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Affiliation
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School of Medicine, Department of Pathology Kanai Laboratory (Shinanomachi)
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Position
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Professor (Keio University)
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KANAI Yae
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National Cancer Center, Pathology Division, Research member
National Cancer Center, Pathology Division, Head of Section
National Cancer Center, Pathology Division, Chief
National Cancer Center Research Institute, Division of Molecular Pathology, Chief
National Cancer Center Research Institute, Deputy Director
Keio University, Medical School
University, Graduated
Keio University, Postgraduate School, Keio University School of Medicine, Pathology Course
Graduate School, Completed
医師免許, 1989.05
死体解剖資格, 1992.02
日本病理学会病理専門医, 1994.08
日本臨床細胞学会細胞診専門医, 1998.12
日本病理学会病理専門医研修指導医, 2006.04
Molecular pathology
Tumor pathology
DNA methylation
Multilayer/integrative comics analysis
Genitourinary Pathology
藏本 純子, 金井 弥栄, 鈴木 秀和, 羊土社, 2023
加藤 光保, 金井 弥栄, 菅野 祐幸, 青笹 克之, 医歯薬出版, 2021
DNA and Histone Methylation as Cancer Targets
Arai E, Yotani T, Kanai Y., Elsevier, 2017
Scope: Liver Cancer
DNA and Histone Methylation in Liver Cancer
Arai E., Yotani T., Kanai Y., Cancer Drug Discovery and Development, 2017
DNA Methylation Alterations in Human Cancers
Yae Kanai, Eri Arai, Elsevier Inc., 2012.12
Molecular subtypes of lung adenocarcinoma present distinct immune tumor microenvironments
Fukuda H., Arai K., Mizuno H., Nishito Y., Motoi N., Arai Y., Hiraoka N., Shibata T., Sonobe Y., Kayukawa Y., Hashimoto E., Takahashi M., Fujii E., Maruyama T., Kuwabara K., Nishizawa T., Mizoguchi Y., Yoshida Y., Watanabe S.i., Yamashita M., Kitano S., Sakamoto H., Nagata Y., Mitsumori R., Ozaki K., Niida S., Kanai Y., Hirayama A., Soga T., Tsukada K., Yabuki N., Shimada M., Kitazawa T., Natori O., Sawada N., Kato A., Yoshida T., Yasuda K., Ochiai A., Tsunoda H., Aoki K.
Cancer Science (Cancer Science) 115 ( 6 ) 1763 - 1777 2024.06
ISSN 13479032
Aberrant cell adhesiveness due to DNA hypermethylation of KLF11 in papillary urothelial carcinomas
Tsumura K., Fujimoto M., Tian Y., Kawahara T., Fujimoto H., Maeshima A.M., Nakagawa T., Kume H., Yoshida T., Kanai Y., Arai E.
Experimental and Molecular Pathology (Experimental and Molecular Pathology) 137 104908 2024.06
ISSN 00144800
Molecular pathological approach to cancer epigenomics and its clinical application
Kanai Y.
