佐藤　泰憲 （サトウ　ヤスノリ）

Sato, Yasunori

写真a

所属（所属キャンパス）

医学部 生物統計学教室 （信濃町）

職名

教授（有期）
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研究分野 【 表示 ／ 非表示 】

  • ライフサイエンス / 薬理学

  • ライフサイエンス / 医療管理学、医療系社会学

  • ライフサイエンス / 衛生学、公衆衛生学分野：実験系を含む

  • ライフサイエンス / 衛生学、公衆衛生学分野：実験系を含まない

  • 情報通信 / 統計科学

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研究キーワード 【 表示 ／ 非表示 】

  • 数理統計学

  • 生物統計学

  • 臨床試験学

  • 遺伝疫学

  • 遺伝統計学

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著書 【 表示 ／ 非表示 】

  • 食品免疫学事典

    日本食品免疫学会, 2021年11月

    担当ページ： 8-20　適切な統計解析法　

  • 臨床試験のための アダプティブデザイン (統計ライブラリー)

    安藤英一, 五所正彦, 佐藤 泰憲, 高橋翔, 竹内久朗, 長島健悟, 中水流嘉臣, 野間久史, 平川晃弘, 藤井陽介, 松岡伸篤, 松永信人, 丸尾和司, 山田雅之, 朝倉書店, 2018年08月

  • 新版 薬効評価

    佐久間昭, 五所正彦, 酒井弘憲, 佐藤泰憲, 竹内久朗 , 東京大学出版会, 2017年02月

  • ゼロから学ぶ 医薬統計教室

    佐藤泰憲, 五所正彦, メジカルビュー社, 2014年09月

  • 生存時間解析入門 原書第2版

    五所正彦, 佐藤泰憲, 竹内久朗, 長島健悟, 中水流嘉臣, 平川晃弘, 松永信人, 山田雅之, 東京大学出版会, 2014年04月

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論文 【 表示 ／ 非表示 】

  • Contact-free assessments of respiratory rate and volume with load cells under the bed legs in ventilated patients: a prospective exploratory observational study.

    Inada A, Inaba S, Matsumura Y, Sugiyama T, Hanaoka N, Fujiyoshi N, Nozaki-Taguchi N, Sato Y, Isono S

    Journal of applied physiology (Bethesda, Md. : 1985) 134 （ 6 ） 1341 - 1348 2023年06月

    ISSN  8750-7587

    　概要を見る

    Development of reliable non-contact unrestrained respiratory monitoring is capable of augmenting the safety of hospitalized patients in the recovery phase. We previously discovered respiratory-related centroid shifts along the long axis of the bed with load cells under the bed legs (bed sensor system: BSS). This prospective exploratory observational study examined whether non-contact measurements of respiratory-related tidal centroid shift amplitude (TA-BSS: primary variable) and respiratory rate (RR-BSS: secondary variable) were correlated with tidal volume (TV-PN) and respiratory rate (RR-PN), respectively measured by pneumotachograph in 14 ICU patients under mechanical ventilation. Among the 10-minute average data automatically obtained for a 48-hour period, 14 data were randomly selected from each patient. Successfully and evenly selected 196 data points for each variable were used for the purpose of this study. A good agreement between TA-BSS and TV-PN (Pearson's r = 0.669) and an excellent agreement between RR-BSS and RR-PN (r = 0.982) were observed. Estimated minute ventilatory volume as 3.86*TA-BSS*RR-BSS (MV-BSS) was found to be in very good agreement with true minute volume (MV-PN) (r = 0.836). Although Bland-Altman analysis evidenced accuracy of MV-BSS by a small insignificant fixed bias (-0.02 liter/min), a significant proportional bias of MV-BSS (r = -0.664) appeared to produce larger precision (1.9 liter/min) of MV-BSS. We conclude that contact-free unconstraint respiratory monitoring with load cells under the bed legs may serve as a new clinical monitoring system, when improved.

