Details of a Researcher - Matsumoto Minako

Matsumoto Minako

写真a

Affiliation: School of Medicine, Department of Preventive Medicine and Public Health (Shinanomachi)

Position: Instructor

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Career 【 Display / hide 】

2014.04

-

2016.03

Faculty of pharmacy, 付属薬局, 薬剤師
2018.04

-

2019.04

医学部, 衛生学公衆衛生学教室, 特任助教
2019.05

-

Present

医学部, 衛生学公衆衛生学教室, 助教

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Academic Background 【 Display / hide 】

2008.04

-

2014.03

Keio University, 薬学部, 薬学科

University, Graduated
2016.04

-

2018.03

Keio University, 健康マネジメント研究科, スポーツマネジメント専修

Graduate School, Graduated, Master's course

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Academic Degrees 【 Display / hide 】

Master of Public Health, Keio University, Coursework, 2018.03
博士（医学）, Keio University, Dissertation, 2025.03

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Licenses and Qualifications 【 Display / hide 】

薬剤師免許, 2014.03

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Research Areas 【 Display / hide 】

Life Science / Hygiene and public health (laboratory)
Life Science / Hygiene and public health (non-laboratory)

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Research Keywords 【 Display / hide 】

メタボロミクス　予防医学　公衆衛生
薬剤疫学

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Books 【 Display / hide 】

症例で学ぶ疫学・生物統計学　臨床研究入門

松元　美奈子,　鈴木　小夜,　落海　浩, 朝倉書店, 2023.06

Original author： Bryan Kestenbaum

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Papers 【 Display / hide 】

Validity Assessment of Self-reported Medication Use for Hypertension, Diabetes, and Dyslipidemia in a Pharmacoepidemiologic Study by Comparison With Health Insurance Claims

Minako Matsumoto, Sei Harada, Miho Iida, Suzuka Kato, Mizuki Sata, Aya Hirata, Kazuyo Kuwabara, Ayano Takeuchi, Daisuke Sugiyama, Tomonori Okamura, Toru Takebayashi

Journal of Epidemiology (Journal of Epidemiology) 31 ( 9 ) 495 - 502 2021

Research paper (scientific journal), Lead author, Accepted, ISSN 1349-9092

　View Summary

Background: Although self-reported questionnaires are widely employed in epidemiologic studies, their validity has not been sufficiently assessed. The aim of this study was to evaluate the validity of a self-reported questionnaire on medication use by comparison with health insurance claims and to identify individual determinants of discordance in the Tsuruoka Metabolomics Cohort Study. Methods: Participants were 2,472 community-dwellers aged 37 to 78 years from the Tsuruoka Metabolomics Cohort Study. Information on lifestyle and medications was collected through a questionnaire. Sensitivity and specificity were determined using health insurance claims from November 2014 to March 2016, which were used as a standard. Potential determinants of discordance were assessed using multivariable logistic regression. Results: The self-reported questionnaire on medication use showed high validity. Sensitivity and specificity were 0.95 (95% CI, 0.93–0.96) and 0.97 (95% CI, 0.96–0.98) for antihypertensive medications, 0.94 (95% CI, 0.91–0.97) and 0.98 (95% CI, 0.98–0.99) for diabetes medications, and 0.84 (95% CI, 0.82–0.87) and 0.98 (95% CI, 0.97–0.99) for dyslipidemia medications, respectively. Males without high education and those who currently smoke cigarettes were found to be associated with discordant reporting which affected sensitivity, especially those with medication use for dyslipidemia. Conclusions: In this population-based cohort study, we found that the self-reported questionnaire on medication use was a valid measure to capture regular medication users. Sensitivity for dyslipidemia medications was lower than those for the other medications. Type of medication, sex, education years, and smoking status influenced discordance, which affected sensitivity in self-reporting.
- Access to Document (DOI)
Evaluation of Medication Adherence Among Prevalent Users in Hypertension, Dyslipidemia, and Diabetes Using Health Insurance Claims: A Population-Based Cohort Study in Japan

Matsumoto M., Harada S., Ikuta H., Iida M., Kato S., Sata M., Shibuki T., Ishibashi Y., Miyagawa N., Hisamatsu M., Hirata A., Kuwabara K., Takeuchi A., Sugiyama D., Suzuki S., Nakamura T., Okamura T., Takebayashi T.

