杉山 大典 (スギヤマ ダイスケ)

Sugiyama, Daisuke

写真a

所属(所属キャンパス)

看護医療学部 (湘南藤沢)

職名

教授

HP

その他の所属・職名 【 表示 / 非表示

  • 医学部, 衛生学公衆衛生学教室, 兼担教授

  • 大学院健康マネジメント研究科, 教授

経歴 【 表示 / 非表示

  • 2003年06月
    -
    2004年03月

    神戸大学医学部附属病院, 医員(研修医)

  • 2006年04月
    -
    2009年09月

    神戸大学医学部附属病院  , 検査部, 医員

  • 2009年10月
    -
    2011年12月

    神戸大学大学院医学研究科, 内科系講座 臨床検査・免疫学分野 立証検査医学部門, 特命助教

  • 2010年05月
    -
    継続中

    先端医療センター研究所 , 先制・予防医療研究開発部 コホート研究チーム , 客員研究員

  • 2012年01月
    -
    2014年03月

    慶應義塾大学医学部, 衛生学公衆衛生学教室 , 助教

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学歴 【 表示 / 非表示

  • 1997年04月
    -
    2003年03月

    神戸大学, 医学部医学科

    大学, 卒業

  • 2004年04月
    -
    2005年03月

    国立保健医療科学院 , 専門課程 生物統計分野

    その他, 修了

  • 2005年04月
    -
    2009年03月

    神戸大学大学院, 医学系研究科 

    大学院, 修了

学位 【 表示 / 非表示

  • Master of Public Health in Biostatistics *現Certified Public Health Professionalに相当, 国立保健医療科学院, 2005年03月

  • 博士(医学), 神戸大学, 課程, 2009年03月

免許・資格 【 表示 / 非表示

  • 日本医師会認定産業医

  • 診療情報管理士

  • 社会医学系専門医協会 専門医・指導医

  • 医師免許, 2003年05月

  • 上級疫学専門家, 2020年04月

 

研究分野 【 表示 / 非表示

  • 疫学・予防医学

  • 衛生学・公衆衛生学

研究キーワード 【 表示 / 非表示

  • 健診の有効性

  • 生活習慣病疫学

  • 臨床検査医学

 

著書 【 表示 / 非表示

  • 健康教育マニュアル

    岡山 明編著(分担執筆), 一般社団法人日本家族計画協会, 2014年07月

論文 【 表示 / 非表示

  • Estimated 24 h urinary sodium-to-potassium ratio is related to renal function decline: A 6-year cohort study of japanese urban residents

    Hattori H., Hirata A., Kubo S., Nishida Y., Nozawa M., Kawamura K., Hirata T., Kubota Y., Sata M., Kuwabara K., Higashiyama A., Kadota A., Sugiyama D., Miyamatsu N., Miyamoto Y., Okamura T.

    International Journal of Environmental Research and Public Health (International Journal of Environmental Research and Public Health)  17 ( 16 ) 1 - 12 2020年08月

    ISSN  16617827

     概要を見る

    The effect of the sodium-to-potassium ratio (Na/K) on renal function within the clinically normal range of renal function are limited. We investigated the effects of an estimated 24 h urinary Na/K (e24hUNa/K) on a 6-year renal function decline among 927 urban Japanese community dwellers with no history of cardiovascular diseases and medication for hypertension, diabetes, or dyslipidemia. We partitioned the subjects into quartiles according to the e24hUNa/K. The estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease epidemiology collaboration (CKD/EPI) formula and renal function decline was defined as an absolute value at or above the third quartile of the eGFR decline rate. A multivariable logistic regression model was used for estimation. Compared with the first quartile of the e24hUNa/K, multivariable-adjusted odds ratios (ORs) for eGFR decline in the second, third, and fourth quartiles were 0.96 (95% confidence interval: 0.61–1.51), 1.06 (0.67–1.66), and 1.65 (1.06–2.57), respectively. These results were similar when the simple spot urine Na/K ratio was used in place of the e24hUNa/K. Apparently healthy urban residents with an almost within normal range mean baseline eGFR and high e24hUNa/K ratios had an increased risk for a future decline in renal function. Reducing the Na/K ratio may be important in the prevention of chronic kidney disease in its early stage.