  • Screening practices of cancer survivors and individuals whose family or friends had a cancer diagnoses-a nationally representative cross-sectional survey in Japan (INFORM Study 2020).

    Akiyama M, Ishida N, Takahashi H, Takahashi M, Otsuki A, Sato Y, Saito J, Yaguchi-Saito A, Fujimori M, Kaji Y, Shimazu T, INFORM Study Group

    Journal of cancer survivorship : research and practice 17 （ 3 ） 663 - 676 2023年06月

    ISSN  1932-2259

    　概要を見る

    PURPOSE: We examined cancer screening practices and related beliefs in cancer survivors and individuals with family or close friends with a cancer diagnosis compared to individuals without the above cancer history for 5 population-based (gastric, colorectal, lung, breast, cervical) and 1 opportunistic (prostate) cancer screenings using nationally representative cross-sectional survey in Japan. METHODS: We analyzed 3269 data from 3605 respondents (response rate, 37.1%) and compared the screening beliefs and practices of cancer survivors (n = 391), individuals with family members (n = 1674), and close friends with a cancer diagnosis (n = 685) to those without any cancer history (n = 519). RESULTS: Being a cancer survivor was associated with screening for gastric (OR, 1.75; 95% CI, 1.04-2.95), colorectal (OR, 1.56; 95% CI, 1.03-2.36), and lung cancer (OR, 1.71; 95% CI, 1.10-2.66) but not breast, cervical cancer or PSA test. Having a family cancer diagnosis was associated with colorectal and lung cancer screening. Having friends with a cancer diagnosis was associated with PSA test. Cancer survivors and family members perceived themselves as being more susceptible and worried about getting cancer than individuals without any cancer history. Cancer survivors strongly believed screening can detect cancer and were more likely to undergo screening. Subgroup analysis indicated an interrelation between gastric and colorectal cancer screening among survivors. CONCLUSIONS: A cancer diagnosis in oneself or family or friend influences an individual's health-related belief and risk perception, which can increase the likelihood of cancer screening. IMPLICATIONS FOR CANCER SURVIVORS: Targeted and tailored communication strategies can increase awareness of cancer screening.

  • Comparison of First-Line Radiosurgery for Small-Cell and Non-Small Cell Lung Cancer Brain Metastases (Cross-FIRE).

    Rusthoven CG, Staley AW, Gao D, Yomo S, Bernhardt D, Wandrey N, El Shafie R, Kraemer A, Padilla O, Chiang V, Faramand AM, Palmer JD, Zacharia BE, Wegner RE, Hattangadi-Gluth JA, Levy A, Bernstein K, Mathieu D, Cagney DN, Chan MD, Grills IS, Braunstein S, Lee CC, Sheehan JP, Kluwe C, Patel S, Halasz LM, Andratschke N, Deibert CP, Verma V, Trifiletti DM, Cifarelli CP, Debus J, Combs SE, Sato Y, Higuchi Y, Aoyagi K, Brown PD, Alami V, Niranjan A, Lunsford LD, Kondziolka D, Camidge DR, Kavanagh BD, Robin TP, Serizawa T, Yamamoto M