Pharmacoepidemiology and Drug Safety 33 ( 8 ) 2024.08

ISSN 10538569

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Purpose: Hypertension (HT), dyslipidemia (DL), and diabetes mellitus (DM) are major risk factors for cardiovascular diseases. Despite the wide availability of medications to reduce this risk, poor adherence to medications remains an issue. The aim of this study is to evaluate medication adherence of prevalent users in these disease medications (HT, DL, DM) using claims data. Factors associated with non-adherence were also examined. Methods: Of 7538 participants of the Tsuruoka Metabolomics Cohort Study, 3693 (HT: 2702, DL: 2112, DM: 661) were identified as prevalent users of these disease medications. Information on lifestyle was collected through a questionnaire. Adherence was assessed by a proportion of days covered (PDC) and participants with PDC ≥0.8 were defined as adherent. Predictors of non-adherence were determined by performing multivariable logistic regression. Results: Medication adherence differed by treatment status. Among those without comorbidities, those with HT-only showed the highest adherence (90.2%), followed by those with DM-only (81.2%) and those with DL-only (80.8%). Factors associated with non-adherence in each medication group were skipping breakfast and poor understanding of medications among those with HT medications, females, having comorbidities, having a history of heart disease, and drinking habit among those with DL medications, and good sleep quality and skipping breakfast among those with DM medications. Conclusion: While participants showed high medication adherence, differences were observed across medication groups. The identified predictors of non-adherence could help target those in need of adherence support.
- Access to Document (DOI)
Reliability of Time-Series Plasma Metabolome Data over 6 Years in a Large-Scale Cohort Study

Miyake A., Harada S., Sugiyama D., Matsumoto M., Hirata A., Miyagawa N., Toki R., Edagawa S., Kuwabara K., Okamura T., Sato A., Amano K., Hirayama A., Sugimoto M., Soga T., Tomita M., Arakawa K., Takebayashi T., Iida M.

Metabolites 14 ( 1 ) 2024.01

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Studies examining long-term longitudinal metabolomic data and their reliability in large-scale populations are limited. Therefore, we aimed to evaluate the reliability of repeated measurements of plasma metabolites in a prospective cohort setting and to explore intra-individual concentration changes at three time points over a 6-year period. The study participants included 2999 individuals (1317 men and 1682 women) from the Tsuruoka Metabolomics Cohort Study, who participated in all three surveys—at baseline, 3 years, and 6 years. In each survey, 94 plasma metabolites were quantified for each individual and quality control (QC) sample. The coefficients of variation of QC, intraclass correlation coefficients, and change rates of QC were calculated for each metabolite, and their reliability was classified into three categories: excellent, fair to good, and poor. Seventy-six percent (71/94) of metabolites were classified as fair to good or better. Of the 39 metabolites grouped as excellent, 29 (74%) in men and 26 (67%) in women showed significant intra-individual changes over 6 years. Overall, our study demonstrated a high degree of reliability for repeated metabolome measurements. Many highly reliable metabolites showed significant changes over the 6-year period, suggesting that repeated longitudinal metabolome measurements are useful for epidemiological studies.
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A population-based urinary and plasma metabolomics study of environmental exposure to cadmium

Ishibashi Y., Harada S., Eitaki Y., Kurihara A., Kato S., Kuwabara K., Iida M., Hirata A., Sata M., Matsumoto M., Shibuki T., Okamura T., Sugiyama D., Sato A., Amano K., Hirayama A., Sugimoto M., Soga T., Tomita M., Takebayashi T.

