杉山　大典 (スギヤマ　ダイスケ)

Sugiyama, Daisuke

写真a

所属（所属キャンパス）

看護医療学部 （湘南藤沢）

職名

教授

HP
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その他の所属・職名 【 表示 ／ 非表示 】

  • 医学部, 衛生学公衆衛生学教室, 兼担教授

  • 大学院健康マネジメント研究科, 教授

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経歴 【 表示 ／ 非表示 】

  • 2003年06月
    -
    2004年03月

    神戸大学医学部附属病院, 医員（研修医）

  • 2006年04月
    -
    2009年09月

    神戸大学医学部附属病院　　, 検査部, 医員

  • 2009年10月
    -
    2011年12月

    神戸大学大学院医学研究科, 内科系講座 臨床検査・免疫学分野 立証検査医学部門, 特命助教

  • 2010年05月
    -
    継続中

    先端医療センター研究所　, 先制・予防医療研究開発部 コホート研究チーム　, 客員研究員

  • 2012年01月
    -
    2014年03月

    慶應義塾大学医学部, 衛生学公衆衛生学教室　, 助教

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学歴 【 表示 ／ 非表示 】

  • 1997年04月
    -
    2003年03月

    神戸大学, 医学部医学科

    大学, 卒業

  • 2004年04月
    -
    2005年03月

    国立保健医療科学院　, 専門課程　生物統計分野

    その他, 修了

  • 2005年04月
    -
    2009年03月

    神戸大学大学院, 医学系研究科　

    大学院, 修了

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学位 【 表示 ／ 非表示 】

  • Master of Public Health in Biostatistics *現Certified Public Health Professionalに相当, 国立保健医療科学院, 2005年03月

  • 博士（医学）, 神戸大学, 課程, 2009年03月

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免許・資格 【 表示 ／ 非表示 】

  • 日本臨床検査医学会 臨床検査専門医

  • 診療情報管理士

  • 社会医学系専門医協会　専門医・指導医

  • 日本医師会認定産業医

  • 医師免許, 2003年05月

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研究分野 【 表示 ／ 非表示 】

  • 疫学・予防医学

  • 衛生学・公衆衛生学

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研究キーワード 【 表示 ／ 非表示 】

  • 健診の有効性

  • 生活習慣病疫学

  • 臨床検査医学

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著書 【 表示 ／ 非表示 】

  • 健康教育マニュアル

    岡山 明編著（分担執筆）, 一般社団法人日本家族計画協会, 2014年07月

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論文 【 表示 ／ 非表示 】

  • Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: The KOBE study

    Kubo S., Nishida Y., Kubota Y., Higashiyama A., Sugiyama D., Hirata T., Miyamatsu N., Tanabe A., Hirata A., Tatsumi Y., Kadota A., Kuwabara K., Nishikawa T., Miyamoto Y., Okamura T.

    BMC Nephrology （BMC Nephrology)  20 （ 1 ）  2019年04月

    　概要を見る

    © 2019 The Author(s). Background: Although several epidemiological studies have suggested that high serum uric acid (SUA) levels are related to a decline in kidney function, only a few studies have investigated using cystatin C to calculate estimated glomerular filtration rate (eGFR). We aimed to clarify the relationship between SUA levels and kidney function assessed by cystatin C in a Japanese general community population without chronic kidney disease (CKD). Methods: We conducted a community-based cross-sectional study that included 1086 healthy participants, aged 40-74 years, without CKD and not undergoing treatment of hyperuricemia, who had participated in the baseline survey of the Kobe Orthopedic and Biomedical Epidemiological (KOBE) study. The preconditions for participation in this study were no past histories of cardiovascular disease or cancer, and not undergoing treatment for diabetes, hypertension, or dyslipidemia. We classified the participants into quartiles stratified by sex according to their SUA level and then examined the relationship with eGFR. The odds ratios for having a low eGFR, defined as the lowest quartile of eGFR (i.e., ≤78.4 mL/min/1. 73m 2 ) was estimated according to SUA quartiles (men, Q1 ≤ 5.0, Q2 5.1-5.9, Q3 6.0-6.6, and Q4 ≥ 6.7; women, Q1 ≤ 3.8, Q2 3.9-4.3, Q3 4.4-4.9, and Q4 ≥ 5.0 mg/dL) after adjustment for age, body mass index, systolic blood pressure, HbA1c, high and low density lipoprotein cholesterol, and smoking and drinking habits. The adjusted mean of each quartile was also calculated. Results: Multivariable-adjusted means of eGFR showed a graded decrease in higher SUA quartiles (men, Q1 90.5, Q2 88.0, Q3 83.5, and Q4 82.0; women, Q1 95.7, Q2 91.3, Q3 89.2, and Q4 86.7). In addition, the multivariable-adjusted odds ratios for having a lower eGFR (95% confidence interval) for each SUA quartile compared with Q1 was Q2 2.29 (0.98, 5.35), Q3 4.94 (2.04, 11.97), and Q4 8.01 (3.20, 20.04) for men, and was Q2 2.20 (1.12, 4.32), Q3 2.68 (1.39, 5.20), and Q4 4.96 (2.62, 9.41) for women. Conclusions: There was a graded inverse relationship between mild elevations in SUA levels and eGFR assessed by cystatin C in an apparently healthy Japanese population without CKD. This association was similar in both men and women.

