Sugiyama, Daisuke

写真a

Affiliation

Faculty of Nursing and Medical Care (Shonan Fujisawa)

Position

Professor

Related Websites

Other Affiliation 【 Display / hide

  • School of Medicine, 衛生学公衆衛生学教室, 兼担教授

  • Graduate School of Health Management, 教授

Career 【 Display / hide

  • 2003.06
    -
    2004.03

    神戸大学医学部附属病院, 医員(研修医)

  • 2006.04
    -
    2009.09

    神戸大学医学部附属病院  , 検査部, 医員

  • 2009.10
    -
    2011.12

    神戸大学大学院医学研究科, 内科系講座 臨床検査・免疫学分野 立証検査医学部門, 特命助教

  • 2010.05
    -
    Present

    先端医療センター研究所 , 先制・予防医療研究開発部 コホート研究チーム , 客員研究員

  • 2012.01
    -
    2014.03

    慶應義塾大学医学部, 衛生学公衆衛生学教室 , 助教

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Academic Background 【 Display / hide

  • 1997.04
    -
    2003.03

    神戸大学, 医学部医学科

    University, Graduated

  • 2004.04
    -
    2005.03

    国立保健医療科学院 , 専門課程 生物統計分野

    Other, Completed

  • 2005.04
    -
    2009.03

    神戸大学大学院, 医学系研究科 

    Graduate School, Completed

Academic Degrees 【 Display / hide

  • Master of Public Health in Biostatistics *現Certified Public Health Professionalに相当, 国立保健医療科学院, 2005.03

  • 博士(医学), 神戸大学, Coursework, 2009.03

Licenses and Qualifications 【 Display / hide

  • 日本臨床検査医学会 臨床検査専門医

  • 診療情報管理士

  • 社会医学系専門医協会 専門医・指導医

  • 日本医師会認定産業医

  • 医師免許, 2003.05

 

Research Areas 【 Display / hide

  • Epidemiology and preventive medicine

  • Hygiene and public health

Research Keywords 【 Display / hide

  • 健診の有効性

  • 生活習慣病疫学

  • 臨床検査医学

 

Books 【 Display / hide

  • 健康教育マニュアル

    Sugiyama Daisuke, 一般社団法人日本家族計画協会, 2014.07

Papers 【 Display / hide

  • Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: The KOBE study

    Kubo S., Nishida Y., Kubota Y., Higashiyama A., Sugiyama D., Hirata T., Miyamatsu N., Tanabe A., Hirata A., Tatsumi Y., Kadota A., Kuwabara K., Nishikawa T., Miyamoto Y., Okamura T.

    BMC Nephrology (BMC Nephrology)  20 ( 1 )  2019.04

     View Summary

    © 2019 The Author(s). Background: Although several epidemiological studies have suggested that high serum uric acid (SUA) levels are related to a decline in kidney function, only a few studies have investigated using cystatin C to calculate estimated glomerular filtration rate (eGFR). We aimed to clarify the relationship between SUA levels and kidney function assessed by cystatin C in a Japanese general community population without chronic kidney disease (CKD). Methods: We conducted a community-based cross-sectional study that included 1086 healthy participants, aged 40-74 years, without CKD and not undergoing treatment of hyperuricemia, who had participated in the baseline survey of the Kobe Orthopedic and Biomedical Epidemiological (KOBE) study. The preconditions for participation in this study were no past histories of cardiovascular disease or cancer, and not undergoing treatment for diabetes, hypertension, or dyslipidemia. We classified the participants into quartiles stratified by sex according to their SUA level and then examined the relationship with eGFR. The odds ratios for having a low eGFR, defined as the lowest quartile of eGFR (i.e., ≤78.4 mL/min/1. 73m 2 ) was estimated according to SUA quartiles (men, Q1 ≤ 5.0, Q2 5.1-5.9, Q3 6.0-6.6, and Q4 ≥ 6.7; women, Q1 ≤ 3.8, Q2 3.9-4.3, Q3 4.4-4.9, and Q4 ≥ 5.0 mg/dL) after adjustment for age, body mass index, systolic blood pressure, HbA1c, high and low density lipoprotein cholesterol, and smoking and drinking habits. The adjusted mean of each quartile was also calculated. Results: Multivariable-adjusted means of eGFR showed a graded decrease in higher SUA quartiles (men, Q1 90.5, Q2 88.0, Q3 83.5, and Q4 82.0; women, Q1 95.7, Q2 91.3, Q3 89.2, and Q4 86.7). In addition, the multivariable-adjusted odds ratios for having a lower eGFR (95% confidence interval) for each SUA quartile compared with Q1 was Q2 2.29 (0.98, 5.35), Q3 4.94 (2.04, 11.97), and Q4 8.01 (3.20, 20.04) for men, and was Q2 2.20 (1.12, 4.32), Q3 2.68 (1.39, 5.20), and Q4 4.96 (2.62, 9.41) for women. Conclusions: There was a graded inverse relationship between mild elevations in SUA levels and eGFR assessed by cystatin C in an apparently healthy Japanese population without CKD. This association was similar in both men and women.