Environmental Health and Preventive Medicine 29 2024

ISSN 1342078X

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Background: The application of metabolomics-based profiles in environmental epidemiological studies is a promising approach to refine the process of health risk assessment. We aimed to identify potential metabolomics-based profiles in urine and plasma for the detection of relatively low-level cadmium (Cd) exposure in large population-based studies. Method: We analyzed 123 urinary metabolites and 94 plasma metabolites detected in fasting urine and plasma samples collected from 1,412 men and 2,022 women involved in the Tsuruoka Metabolomics Cohort Study. Regression analysis was performed for urinary N-acetyl-beta-D-glucosaminidase (NAG), plasma, and urinary metabolites as dependent variables, and urinary Cd (U-Cd, quartile) as an independent variable. The multivariable regression model included age, gender, systolic blood pressure, smoking, rice intake, BMI, glycated hemoglobin, low-density lipoprotein cholesterol, alcohol consumption, physical activity, educational history, dietary energy intake, urinary Na/K ratio, and uric acid. Pathway-network analysis was carried out to visualize the metabolite networks linked to Cd exposure. Result: Urinary NAG was positively associated with U-Cd, but not at lower concentrations (Q2). Among urinary metabolites in the total population, 45 metabolites showed associations with U-Cd in the unadjusted and adjusted models after adjusting for the multiplicity of comparison with FDR. There were 12 urinary metabolites which showed consistent associations between Cd exposure from Q2 to Q4. Among plasma metabolites, six cations and one anion were positively associated with U-Cd, whereas alanine, creatinine, and isoleucine were negatively associated with U-Cd. Our results were robust by statistical adjustment of various confounders. Pathway-network analysis revealed metabolites and upstream regulator changes associated with mitochondria (ACACB, UCP2, and metabolites related to the TCA cycle). Conclusion: These results suggested that U-Cd was associated with metabolites related to upstream mitochondrial dysfunction in a dose-dependent manner. Our data will help develop environmental Cd exposure profiles for human populations.
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Association of Nonalcoholic Fatty Liver Disease with Arterial Stiffness and its Metabolomic Profiling in Japanese Community-Dwellers

Hirata A., Harada S., Iida M., Kurihara A., Fukai K., Kuwabara K., Kato S., Matsumoto M., Sata M., Miyagawa N., Toki R., Edagawa S., Sugiyama D., Sato A., Hirayama A., Sugimoto M., Soga T., Tomita M., Okamura T., Takebayashi T.

Journal of Atherosclerosis and Thrombosis 31 ( 7 ) 1031 - 1047 2024

ISSN 13403478

　View Summary

Aims: Nonalcoholic fatty liver disease (NAFLD) is known to be associated with atherosclerosis. This study focused on upstream changes in the process by which NAFLD leads to atherosclerosis. The study aimed to confirm the association between NAFLD and the cardio-ankle vascular index (CAVI), an indicator of subclinical atherosclerosis, and explore metabolites involved in both by assessing 94 plasma polar metabolites.Methods: A total of 928 Japanese community-dwellers (306 men and 622 women) were included in this study. The association between NAFLD and CAVI was examined using a multivariable regression model adjusted for confounders. Metabolites commonly associated with NAFLD and CAVI were investigated using linear mixed-effects models in which batch numbers of metabolite measurements were used as a random-effects variable, and false discovery rate-adjusted p-values were calculated. To determine the extent to which these metabolites mediated the association between NAFLD and CAVI, mediation analysis was conducted.Results: NAFLD was positively associated with CAVI (coefficients [95% Confidence intervals (CI)]=0.23 [0.09–0.37]; p=0.001). A total of 10 metabolites were involved in NAFLD and CAVI, namely, branched-chain amino acids (BCAAs; valine, leucine, and isoleucine), aromatic amino acids (AAAs; tyrosine and tryptophan), alanine, proline, glutamic acid, glycerophosphorylcholine, and 4-methyl-2-oxopentanoate. Mediation analysis showed that BCAAs mediated more than 20% of the total effect in the association between NAFLD and CAVI.Conclusions: NAFLD was associated with a marker of atherosclerosis, and several metabolites related to insulin resistance, including BCAAs and AAAs, could be involved in the process by which NAFLD leads to atherosclerosis.
- Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Association between statin use and risk of diabetes from metabolomics study in epidemiologic research

Matsumoto, Minako

科学研究費補助金研究成果報告書 2020

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Presentations 【 Display / hide 】

