松元　美奈子 （マツモト　ミナコ）

Matsumoto Minako

写真a

所属（所属キャンパス）

医学部 衛生学公衆衛生学教室 （信濃町）

職名

助教（有期）
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経歴 【 表示 ／ 非表示 】

  • 2014年04月
    -
    2016年03月

    薬学部, 付属薬局, 薬剤師

  • 2018年04月
    -
    2019年04月

    医学部, 衛生学公衆衛生学教室, 特任助教

  • 2019年05月
    -
    継続中

    医学部, 衛生学公衆衛生学教室, 助教

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学歴 【 表示 ／ 非表示 】

  • 2008年04月
    -
    2014年03月

    慶應義塾大学, 薬学部, 薬学科

    大学, 卒業

  • 2016年04月
    -
    2018年03月

    慶應義塾大学, 健康マネジメント研究科, スポーツマネジメント専修

    大学院, 卒業, 修士

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学位 【 表示 ／ 非表示 】

  • 修士（公衆衛生学）, 慶應義塾大学, 課程, 2018年03月

  • 博士（医学）, 慶應義塾大学, 論文, 2025年03月

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免許・資格 【 表示 ／ 非表示 】

  • 薬剤師免許, 2014年03月

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研究分野 【 表示 ／ 非表示 】

  • ライフサイエンス / 衛生学、公衆衛生学分野：実験系を含む

  • ライフサイエンス / 衛生学、公衆衛生学分野：実験系を含まない

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研究キーワード 【 表示 ／ 非表示 】

  • メタボロミクス　予防医学　公衆衛生

  • 薬剤疫学

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著書 【 表示 ／ 非表示 】

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論文 【 表示 ／ 非表示 】

  • Validity assessment of self-reported medication use for hypertension, diabetes, and dyslipidemia in a pharmacoepidemiologic study by comparison with health insurance claims

    Matsumoto M., Harada S., Iida M., Kato S., Sata M., Hirata A., Kuwabara K., Takeuchi A., Sugiyama D., Okamura T., Takebayashi T.

    Journal of Epidemiology （Journal of Epidemiology）  31 （ 9 ） 495 - 502 2021年

    研究論文（学術雑誌）, 筆頭著者, 査読有り,  ISSN  1349-9092

    　概要を見る

    Background: Although self-reported questionnaires are widely employed in epidemiologic studies, their validity has not been sufficiently assessed. The aim of this study was to evaluate the validity of a self-reported questionnaire on medication use by comparison with health insurance claims and to identify individual determinants of discordance in the Tsuruoka Metabolomics Cohort Study. Methods: Participants were 2,472 community-dwellers aged 37 to 78 years from the Tsuruoka Metabolomics Cohort Study. Information on lifestyle and medications was collected through a questionnaire. Sensitivity and specificity were determined using health insurance claims from November 2014 to March 2016, which were used as a standard. Potential determinants of discordance were assessed using multivariable logistic regression. Results: The self-reported questionnaire on medication use showed high validity. Sensitivity and specificity were 0.95 (95% CI, 0.93–0.96) and 0.97 (95% CI, 0.96–0.98) for antihypertensive medications, 0.94 (95% CI, 0.91–0.97) and 0.98 (95% CI, 0.98–0.99) for diabetes medications, and 0.84 (95% CI, 0.82–0.87) and 0.98 (95% CI, 0.97–0.99) for dyslipidemia medications, respectively. Males without high education and those who currently smoke cigarettes were found to be associated with discordant reporting which affected sensitivity, especially those with medication use for dyslipidemia. Conclusions: In this population-based cohort study, we found that the self-reported questionnaire on medication use was a valid measure to capture regular medication users. Sensitivity for dyslipidemia medications was lower than those for the other medications. Type of medication, sex, education years, and smoking status influenced discordance, which affected sensitivity in self-reporting.

  • Evaluation of Medication Adherence Among Prevalent Users in Hypertension, Dyslipidemia, and Diabetes Using Health Insurance Claims: A Population-Based Cohort Study in Japan

    Matsumoto M., Harada S., Ikuta H., Iida M., Kato S., Sata M., Shibuki T., Ishibashi Y., Miyagawa N., Hisamatsu M., Hirata A., Kuwabara K., Takeuchi A., Sugiyama D., Suzuki S., Nakamura T., Okamura T., Takebayashi T.

