Iida, Miho

写真a

Affiliation

School of Medicine, Department of Preventive Medicine and Public Health Department of Preventive Medicine and Public Health, Keio University School of Medicine (Shinanomachi)

Position

Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

Related Websites
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Other Affiliation 【 Display / hide 】

  • School of Medicine, Obstetrics and Gynecology

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Career 【 Display / hide 】

  • 2008.04
    -
    2010.03

    Kameda Medical Center, Residency

  • 2010.04
    -
    2014.03

    Keio University Hospital, Obstetrics and Gynecology, Residency/Fellowship

  • 2011.04
    -
    2012.03

    Saiseikai Utsunomiya Hospital, Obstetrics and Gynecology, Residency/Fellowship

  • 2012.04
    -
    2013.03

    Kawasaki Municipal Hospital, Obstetrics and Gynecology, Residency/Fellowship

  • 2017.10
    -
    2018.03

    Keio University Hospital, Obstetrics and Gynecology, Assistant Professor

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Academic Background 【 Display / hide 】

  • 2002.04
    -
    2008.03

    Keio University, School of Medicine, 医学科

    University, Graduated, Master's course

  • 2014.04
    -
    2017.09

    Keio University, Graduate School of Medicine, PhD Course

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • PhD (medicine), Keio University School of Medicine, Coursework, 2017.09

    Profiling of plasma metabolites in postmenopausal women with metabolic syndrome

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Licenses and Qualifications 【 Display / hide 】

  • Board Certified Supervisory Physician for Public Health and Social Medicine, 2022.04

  • Medical license, 2008.04

  • Board Certified Physician for Obstetrics and Gynecology, 2013.10

  • Board Certified Physician for Anti-Aging Medicine, 2017.01

  • Board Certified Physician for Public Health and Social Medicine , 2017.04

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Research Areas 【 Display / hide 】

  • Life Science / Obstetrics and gynecology

  • Life Science / Hygiene and public health (laboratory)

  • Life Science / Hygiene and public health (non-laboratory)

  • Life Science / Medical management and medical sociology

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Research Keywords 【 Display / hide 】

  • Metabolomics

  • Preventive Medicine

  • Public Health

  • Women's Health

  • Occupational Health

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Books 【 Display / hide 】

  • 更年期以降の健康課題×フェムテック

    飯田　美穂, （株）ロギカ書房, 2022.10

    Contact page： 205-214

  • Endometrial Cancer: Current Epidemiology, Detection and Management

    Banno K, IIDA Miho, Farghaly SA, Umene K, Kisu I, Aoki D, Nova Science Publishers, Inc., 2014,  Page： 17

    Scope: Novel Therapeutic Agents for Treatment of Endometrial Cancer,  Contact page： 321-337

    　View Summary

    Endometrial cancer is a female genital cancer that occurs frequently in Europe and the United States. Conventional therapy for endometrial cancer does not permit fertility preservation or have effects on advanced and recurrent cancers, and new pharmacotherapies are needed. The fourth-generation progestin, dienogest, blocks excessive estrogenic activity and inhibits endometrial overgrowth. Metformin is an antidiabetic drug that may have an effect on endometrial cancer through targeting of the mammalian target of rapamycin (mTOR) pathway. mTOR inhibitors block cancer growth by arresting the cell cycle in G1 phase and clinical trials of new generation drugs with multiple sites of action in the mTOR pathway are underway. To inhibit down regulation of tumor suppressor genes by DNA hypermethylation and histone deacetylation, drugs targeting DNA methyltransferase (DNMT), microRNA (miRNA) and histone deacetylase (HDAC) are under development. AEZS-108 targeted to LHRH receptors on tumors is an effective compound for chemotherapy of endometrial cancer. In addition, targeting STAT3 or Wnt/β-catenin pathway by specific inhibitor in tumor cells and immunosuppressive cells, or along with other immunotherapy, might restore the immunocompetence of endometrial cancer patients. The oncogenic mechanisms underlying endometrial cancer, and regulatory factors based on the characteristics of endometrial cancer cells are gradually emerging. These data are likely to lead to development of new effective therapy for this disease.