  • Outcomes of transcatheter mitral valve replacement for degenerated bioprostheses, failed annuloplasty rings, and mitral annular calcification

    Yoon S., Whisenant B., Bleiziffer S., Delgado V., Dhoble A., Schofer N., Eschenbach L., Bansal E., Murdoch D., Ancona M., Schmidt T., Yzeiraj E., Vincent F., Niikura H., Kim W., Asami M., Unbehaun A., Hirji S., Fujita B., Silaschi M., Tang G., Kuwata S., Wong S., Frangieh A., Barker C., Davies J., Lauten A., Deuschl F., Nombela-Franco L., Rampat R., Nicz P., Masson J., Wijeysundera H., Sievert H., Blackman D., Gutierrez-Ibanes E., Sugiyama D., Chakravarty T., Hildick-Smith D., De Brito F., Jensen C., Jung C., Smalling R., Arnold M., Redwood S., Kasel A., Maisano F., Treede H., Ensminger S., Kar S., Kaneko T., Pilgrim T., Sorajja P., Van Belle E., Prendergast B., Bapat V., Modine T., Schofer J., Frerker C., Kempfert J., Attizzani G., Latib A., Schaefer U., Webb J., Bax J., Makkar R.

    European Heart Journal （European Heart Journal)  40 （ 5 ） 441 - 451 2019年

    ISSN  0195668X

    　概要を見る

    © 2018 The Author(s). All rights reserved. Aims: We sought to evaluate the outcomes of transcatheter mitral valve replacement (TMVR) for patients with degenerated bioprostheses [valve-in-valve (ViV)], failed annuloplasty rings [valve-in-ring (ViR)], and severe mitral annular calcification [valve-in-mitral annular calcification (ViMAC)]. Methods and results: From the TMVR multicentre registry, procedural and clinical outcomes of ViV, ViR, and ViMAC were compared according to Mitral Valve Academic Research Consortium (MVARC) criteria. A total of 521 patients with mean Society of Thoracic Surgeons score of 9.0± 7.0% underwent TMVR (322 patients with ViV, 141 with ViR, and 58 with ViMAC). Trans-septal access and the Sapien valves were used in 39.5% and 90.0%, respectively. Overall technical success was excellent at 87.1%. However, left ventricular outflow tract obstruction occurred more frequently after ViMAC compared with ViR and ViV (39.7% vs. 5.0% vs. 2.2%; P < 0.001), whereas second valve implantation was more frequent in ViR compared with ViMAC and ViV (12.1% vs. 5.2% vs. 2.5%; P< 0.001). Accordingly, technical success rate was higher after ViV compared with ViR and ViMAC (94.4% vs. 80.9% vs. 62.1%; P< 0.001). Compared with ViMAC and ViV groups, ViR group had more frequent post-procedural mitral regurgitation ≥moderate (18.4% vs. 13.8% vs. 5.6%; P< 0.001) and subsequent paravalvular leak closure (7.8% vs. 0.0% vs. 2.2%; P = 0.006). All-cause mortality was higher after ViMAC compared with ViR and ViV at 30 days (34.5% vs. 9.9% vs. 6.2%; log-rank P<0.001) and 1 year (62.8% vs. 30.6% vs. 14.0%; log-rank P< 0.001). On multivariable analysis, patients with failed annuloplasty rings and severe MAC were at increased risk of mortality after TMVR [ViR vs. ViV, hazard ratio (HR) 1.99, 95% confidence interval (CI) 1.27-3.12; P= 0.003; ViMAC vs. ViV, HR 5.29, 95% CI 3.29-8.51; P < 0.001]. Conclusion: The TMVR provided excellent outcomes for patients with degenerated bioprostheses despite high surgical risk. However, ViR and ViMAC were associated with higher rates of adverse events and mid-term mortality compared with ViV.