  • US detection of medial meniscus extrusion can predict the risk of developing radiographic knee osteoarthritis: a 5-year cohort study

    Chiba D., Sasaki E., Ota S., Maeda S., Sugiyama D., Nakaji S., Ishibashi Y.

    European Radiology (European Radiology)  30 ( 7 ) 3996 - 4004 2020年07月

    ISSN  09387994

     概要を見る

    Objectives: To clarify the relationship between the baseline value of medial meniscus extrusion (MME) and the radiographic change of knee osteoarthritis (KOA) through a 5-year follow-up. Methods: Overall, 472 participants and 944 knees were eligible. MME (mm) was measured at the baseline, and KOA was radiographically evaluated at both baseline and 5-year follow-up by Kellgren-Lawrence grade (KLG). Radiographic KOA (ROA) was defined as the knee showing KLG ≥ 2. Incident ROA (iROA) was defined if the baseline KLG of 0–1 increased to KLG ≥ 2 in 5 years. Progressive ROA (pROA) was defined if the baseline KLG of 2–3 worsened to a higher grade in 5 years. Receiver operating characteristic (ROC) curve and generalized estimating equations were used for analysis. Results: Of 574 non-ROA knees at the baseline, 43 knees (7.5%) developed iROA; of 370 ROA knees, 47 knees (12.7%) developed pROA. Based on the ROC curves, 4 mm was the optimal cutoff to detect the risk of iROA (area under curve [AUC] 0.639 [right knee]; AUC 0.641 [left knee]) and that of pROA (AUC 0.750 [right knee]; AUC 0.863 [left knee]). Multiple regression analysis showed that the 4-mm cutoff of MME was significantly associated with both the prevalence of iROA (regression coefficient [B] 1.909; p ≤ 0.001; adjusted odds ratio [aOR] 6.746) and that of pROA (B 1.791; p ≤ 0.001; aOR 5.993). Conclusions: On ultrasonography, the participants with more extruded medial meniscus showed a higher prevalence of both iROA and pROA. Ultrasonography could identify patients who had a risk of developing KOA. Key Points: • Through a 5-year follow-up, the current cohort study was conducted to clarify the relationship between the baseline value of medial meniscus extrusion (MME) and the radiographic change of knee osteoarthritis (KOA). • More extruded medial meniscus evaluated by ultrasonography was associated with the development of radiographic KOA. • Ultrasonography could identify the patients who had a risk of developing KOA, and the 4-mm cutoff of MME was optimal to detect this risk.

  • Hypercholesterolemia and lifetime risk of coronary heart disease in the general japanese population: Results from the suita cohort study

    Sugiyama D., Turin T.C., Yeasmin F., Rumana N., Watanabe M., Higashiyama A., Takegami M., Kokubo Y., Okamura T., Miyamoto Y.

    Journal of Atherosclerosis and Thrombosis (Journal of Atherosclerosis and Thrombosis)  27 ( 1 ) 60 - 70 2020年

    ISSN  13403478

     概要を見る

    Lifetime risk (LTR) is a measure of disease burden, which presents the probability of occurrence of a specific disease in the remaining lifetime of a group of people for a given index age. This measure is useful for presenting the risk dynamics of a disease at the population level, which constitutes important public health information toward prevention. To date, there have been no studies investigating the LTR for coronary heart diseases (CHDs) in relation to hypercholesterolemia in Asian populations. Therefore, we estimated the LTR of CHDs according to serum low-density lipoprotein cholesterol (LDL-C). Methods: The participants included in this study were 2,559 men and 2,848 women, enrolled in the Suita Cohort Study of urban residents followed up from 1989 to 2007 for a total of 69,823 person-years. We estimated the sex-and index-age-specific LTR for the first CHD event among participants with or without hypercholesterolemia (LDL-C ≥ 160 mg/dL), accounting for the competing risk for mortality. Results: For men with hypercholesterolemia, the LTR was 47.2% (95% confidence interval [CI]: 29.3–65.1%) and 44.5% (95% CI: 21.4–68.5%) for those aged 45 and 75, respectively. The LTRs of women with hypercholesterolemia were also higher than of those without hypercholesterolemia. However, their LTRs were lower for all index ages compared to men. These results did not differ for hypercholesterolemia defined by non-high-density lipoprotein cholesterol. Conclusions: The presence of hypercholesterolemia increases the LTR for CHDs in the Japanese population, especially in men. This estimate can be used in preventive knowledge translation efforts at the population level.