    Journal of the National Cancer Institute 2023年05月

    ISSN  0027-8874

    　概要を見る

    INTRODUCTION: Historical reservations regarding radiosurgery (SRS) for small-cell-lung-cancer (SCLC) brain metastases (BrM) include concerns for short-interval/diffuse CNS-progression, poor prognoses, and increased neurological mortality specific to SCLC histology. We compared SRS outcomes for SCLC and non-small-cell-lung-cancer (NSCLC) where SRS is well established. METHODS: Multicenter first-line SRS outcomes for SCLC and NSCLC from 2000-2022 were retrospectively collected (N=892-SCLC/N=4,785-NSCLC). Data from the prospective JLGK0901 SRS trial were analyzed as a comparison cohort (N=98-SCLC/N=794-NSCLC). OS and CNS-progression were analyzed using Cox-Proportional-Hazard and Fine-Gray models, respectively, with multivariable (MV) adjustment (including age/sex/performance-status/year/extracranial disease/BrM-number/BrM-volume). Mutation-stratified analyses were performed in propensity score-matched (PSM) retrospective cohorts of EGFR/ALK-positive-NSCLC, mutation-negative-NSCLC, and SCLC. RESULTS: OS was superior with NSCLC over SCLC in the retrospective dataset (median-OS, 10.5 vs 8.6 months, MV-p<0.001) and JLGK0901. Hazard estimates for first CNS-progression favoring NSCLC were similar in both datasets but reached significance in the retrospective dataset only (MV-HR:0.82 [95%-CI:0.73-0.92], p=0.001). In the PSM cohorts, there were continued OS advantages for NSCLC (median-OS, 23.7 [EGFR/ALK-positive-NSCLC] vs 13.6 [mutation-negative-NSCLC] vs 10.4 months [SCLC], pairwise-p-values<0.001), but no significant differences in CNS-progression. Neurological mortality and number of lesions at CNS-progression were similar for NSCLC and SCLC patients. Leptomeningeal-progression was increased in NSCLC patients in the retrospective dataset only (MV-HR:1.61 [95%-CI:1.14-2.26], p=0.007). CONCLUSION: After SRS, SCLC was associated with shorter OS compared to NSCLC. CNS progression occurred earlier in SCLC overall but was similar in patients matched on baseline characteristics. Neurological mortality, lesions at CNS-progression, and leptomeningeal-progression were comparable. These findings may better inform clinical decision-making for SCLC patients.

  • Thrombus formation at the stump of the pulmonary vein after lobectomy: a prospective multi-institutional study.

    Yamamoto T, Suzuki H, Sakairi Y, Iwata T, Iizasa T, Tagawa T, Yoshida S, Takemura R, Sato Y, Yoshino I

    Surgery today 16 （ 3 ） S262 - S262 2023年05月

    ISSN  0941-1291

    　概要を見る

    PURPOSE: Recent reports suggest that postoperative cerebral infarction following lung cancer surgery is caused by thrombus formation at the stump of the pulmonary vein and that the risk is highest after left upper lobectomy (LUL). Thrombosis at the stump of the pulmonary vein and the incidence of cerebral infarction was investigated prospectively in patients who underwent lobectomy for lung cancer. METHODS: Lung cancer patients undergoing planned pulmonary lobectomy were enrolled. The endpoint was to confirm if there is a higher incidence of thrombus formation (primary) and a higher incidence of cerebral infarction (secondary) in patients undergoing LUL. We planned to accrue 600 patients. An interim analysis was scheduled for just after the data center received the final clinical review form of the 300th patient. RESULTS: The interim analysis revealed a significant difference in the primary endpoint. In the final analysis, thrombus was identified in 16 of 88 LUL patients (20.5%), and in 4 of 247 patients who underwent other types of lobectomy (1.6%) (p < 0.05). Cerebral infarction was identified in 1 of the LUL patients (1.3%) and in 9 of the other patients (3.6%) (p = 0.318). CONCLUSIONS: Thrombus frequently forms at the stump of the left superior pulmonary vein after LUL. However, our study did not identify a relationship between thrombosis and cerebral infarction.

  • Establishment and validation of reference values for abdominal skeletal muscle compartments in children.

