Sato, Yasunori

写真a

Affiliation

School of Medicine, Department of Biostatistics (Shinanomachi)

Position

Professor
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Research Areas 【 Display / hide 】

  • Life Science / Pharmacology

  • Life Science / Medical management and medical sociology

  • Life Science / Hygiene and public health (laboratory)

  • Life Science / Hygiene and public health (non-laboratory)

  • Informatics / Statistical science

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Research Keywords 【 Display / hide 】

  • 数理統計学

  • Biostatistocs

  • 臨床試験学

  • 遺伝疫学

  • 遺伝統計学

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Books 【 Display / hide 】

  • 食品免疫学事典

    日本食品免疫学会, 2021.11

    Contact page： 8-20　適切な統計解析法　

  • 臨床試験のための アダプティブデザイン (統計ライブラリー)

    SATO Yasunori, 朝倉書店, 2018.08

  • 新版 薬効評価

    SATO Yasunori, 東京大学出版会, 2017.02

  • ゼロから学ぶ 医薬統計教室

    SATO Yasunori, メジカルビュー社, 2014.09

  • 生存時間解析入門 原書第2版

    SATO Yasunori, 東京大学出版会, 2014.04

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Papers 【 Display / hide 】

  • Contact-free assessments of respiratory rate and volume with load cells under the bed legs in ventilated patients: A prospective exploratory observational study.

    Azusa Inada, Shin Inaba, Yosuke Matsumura, Takuya Sugiyama, Noriyuki Hanaoka, Naohiko Fujiyoshi, Natsuko Nozaki-Taguchi, Yasunori Sato, Shiroh Isono

    Journal of applied physiology (Bethesda, Md. : 1985) 134 ( 6 ) 1341 - 1348 2023.06

    ISSN  8750-7587

    　View Summary

    Development of reliable non-contact unrestrained respiratory monitoring is capable of augmenting the safety of hospitalized patients in the recovery phase. We previously discovered respiratory-related centroid shifts along the long axis of the bed with load cells under the bed legs (bed sensor system: BSS). This prospective exploratory observational study examined whether non-contact measurements of respiratory-related tidal centroid shift amplitude (TA-BSS: primary variable) and respiratory rate (RR-BSS: secondary variable) were correlated with tidal volume (TV-PN) and respiratory rate (RR-PN), respectively measured by pneumotachograph in 14 ICU patients under mechanical ventilation. Among the 10-minute average data automatically obtained for a 48-hour period, 14 data were randomly selected from each patient. Successfully and evenly selected 196 data points for each variable were used for the purpose of this study. A good agreement between TA-BSS and TV-PN (Pearson's r = 0.669) and an excellent agreement between RR-BSS and RR-PN (r = 0.982) were observed. Estimated minute ventilatory volume as 3.86*TA-BSS*RR-BSS (MV-BSS) was found to be in very good agreement with true minute volume (MV-PN) (r = 0.836). Although Bland-Altman analysis evidenced accuracy of MV-BSS by a small insignificant fixed bias (-0.02 liter/min), a significant proportional bias of MV-BSS (r = -0.664) appeared to produce larger precision (1.9 liter/min) of MV-BSS. We conclude that contact-free unconstraint respiratory monitoring with load cells under the bed legs may serve as a new clinical monitoring system, when improved.

  • Screening practices of cancer survivors and individuals whose family or friends had a cancer diagnoses-a nationally representative cross-sectional survey in Japan (INFORM Study 2020).

    Miki Akiyama, Noriyuki Ishida, Hiroyasu Takahashi, Miyako Takahashi, Aki Otsuki, Yasunori Sato, Junko Saito, Akiko Yaguchi-Saito, Maiko Fujimori, Yuki Kaji, Taichi Shimazu

    Journal of cancer survivorship : research and practice 17 ( 3 ) 663 - 676 2023.06

    ISSN  1932-2259

    　View Summary

    PURPOSE: We examined cancer screening practices and related beliefs in cancer survivors and individuals with family or close friends with a cancer diagnosis compared to individuals without the above cancer history for 5 population-based (gastric, colorectal, lung, breast, cervical) and 1 opportunistic (prostate) cancer screenings using nationally representative cross-sectional survey in Japan. METHODS: We analyzed 3269 data from 3605 respondents (response rate, 37.1%) and compared the screening beliefs and practices of cancer survivors (n = 391), individuals with family members (n = 1674), and close friends with a cancer diagnosis (n = 685) to those without any cancer history (n = 519). RESULTS: Being a cancer survivor was associated with screening for gastric (OR, 1.75; 95% CI, 1.04-2.95), colorectal (OR, 1.56; 95% CI, 1.03-2.36), and lung cancer (OR, 1.71; 95% CI, 1.10-2.66) but not breast, cervical cancer or PSA test. Having a family cancer diagnosis was associated with colorectal and lung cancer screening. Having friends with a cancer diagnosis was associated with PSA test. Cancer survivors and family members perceived themselves as being more susceptible and worried about getting cancer than individuals without any cancer history. Cancer survivors strongly believed screening can detect cancer and were more likely to undergo screening. Subgroup analysis indicated an interrelation between gastric and colorectal cancer screening among survivors. CONCLUSIONS: A cancer diagnosis in oneself or family or friend influences an individual's health-related belief and risk perception, which can increase the likelihood of cancer screening. IMPLICATIONS FOR CANCER SURVIVORS: Targeted and tailored communication strategies can increase awareness of cancer screening.

