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Affiliation
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School of Medicine, Department of Pathology Kanai Laboratory (Shinanomachi)
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Position
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Professor (Keio University)
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KANAI Yae
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National Cancer Center, Pathology Division, Research member
National Cancer Center, Pathology Division, Head of Section
National Cancer Center, Pathology Division, Chief
National Cancer Center Research Institute, Division of Molecular Pathology, Chief
National Cancer Center Research Institute, Deputy Director
Keio University, Medical School
University, Graduated
Keio University, Postgraduate School, Keio University School of Medicine, Pathology Course
Graduate School, Completed
医師免許, 1989.05
死体解剖資格, 1992.02
日本病理学会病理専門医, 1994.08
日本臨床細胞学会細胞診専門医, 1998.12
日本病理学会病理専門医研修指導医, 2006.04
Molecular pathology
Tumor pathology
DNA methylation
Multilayer/integrative comics analysis
Genitourinary Pathology
加藤 光保, 金井 弥栄, 菅野 祐幸, 青笹 克之, 医歯薬出版, 2021
DNA and Histone Methylation as Cancer Targets
Arai E, Yotani T, Kanai Y., Elsevier, 2017
Scope: Liver Cancer
DNA and Histone Methylation in Liver Cancer
Arai E., Yotani T., Kanai Y., Cancer Drug Discovery and Development, 2017
DNA Methylation Alterations in Human Cancers
Yae Kanai, Eri Arai, Elsevier Inc., 2012.12
DNA methylation alterations in human cancers. In: Epigenetics in Human Disease. ed. Tollefsbol T.
Kanai Y, Arai E., Elsevier, Amsterdam, 2012, Page: 29-52
Epigenetic profile of Japanese supercentenarians: a cross-sectional study.
Komaki S, Nagata M, Arai E, Otomo R, Ono K, Abe Y, Ohmomo H, Umekage S, Shinozaki NO, Hachiya T, Sutoh Y, Otsuka-Yamasaki Y, Arai Y, Hirose N, Yoneyama A, Okano H, Sasaki M, Kanai Y, Shimizu A
The lancet. Healthy longevity 4 ( 2 ) e83 - e90 2023.02
Single-cell analysis reveals a CD4+ T cell cluster that correlates with PD-1 blockade efficacy.
H Kagamu, S Yamasaki, S Kitano, O Yamaguchi, A Mouri, A Shiono, ...
Cancer Research, CAN-22 (Cancer research) 82 ( 24 ) 4641 - 4653 2022.10
ISSN 0008-5472
The Anterior Eye Chamber as a Visible Medium for In Vivo Tumorigenicity Tests
E Inagaki, E Arai, S Hatou, T Sayano, H Taniguchi, K Negishi, Y Kanai, ...
Stem Cells Translational Medicine (Stem cells translational medicine) 11 ( 8 ) 841 - 849 2022.06
Accepted, ISSN 2157-6564
Lymphomatoid gastropathy/NK-cell enteropathy involving the stomach and intestine
M Nakajima, M Shimoda, K Takeuchi, A Dobashi, T Kanai, Y Kanai, ...
Journal of Clinical and Experimental Hematopathology, 21032 (The Japanese Society for Lymphoreticular Tissue Research) advpub ( 0 ) 114 - 118 2022.04
Accepted, ISSN 1346-4280
Alteration of protein glycosylation in renal carcinogenesis
Kitazume Yoshiko, Arai Eri, Matsuda Atsushi, Kakuda Shuichi, Ohara Kentaro, Maeshima Akiko, Kuno Atsushi, Yoshida Teruhiko, Kanai Yae
CANCER SCIENCE 113 1284 - 1284 2022.02
ISSN 1347-9032
Kanai, Yae
科学研究費補助金研究成果報告書 2020
Kanai, Yae
科学研究費補助金研究成果報告書 2019
Risk estimation of pancreatic adenocarcinomas based on epigenome-wide association study
Kanai, Yae
科学研究費補助金研究成果報告書 2018