    Pharmacoepidemiology and Drug Safety 33 （ 8 ）  2024年08月

    ISSN  10538569

    　概要を見る

    Purpose: Hypertension (HT), dyslipidemia (DL), and diabetes mellitus (DM) are major risk factors for cardiovascular diseases. Despite the wide availability of medications to reduce this risk, poor adherence to medications remains an issue. The aim of this study is to evaluate medication adherence of prevalent users in these disease medications (HT, DL, DM) using claims data. Factors associated with non-adherence were also examined. Methods: Of 7538 participants of the Tsuruoka Metabolomics Cohort Study, 3693 (HT: 2702, DL: 2112, DM: 661) were identified as prevalent users of these disease medications. Information on lifestyle was collected through a questionnaire. Adherence was assessed by a proportion of days covered (PDC) and participants with PDC ≥0.8 were defined as adherent. Predictors of non-adherence were determined by performing multivariable logistic regression. Results: Medication adherence differed by treatment status. Among those without comorbidities, those with HT-only showed the highest adherence (90.2%), followed by those with DM-only (81.2%) and those with DL-only (80.8%). Factors associated with non-adherence in each medication group were skipping breakfast and poor understanding of medications among those with HT medications, females, having comorbidities, having a history of heart disease, and drinking habit among those with DL medications, and good sleep quality and skipping breakfast among those with DM medications. Conclusion: While participants showed high medication adherence, differences were observed across medication groups. The identified predictors of non-adherence could help target those in need of adherence support.

  • Reliability of Time-Series Plasma Metabolome Data over 6 Years in a Large-Scale Cohort Study

    Miyake A., Harada S., Sugiyama D., Matsumoto M., Hirata A., Miyagawa N., Toki R., Edagawa S., Kuwabara K., Okamura T., Sato A., Amano K., Hirayama A., Sugimoto M., Soga T., Tomita M., Arakawa K., Takebayashi T., Iida M.

    Metabolites 14 （ 1 ）  2024年01月

    　概要を見る

    Studies examining long-term longitudinal metabolomic data and their reliability in large-scale populations are limited. Therefore, we aimed to evaluate the reliability of repeated measurements of plasma metabolites in a prospective cohort setting and to explore intra-individual concentration changes at three time points over a 6-year period. The study participants included 2999 individuals (1317 men and 1682 women) from the Tsuruoka Metabolomics Cohort Study, who participated in all three surveys—at baseline, 3 years, and 6 years. In each survey, 94 plasma metabolites were quantified for each individual and quality control (QC) sample. The coefficients of variation of QC, intraclass correlation coefficients, and change rates of QC were calculated for each metabolite, and their reliability was classified into three categories: excellent, fair to good, and poor. Seventy-six percent (71/94) of metabolites were classified as fair to good or better. Of the 39 metabolites grouped as excellent, 29 (74%) in men and 26 (67%) in women showed significant intra-individual changes over 6 years. Overall, our study demonstrated a high degree of reliability for repeated metabolome measurements. Many highly reliable metabolites showed significant changes over the 6-year period, suggesting that repeated longitudinal metabolome measurements are useful for epidemiological studies.

  • A population-based urinary and plasma metabolomics study of environmental exposure to cadmium

    Ishibashi Y., Harada S., Eitaki Y., Kurihara A., Kato S., Kuwabara K., Iida M., Hirata A., Sata M., Matsumoto M., Shibuki T., Okamura T., Sugiyama D., Sato A., Amano K., Hirayama A., Sugimoto M., Soga T., Tomita M., Takebayashi T.

    Environmental Health and Preventive Medicine 29 2024年

    ISSN  1342078X

    　概要を見る

    Background: The application of metabolomics-based profiles in environmental epidemiological studies is a promising approach to refine the process of health risk assessment. We aimed to identify potential metabolomics-based profiles in urine and plasma for the detection of relatively low-level cadmium (Cd) exposure in large population-based studies. Method: We analyzed 123 urinary metabolites and 94 plasma metabolites detected in fasting urine and plasma samples collected from 1,412 men and 2,022 women involved in the Tsuruoka Metabolomics Cohort Study. Regression analysis was performed for urinary N-acetyl-beta-D-glucosaminidase (NAG), plasma, and urinary metabolites as dependent variables, and urinary Cd (U-Cd, quartile) as an independent variable. The multivariable regression model included age, gender, systolic blood pressure, smoking, rice intake, BMI, glycated hemoglobin, low-density lipoprotein cholesterol, alcohol consumption, physical activity, educational history, dietary energy intake, urinary Na/K ratio, and uric acid. Pathway-network analysis was carried out to visualize the metabolite networks linked to Cd exposure. Result: Urinary NAG was positively associated with U-Cd, but not at lower concentrations (Q2). Among urinary metabolites in the total population, 45 metabolites showed associations with U-Cd in the unadjusted and adjusted models after adjusting for the multiplicity of comparison with FDR. There were 12 urinary metabolites which showed consistent associations between Cd exposure from Q2 to Q4. Among plasma metabolites, six cations and one anion were positively associated with U-Cd, whereas alanine, creatinine, and isoleucine were negatively associated with U-Cd. Our results were robust by statistical adjustment of various confounders. Pathway-network analysis revealed metabolites and upstream regulator changes associated with mitochondria (ACACB, UCP2, and metabolites related to the TCA cycle). Conclusion: These results suggested that U-Cd was associated with metabolites related to upstream mitochondrial dysfunction in a dose-dependent manner. Our data will help develop environmental Cd exposure profiles for human populations.