  • Comparison of First-Line Radiosurgery for Small-Cell and Non-Small Cell Lung Cancer Brain Metastases (Cross-FIRE).

    Chad G Rusthoven, Alyse W Staley, Dexiang Gao, Shoji Yomo, Denise Bernhardt, Narine Wandrey, Rami El Shafie, Anna Kraemer, Oscar Padilla, Veronica Chiang, Andrew M Faramand, Joshua D Palmer, Brad E Zacharia, Rodney E Wegner, Jona A Hattangadi-Gluth, Antonin Levy, Kenneth Bernstein, David Mathieu, Daniel N Cagney, Michael D Chan, Inga S Grills, Steve Braunstein, Cheng-Chia Lee, Jason P Sheehan, Christien Kluwe, Samir Patel, Lia M Halasz, Nicolaus Andratschke, Christopher P Deibert, Vivek Verma, Daniel M Trifiletti, Christopher P Cifarelli, Jürgen Debus, Stephanie E Combs, Yasunori Sato, Yoshinori Higuchi, Kyoko Aoyagi, Paul D Brown, Vida Alami, Ajay Niranjan, L Dade Lunsford, Douglas Kondziolka, D Ross Camidge, Brian D Kavanagh, Tyler P Robin, Toru Serizawa, Masaaki Yamamoto

    Journal of the National Cancer Institute  2023.05

    ISSN  0027-8874

    　View Summary

    INTRODUCTION: Historical reservations regarding radiosurgery (SRS) for small-cell-lung-cancer (SCLC) brain metastases (BrM) include concerns for short-interval/diffuse CNS-progression, poor prognoses, and increased neurological mortality specific to SCLC histology. We compared SRS outcomes for SCLC and non-small-cell-lung-cancer (NSCLC) where SRS is well established. METHODS: Multicenter first-line SRS outcomes for SCLC and NSCLC from 2000-2022 were retrospectively collected (N=892-SCLC/N=4,785-NSCLC). Data from the prospective JLGK0901 SRS trial were analyzed as a comparison cohort (N=98-SCLC/N=794-NSCLC). OS and CNS-progression were analyzed using Cox-Proportional-Hazard and Fine-Gray models, respectively, with multivariable (MV) adjustment (including age/sex/performance-status/year/extracranial disease/BrM-number/BrM-volume). Mutation-stratified analyses were performed in propensity score-matched (PSM) retrospective cohorts of EGFR/ALK-positive-NSCLC, mutation-negative-NSCLC, and SCLC. RESULTS: OS was superior with NSCLC over SCLC in the retrospective dataset (median-OS, 10.5 vs 8.6 months, MV-p<0.001) and JLGK0901. Hazard estimates for first CNS-progression favoring NSCLC were similar in both datasets but reached significance in the retrospective dataset only (MV-HR:0.82 [95%-CI:0.73-0.92], p=0.001). In the PSM cohorts, there were continued OS advantages for NSCLC (median-OS, 23.7 [EGFR/ALK-positive-NSCLC] vs 13.6 [mutation-negative-NSCLC] vs 10.4 months [SCLC], pairwise-p-values<0.001), but no significant differences in CNS-progression. Neurological mortality and number of lesions at CNS-progression were similar for NSCLC and SCLC patients. Leptomeningeal-progression was increased in NSCLC patients in the retrospective dataset only (MV-HR:1.61 [95%-CI:1.14-2.26], p=0.007). CONCLUSION: After SRS, SCLC was associated with shorter OS compared to NSCLC. CNS progression occurred earlier in SCLC overall but was similar in patients matched on baseline characteristics. Neurological mortality, lesions at CNS-progression, and leptomeningeal-progression were comparable. These findings may better inform clinical decision-making for SCLC patients.

  • Thrombus formation at the stump of the pulmonary vein after lobectomy: a prospective multi-institutional study.