  • Association between dyslipidemia and plasma levels of branched-chain amino acids in the Japanese population without diabetes mellitus

    Fukushima K., Harada S., Takeuchi A., Kurihara A., Iida M., Fukai K., Kuwabara K., Kato S., Matsumoto M., Hirata A., Akiyama M., Tomita M., Hirayama A., Sato A., Suzuki C., Sugimoto M., Soga T., Sugiyama D., Okamura T., Takebayashi T.

    Journal of Clinical Lipidology (Journal of Clinical Lipidology)  13 ( 6 ) 932 - 939.e2 2019年11月

    ISSN  19332874

     概要を見る

    Background: Branched-chain amino acids (BCAAs) play a key role in energy homeostasis. Objective: We aimed to investigate the association between plasma BCAA levels and dyslipidemia in the Japanese population without diabetes mellitus. Methods: This cross-sectional study included 4952 participants without diabetes mellitus, enrolled in the Tsuruoka Metabolomic Cohort Study. Plasma BCAA levels were measured by capillary electrophoresis–mass spectrometry. Correlations between lipid and BCAA profiles were evaluated by sex-stratified multiple linear regression analyses, after adjusting for confounders. Logistic regression was used to identify associations between BCAAs and metabolic dyslipidemia (MD) defined as triglyceride levels ≥150 mg/dL, high-density lipoprotein cholesterol levels ≤40 mg/dL for men and ≤50 mg/dL for women, or low-density lipoprotein cholesterol (LDL-C) levels ≥140 mg/dL. Results: In both sexes, the levels of individual BCAAs and the total BCAA levels correlated positively with triglyceride levels and negatively with high-density lipoprotein cholesterol levels. Valine, leucine, and total BCAA levels were weakly and positively correlated with LDL-C levels. Increased BCAA levels showed positive associations with MD. However, associations between BCAAs and elevated LDL-C levels were unclear. Furthermore, the associations between BCAA levels and MD regardless of fasting blood sugar (FBS) levels (high or low). Although valine, leucine, and total BCAA levels were weakly associated with elevated LDL-C levels in the high-FBS group, no such association was observed in the low-FBS group. Conclusions: BCAAs might be associated with MD independently of the FBS level and might play an important role in lipid metabolism and dyslipidemia.

  • Effect of high-dose marine omega-3 fatty acids on atherosclerosis: A systematic review and meta-analysis of randomized clinical trials

    Sekikawa A., Cui C., Sugiyama D., Fabio A., Harris W.S., Zhang X.

    Nutrients (Nutrients)  11 ( 11 )  2019年11月

     概要を見る

    A recent randomized controlled trial (RCT), the Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial (REDUCE-IT), reported that high-dose marine omega-3 fatty acids (OM3) significantly reduce cardiovascular disease (CVD) outcomes, yet the mechanisms responsible for this benefit remain unknown. To test the hypothesis that high-dose OM3 is anti-atherosclerotic, we performed a systematic review and meta-analysis of RCT of high-dose OM3 on atherosclerosis. The protocol of this systematic review was registered with PROSPERO (CRD42019125566). PubMed, Embase, Cochran Central Register for Controlled Trials, and Clinicaltrials.gov databases were searched using the following criteria: adult participants, high-dose OM3 (defined as ≥3.0 g/day, or in Japan 1.8 g/day and purity ≥90%) as the intervention, changes in atherosclerosis as the outcome, and RCTs with an intervention duration of ≥6 months. A random-effects meta-analysis was used to pool estimates across studies. Among the 598 articles retrieved, six articles met our criteria. Four RCTs evaluated atherosclerosis in the coronary and two in the carotid arteries. High-dose OM3 significantly slowed the progression of atherosclerosis (standardized mean difference −1.97, 95% confidence interval −3.01, −0.94, p < 0.001). The results indicate that anti-atherosclerotic effect of high-dose OM3 is one potential mechanism in reducing CVD outcomes demonstrated in the REDUCE-IT trial.