  • Influence of workplace environment, working conditions and health status of taxi drivers on vehicle collisions or near-miss events

    Baba M., Miyama G., Sugiyama D., Hitosugi M.

    Industrial Health （Industrial Health)  57 （ 4 ） 530 - 536 2019年

    ISSN  00198366

    　概要を見る

    © 2019 National Institute of Occupational Safety and Health. Sudden illness while driving has been identified as a major cause of vehicle collisions, particularly among taxi drivers. However, no previous studies have examined the factors contributing to the occurrence of health-related vehicle collisions. The current study aimed to identify the risk factors causing health-related vehicle collisions among taxi drivers, and to inform preventative interventions. A cross-sectional survey involving a written anonymous questionnaire was conducted for company-employed taxi drivers in Chiba Prefecture, Japan. A total of 1,739 drivers returned questionnaires. Drivers were classified into those who had experienced collisions or near-miss incidents caused by health problems (Event group), and those who had not (Non-event group). According to a multivariable logistic regression analysis, being unable to take vacation time (odds ratio [OR] 4.59, 95% confidence interval [CI] 2.2–9.58), having chronic diseases (OR 1.52, 95% CI 1.02–2.27), taking insufficient vacation time (OR 1.81, 95% CI 1.19–2.79), and difficulty reporting poor health conditions (OR 2.29, 95% CI 1.36–3.87) were significant factors for the likelihood of an event. Support for drivers to maintain well-balanced control of illnesses and improvement of working environments could prevent health-related events while driving.

  • Association between impairment of salty taste recognition and masked hypertension based on home blood pressure in Japanese residents: the KOBE study

    Kubota Y., Higashiyama A., Sugiyama D., Nishida Y., Kubo S., Hirata T., Kadota A., Miyamatsu N., Wakabayashi I., Miyamoto Y., Okamura T.

    Hypertension Research （Hypertension Research)  41 （ 9 ） 756 - 762 2018年09月

    ISSN  09169636

    　概要を見る

    © 2018, The Japanese Society of Hypertension. Excessive salt intake is an established risk factor for hypertension. We conducted a cross-sectional study to examine the association between salty taste recognition and estimated salt intake and masked hypertension in a healthy Japanese normotensive population. The participants were 892 apparently healthy community residents (246 men and 646 women) aged between 40 and 74 years with blood pressure below 140/90 mm Hg. Salty taste recognition was assessed using a salt-impregnated taste strip. Daily salt intake was calculated as estimated 24 h urinary sodium excretion using spot urine tests. Each participant performed home blood pressure measurements for a minimum of 5 days per week. The participants were classified into three groups according to their salty taste recognition threshold evaluated by the salt concentrations of the taste strips (0.6%, 0.8%, and ≥ 1.0%). In women, the multivariate odds ratio (95% confidence interval) for masked hypertension (≥ 135/85 mm Hg) was 2.98 (1.16–7.64) in the ≥ 1.0% group compared with that in the 0.6% group. In men, the proportion of masked hypertension in the ≥ 1.0% group did not differ from that in the 0.6% group, and no correlation was identified between estimated daily salt intake and the salty taste recognition threshold. In conclusion, impairment of salty taste recognition was associated with masked hypertension in women even with normal blood pressure in the clinical setting.

  • Fatty liver index predicts incident diabetes in a Japanese general population with and without impaired fasting glucose

    Hirata A., Sugiyama D., Kuwabara K., Hirata T., Tsutatani H., Funamoto M., Watanabe K., Miyamatsu N., Okamura T.

    Hepatology Research （Hepatology Research)  48 （ 9 ） 708 - 716 2018年08月

    ISSN  13866346

    　概要を見る

    © 2018 The Japan Society of Hepatology Aim: Fatty liver is associated with the development of diabetes. However, to our knowledge, no study has examined the relationship between the fatty liver index (FLI), calculated scores of hepatic steatosis, and the development of diabetes among individuals without impaired fasting glucose (IFG). We aimed to examine whether FLI predicts the development of diabetes in individuals with and without IFG in a Japanese general population. Methods: We selected 1498 men and 2941 women who participated in Specific Health Checkups in Japan. We divided all participants into six groups according to tertiles of FLI (low, moderate, and high) and the presence or absence of IFG, by sex. We calculated hazard ratios for incident diabetes for each group using a Cox proportional hazard model, adjusting for potential confounders. Results: During a mean follow-up period of 3.0 years, 176 cases of diabetes in men and 320 cases in women were identified. Compared with the low FLI group without IFG, the high FLI group without IFG was significantly associated with incident diabetes in both men (hazard ratio, 1.90; 95% confidence interval, 1.08–3.36) and women (hazard ratio, 1.72; 95% confidence interval, 1.18–2.51). All IFG groups were significantly associated with incident diabetes regardless of FLI levels. Conclusions: Our results showed that FLI is associated with the development of diabetes regardless of sex and the presence or absence of IFG, and that it may be a useful predictor of future risk of incident diabetes even in individuals without IFG.

