Ueno, Akihisa

写真a

Affiliation

School of Medicine, Department of Pathology (Shinanomachi)

Position

Instructor

Career 【 Display / hide

  • 2000.05
    -
    2002.04

    Keio University School of Medicine, Department of Radiology, Resident(Course)

  • 2002.05
    -
    2003.06

    Keio University School of Medicine, Department of Radiology, Postgraduate Training Course

  • 2003.07
    -
    2005.06

    Nippon Koukan Hospital, Department of Radiolgy, Doctor

  • 2005.07
    -
    2006.04

    Keio University School of Medicine, Department of Radiology, Postgraduate Training Course

  • 2006.05
    -
    2010.03

    Keio University School of Medicine, Department ofRadiology, Assistant

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Academic Background 【 Display / hide

  • 1993.04
    -
    2000.03

    Chiba University, 医学部

    University, Graduated

  • 2010.04
    -
    2014.03

    Keio University, 医学研究科, 医学研究系

    Graduate School, Withdrawal after completion of doctoral course requirements, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(医学), Keio University, Coursework, 2015.01

    OATP1B3 expression is strongly associated with Wnt/β-catenin signalling and represents the transporter of gadoxetic acid in hepatocellular carcinoma.

Licenses and Qualifications 【 Display / hide

  • Medical licence, 2000.06

  • 放射線診断専門医, 2005.10

 

Research Areas 【 Display / hide

  • Human pathology

  • Experimental pathology

  • Radiation science

Research Keywords 【 Display / hide

  • Hepatocellular carcinoma

Research Themes 【 Display / hide

  • 肝細胞癌の画像病理対比, 

    2009.04
    -
    Present

 

Books 【 Display / hide

  • 腹部のCT 第3版

    上野彰久 佐藤浩三 松坂陽至 上野彰久, メディカルサイエンス・インターナショナル, 2017.04

    Scope: III. 肝臓 IV.胆嚢・胆管

  • EOB-MRI/Sonazoid超音波による肝癌の診断と治療

    上野彰久 坂元亨宇, 医学書院, 2013.06

    Scope: 第7章 EOB-MRIの早期歓談と異型結節(DN)の鑑別診断能  1. 早期肝癌の病理診断 1分子病理

  • 腹部のCT 第2版

    上野彰久 倉田忠宜, メディカルサイエンス・インターナショナル, 2010.04

    Scope: V. 胆嚢・胆管

Papers 【 Display / hide

  • Characterization of spatial distribution of tumor-infiltrating CD8<sup>+</sup> T cells refines their prognostic utility for pancreatic cancer survival

    Masugi Y., Abe T., Ueno A., Fujii-Nishimura Y., Ojima H., Endo Y., Fujita Y., Kitago M., Shinoda M., Kitagawa Y., Sakamoto M.

    Modern Pathology (Modern Pathology)  32 ( 10 ) 1495 - 1507 2019

    ISSN  08933952

     View Summary

    © 2019, United States & Canadian Academy of Pathology. The abundance of cytotoxic T-cell infiltrates has important implications for patient outcome and therapeutic design for pancreatic ductal adenocarcinoma. However, intratumoral heterogeneity remains a challenge to understanding the complex immune microenvironment. We hypothesized that characterizing CD8+ cell distribution within pancreatic adenocarcinoma tissues might refine the prognostic value of tumor-infiltrating CD8+ lymphocytes. Using multiplex immunohistochemistry-based image analysis on whole-tissue sections of 214 pancreatic ductal adenocarcinomas, we measured CD8+ cell densities in the tumor center, the tumor margin, and the whole tumor, along with the proximity of CD8+ cells to carcinoma cells. Multivariable Cox regression analysis was performed to assess the associations of CD8+ cell densities with pancreatic cancer-specific survival, adjusting for clinicopathologic and immune-related features, including tumor expressions of TP53, SMAD4, and the programmed cell death 1 ligand 1 (CD274, PD-L1) and the extent of tertiary lymphoid structures. There was substantial heterogeneity in CD8+ cell density, with the mean density in the tumor center less than half that in the tumor margin. Tumor CD274 expression and extensive tertiary lymphoid structures were appeared to be associated with higher CD8+ cell density in the tumor margin (P = 0.037 and P = 0.005, respectively), but not with that in the tumor center (P > 0.50). The association of higher CD8+ cell density with prolonged survival was significant for the whole tumor (Ptrend = 0.009); however, the association was stronger for the tumor center (Ptrend = 0.002) and insignificant for the tumor margin (Ptrend = 0.07). Tumor cell–CD8+ cell distance correlated strongly with CD8+ cell density, whereas the density of CD8+ cells proximate to cancer cells exhibited no prognostic association. In conclusion, spatial computational analysis on pancreatic ductal adenocarcinoma reveals the prognostic validity of CD8+ cell density in the tumor center, where CD8+ cell infiltration is ununiformly restricted, likely suggesting pro-tumorigenic roles of the immunosuppressive tumor microenvironment of pancreatic cancer.