  • Association of Nonalcoholic Fatty Liver Disease with Arterial Stiffness and its Metabolomic Profiling in Japanese Community-Dwellers

    Hirata A., Harada S., Iida M., Kurihara A., Fukai K., Kuwabara K., Kato S., Matsumoto M., Sata M., Miyagawa N., Toki R., Edagawa S., Sugiyama D., Sato A., Hirayama A., Sugimoto M., Soga T., Tomita M., Okamura T., Takebayashi T.

    Journal of Atherosclerosis and Thrombosis 31 （ 7 ） 1031 - 1047 2024年

    ISSN  13403478

    　概要を見る

    Aims: Nonalcoholic fatty liver disease (NAFLD) is known to be associated with atherosclerosis. This study focused on upstream changes in the process by which NAFLD leads to atherosclerosis. The study aimed to confirm the association between NAFLD and the cardio-ankle vascular index (CAVI), an indicator of subclinical atherosclerosis, and explore metabolites involved in both by assessing 94 plasma polar metabolites.Methods: A total of 928 Japanese community-dwellers (306 men and 622 women) were included in this study. The association between NAFLD and CAVI was examined using a multivariable regression model adjusted for confounders. Metabolites commonly associated with NAFLD and CAVI were investigated using linear mixed-effects models in which batch numbers of metabolite measurements were used as a random-effects variable, and false discovery rate-adjusted p-values were calculated. To determine the extent to which these metabolites mediated the association between NAFLD and CAVI, mediation analysis was conducted.Results: NAFLD was positively associated with CAVI (coefficients [95% Confidence intervals (CI)]=0.23 [0.09–0.37]; p=0.001). A total of 10 metabolites were involved in NAFLD and CAVI, namely, branched-chain amino acids (BCAAs; valine, leucine, and isoleucine), aromatic amino acids (AAAs; tyrosine and tryptophan), alanine, proline, glutamic acid, glycerophosphorylcholine, and 4-methyl-2-oxopentanoate. Mediation analysis showed that BCAAs mediated more than 20% of the total effect in the association between NAFLD and CAVI.Conclusions: NAFLD was associated with a marker of atherosclerosis, and several metabolites related to insulin resistance, including BCAAs and AAAs, could be involved in the process by which NAFLD leads to atherosclerosis.

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KOARA（リポジトリ）収録論文等 【 表示 ／ 非表示 】

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研究発表 【 表示 ／ 非表示 】

  • 生活習慣病を有する地域在住者の自覚的健康観に影響を与える日常生活活動・健康行動の研究

    濱田蘭奈, 松元美奈子, 地引綾, 横山雄太, 鈴木小夜, 中村智徳, 武林亨

    日本薬学会第145年会（福岡）, 

    2025年03月
    , 

    ポスター発表

  • 健診において気流閉塞を認めた地域在住者の実態の検討：鶴岡メタボロームコホート研究

    松元美奈子,原田成,飯田美穂,平田あや,宮川尚子,桑原和代,土岐了大,枝川俊,三宅温子,杉山大典,岡村智教,武林亨

    2023年11月
    , 

    ポスター発表

  • Factors associated with failure to undergo secondary examinations after an annual checkup from population-based cohort study（Tsuruoka Metabolomics Cohort Study）

    Minako Matsumoto, Sei Harada, Miho Iida, Aya Hirata, Kazuyo Kuwabara, Naoko Miyagawa, Tomonori Okamura, Toru Takebayashi