    Takayoshi Yamamoto, Hidemi Suzuki, Yuichi Sakairi, Takekazu Iwata, Toshihiko Iizasa, Tetsuzo Tagawa, Shigetoshi Yoshida, Ryo Takemura, Yasunori Sato, Ichiro Yoshino

    Surgery today 16 ( 3 ) S262 - S262 2023.05

    ISSN  0941-1291

    　View Summary

    PURPOSE: Recent reports suggest that postoperative cerebral infarction following lung cancer surgery is caused by thrombus formation at the stump of the pulmonary vein and that the risk is highest after left upper lobectomy (LUL). Thrombosis at the stump of the pulmonary vein and the incidence of cerebral infarction was investigated prospectively in patients who underwent lobectomy for lung cancer. METHODS: Lung cancer patients undergoing planned pulmonary lobectomy were enrolled. The endpoint was to confirm if there is a higher incidence of thrombus formation (primary) and a higher incidence of cerebral infarction (secondary) in patients undergoing LUL. We planned to accrue 600 patients. An interim analysis was scheduled for just after the data center received the final clinical review form of the 300th patient. RESULTS: The interim analysis revealed a significant difference in the primary endpoint. In the final analysis, thrombus was identified in 16 of 88 LUL patients (20.5%), and in 4 of 247 patients who underwent other types of lobectomy (1.6%) (p < 0.05). Cerebral infarction was identified in 1 of the LUL patients (1.3%) and in 9 of the other patients (3.6%) (p = 0.318). CONCLUSIONS: Thrombus frequently forms at the stump of the left superior pulmonary vein after LUL. However, our study did not identify a relationship between thrombosis and cerebral infarction.

  • Establishment and validation of reference values for abdominal skeletal muscle compartments in children.

    Wataru Kudo, Keita Terui, Shinya Hattori, Ayako Takenouchi, Shugo Komatsu, Satoru Oita, Yasunori Sato, Tomoro Hishiki

    Clinical nutrition (Edinburgh, Scotland) (Clinical Nutrition)  42 ( 5 ) 653 - 660 2023.05

    ISSN  0261-5614

    　View Summary

    BACKGROUND & AIMS: Sarcopenia, resulting from skeletal muscle loss, is a serious concern in children, for whom nutrition and physical activity are essential for growth. In sarcopenia research, the skeletal muscle mass is often obtained from computed tomography (CT) cross-sectional images in both adults and children; however, the method of evaluating skeletal muscle using CT, especially the area range to be measured, has not yet been validated in children. The aim of this study is to establish reference values for three compartments of the abdominal skeletal muscle area (aSMA) obtained from cross-sectional CT images, and to validate the differences among them by assessing correlations with physical development. METHODS: We conducted a single-centre, retrospective, cross-sectional study and included patients aged 1-17 years who underwent abdominal CT at Chiba University Hospital from 2007 to 2020. Patients with chronic diseases such as malignant tumours and inflammatory bowel disease were excluded from the analysis. aSMA was obtained from CT cross-sections at the lumbar L3-L4 intervertebral disc level by dividing it into three compartments: the psoas muscle area (PMA), paraspinal muscle area (PSMA), and total skeletal muscle area (TSMA). Quartile regression curves by sex and muscle compartment were generated using non-crossover and nonparametric regression quantile estimation. The correlation between each compartment of aSMA with height and weight was assessed using Spearman's rank correlation coefficient. RESULTS: We analysed the abdominal CT images of 593 children (male: n = 335, female: n = 258) and generated curves predictive for the 5th, 25th, 50th, 75th, and 95th percentiles for each compartment of aSMA by sex. In patients aged 13 years and older, boys had significantly larger aSMA areas than girls in all three compartments. Among the three compartments, PSMA had the strongest correlation coefficient with height and weight for both boys and girls. CONCLUSIONS: We generated quantile regression curves for three aSMA compartments obtained from cross-sectional CT images and established reference values in children. PSMA values were most strongly correlated with height and weight among the three aSMA compartments.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • Vulnerable臨床病期IB-III食道癌に対するパクリタキセル併用放射線療法の第I相試験