  • Long-term complete response of advanced hepatocellular carcinoma treated with multidisciplinary therapy including reduced dose of sorafenib: case report and review of the literature

    Shinoda, Masahiro, Kishida, Norihiro, Itano, Osamu, Ei, Shigenori, Ueno, Akihisa, Kitago, Minoru, Abe, Yuta, Hibi, Taizo, Yagi, Hiroshi, Masugi, Yohei, Tanabe, Minoru, Aiura, Koichi, Sakamaoto, Michiie, Tanimoto, Akihiro, Kitagawa, Yuko

    WORLD JOURNAL OF SURGICAL ONCOLOGY 13 2015.04

    Research paper (scientific journal),  ISSN  1477-7819

  • OATP1B3 expression is strongly associated with Wnt/beta-catenin signalling and represents the transporter of gadoxetic acid in hepatocellular carcinoma

    Ueno, Akihisa, Masugi, Yohei, Yamazaki, Ken, Komuta, Mina, Effendi, Kathryn, Tanami, Yutaka, Tsujikawa, Hanako, Tanimoto, Akihiro, Okuda, Shigeo, Itano, Osamu, Kitagawa, Yuko, Kuribayashi, Sachio, Sakamoto, Michiie

    JOURNAL OF HEPATOLOGY 61 ( 5 ) 1080 - 1087 2014.11

    Research paper (scientific journal),  ISSN  0168-8278

  • Cystic tumor of the liver without ovarian-like stroma or bile duct communication: two case reports and a review of the literature

    Kishida, Norihiro, Shinoda, Masahiro, Masugi, Yohei, Itano, Osamu, Fujii-Nishimura, Yoko, Ueno, Akihisa, Kitago, Minoru, Hibi, Taizo, Abe, Yuta, Yagi, Hiroshi, Tanimoto, Akihiro, Tanabe, Minoru, Sakamaoto, Michiie, Kitagawa, Yuko

    WORLD JOURNAL OF SURGICAL ONCOLOGY 12   1080 - 1087 2014.07

    Research paper (scientific journal),  ISSN  1477-7819

  • Preoperative and intraoperative assessment of myometrial invasion in endometrial cancer: comparison of magnetic resonance imaging and frozen sections

    Kisu, Iori, Banno, Kouji, Lin, Li-Yu, Ueno, Akihisa, Abe, Takayuki, Kouyama, Keisuke, Okuda, Shigeo, Masugi, Yohei, Umene, Kiyoko, Nogami, Yuya, Tsuji, Kosuke, Masuda, Kenta, Ueki, Arisa, Kobayashi, Yusuke, Yamagami, Wataru, Susumu, Nobuyuki, Aoki, Daisuke

    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 92 ( 5 ) 525 - 535 2013.05

    Research paper (scientific journal),  ISSN  0001-6349

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Reviews, Commentaries, etc. 【 Display / hide