  • Outcomes of transcatheter mitral valve replacement for degenerated bioprostheses, failed annuloplasty rings, and mitral annular calcification

    Yoon S., Whisenant B., Bleiziffer S., Delgado V., Dhoble A., Schofer N., Eschenbach L., Bansal E., Murdoch D., Ancona M., Schmidt T., Yzeiraj E., Vincent F., Niikura H., Kim W., Asami M., Unbehaun A., Hirji S., Fujita B., Silaschi M., Tang G., Kuwata S., Wong S., Frangieh A., Barker C., Davies J., Lauten A., Deuschl F., Nombela-Franco L., Rampat R., Nicz P., Masson J., Wijeysundera H., Sievert H., Blackman D., Gutierrez-Ibanes E., Sugiyama D., Chakravarty T., Hildick-Smith D., De Brito F., Jensen C., Jung C., Smalling R., Arnold M., Redwood S., Kasel A., Maisano F., Treede H., Ensminger S., Kar S., Kaneko T., Pilgrim T., Sorajja P., Van Belle E., Prendergast B., Bapat V., Modine T., Schofer J., Frerker C., Kempfert J., Attizzani G., Latib A., Schaefer U., Webb J., Bax J., Makkar R.

    European Heart Journal (European Heart Journal)  40 ( 5 ) 441 - 451 2019

    ISSN  0195668X

     View Summary

    © 2018 The Author(s). All rights reserved. Aims: We sought to evaluate the outcomes of transcatheter mitral valve replacement (TMVR) for patients with degenerated bioprostheses [valve-in-valve (ViV)], failed annuloplasty rings [valve-in-ring (ViR)], and severe mitral annular calcification [valve-in-mitral annular calcification (ViMAC)]. Methods and results: From the TMVR multicentre registry, procedural and clinical outcomes of ViV, ViR, and ViMAC were compared according to Mitral Valve Academic Research Consortium (MVARC) criteria. A total of 521 patients with mean Society of Thoracic Surgeons score of 9.0± 7.0% underwent TMVR (322 patients with ViV, 141 with ViR, and 58 with ViMAC). Trans-septal access and the Sapien valves were used in 39.5% and 90.0%, respectively. Overall technical success was excellent at 87.1%. However, left ventricular outflow tract obstruction occurred more frequently after ViMAC compared with ViR and ViV (39.7% vs. 5.0% vs. 2.2%; P < 0.001), whereas second valve implantation was more frequent in ViR compared with ViMAC and ViV (12.1% vs. 5.2% vs. 2.5%; P< 0.001). Accordingly, technical success rate was higher after ViV compared with ViR and ViMAC (94.4% vs. 80.9% vs. 62.1%; P< 0.001). Compared with ViMAC and ViV groups, ViR group had more frequent post-procedural mitral regurgitation ≥moderate (18.4% vs. 13.8% vs. 5.6%; P< 0.001) and subsequent paravalvular leak closure (7.8% vs. 0.0% vs. 2.2%; P = 0.006). All-cause mortality was higher after ViMAC compared with ViR and ViV at 30 days (34.5% vs. 9.9% vs. 6.2%; log-rank P<0.001) and 1 year (62.8% vs. 30.6% vs. 14.0%; log-rank P< 0.001). On multivariable analysis, patients with failed annuloplasty rings and severe MAC were at increased risk of mortality after TMVR [ViR vs. ViV, hazard ratio (HR) 1.99, 95% confidence interval (CI) 1.27-3.12; P= 0.003; ViMAC vs. ViV, HR 5.29, 95% CI 3.29-8.51; P < 0.001]. Conclusion: The TMVR provided excellent outcomes for patients with degenerated bioprostheses despite high surgical risk. However, ViR and ViMAC were associated with higher rates of adverse events and mid-term mortality compared with ViV.

