, S Tonegawa, Y Kanai, ...

2018年

Somatic mutations in IFN-γ-Signal molecules in human uterine leiomyosarcoma

T Hayashi, T Ichimura, M Kasai, K Sano, S Tonegawa, Y Kanai, ...

2018年

Somatic mutations in IFN-γ-Signal molecules in human uterine leiomyosarcoma

T Hayashi, T Ichimura, M Kasai, K Sano, S Tonegawa, Y Kanai, ...

2018年

Risk estimation for hepatocellular carcinoma by DNA methylation analysis using high performance liquid chromatography

E Sunamura, T Yotani, F Arai, Y Tian, A Skeda, H Ojima, T Yoshida, ...

CANCER SCIENCE 109, 243-244 2018年

Risk estimation for hepatocellular carcinoma by DNA methylation analysis using high performance liquid chromatography

E Sunamura, T Yotani, F Arai, Y Tian, A Skeda, H Ojima, T Yoshida, ...

CANCER SCIENCE 109, 243-244 2018年

Risk estimation for hepatocellular carcinoma by DNA methylation analysis using high performance liquid chromatography

E Sunamura, T Yotani, F Arai, Y Tian, A Skeda, H Ojima, T Yoshida, ...

CANCER SCIENCE 109, 243-244 2018年

Risk estimation for hepatocellular carcinoma by DNA methylation analysis using high performance liquid chromatography

E Sunamura, T Yotani, F Arai, Y Tian, A Skeda, H Ojima, T Yoshida, ...

CANCER SCIENCE 109, 243-244 2018年

Patient Background and Responses in Providing Informed Consent for the National Cancer Center Biobank Project.

T Yamane, S Yamagami, N Yamashita, T Yoshida, K Tobinai, Y Kanai, ...

CANCER SCIENCE 109, 789-789 2018年

Patient Background and Responses in Providing Informed Consent for the National Cancer Center Biobank Project.

T Yamane, S Yamagami, N Yamashita, T Yoshida, K Tobinai, Y Kanai, ...

CANCER SCIENCE 109, 789-789 2018年

Patient Background and Responses in Providing Informed Consent for the National Cancer Center Biobank Project.

T Yamane, S Yamagami, N Yamashita, T Yoshida, K Tobinai, Y Kanai, ...

CANCER SCIENCE 109, 789-789 2018年

Patient Background and Responses in Providing Informed Consent for the National Cancer Center Biobank Project.

T Yamane, S Yamagami, N Yamashita, T Yoshida, K Tobinai, Y Kanai, ...

CANCER SCIENCE 109, 789-789 2018年

Novel method for DNA methylation analysis using high‐performance liquid chromatography and its clinical application

T Yotani, Y Yamada, E Arai, Y Tian, M Gotoh, M Komiyama, H Fujimoto, ...

Cancer science 109 (5), 1690-1700 2018年

Novel method for DNA methylation analysis using high‐performance liquid chromatography and its clinical application

T Yotani, Y Yamada, E Arai, Y Tian, M Gotoh, M Komiyama, H Fujimoto, ...

Cancer science 109 (5), 1690-1700 2018年

Novel method for DNA methylation analysis using high‐performance liquid chromatography and its clinical application

T Yotani, Y Yamada, E Arai, Y Tian, M Gotoh, M Komiyama, H Fujimoto, ...

Cancer science 109 (5), 1690-1700 2018年

Method for determining prognosis of renal cell carcinoma

Y Kanai, E Arai, Y Nemoto, T Yotani

US Patent App. 16/000,532 2018年

Method for determining prognosis of renal cell carcinoma

Y Kanai, E Arai, Y Nemoto, T Yotani

US Patent App. 16/000,532 2018年

Method for determining prognosis of renal cell carcinoma

Y Kanai, E Arai, Y Nemoto, T Yotani

US Patent App. 16/000,532 2018年

Hyaluronan binding protein involved in hyaluronan depolymerization(HYBID)はヒアルロン酸代謝を介して内軟骨性骨形成を制御する

下田 将之, 吉田 浩之, 水野 早希子, 弘實 透, 堀内 圭輔, 吉野 雄太, 原 英彰, 金井 弥栄, 井上 紳太郎, 石島 旨章, 岡田 保典

日本結合組織学会学術大会プログラム・抄録集 （日本結合組織学会）  49回   42 - 42 2017年06月

査読有り

長管骨形成に関わるHYBIDの役割解析

下田 将之, 吉田 浩之, 水野 早希子, 堀内 圭輔, 吉野 雄太, 原 英彰, 金井 弥栄, 井上 紳太郎, 石島 旨章, 岡田 保典

日本病理学会会誌 （(一社)日本病理学会）  106 （ 1 ） 307 - 307 2017年03月

査読有り,  ISSN  0300-9181

Genome-wide DNA methylation analysis during nonalcoholic steatohepatitis-related multistage hepatocarcinogenesis: Comparison with hepatitis virus-related carcinogenesis

金井 弥栄

CANCER RESEARCH （Carcinogenesis）  38 （ 13 ） :261 - 270 2017年

査読有り,  ISSN  0008-5472

　概要を見る

© The Author 2017. The aim of this study was to clarify the significance of DNA methylation alterations during non-alcoholic steatohepatitis (NASH)-related hepatocarcinogenesis. Single-CpG-resolution genome-wide DNA methylation analysis was performed on 264 liver tissue samples using the Illumina Infinium HumanMethylation450 BeadChip. After Bonferroni correction, 3331 probes showed significant DNA methylation alterations in 113 samples of non-cancerous liver tissue showing NASH (NASH-N) as compared with 55 samples of normal liver tissue (NLT). Principal component analysis using the 3331 probes revealed distinct DNA methylation profiles of NASH-N samples that were different from those of NLT samples and 37 samples of non-cancerous liver tissue showing chronic hepatitis or cirrhosis associated with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection (viral-N). Receiver operating characteristic curve analysis identified 194 probes that were able to discriminate NASH-N samples from viral-N samples with area under the curve values of more than 0.95. Jonckheere- Terptsra trend test revealed that DNA methylation alterations in NASH-N samples from patients without hepatocellular carcinoma (HCC) were inherited by or strengthened in NASH-N samples from patients with HCC, and then inherited by or further strengthened in 22 samples of NASH-related HCC (NASH-T) themselves. NASH- and NASH-related HCC-specific DNA methylation alterations, which were not evident in viral-N samples and 37 samples of HCC associated with HBV or HCV infection, were observed in tumor-related genes, such as WHSC1, and were frequently associated with mRNA expression abnormalities. These data suggested that NASH-specific DNA methylation alterations may participate in NASH-related multistage hepatocarcinogenesis.

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