Matsumoto, Minako



School of Medicine, Department of Preventive Medicine and Public Health (Shinanomachi)



Career 【 Display / hide

  • 2014.04

    Faculty of pharmacy, 付属薬局, 薬剤師

  • 2018.04

    医学部, 衛生学公衆衛生学教室, 特任助教

  • 2019.05

    医学部, 衛生学公衆衛生学教室, 助教

Academic Background 【 Display / hide

  • 2008.04

    Keio University, 薬学部, 薬学科

    University, Graduated

  • 2016.04

    Keio University, 健康マネジメント研究科, スポーツマネジメント専修

    Graduate School, Graduated, Master's course

Academic Degrees 【 Display / hide

  • Master of Public Health, Keio University, Coursework, 2018.03

Licenses and Qualifications 【 Display / hide

  • 薬剤師免許, 2014.03


Research Areas 【 Display / hide

  • Life Science / Hygiene and public health (laboratory)

  • Life Science / Hygiene and public health (non-laboratory)

Research Keywords 【 Display / hide

  • メタボロミクス 予防医学 公衆衛生


Papers 【 Display / hide

  • Validity Assessment of Self-reported Medication Use for Hypertension, Diabetes, and Dyslipidemia in a Pharmacoepidemiologic Study by Comparison With Health Insurance Claims

    Minako Matsumoto, Sei Harada, Miho Iida, Suzuka Kato, Mizuki Sata, Aya Hirata, Kazuyo Kuwabara, Ayano Takeuchi, Daisuke Sugiyama, Tomonori Okamura, Toru Takebayashi

    Journal of Epidemiology (Journal of Epidemiology)  31 ( 9 ) 495 - 502 2021

    Research paper (scientific journal), Single Work, Accepted,  ISSN  1349-9092

     View Summary

    Background: Although self-reported questionnaires are widely employed in epidemiologic studies, their validity has not been sufficiently assessed. The aim of this study was to evaluate the validity of a self-reported questionnaire on medication use by comparison with health insurance claims and to identify individual determinants of discordance in the Tsuruoka Metabolomics Cohort Study. Methods: Participants were 2,472 community-dwellers aged 37 to 78 years from the Tsuruoka Metabolomics Cohort Study. Information on lifestyle and medications was collected through a questionnaire. Sensitivity and specificity were determined using health insurance claims from November 2014 to March 2016, which were used as a standard. Potential determinants of discordance were assessed using multivariable logistic regression. Results: The self-reported questionnaire on medication use showed high validity. Sensitivity and specificity were 0.95 (95% CI, 0.93–0.96) and 0.97 (95% CI, 0.96–0.98) for antihypertensive medications, 0.94 (95% CI, 0.91–0.97) and 0.98 (95% CI, 0.98–0.99) for diabetes medications, and 0.84 (95% CI, 0.82–0.87) and 0.98 (95% CI, 0.97–0.99) for dyslipidemia medications, respectively. Males without high education and those who currently smoke cigarettes were found to be associated with discordant reporting which affected sensitivity, especially those with medication use for dyslipidemia. Conclusions: In this population-based cohort study, we found that the self-reported questionnaire on medication use was a valid measure to capture regular medication users. Sensitivity for dyslipidemia medications was lower than those for the other medications. Type of medication, sex, education years, and smoking status influenced discordance, which affected sensitivity in self-reporting.

  • Sars-cov-2 infection among medical institution faculty and healthcare workers in tokyo, japan

    Nishimura T., Uwamino Y., Uno S., Kashimura S., Shiraki T., Kurafuji T., Morita M., Noguchi M., Azegami T., Yamada-Goto N., Murai-Takeda A., Yokoyama H., Kuwabara K., Kato S., Matsumoto M., Hirata A., Iida M., Harada S., Ishizaka T., Misawa K., Murata M., Saya H., Amagai M., Kitagawa Y., Takeuchi T., Mori M., Takebayashi T., Hasegawa N.