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KOARA（リポジトリ）収録論文等 【 表示 ／ 非表示 】

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研究発表 【 表示 ／ 非表示 】

  • 能動喫煙・受動喫煙が精神的健康状態に与える影響

    杉山 大典

    第52回日本アルコール・アディクション医学会, 2017年09月, ポスター（一般）

  • 地域住民における耐糖能異常の有無による飲酒習慣の糖尿病発症リスクに関する検討

    杉山 大典

    第52回日本アルコール・アディクション医学会, 2017年09月, ポスター（一般）

  • 酒状況が精神的健康状態に与える影響：神戸研究

    杉山 大典

    第52回日本アルコール・アディクション医学会, 2017年09月, 口頭（一般）

  • 男性の飲酒とCVD死亡の関連における脂質異常症およびγ-GTP値の影響：NIPPON DATA90

    杉山 大典

    第52回日本アルコール・アディクション医学会, 2017年09月

  • 非メタボリック症候群対象者における飲酒と正常高値以上血圧の新規発症の関連　羽曳野市特定健診での検討

    杉山 大典

    第52回日本アルコール・アディクション医学会, 2017年09月, 口頭（一般）

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競争的資金等の研究課題 【 表示 ／ 非表示 】

  • 一般地域住民における自己抗体陽性率の評価及びその臨床的意義の解明

    2020年04月
    -
    2025年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 杉山 大典, 基盤研究(C), 補助金,  代表

  • 軽度認知機能障害と動脈硬化性疾患リスクファクターの関連：都市部住民における検討

    2017年
    -
    2019年

    科学研究費補助金(文部科学省・日本学術振興会）, 補助金,  代表

  • メタボリック症候群と投薬加療が必要な糖尿病の新規発症の関連について：一般市民集団を対象とした研究

    2016年04月
    -
    2017年03月

    一般財団法人日本健康増進財団, 生活習慣病予防に関する研究助成, その他,  代表

  • 都市部住民における自己抗体の発現と生活習慣病との関係性の解明

    2013年
    -
    2015年

    科学研究費補助金(文部科学省・日本学術振興会）, 補助金,  代表

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受賞 【 表示 ／ 非表示 】

  • Thrombosis Research awarded Outstanding Reviewer Status

    2017年03月

    受賞区分： その他の賞

  • Thrombosis Research awarded Outstanding Reviewer Status

    2017年03月

  • 第75回日本公衆衛生学会　示説（ポスター）賞

    2016年10月

  • 示説（ポスター）賞

    2016年10月, 第75回日本公衆衛生学会

    受賞区分： 国内学会・会議・シンポジウム等の賞

  • 日本動脈硬化学会　第8回JAT賞受賞

    2016年07月

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担当授業科目 【 表示 ／ 非表示 】

  • 基礎生物統計学Ⅰ

    2020年度

  • 基礎生物統計学Ⅱ

    2020年度

  • 応用生物統計学

    2020年度

  • 特別研究

    2020年度

  • 保健統計学

    2020年度

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担当経験のある授業科目 【 表示 ／ 非表示 】

  • 基礎生物統計学I

    慶應義塾, 2018年度, 春学期, 専門科目, 講義, 兼担

    健康マネジメント研究科・医学研究科共通科目

  • 臨床疫学

    慶應義塾, 2018年度, 春学期, 講義, 兼担

  • 基礎生物統計学II

    慶應義塾, 2018年度, 春学期, 専門科目, 講義, 兼担

    健康マネジメント研究科・医学研究科共通科目

  • 応用生物統計学

    慶應義塾, 2017年度, 秋学期, 専門科目, 兼担

    健康マネジメント研究科・医学研究科共通科目

  • 衛生学

    慶應義塾, 2017年度, 秋学期, 専門科目, 講義, 兼担

    基礎疫学・疫学演習担当

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社会活動 【 表示 ／ 非表示 】

  • 日本動脈硬化学会

    2017年07月
    -
    継続中

    　概要を見る

    評議員

  • 日本疫学会

    2017年06月
    -
    継続中

    　概要を見る

    代議員

  • 日本循環器病予防学会

    2017年06月
    -
    継続中

    　概要を見る

    評議員

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