Pathology International (Pathology International) 74 ( 4 ) 167 - 186 2024.04
ISSN 13205463
特集 ゲノム医学を外科診療に活かす! ゲノム医療の最新動向 ゲノム解析に適した手術検体の取り扱い
金井 弥栄
臨床外科 (株式会社医学書院) 79 ( 2 ) 138 - 143 2024.02
ISSN 03869857
Kuramoto J, Kobayashi K, Hirai I, Nakamura Y, Funakoshi T, Kanai Y
Pathology Research and Practice (Pathology Research and Practice) 249 154775 2023.09
ISSN 03440338
Kanai, Yae
科学研究費補助金研究成果報告書 2020
Kanai, Yae
科学研究費補助金研究成果報告書 2019
Risk estimation of pancreatic adenocarcinomas based on epigenome-wide association study
Kanai, Yae
科学研究費補助金研究成果報告書 2018
Cross-organ analysis of DNA methylation alteration during multi-organ carcinogenesis
Kanai, Yae
科学研究費補助金研究成果報告書 2018
Analysis of cancer-associated fibroblasts from the perspective of proteinases and epigenetics
Kanai, Yae
科学研究費補助金研究成果報告書 2018
【ゲノム医学を外科診療に活かす!】ゲノム医療の最新動向 ゲノム解析に適した手術検体の取り扱い
金井 弥栄
臨床外科 ((株)医学書院) 79 ( 2 ) 138 - 143 2024.02
ISSN 0386-9857
難治性精巣腫瘍に対して化学療法とdesperation surgeryを施行し完全奏効を得た一例
蛭田 慎之介, 田中 伸之, 小森 貴大, 岩澤 智裕, 小坂 威雄, 水野 隆一, 浅沼 宏, 大家 基嗣, 新井 恵吏, 金井 弥栄
泌尿器外科 (医学図書出版(株)) 36 ( 10 ) 1167 - 1167 2023.10
ISSN 0914-6180
尿道憩室に存在した腸上皮に発生した腺癌の1例
星野 佑介, 松本 一宏, 馬場 優人, 秋田 大宇, 新井 恵吏, 安水 洋太, 田中 伸之, 武田 利和, 森田 伸也, 小坂 威雄, 水野 隆一, 浅沼 宏, 陣崎 雅弘, 金井 弥栄, 大家 基嗣
泌尿器外科 (医学図書出版(株)) 36 ( 10 ) 1162 - 1163 2023.10
ISSN 0914-6180
がん免疫研究の基礎と臨床 抗腫瘍免疫を司る2つのTh1-like CD4+T-cell clusters
各務 博, 山崎 智, 北野 滋久, 金井 弥栄, 柴田 龍弘, 堀本 勝久
肺癌 ((NPO)日本肺癌学会) 63 ( 5 ) 404 - 404 2023.10
ISSN 0386-9628
日米の非アルコール性脂肪性肝炎由来肝細胞がんにおけるゲノム網羅的DNAメチル化解析(Genome-wide DNA methylation analysis of non-alcoholic steatohepatitis in Japanese and American cohorts)
藏本 純子, 新井 恵吏, 藤本 真央, 牧内 里美, 津田 昇, 安田 和基, 平岡 伸介, 吉田 輝彦, Evason Kimberley, 金井 弥栄
日本癌学会総会記事 ((一社)日本癌学会) 82回 1615 - 1615 2023.09
ISSN 0546-0476
Quantification of DNA methylation for carcinogenic risk estimation in patients with non-alcoholic steatohepatitis.
Junko Kuramoto, Eri Arai, Mao Fujimoto, Ying Tian, Yuriko Yamada, Takuya Yotani, Satomi Makiuchi, Noboru Tsuda, Hidenori Ojima, Moto Fukai, Yosuke Seki, Kazunori Kasama, Nobuaki Funahashi, Haruhide Udagawa, Takao Nammo, Kazuki Yasuda, Akinobu Taketomi, Tatsuya Kanto, Yae Kanai.
America Association for Cancer Research Annual Meeting 2022,
Correlations between genome-wide DNA methylation profiles and genomic driver aberrations during multistage lung adenocarcinogenesis.
Kenichi Hamada, Ying Tian, Mao Fujimoto, Yoriko Takahashi, Takashi Kohno, Koji Tsuta, Shun-ichi Watanabe, Teruhiko Yoshida, Hisao Asamura, Yae Kanai, Eri Arai.
America Association for Cancer Research Annual Meeting 2021,
Simple vs. comprehensive prediction models of homologous recombination deficiency based on mutational and clinical features in three independent breast cancer datasets.
Maki Tanioka, Tomoko Watanabe, Takayuki Honda, Hirohiko Totsuka, Eri Arai, Yae Kanai, Kouya Shiraishi, Kenji Tamura, Takashi Kohno.
America Association for Cancer Research Annual Meeting 2020,
Establishment of diagnostic criteria for upper urinary tract urothelial carcinoma based on genome-wide DNA methylation analysis.
Mao Fujimoto, Eri Arai, Koji Tsumura, Takuya Yotani, Yuriko Yamada, Yoriko Takahashi, Akiko Miyagi Maeshima, Hiroyuki Fujimoto, Teruhiko Yoshida, Yae Kanai.
America Association for Cancer Research Annual Meeting 2020 ,
Intratumor DNA methylation heterogeneity reflects differentiation plasticity and malignant progression of human glioblastoma: a methylome analysis using microdissected specimens.