Cross-organ analysis of DNA methylation alteration during multi-organ carcinogenesis
Kanai, Yae
科学研究費補助金研究成果報告書 2018
Analysis of cancer-associated fibroblasts from the perspective of proteinases and epigenetics
Kanai, Yae
科学研究費補助金研究成果報告書 2018
非アルコール性脂肪性肝炎由来肝細胞がんにおけるSPHK1ならびにLTB遺伝子のDNAメチル化異常(DNA methylation alterations of SPHK1 and LTB in non-alcoholic steatohepatitis-related hepatocellular carcinomas)
津田 昇, 田 迎, 藤本 真央, 藏本 純子, 牧内 里美, 尾島 英知, 後藤 政広, 平岡 伸介, 吉田 輝彦, 金井 弥栄, 新井 恵吏
日本癌学会総会記事 ((一社)日本癌学会) 81回 E - 1005 2022.09
ISSN 0546-0476
諸臓器の多段階発がん過程早期に普遍的なDNAメチル化プロファイル(Genome-wide DNA methylation profiling during the early step of multistage carcinogenesis in various organs)
中山 雄二, 新井 恵吏, 藤本 真央, 津田 昇, 牧内 里美, 田 迎, 藏本 純子, 金井 弥栄
日本癌学会総会記事 ((一社)日本癌学会) 81回 P - 1099 2022.09
ISSN 0546-0476
誘導性CRISPR/dCas9を用いりC19MCの肝内胆管癌オルガノイドの分化における役割の解明(Exploring the Role of C19MC on the differentiation Status of IHCC Organoids by Inducible CRISPR/dCas9)
葉 子祥, 松崎 潤太郎, 及川 千尋, 金井 弥栄, 齋藤 義正
日本癌学会総会記事 ((一社)日本癌学会) 81回 J - 1017 2022.09
ISSN 0546-0476
肺腺がんのDNAメチル化プロファイルに対する免疫微小環境の影響(Impact of the immune microenvironment on genome-wide DNA methylation profiles of lung adenocarcinomas)
河原 徹, 藤本 真央, 下田 将之, 淺村 尚生, 金井 弥栄, 新井 恵吏
日本癌学会総会記事 ((一社)日本癌学会) 81回 P - 1093 2022.09
ISSN 0546-0476
全血由来DNAにおけるエピゲノム関連解析による淡明細胞型腎細胞がんの検出に有用なDNAメチル化バイオマーカー候補の同定(Potential DNA methylation biomarkers for ccRCC identified by a whole blood-based epigenome-wide association study)
大桃 秀樹, 新井 恵吏, 吉田 輝彦, 金井 弥栄, 清水 厚志
日本癌学会総会記事 ((一社)日本癌学会) 81回 P - 1088 2022.09
ISSN 0546-0476
Quantification of DNA methylation for carcinogenic risk estimation in patients with non-alcoholic steatohepatitis.
Junko Kuramoto, Eri Arai, Mao Fujimoto, Ying Tian, Yuriko Yamada, Takuya Yotani, Satomi Makiuchi, Noboru Tsuda, Hidenori Ojima, Moto Fukai, Yosuke Seki, Kazunori Kasama, Nobuaki Funahashi, Haruhide Udagawa, Takao Nammo, Kazuki Yasuda, Akinobu Taketomi, Tatsuya Kanto, Yae Kanai.
America Association for Cancer Research Annual Meeting 2022,
Correlations between genome-wide DNA methylation profiles and genomic driver aberrations during multistage lung adenocarcinogenesis.
Kenichi Hamada, Ying Tian, Mao Fujimoto, Yoriko Takahashi, Takashi Kohno, Koji Tsuta, Shun-ichi Watanabe, Teruhiko Yoshida, Hisao Asamura, Yae Kanai, Eri Arai.
America Association for Cancer Research Annual Meeting 2021,
Simple vs. comprehensive prediction models of homologous recombination deficiency based on mutational and clinical features in three independent breast cancer datasets.
Maki Tanioka, Tomoko Watanabe, Takayuki Honda, Hirohiko Totsuka, Eri Arai, Yae Kanai, Kouya Shiraishi, Kenji Tamura, Takashi Kohno.
America Association for Cancer Research Annual Meeting 2020,
Establishment of diagnostic criteria for upper urinary tract urothelial carcinoma based on genome-wide DNA methylation analysis.
Mao Fujimoto, Eri Arai, Koji Tsumura, Takuya Yotani, Yuriko Yamada, Yoriko Takahashi, Akiko Miyagi Maeshima, Hiroyuki Fujimoto, Teruhiko Yoshida, Yae Kanai.
America Association for Cancer Research Annual Meeting 2020 ,
Intratumor DNA methylation heterogeneity reflects differentiation plasticity and malignant progression of human glioblastoma: a methylome analysis using microdissected specimens.
Kentaro Ohara, Eri Arai, Hikaru Sasaki, Masashi Nakatsukasa, Kazunari Yoshida, Yae Kanai.