  • Influence of workplace environment, working conditions and health status of taxi drivers on vehicle collisions or near-miss events

    Baba M., Miyama G., Sugiyama D., Hitosugi M.

    Industrial Health (Industrial Health)  57 ( 4 ) 530 - 536 2019

    ISSN  00198366

     View Summary

    © 2019 National Institute of Occupational Safety and Health. Sudden illness while driving has been identified as a major cause of vehicle collisions, particularly among taxi drivers. However, no previous studies have examined the factors contributing to the occurrence of health-related vehicle collisions. The current study aimed to identify the risk factors causing health-related vehicle collisions among taxi drivers, and to inform preventative interventions. A cross-sectional survey involving a written anonymous questionnaire was conducted for company-employed taxi drivers in Chiba Prefecture, Japan. A total of 1,739 drivers returned questionnaires. Drivers were classified into those who had experienced collisions or near-miss incidents caused by health problems (Event group), and those who had not (Non-event group). According to a multivariable logistic regression analysis, being unable to take vacation time (odds ratio [OR] 4.59, 95% confidence interval [CI] 2.2–9.58), having chronic diseases (OR 1.52, 95% CI 1.02–2.27), taking insufficient vacation time (OR 1.81, 95% CI 1.19–2.79), and difficulty reporting poor health conditions (OR 2.29, 95% CI 1.36–3.87) were significant factors for the likelihood of an event. Support for drivers to maintain well-balanced control of illnesses and improvement of working environments could prevent health-related events while driving.

  • Association between impairment of salty taste recognition and masked hypertension based on home blood pressure in Japanese residents: the KOBE study

    Kubota Y., Higashiyama A., Sugiyama D., Nishida Y., Kubo S., Hirata T., Kadota A., Miyamatsu N., Wakabayashi I., Miyamoto Y., Okamura T.

    Hypertension Research (Hypertension Research)  41 ( 9 ) 756 - 762 2018.09

    ISSN  09169636

     View Summary

    © 2018, The Japanese Society of Hypertension. Excessive salt intake is an established risk factor for hypertension. We conducted a cross-sectional study to examine the association between salty taste recognition and estimated salt intake and masked hypertension in a healthy Japanese normotensive population. The participants were 892 apparently healthy community residents (246 men and 646 women) aged between 40 and 74 years with blood pressure below 140/90 mm Hg. Salty taste recognition was assessed using a salt-impregnated taste strip. Daily salt intake was calculated as estimated 24 h urinary sodium excretion using spot urine tests. Each participant performed home blood pressure measurements for a minimum of 5 days per week. The participants were classified into three groups according to their salty taste recognition threshold evaluated by the salt concentrations of the taste strips (0.6%, 0.8%, and ≥ 1.0%). In women, the multivariate odds ratio (95% confidence interval) for masked hypertension (≥ 135/85 mm Hg) was 2.98 (1.16–7.64) in the ≥ 1.0% group compared with that in the 0.6% group. In men, the proportion of masked hypertension in the ≥ 1.0% group did not differ from that in the 0.6% group, and no correlation was identified between estimated daily salt intake and the salty taste recognition threshold. In conclusion, impairment of salty taste recognition was associated with masked hypertension in women even with normal blood pressure in the clinical setting.

  • Fatty liver index predicts incident diabetes in a Japanese general population with and without impaired fasting glucose

    Hirata A., Sugiyama D., Kuwabara K., Hirata T., Tsutatani H., Funamoto M., Watanabe K., Miyamatsu N., Okamura T.

    Hepatology Research (Hepatology Research)  48 ( 9 ) 708 - 716 2018.08

    ISSN  13866346

     View Summary

    © 2018 The Japan Society of Hepatology Aim: Fatty liver is associated with the development of diabetes. However, to our knowledge, no study has examined the relationship between the fatty liver index (FLI), calculated scores of hepatic steatosis, and the development of diabetes among individuals without impaired fasting glucose (IFG). We aimed to examine whether FLI predicts the development of diabetes in individuals with and without IFG in a Japanese general population. Methods: We selected 1498 men and 2941 women who participated in Specific Health Checkups in Japan. We divided all participants into six groups according to tertiles of FLI (low, moderate, and high) and the presence or absence of IFG, by sex. We calculated hazard ratios for incident diabetes for each group using a Cox proportional hazard model, adjusting for potential confounders. Results: During a mean follow-up period of 3.0 years, 176 cases of diabetes in men and 320 cases in women were identified. Compared with the low FLI group without IFG, the high FLI group without IFG was significantly associated with incident diabetes in both men (hazard ratio, 1.90; 95% confidence interval, 1.08–3.36) and women (hazard ratio, 1.72; 95% confidence interval, 1.18–2.51). All IFG groups were significantly associated with incident diabetes regardless of FLI levels. Conclusions: Our results showed that FLI is associated with the development of diabetes regardless of sex and the presence or absence of IFG, and that it may be a useful predictor of future risk of incident diabetes even in individuals without IFG.