    Kudo W, Terui K, Hattori S, Takenouchi A, Komatsu S, Oita S, Sato Y, Hishiki T

    Clinical nutrition (Edinburgh, Scotland) （Clinical Nutrition）  42 （ 5 ） 653 - 660 2023年05月

    ISSN  0261-5614

    　概要を見る

    Background & aims: Sarcopenia, resulting from skeletal muscle loss, is a serious concern in children, for whom nutrition and physical activity are essential for growth. In sarcopenia research, the skeletal muscle mass is often obtained from computed tomography (CT) cross-sectional images in both adults and children; however, the method of evaluating skeletal muscle using CT, especially the area range to be measured, has not yet been validated in children. The aim of this study is to establish reference values for three compartments of the abdominal skeletal muscle area (aSMA) obtained from cross-sectional CT images, and to validate the differences among them by assessing correlations with physical development. Methods: We conducted a single-centre, retrospective, cross-sectional study and included patients aged 1–17 years who underwent abdominal CT at Chiba University Hospital from 2007 to 2020. Patients with chronic diseases such as malignant tumours and inflammatory bowel disease were excluded from the analysis. aSMA was obtained from CT cross-sections at the lumbar L3-L4 intervertebral disc level by dividing it into three compartments: the psoas muscle area (PMA), paraspinal muscle area (PSMA), and total skeletal muscle area (TSMA). Quartile regression curves by sex and muscle compartment were generated using non-crossover and nonparametric regression quantile estimation. The correlation between each compartment of aSMA with height and weight was assessed using Spearman's rank correlation coefficient. Results: We analysed the abdominal CT images of 593 children (male: n = 335, female: n = 258) and generated curves predictive for the 5th, 25th, 50th, 75th, and 95th percentiles for each compartment of aSMA by sex. In patients aged 13 years and older, boys had significantly larger aSMA areas than girls in all three compartments. Among the three compartments, PSMA had the strongest correlation coefficient with height and weight for both boys and girls. Conclusions: We generated quantile regression curves for three aSMA compartments obtained from cross-sectional CT images and established reference values in children. PSMA values were most strongly correlated with height and weight among the three aSMA compartments.

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総説・解説等 【 表示 ／ 非表示 】

  • Vulnerable臨床病期IB-III食道癌に対するパクリタキセル併用放射線療法の第I相試験

    平田 賢郎, 吉田 佳代, 堅田 親利, 對馬 隆浩, 紀 貴之, 山本 幸子, 石川 秀樹, 佐藤 泰憲, 伊藤 芳紀, 加藤 健, 浜本 康夫

    日本食道学会学術集会プログラム・抄録集 （(NPO)日本食道学会）  75回   124 - 124 2021年09月

  • アレルギー疾患児の養育者が抱える負担感の可視化に関する研究

    佐野 英子, 佐藤 泰憲, 長尾 みづほ, 松永 真由美, 浜田 佳奈, 高瀬 貴文, 安田 泰明, 野上 和剛, 藤澤 隆夫

    日本小児アレルギー学会誌 （(一社)日本小児アレルギー学会）  35 （ 4 ） 406 - 406 2021年09月

    ISSN  0914-2649

  • 悪性症候群に対する修正型電気けいれん療法の有用性を検討する多施設における後方視的カルテ調査研究

    橘 真澄, 新津 富央, 佐藤 泰憲, 赤田 弘一, 野々村 司, 青木 勉, 小石川 比良来, 伊豫 雅臣

    精神神経学雑誌 （(公社)日本精神神経学会）   （ 2021特別号 ） S606 - S606 2021年09月

    ISSN  0033-2658

  • 乳幼児期アレルギー疾患に関わる養育者負担評価質問票の開発:アンメットニーズに応えるために

    水野 友美, 長尾 みづほ, 高瀬 貴文, 松永 真由美, 安田 泰明, 野上 和剛, 星 みゆき, 浜田 佳奈, 貝沼 圭吾, 中川 敦夫, 佐藤 泰憲, 藤澤 隆夫