11th AACR-JCA Joint Conference on Breakthroughs in Cancer. (Hawaii) ,
Poster presentation
Keio University, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), No Setting
Keio University, Grants-in-Aid for Scientific Research, Saito Yoshimasa, Challenging Research (Exploratory), No Setting
Established epigenetic treatment for chemotherapy-resistant metastatic bladder cancer
University of Toyama, Grants-in-Aid for Scientific Research, Nishiyama Naotaka, Grant-in-Aid for Scientific Research (C), No Setting
免疫応答モニタリングによるがん免疫の全容理解に基づく新規層別化マーカーの開発
日本医療研究開発機構, 次世代治療・診断実現のための創薬基盤技術開発事業, Coinvestigator(s)
NASH 肝がんの リピド・ゲノミクス 研究に基づく個別化医療の開発
日本医療研究開発機構, 肝炎等克服実用化研究事業, Coinvestigator(s)
尿路上皮癌のリスク判定方法
Date applied: PCT/JP2019/011442 2019.03
Patent, Joint
子宮体癌の予後の判定方法
Date applied: 特願2018-228276 2018.11
Patent, Joint
Method for assessing risk of hepatocellular carcinoma
Date applied: PCT/JP2018/031092 2018.08
Patent, Joint
尿路上皮癌のリスク判定方法
Date applied: 特願2018-051464 2018.03
Patent, Single
肝細胞癌のリスク評価方法
Date applied: 特願2017-160284 2017.08
Patent, Joint
JCA Women Scientists Award
Yae Kanai, 2018.09, Japanese Cancer Association, Molecular pathological approach ti epigenome mechanisms of multistage human carcinogenesis
Type of Award: Award from Japanese society, conference, symposium, etc.
Tamiya Prize
2006.02, Foundation for Promotion of Cancer Research, Cancer development, invasion and metastasis: Epigenetic research based on histopathological approach
Type of Award: Award from publisher, newspaper, foundation, etc.
Incitement Award of the Japanese Cancer Association
2003.09, Japanese Cancer Association, DNA methylation abnormalities participating in multistage human carcinogenesis
Type of Award: Award from Japanese society, conference, symposium, etc.
Incitement Award of the Japanese Society of Pathology
Yae Kanai, 2002.03, Japanese Society of Pathology, DNA methylation alterations during multistage human carcinogenesis
Type of Award: Award from Japanese society, conference, symposium, etc.
Baelz Prize
Setsuo Hirohashi, Atsushi Ochiai, Yae Kanai, 2000.11, ベルツ財団, Inactivation of E-cadherin cell adhesion system in human cancer invasion and metastasis
GENERAL PATHOLOGY
2023
DISEASES OF ORGAN SYSTEMS
2023
CUTTING-EDGE GENOMIC MEDICINE
2023
BASIC ONCOLOGY
2023
ADVANCED PATHOLOGY
2023
General Pathology
Keio University
Full academic year, Lecture
Diseases of organ systems
Keio University
Full academic year, Lecture
症例検討 (基礎臨床統合医学)
Keio University
医学概論 (大学院医学研究科修士課程)
Keio University
医学特別講義 (大学院医学研究科博士課程)
Keio University
Associate member, Science Council of Japan,
日本病理学会: 拡大常任理事・学術評議員 (病理専門医、病理専門医研修指導医、分子病理専門医、ゲノム病理診断検討委員会委員長・ゲノム研究用病理組織検体取扱い規程策定委員会委員長・ゲノム病理標準化講習会委員会委員長・教育委員会委員長・病理診療ガイドライン作成委員会委員長・固形癌HER2病理診断ガイドライン策定ワーキンググループ委員長・企画委員会委員・学術委員会委員・編集委員会委員・ゲノム診療用病理組織検体取扱い規程策定ワーキンググループ委員・病理専門医制度運営委員会委員等),
日本癌学会: 評議員 (女性科学者委員会委員),
日本臨床細胞学会
日本エピジェネティクス研究会 (幹事)
厚生労働省がんゲノム医療中核拠点病院等の指定要件に関するワーキンググループ構成員
日本学術振興会学術システム研究センタープログラムオフィサー (専門研究員)
科学技術振興機構NBDCヒトデータベース倫理審査委員会委員
日本医療研究開発機構プログラムオフィサー・課題評価委員会委員・アドバイザー
文部科学省科学研究費補助金における評価に関する委員会生物系委員会委員