    Internal Medicine (Internal Medicine)  60 ( 16 ) 2569 - 2575 2021

    ISSN  09182918

     View Summary

    Objective To consider effective measures against severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) infection in medical institutions, this study estimated the SARS-CoV-2 infection rate among healthcare workers (HCWs) in Tokyo, Japan, and determined the specific findings for mild coronavirus disease 2019 (COVID-19) cases. Methods This study analyzed the results of serologic tests to detect immunoglobulin G antibodies against SARS-CoV-2 and evaluated the demographic and clinical characteristics of the faculty and HCWs at a Tokyo medical institution in August 2020. The demographic and clinical characteristics of participants with antibody-positive results were compared to those of participants with antibody-negative results. Materials This study recruited 2,341 faculty and HCWs at a Tokyo medical institution, 21 of whom had a COVID-19 history. Results Of the 2,320 participants without a COVID-19 history, 20 (0.862%) had positive serologic test results. A fever and dysgeusia or dysosmia occurred with greater frequency among the participants with positive test results than in those with negative results [odds ratio (OR), 5.475; 95% confidence interval (CI), 1.960-15.293 and OR, 24.158; 95% CI, 2.693-216.720, respectively]. No significant difference was observed in the positivity rate between HCWs providing medical care for COVID-19 patients using adequate protection and other HCWs (OR, 2.514; 95% CI, 0.959-6.588). Conclusion To reduce the risk of COVID-19 spread in medical institutions, faculty and HCWs should follow standard and necessary transmission-based precautions, and those with a fever and dysgeusia or dysosmia should excuse themselves from work as soon as possible.

  • Control of a Nosocomial Outbreak of COVID-19 in a University Hospital

    Harada S., Uno S., Ando T., Iida M., Takano Y., Ishibashi Y., Uwamino Y., Nishimura T., Takeda A., Uchida S., Hirata A., Sata M., Matsumoto M., Takeuchi A., Obara H., Yokoyama H., Fukunaga K., Amagai M., Kitagawa Y., Takebayashi T., Hasegawa N.

    Open Forum Infectious Diseases (Open Forum Infectious Diseases)  7 ( 12 ) 1 - 9 2020.12

     View Summary

    © 2020 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America. Background: Nosocomial spread of coronavirus disease 2019 (COVID-19) causes clusters of infection among high-risk individuals. Controlling this spread is critical to reducing COVID-19 morbidity and mortality. We describe an outbreak of COVID-19 in Keio University Hospital, Japan, and its control and propose effective control measures. Methods: When an outbreak was suspected, immediate isolation and thorough polymerase chain reaction (PCR) testing of patients and health care workers (HCWs) using an in-house system, together with extensive contact tracing and social distancing measures, were conducted. Nosocomial infections (NIs) were defined as having an onset or positive test after the fifth day of admission for patients and having high-risk contacts in our hospital for HCWs. We performed descriptive analyses for this outbreak. Results: Between March 24 and April 24, 2020, 27 of 562 tested patients were confirmed positive, of whom 5 (18.5%) were suspected as NIs. For HCWs, 52 of 697 tested positive, and 40 (76.9%) were considered NIs. Among transmissions, 95.5% were suspected of having occurred during the asymptomatic period. Large-scale isolation and testing at the first sign of outbreak terminated NIs. The number of secondary cases directly generated by a single primary case found before March 31 was 1.74, compared with 0 after April 1. Only 4 of 28 primary cases generated definite secondary infection; these were all asymptomatic. Conclusions: Viral shedding from asymptomatic cases played a major role in NIs. PCR screening of asymptomatic individuals helped clarify the pattern of spread. Immediate large-scale isolation, contact tracing, and social distancing measures were essential to containing outbreaks.

  • Association between dyslipidemia and plasma levels of branched-chain amino acids in the Japanese population without diabetes mellitus

    Fukushima K., Harada S., Takeuchi A., Kurihara A., Iida M., Fukai K., Kuwabara K., Kato S., Matsumoto M., Hirata A., Akiyama M., Tomita M., Hirayama A., Sato A., Suzuki C., Sugimoto M., Soga T., Sugiyama D., Okamura T., Takebayashi T.