  • 大腸癌肝転移-最新の治療ストラテジー】 大腸癌肝転移の画像診断

    上野彰久 陣崎雅弘

    臨床外科 71 ( 4 ) 393 - 403 2016.04

    Introduction and explanation (commerce magazine), Joint Work

  • 【エコーとの対比で学ぶCT・MRI画像の読み方-各モダリティの利点と弱点を理解するために】 各領域におけるエコー・CT・MRI画像の有用性 消化器領域 肝臓

    上野彰久 大熊潔

    Medical Technology 43 ( 12 ) 1243 - 1257 2015.12

    Introduction and explanation (commerce magazine), Joint Work,  ISSN  0389-1887

  • 【胆嚢・胆管と膵臓の画像診断update:病理・画像・治療のtriangle】 胆道疾患の画像

    上野彰久

    臨床画像 31 ( 11 ) 1300 - 1314 2015.11

    Introduction and explanation (commerce magazine), Single Work,  ISSN  0911-1069

  • 【肝胆膵イメージング:画像が映す分子病理】 肝疾患 肝細胞癌のGd-EOB-DTPA造影を規定するメカニズム

    上野彰久 坂本亨宇

    肝・胆・膵 70 ( 4 ) 507 - 513 2015.04

    Introduction and explanation (commerce magazine), Joint Work,  ISSN  0389-4991

  • 消化器MRIの読み方 臨床に役立つ最新知識と読影のポイント EOBの適応と臨床的有用性

    上野彰久 谷本伸弘

    臨床消化器内科 29 ( 6 ) 739 - 746 2014

    Introduction and explanation (commerce magazine),  ISSN  0911-061X

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Presentations 【 Display / hide

  • 胆嚢原発の脱分化型脂肪肉腫の一例

    上野彰久 尾島英知 眞杉洋平 大島剛 紅林泰 久保田直人 阿部雄太 北川雄光 大喜多肇 坂元亨宇

    第107回日本病理学会総会, 2018.06, Poster (general)

  • EOB-MRIによるWnt/β-catenin activated subtype HCCの検出能に関する検討

    上野彰久 真杉洋平 山崎剣 Effendi Kathryn 辻川華子 谷本伸弘 奥田茂男 板野理 北川雄光 陣崎雅弘 坂元亨宇

    第11回 日本肝がん分子標的治療研究会, 2015.01, Poster (general)

  • 胆管疾患up-to-date 画像

    UENO AKIHISA

    第33回 画像医学会, 2014.02, Public discourse, seminar, tutorial, course, lecture and others

  • 肝細胞癌におけるGd-EOB-DTPAのトランスポーターの網羅的解析

    上野彰久 谷本伸弘 坂元亨宇

    第39回 肝臓学会東部会, 2012.12, Symposium, Workshop, Panelist (public offering)

  • Reduction of Blooming Artifact of Calcification with Prototype Fine-Cell Detector Computed Tomography (0.3mm collimation): Comparison with 64-Slice MDCT

    Tanami, Yutaka, Jinzaki, Masahiro, Sato, Kozo, Ueno, Akihisa, Yamada, Minoru, Kuribayashi, Sachio

    CIRCULATION, 2008.10

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Awards 【 Display / hide

  • MOST VIEWS JRS ELECTRONIC EXHIBIT DURING ARRS 2015 ANUAL MEETING

    2015.06, American Roentgen Ray Society, OATP1B3 expression is strongly associated with Wnt/β-catenin signaling and represents the transporter of Gd-EOB-DTPA in hepatocellular carcinoma

    Country: USA

  • Cypos Gold Medal

    2014.04, 日本医学放射線学会

  • Cypos Gold Medal

    2014.04, 日本医学放射線学会, OATP1B3 expression is strongly associated with Wnt/β-catenin signaling and represents the transporter of Gd-EOB-DTPA in hepatocellular carcinoma

  • 板井悠二賞

    2010.01, 肝血流動態イメージ研究会, EOBプリモビスト造影MRIの肝細胞相で低信号を呈する乏血性結節の転帰に関する検討

  • 板井悠二賞

    2010.01, 肝血流動態イメージ研究会, EOBプリモビスト造影MRIの肝細胞相で低信号を呈する乏血性結節の転帰に関する検討

 

Courses Taught 【 Display / hide

  • GENERAL PATHOLOGY

    2020

Courses Previously Taught 【 Display / hide

  • 病理学総論

    Keio University, 2018, Full academic year, Major subject, Laboratory work/practical work/exercise

  • 病理学各論

    Keio University, 2018, Full academic year, Major subject, Laboratory work/practical work/exercise