    第33回日本医療薬学会年会, 

    2023年11月
    , 

    口頭発表（一般）

  • お薬手帳と比較した自記式質問紙による服薬情報の妥当性研究

    矢嶋里菜,松元美奈子,原田成,飯田美穂,平田あや,桑原和代,宮川尚子,中村智徳,岡村智教,武林亨

    第82回日本公衆衛生学会総会, 

    2023年10月
    -
    2023年11月
    , 

    ポスター発表

  • 健診における受診勧奨に基づく国保・後期高齢者の二次健診受診要因の検討

    松元美奈子、原田成、飯田美穂、加藤寿寿華、佐田みずき、平田あや、宮川尚子、桑原和代、杉山大典、岡村智教、武林亨

    第33回日本疫学会学術総会 （アクトシティ浜松（浜松市）） , 

    2023年02月
    , 

    ポスター発表

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競争的研究費の研究課題 【 表示 ／ 非表示 】

  • 薬局におけるPHR活用方法とその推進に関する実証的研究

    2025年04月
    -
    2027年03月

    厚生労働省 , 令和７年度厚生労働科学研究費補助金, 補助金,  研究分担者

  • バイオ後続品の有効性・安全性をリアルワールドで体系的に評価するシステムの確立

    2024年10月
    -
    2025年03月

    厚生労働省 , 令和6年度厚生労働行政推進調査事業費補助金（厚生労働科学特別研究事業）, 補助金,  研究分担者

  • 健診における受診勧奨に基づく国保・後期高齢者の二次健診受診要因の検討

    2021年10月
    -
    2022年09月

    医療経済研究機構, 松元　美奈子, その他,  研究代表者

  • スタチン使用による糖尿病発症リスクに関するメタボローム疫学研究

    2019年04月
    -
    2020年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 松元　美奈子, 研究活動スタート支援, 補助金,  研究代表者

  • スタチン使用による糖尿病発症リスクに関するメタボローム疫学研究

    2018年10月
    -
    継続中

    文部科学省・日本学術振興会, 科学研究費助成事業, 松元　美奈子, 研究活動スタート支援, 補助金,  研究代表者

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受賞 【 表示 ／ 非表示 】

  • 学生優秀発表賞

    濱田蘭奈, 松元美奈子, 地引綾, 横山雄太, 鈴木小夜, 中村智徳, 武林亨, 2025年04月, 日本薬学会第145年会, 生活習慣病を有する地域在住者の自覚的健康観に影響を与える日常生活活動・健康行動の研究

    受賞区分： 国内学会・会議・シンポジウム等の賞

  • 学生優秀発表賞

    幾田 遥史、松元 美奈子、地引 綾、横山 雄太、河添 仁、鈴木 小夜、中村 智徳、武林 亨, 2021年03月, 日本薬学会第141年会, 高齢者における三大生活習慣病と服薬アドヒアランスの検討

    受賞区分： 国内学会・会議・シンポジウム等の賞

  • Spotlight poster presentation

    Minako Matsumoto, Sei Harada, Miho Iida, Tomonori Okamura, Toru Takebayashi, 2019年10月, 12th ISPE ACPE Conference, Validity assessment of self-reported medication use in a pharmacoepidemiology research (by comparing to medical and pharmacy insurance claims)

    受賞区分： 国際学会・会議・シンポジウム等の賞

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担当授業科目 【 表示 ／ 非表示 】

  • 医学統計・医療情報

    2025年度

  • 三学部合同教育

    2024年度, その他, 学部専門科目, 実習・実験

  • 衛生学Ⅰ

    2023年度, 秋学期, 学部専門科目, 講義

  • 衛生学Ⅱ

    2023年度, 秋学期, 学部専門科目, 講義

  • 公衆衛生学Ⅱ

    2023年度, 秋学期, 学部専門科目, 実習・実験

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社会活動 【 表示 ／ 非表示 】

  • 鶴岡みらい健康づくり活動

    2017年
    -
    継続中
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所属学協会 【 表示 ／ 非表示 】

  • 日本産業衛生学会, 

    2018年04月
    -
    継続中

  • 日本薬剤疫学会, 

    2018年
    -
    継続中

  • 日本循環器予防学会, 

    2018年
    -
    継続中

  • 日本動脈硬化学会, 

    2018年
    -
    継続中

  • 日本疫学会, 

    2018年
    -
    継続中

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委員歴 【 表示 ／ 非表示 】

  • 2025年04月
    -
    継続中

    Asian Conference Pharmacoepidemiology Program Committee

  • 2023年12月
    -
    継続中

    日本薬剤疫学会　拡充委員会

  • 2023年08月
    -
    継続中

    日本薬剤疫学会, Webサイトリニューアルタスクフォースの委員

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