    Journal of Clinical Lipidology (Journal of Clinical Lipidology)  13 ( 6 ) 932 - 939.e2 2019

    ISSN  19332874

     View Summary

    © 2019 National Lipid Association Background: Branched-chain amino acids (BCAAs) play a key role in energy homeostasis. Objective: We aimed to investigate the association between plasma BCAA levels and dyslipidemia in the Japanese population without diabetes mellitus. Methods: This cross-sectional study included 4952 participants without diabetes mellitus, enrolled in the Tsuruoka Metabolomic Cohort Study. Plasma BCAA levels were measured by capillary electrophoresis–mass spectrometry. Correlations between lipid and BCAA profiles were evaluated by sex-stratified multiple linear regression analyses, after adjusting for confounders. Logistic regression was used to identify associations between BCAAs and metabolic dyslipidemia (MD) defined as triglyceride levels ≥150 mg/dL, high-density lipoprotein cholesterol levels ≤40 mg/dL for men and ≤50 mg/dL for women, or low-density lipoprotein cholesterol (LDL-C) levels ≥140 mg/dL. Results: In both sexes, the levels of individual BCAAs and the total BCAA levels correlated positively with triglyceride levels and negatively with high-density lipoprotein cholesterol levels. Valine, leucine, and total BCAA levels were weakly and positively correlated with LDL-C levels. Increased BCAA levels showed positive associations with MD. However, associations between BCAAs and elevated LDL-C levels were unclear. Furthermore, the associations between BCAA levels and MD regardless of fasting blood sugar (FBS) levels (high or low). Although valine, leucine, and total BCAA levels were weakly associated with elevated LDL-C levels in the high-FBS group, no such association was observed in the low-FBS group. Conclusions: BCAAs might be associated with MD independently of the FBS level and might play an important role in lipid metabolism and dyslipidemia.

Papers, etc., Registered in KOARA 【 Display / hide

Presentations 【 Display / hide

  • Validity assessment of self-reported medication use in a pharmacoepidemiology research (by comparing to medical and pharmacy insurance claims)

    Minako Matsumoto, Sei Harada, Miho Iida, Tomonori Okamura, Toru Takebayashi

    ISPE’s 12th Asian Conference on Pharmacoepidemiology and 25th Japanese Conference on Pharmacoepidemiology joint meeting (KYOTO) , 


    Poster presentation

  • レセプトデータを用いた脂質異常症治療薬(スタチン)服用群と脂質異常症治療薬非服用群の特性の検討


    第51回日本動脈硬化学会総会・学術集会 (京都) , 


    Poster presentation

  • Metabolomic alterations in hypocholesterolemic drug users

    Minako Matsumoto, Sei Harada, Miho Iida, Tomonori Okamura, Toru Takebayashi

    Metabolomics 2019 (HAGUE) , 


    Poster presentation

  • 脂質異常症治療薬使用の糖尿病発症リスクに関するメタボローム疫学研究 


    第29回日本疫学会学術総会 (東京) , 


    Poster presentation

  • 男性勤労者におけるストレス対処パターンと血圧値との関連の時間断面研究


    第76回日本公衆衛生学会総会 (鹿児島) , 


    Poster presentation

Research Projects of Competitive Funds, etc. 【 Display / hide

  • 健診における受診勧奨に基づく国保・後期高齢者の二次健診受診要因の検討


    医療経済研究機構, Other, Principal investigator

  • スタチン使用による糖尿病発症リスクに関するメタボローム疫学研究


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up , Principal investigator

  • スタチン使用による糖尿病発症リスクに関するメタボローム疫学研究


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Minako Matsutmoto, Grant-in-Aid for Research Activity Start-up , Research grant, Principal investigator

Awards 【 Display / hide

  • 学生優秀発表賞

    幾田 遥史、松元 美奈子、地引 綾、横山 雄太、河添 仁、鈴木 小夜、中村 智徳、武林 亨, 2021.03, 日本薬学会第141年会, 高齢者における三大生活習慣病と服薬アドヒアランスの検討

    Type of Award: Award from Japanese society, conference, symposium, etc.

  • Spotlight poster presentation

    Minako Matsumoto, Sei Harada, Miho Iida, Tomonori Okamura, Toru Takebayashi, 2019.10, 12th ISPE ACPE Conference, Validity assessment of self-reported medication use in a pharmacoepidemiology research (by comparing to medical and pharmacy insurance claims)

    Type of Award: Award from international society, conference, symposium, etc.


Courses Taught 【 Display / hide




Social Activities 【 Display / hide

  • 鶴岡みらい健康づくり活動


Memberships in Academic Societies 【 Display / hide

  • 日本産業衛生学会, 

  • 日本薬剤疫学会, 

  • 日本循環器予防学会, 

  • 日本動脈硬化学会, 

  • 日本疫学会, 


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