    平田 賢郎, 吉田 佳代, 堅田 親利, 對馬 隆浩, 紀 貴之, 山本 幸子, 石川 秀樹, 佐藤 泰憲, 伊藤 芳紀, 加藤 健, 浜本 康夫

    日本食道学会学術集会プログラム・抄録集 ((NPO)日本食道学会)  75回   124 - 124 2021.09

  • アレルギー疾患児の養育者が抱える負担感の可視化に関する研究

    佐野 英子, 佐藤 泰憲, 長尾 みづほ, 松永 真由美, 浜田 佳奈, 高瀬 貴文, 安田 泰明, 野上 和剛, 藤澤 隆夫

    日本小児アレルギー学会誌 ((一社)日本小児アレルギー学会)  35 ( 4 ) 406 - 406 2021.09

    ISSN  0914-2649

  • 悪性症候群に対する修正型電気けいれん療法の有用性を検討する多施設における後方視的カルテ調査研究

    橘 真澄, 新津 富央, 佐藤 泰憲, 赤田 弘一, 野々村 司, 青木 勉, 小石川 比良来, 伊豫 雅臣

    精神神経学雑誌 ((公社)日本精神神経学会)   ( 2021特別号 ) S606 - S606 2021.09

    ISSN  0033-2658

  • 乳幼児期アレルギー疾患に関わる養育者負担評価質問票の開発:アンメットニーズに応えるために

    水野 友美, 長尾 みづほ, 高瀬 貴文, 松永 真由美, 安田 泰明, 野上 和剛, 星 みゆき, 浜田 佳奈, 貝沼 圭吾, 中川 敦夫, 佐藤 泰憲, 藤澤 隆夫

    日本小児アレルギー学会誌 ((一社)日本小児アレルギー学会)  35 ( 4 ) 406 - 406 2021.09

    ISSN  0914-2649

  • 非接触型ベッドセンサーを用いた終末期緩和ケア患者の呼吸状態評価　オピオイド投与量と呼吸パターンの異常

    磯野 史朗, 長谷川 誠, 田口 奈津子, 鍾野 弘洋, 水野 裕子, 高井 啓有, 佐藤 泰憲

    日本睡眠学会定期学術集会プログラム・抄録集 ((一社)日本睡眠学会)  46回   225 - 225 2021.09

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Development of guidance and tools for biostatistical education in the medical and health sciences

    2019.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

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Awards 【 Display / hide 】

  • Best Teacher Award 2021

    2022.06, KEIO University

    Type of Award： Keio commendation etc.

  • Best Teacher Award 2020

    2021.06, KEIO University

    Type of Award： Other

  • 日本臨床精神神経薬理学会 学会奨励賞

    吉村健佑、橋本佐、佐藤泰憲、佐藤愛子、竹内崇、渡邉博幸、寺尾岳 、中里道子、伊豫雅臣, 2019, 日本臨床精神神経薬理学会

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 日本臨床薬理学会海外研修助成

    2006.10

    Type of Award： Award from Japanese society, conference, symposium, etc.

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Courses Taught 【 Display / hide 】

  • PUBLIC HEALTH 2 (ADVANCED)

    2025

  • JOINT SEMINAR ON HEALTH MANAGEMENT

    2025

  • INDEPENDENT RESEARCH

    2025

  • DESIGN AND ANALYSIS OF CLINICAL TRIALS

    2025

  • BIOSTATISTICS: SEMINAR

    2025

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Courses Previously Taught 【 Display / hide 】

  • 医学方法論

    Keio University

    2018.04
    -
    2019.03
    , 

    Lecture, Outside own faculty (within Keio), 2h, 10people

    医学統計

  • 医薬統計概論

    千葉大学

    2018.04
    -
    2019.03

  • 推測統計学

    千葉大学

    2018.04
    -
    2019.03

  • 臨床試験特論

    群馬大学医学部

    2018.04
    -
    2019.03

  • 臨床薬理学

    群馬大学医学部

    2018.04
    -
    2019.03

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Social Activities 【 Display / hide 】

  • JAPAN-CHINA MEDICAL COMMUNICATION CENTER　board member

    2022.06
    -
    Present

  • PLOS ONE Editorial Board Academic Editor

    PLOS ONE

    , 
    2022.05
    -
    Present

  • 日本食品免疫学会ワーキンググループプロジェクトチーム

    2017.10
    -
    Present

  • 厚生労働省　薬事・食品衛生審議会　医薬品等安全対策部会

    2017.01
    -
    Present

  • 日本医師会　倫理審査委員会　事前評価委員

    2016.04
    -
    Present

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Memberships in Academic Societies 【 Display / hide 】

  • 日本臨床試験学会, 

    2021.06
    -
    Present

  • 日本産業衛生学会, 

    2018.06
    -
    Present

  • 日本疫学会, 

    2018.06
    -
    Present

  • 日本衛生学会, 

    2018.06
    -
    Present

  • 日本公衆衛生学会, 

    2018.06
    -
    Present

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Committee Experiences 【 Display / hide 】

  • 2022.05
    -
    Present

    PLOS ONE Editorial Board Academic Editor, PLOS ONE

  • 2018.10
    -
    Present

    Associate Editor (Statistical Consulting), Circulation Reports

  • 2017.10
    -
    Present

    日本食品免疫学会ワーキンググループプロジェクトチーム, 日本食品免疫学会

  • 2017.01
    -
    Present

    薬事・食品衛生審議会　医薬品等安全対策部会 委員, 厚生労働省　

  • 2016.04
    -
    Present

    中央認定再生医療等委員会 委員, 国立病院機構

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