生活習慣病を有する地域在住者の自覚的健康観に影響を与える日常生活活動・健康行動の研究

濱田蘭奈, 松元美奈子, 地引綾, 横山雄太, 鈴木小夜, 中村智徳, 武林亨

日本薬学会第145年会（福岡）,

2025.03
,
Poster presentation
健診において気流閉塞を認めた地域在住者の実態の検討：鶴岡メタボロームコホート研究

松元美奈子,原田成,飯田美穂,平田あや,宮川尚子,桑原和代,土岐了大,枝川俊,三宅温子,杉山大典,岡村智教,武林亨

2023.11
,
Poster presentation
Factors associated with failure to undergo secondary examinations after an annual checkup from population-based cohort study（Tsuruoka Metabolomics Cohort Study）

Minako Matsumoto, Sei Harada, Miho Iida, Aya Hirata, Kazuyo Kuwabara, Naoko Miyagawa, Tomonori Okamura, Toru Takebayashi

第33回日本医療薬学会年会,

2023.11
,
Oral presentation (general)
お薬手帳と比較した自記式質問紙による服薬情報の妥当性研究

矢嶋里菜,松元美奈子,原田成,飯田美穂,平田あや,桑原和代,宮川尚子,中村智徳,岡村智教,武林亨

第82回日本公衆衛生学会総会,

2023.10

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2023.11
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Poster presentation
健診における受診勧奨に基づく国保・後期高齢者の二次健診受診要因の検討

松元美奈子、原田成、飯田美穂、加藤寿寿華、佐田みずき、平田あや、宮川尚子、桑原和代、杉山大典、岡村智教、武林亨

第33回日本疫学会学術総会 (アクトシティ浜松（浜松市）) ,

2023.02
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Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

薬局におけるPHR活用方法とその推進に関する実証的研究

2025.04

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2027.03

厚生労働省 , 令和７年度厚生労働科学研究費補助金, Research grant, Coinvestigator(s)
バイオ後続品の有効性・安全性をリアルワールドで体系的に評価するシステムの確立

2024.10

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2025.03

厚生労働省 , 令和6年度厚生労働行政推進調査事業費補助金（厚生労働科学特別研究事業）, Research grant, Coinvestigator(s)
健診における受診勧奨に基づく国保・後期高齢者の二次健診受診要因の検討

2021.10

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2022.09

医療経済研究機構, Other, Principal investigator
スタチン使用による糖尿病発症リスクに関するメタボローム疫学研究

2019.04

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2020.03

MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up , Principal investigator
スタチン使用による糖尿病発症リスクに関するメタボローム疫学研究

2018.10

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Present

MEXT,JSPS, Grant-in-Aid for Scientific Research, Minako　Matsutmoto, Grant-in-Aid for Research Activity Start-up , Research grant, Principal investigator

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Awards 【 Display / hide 】

学生優秀発表賞

濱田蘭奈, 松元美奈子, 地引綾, 横山雄太, 鈴木小夜, 中村智徳, 武林亨, 2025.04, 日本薬学会第145年会, 生活習慣病を有する地域在住者の自覚的健康観に影響を与える日常生活活動・健康行動の研究

Type of Award： Award from Japanese society, conference, symposium, etc.
学生優秀発表賞

幾田遥史、松元美奈子、地引綾、横山雄太、河添仁、鈴木小夜、中村智徳、武林亨, 2021.03, 日本薬学会第141年会, 高齢者における三大生活習慣病と服薬アドヒアランスの検討

Type of Award： Award from Japanese society, conference, symposium, etc.
Spotlight poster presentation

Minako Matsumoto, Sei Harada, Miho Iida, Tomonori Okamura, Toru Takebayashi, 2019.10, 12th ISPE ACPE Conference, Validity assessment of self-reported medication use in a pharmacoepidemiology research (by comparing to medical and pharmacy insurance claims)

Type of Award： Award from international society, conference, symposium, etc.

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Courses Taught 【 Display / hide 】

BIOSTATISTICS AND MEDICAL INFORMATICS

2025
三学部合同教育

2024, Other, Undergraduate (specialized), Laboratory work/practical work/exercise
衛生学Ⅰ

2023, Autumn Semester, Undergraduate (specialized), Lecture
衛生学Ⅱ

2023, Autumn Semester, Undergraduate (specialized), Lecture
公衆衛生学Ⅱ

2023, Autumn Semester, Undergraduate (specialized), Laboratory work/practical work/exercise