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Papers, etc., Registered in KOARA 【 Display / hide

Presentations 【 Display / hide

  • 能動喫煙・受動喫煙が精神的健康状態に与える影響

    Sugiyama Daisuke

    第52回日本アルコール・アディクション医学会, 2017.09, Poster (general)

  • 地域住民における耐糖能異常の有無による飲酒習慣の糖尿病発症リスクに関する検討

    Sugiyama Daisuke

    第52回日本アルコール・アディクション医学会, 2017.09, Poster (general)

  • 酒状況が精神的健康状態に与える影響:神戸研究

    Sugiyama Daisuke

    第52回日本アルコール・アディクション医学会, 2017.09, Oral Presentation(general)

  • 男性の飲酒とCVD死亡の関連における脂質異常症およびγ-GTP値の影響:NIPPON DATA90

    Sugiyama Daisuke

    第52回日本アルコール・アディクション医学会, 2017.09

  • 非メタボリック症候群対象者における飲酒と正常高値以上血圧の新規発症の関連 羽曳野市特定健診での検討

    Sugiyama Daisuke

    第52回日本アルコール・アディクション医学会, 2017.09, Oral Presentation(general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 軽度認知機能障害と動脈硬化性疾患リスクファクターの関連:都市部住民における検討

    2017
    -
    2019

    Grant-in-Aid for Scientific Research, Research grant, Principal Investigator

  • メタボリック症候群と投薬加療が必要な糖尿病の新規発症の関連について:一般市民集団を対象とした研究

    2016.04
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    2017.03

    一般財団法人日本健康増進財団, 生活習慣病予防に関する研究助成, Other, Principal Investigator

  • 都市部住民における自己抗体の発現と生活習慣病との関係性の解明

    2013
    -
    2015

    Grant-in-Aid for Scientific Research, Research grant, Principal Investigator

Awards 【 Display / hide

  • Thrombosis Research awarded Outstanding Reviewer Status

    2017.03

    Type of Award: Other Awards

  • Thrombosis Research awarded Outstanding Reviewer Status

    2017.03

  • 第75回日本公衆衛生学会 示説(ポスター)賞

    2016.10

  • 示説(ポスター)賞

    2016.10, 第75回日本公衆衛生学会

    Type of Award: Awards of National Conference, Council and Symposium

  • 日本動脈硬化学会 第8回JAT賞受賞

    2016.07

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Courses Taught 【 Display / hide

  • STATISTICAL METHODS IN EPIDEMIOLOGY

    2019

  • STATISTICAL METHODS IN EPIDEMIOLOGIC RESEARCH

    2019

  • PUBLIC HEALTH

    2019

  • PHARMACOLOGY FOR NURSING AND HEALTH CARE

    2019

  • NUTRITION FOR NURSING AND HEALTH CARE

    2019

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Courses Previously Taught 【 Display / hide

  • 臨床疫学

    Keio University, 2018, Spring Semester, Lecture, Lecturer outside of Keio

  • 基礎生物統計学II

    Keio University, 2018, Spring Semester, Major subject, Lecture, Lecturer outside of Keio

    健康マネジメント研究科・医学研究科共通科目

  • 基礎生物統計学I

    Keio University, 2018, Spring Semester, Major subject, Lecture, Lecturer outside of Keio

    健康マネジメント研究科・医学研究科共通科目

  • 公衆衛生学

    Keio University, 2017, Autumn Semester, Laboratory work/practical work/exercise, Lecturer outside of Keio

  • 疫学研究の統計的手法

    Keio University, 2017, Autumn Semester, Major subject, Lecturer outside of Keio

    健康マネジメント研究科・医学研究科共通科目

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Social Activities 【 Display / hide

  • 日本動脈硬化学会

    2017.07
    -
    Present

     View Summary

    評議員

  • 日本疫学会

    2017.06
    -
    Present

     View Summary

    代議員

  • 日本循環器病予防学会

    2017.06
    -
    Present

     View Summary

    評議員