    日本小児アレルギー学会誌 （(一社)日本小児アレルギー学会）  35 （ 4 ） 406 - 406 2021年09月

    ISSN  0914-2649

  • 非接触型ベッドセンサーを用いた終末期緩和ケア患者の呼吸状態評価　オピオイド投与量と呼吸パターンの異常

    磯野 史朗, 長谷川 誠, 田口 奈津子, 鍾野 弘洋, 水野 裕子, 高井 啓有, 佐藤 泰憲

    日本睡眠学会定期学術集会プログラム・抄録集 （(一社)日本睡眠学会）  46回   225 - 225 2021年09月

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競争的研究費の研究課題 【 表示 ／ 非表示 】

  • 医学・薬学・健康科学における生物統計教育ツール・カリキュラム開発

    2019年04月
    -
    2022年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 佐藤　泰憲, 基盤研究（Ｃ）, 補助金,  研究代表者

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受賞 【 表示 ／ 非表示 】

  • 2021年度Best Teacher Award

    2022年06月, 慶應義塾大学

    受賞区分： 塾内表彰等

  • 2020年度Best Teacher Award

    2021年06月, 慶應義塾大学

    受賞区分： その他

  • 日本臨床精神神経薬理学会 学会奨励賞

    吉村健佑、橋本佐、佐藤泰憲、佐藤愛子、竹内崇、渡邉博幸、寺尾岳 、中里道子、伊豫雅臣, 2019年, 日本臨床精神神経薬理学会

    受賞区分： 国内学会・会議・シンポジウム等の賞

  • 日本臨床薬理学会海外研修助成

    2006年10月

    受賞区分： 国内学会・会議・シンポジウム等の賞

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担当授業科目 【 表示 ／ 非表示 】

  • 公衆衛生学Ⅱ

    2024年度

  • 公衆衛生学Ⅰ

    2024年度

  • 健康マネジメント合同演習

    2024年度

  • 臨床試験方法論

    2024年度

  • 生物統計学演習

    2024年度

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担当経験のある授業科目 【 表示 ／ 非表示 】

  • 医学方法論

    慶應義塾

    2018年04月
    -
    2019年03月
    , 

    講義, 兼任, 2時間, 10人

    医学統計

  • 医療統計学Ⅰ

    千葉大学

    2018年04月
    -
    2019年03月

  • 医療統計Ⅱ

    千葉大学

    2018年04月
    -
    2019年03月

  • 臨床試験第I・II相試験

    千葉大学

    2018年04月
    -
    2019年03月

  • 臨床試験第III相試験・メタアナリシス

    千葉大学

    2018年04月
    -
    2019年03月

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社会活動 【 表示 ／ 非表示 】

  • 日中医学交流センター　理事

    2022年06月
    -
    継続中

  • PLOS ONE Editorial Board Academic Editor

    PLOS ONE

    , 
    2022年05月
    -
    継続中

  • 日本食品免疫学会ワーキンググループプロジェクトチーム

    2017年10月
    -
    継続中

  • 厚生労働省　薬事・食品衛生審議会　医薬品等安全対策部会

    2017年01月
    -
    継続中

  • 日本医師会　倫理審査委員会　事前評価委員

    2016年04月
    -
    継続中

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所属学協会 【 表示 ／ 非表示 】

  • 日本臨床試験学会, 

    2021年06月
    -
    継続中

  • 日本産業衛生学会, 

    2018年06月
    -
    継続中

  • 日本疫学会, 

    2018年06月
    -
    継続中

  • 日本衛生学会, 

    2018年06月
    -
    継続中

  • 日本公衆衛生学会, 

    2018年06月
    -
    継続中

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委員歴 【 表示 ／ 非表示 】

  • 2022年05月
    -
    継続中

    PLOS ONE Editorial Board Academic Editor, PLOS ONE

  • 2018年10月
    -
    継続中

    Associate Editor (Statistical Consulting), Circulation Reports

  • 2017年10月
    -
    継続中

    日本食品免疫学会ワーキンググループプロジェクトチーム, 日本食品免疫学会

  • 2017年01月
    -
    継続中

    薬事・食品衛生審議会　医薬品等安全対策部会 委員, 厚生労働省　

  • 2016年04月
    -
    継続中

    中央認定再生医療等委員会 委員, 国立病院機構

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