Kentaro Ohara, Eri Arai, Hikaru Sasaki, Masashi Nakatsukasa, Kazunari Yoshida, Yae Kanai.
11th AACR-JCA Joint Conference on Breakthroughs in Cancer. (Hawaii) ,
Poster presentation
Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), No Setting
尿路上皮がんに対する新規エピゲノム解析による治療効果予測バイオマーカー開発
Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), No Setting
Keio University, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), No Setting
Keio University, Grants-in-Aid for Scientific Research, Saito Yoshimasa, Challenging Research (Exploratory), No Setting
Established epigenetic treatment for chemotherapy-resistant metastatic bladder cancer
University of Toyama, Grants-in-Aid for Scientific Research, Nishiyama Naotaka, Grant-in-Aid for Scientific Research (C), No Setting
尿路上皮癌のリスク判定方法
Date applied: PCT/JP2019/011442 2019.03
Patent, Joint
子宮体癌の予後の判定方法
Date applied: 特願2018-228276 2018.11
Patent, Joint
Method for assessing risk of hepatocellular carcinoma
Date applied: PCT/JP2018/031092 2018.08
Patent, Joint
尿路上皮癌のリスク判定方法
Date applied: 特願2018-051464 2018.03
Patent, Single
肝細胞癌のリスク評価方法
Date applied: 特願2017-160284 2017.08
Patent, Joint
JCA Women Scientists Award
Yae Kanai, 2018.09, Japanese Cancer Association, Molecular pathological approach ti epigenome mechanisms of multistage human carcinogenesis
Type of Award: Award from Japanese society, conference, symposium, etc.
Tamiya Prize
2006.02, Foundation for Promotion of Cancer Research, Cancer development, invasion and metastasis: Epigenetic research based on histopathological approach
Type of Award: Award from publisher, newspaper, foundation, etc.
Incitement Award of the Japanese Cancer Association
2003.09, Japanese Cancer Association, DNA methylation abnormalities participating in multistage human carcinogenesis
Type of Award: Award from Japanese society, conference, symposium, etc.
Incitement Award of the Japanese Society of Pathology
Yae Kanai, 2002.03, Japanese Society of Pathology, DNA methylation alterations during multistage human carcinogenesis
Type of Award: Award from Japanese society, conference, symposium, etc.
Baelz Prize
Setsuo Hirohashi, Atsushi Ochiai, Yae Kanai, 2000.11, ベルツ財団, Inactivation of E-cadherin cell adhesion system in human cancer invasion and metastasis
PATHOLOGY: SEMINAR
2024
PATHOLOGY: PRACTICE
2024
PATHOLOGY
2024
GENERAL PATHOLOGY
2024
DISEASES OF ORGAN SYSTEMS
2024
General Pathology
Keio University
Full academic year, Lecture
Diseases of organ systems
Keio University
Full academic year, Lecture
症例検討 (基礎臨床統合医学)
Keio University
医学概論 (大学院医学研究科修士課程)
Keio University
医学特別講義 (大学院医学研究科博士課程)
Keio University
Associate member, Science Council of Japan,
日本病理学会: 拡大常任理事・学術評議員 (病理専門医、病理専門医研修指導医、分子病理専門医、ゲノム病理診断検討委員会委員長・ゲノム研究用病理組織検体取扱い規程策定委員会委員長・ゲノム病理標準化講習会委員会委員長・教育委員会委員長・病理診療ガイドライン作成委員会委員長・固形癌HER2病理診断ガイドライン策定ワーキンググループ委員長・企画委員会委員・学術委員会委員・編集委員会委員・ゲノム診療用病理組織検体取扱い規程策定ワーキンググループ委員・病理専門医制度運営委員会委員等),
日本癌学会: 評議員 (女性科学者委員会委員),
日本臨床細胞学会
日本エピジェネティクス研究会 (幹事)
厚生労働省がんゲノム医療中核拠点病院等の指定要件に関するワーキンググループ構成員
日本学術振興会学術システム研究センタープログラムオフィサー (専門研究員)
科学技術振興機構NBDCヒトデータベース倫理審査委員会委員
日本医療研究開発機構プログラムオフィサー・課題評価委員会委員・アドバイザー
文部科学省科学研究費補助金における評価に関する委員会生物系委員会委員