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

研究発表 【 表示 / 非表示

  • 能動喫煙・受動喫煙が精神的健康状態に与える影響

    杉山 大典

    第52回日本アルコール・アディクション医学会, 2017年09月, ポスター(一般)

  • 地域住民における耐糖能異常の有無による飲酒習慣の糖尿病発症リスクに関する検討

    杉山 大典

    第52回日本アルコール・アディクション医学会, 2017年09月, ポスター(一般)

  • 酒状況が精神的健康状態に与える影響:神戸研究

    杉山 大典

    第52回日本アルコール・アディクション医学会, 2017年09月, 口頭(一般)

  • 男性の飲酒とCVD死亡の関連における脂質異常症およびγ-GTP値の影響:NIPPON DATA90

    杉山 大典

    第52回日本アルコール・アディクション医学会, 2017年09月

  • 非メタボリック症候群対象者における飲酒と正常高値以上血圧の新規発症の関連 羽曳野市特定健診での検討

    杉山 大典

    第52回日本アルコール・アディクション医学会, 2017年09月, 口頭(一般)

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競争的資金等の研究課題 【 表示 / 非表示

  • 一般地域住民における自己抗体陽性率の評価及びその臨床的意義の解明

    2020年04月
    -
    2025年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 杉山 大典, 基盤研究(C), 補助金,  代表

  • 軽度認知機能障害と動脈硬化性疾患リスクファクターの関連:都市部住民における検討

    2017年
    -
    2019年

    科学研究費補助金(文部科学省・日本学術振興会), 補助金,  代表

  • メタボリック症候群と投薬加療が必要な糖尿病の新規発症の関連について:一般市民集団を対象とした研究

    2016年04月
    -
    2017年03月

    一般財団法人日本健康増進財団, 生活習慣病予防に関する研究助成, その他,  代表

  • 都市部住民における自己抗体の発現と生活習慣病との関係性の解明

    2013年
    -
    2015年

    科学研究費補助金(文部科学省・日本学術振興会), 補助金,  代表

受賞 【 表示 / 非表示

  • Thrombosis Research awarded Outstanding Reviewer Status

    2017年03月

    受賞区分: その他の賞

  • Thrombosis Research awarded Outstanding Reviewer Status

    2017年03月

  • 第75回日本公衆衛生学会 示説(ポスター)賞

    2016年10月

  • 示説(ポスター)賞

    2016年10月, 第75回日本公衆衛生学会

    受賞区分: 国内学会・会議・シンポジウム等の賞

  • 日本動脈硬化学会 第8回JAT賞受賞

    2016年07月

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担当授業科目 【 表示 / 非表示

  • 疫学研究の統計的方法

    2021年度

  • 疫学研究の統計的方法

    2021年度

  • プロジェクトⅡ(応用)

    2021年度

  • プロジェクトⅠ(基礎)

    2021年度

  • 公衆衛生学

    2021年度

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担当経験のある授業科目 【 表示 / 非表示

  • 基礎生物統計学I

    慶應義塾, 2018年度, 春学期, 専門科目, 講義, 兼担

    健康マネジメント研究科・医学研究科共通科目

  • 臨床疫学

    慶應義塾, 2018年度, 春学期, 講義, 兼担

  • 基礎生物統計学II

    慶應義塾, 2018年度, 春学期, 専門科目, 講義, 兼担

    健康マネジメント研究科・医学研究科共通科目

  • 衛生学

    慶應義塾, 2017年度, 秋学期, 専門科目, 講義, 兼担

    基礎疫学・疫学演習担当

  • 臨床疫学

    慶應義塾, 2017年度, 春学期, 講義, 兼担

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社会活動 【 表示 / 非表示

  • 日本動脈硬化学会

    2017年07月
    -
    継続中

     概要を見る

    評議員

  • 日本疫学会

    2017年06月
    -
    継続中

     概要を見る

    代議員

  • 日本循環器病予防学会

    2017年06月
    -
    継続中

     概要を見る

    評議員