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Papers 【 Display / hide 】

  • Recognizing Female Reproductive Factors in Interpreting Changes in Disease Burden Among Populations

    Iida M.

    Journal of epidemiology 34 ( 8 ) 363 - 364 2024.08

  • Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS)

    Harada S., Iida M., Miyagawa N., Hirata A., Kuwabara K., Matsumoto M., Okamura T., Edagawa S., Kawada Y., Miyake A., Toki R., Akiyama M., Kawai A., Sugiyama D., Sato Y., Takemura R., Fukai K., Ishibashi Y., Kato S., Kurihara A., Sata M., Shibuki T., Takeuchi A., Kohsaka S., Sawano M., Shoji S., Izawa Y., Katsumata M., Oki K., Takahashi S., Takizawa T., Maruya H., Nishiwaki Y., Kawasaki R., Hirayama A., Ishikawa T., Saito R., Sato A., Soga T., Sugimoto M., Tomita M., Komaki S., Ohmomo H., Ono K., Otsuka-Yamasaki Y., Shimizu A., Sutoh Y., Hozawa A., Kinoshita K., Koshiba S., Kumada K., Ogishima S., Sakurai-Yageta M., Tamiya G., Takebayashi T.

    Journal of epidemiology 34 ( 8 ) 393 - 401 2024.08

    　View Summary

    The Tsuruoka Metabolomics Cohort Study (TMCS) is an ongoing population-based cohort study being conducted in the rural area of Yamagata Prefecture, Japan. This study aimed to enhance the precision prevention of multi-factorial, complex diseases, including non-communicable and aging-associated diseases, by improving risk stratification and prediction measures. At baseline, 11,002 participants aged 35-74 years were recruited in Tsuruoka City, Yamagata Prefecture, Japan, between 2012 and 2015, with an ongoing follow-up survey. Participants underwent various measurements, examinations, tests, and questionnaires on their health, lifestyle, and social factors. This study uses an integrative approach with deep molecular profiling to identify potential biomarkers linked to phenotypes that underpin disease pathophysiology and provide better mechanistic insights into social health determinants. The TMCS incorporates multi-omics data, including genetic and metabolomic analyses of 10,933 participants, and comprehensive data collection ranging from physical, psychological, behavioral, and social to biological data. The metabolome is used as a phenotypic probe because it is sensitive to changes in physiological and external conditions. The TMCS focuses on collecting outcomes for cardiovascular disease, cancer incidence and mortality, disability and functional decline due to aging and disease sequelae, and the variation in health status within the body represented by omics analysis that lies between exposure and disease. It contains several sub-studies on aging, heated tobacco products, and women's health. This study is notable for its robust design, high participation rate (89%), and long-term repeated surveys. Moreover, it contributes to precision prevention in Japan and East Asia as a well-established multi-omics platform.

  • Association of Nonalcoholic Fatty Liver Disease with Arterial Stiffness and its Metabolomic Profiling in Japanese Community-Dwellers

    Hirata A., Harada S., Iida M., Kurihara A., Fukai K., Kuwabara K., Kato S., Matsumoto M., Sata M., Miyagawa N., Toki R., Edagawa S., Sugiyama D., Sato A., Hirayama A., Sugimoto M., Soga T., Tomita M., Okamura T., Takebayashi T.

    Journal of atherosclerosis and thrombosis 31 ( 7 ) 1031 - 1047 2024.07

    　View Summary

    AIMS: Nonalcoholic fatty liver disease (NAFLD) is known to be associated with atherosclerosis. This study focused on upstream changes in the process by which NAFLD leads to atherosclerosis. The study aimed to confirm the association between NAFLD and the cardio-ankle vascular index (CAVI), an indicator of subclinical atherosclerosis, and explore metabolites involved in both by assessing 94 plasma polar metabolites. METHODS: A total of 928 Japanese community-dwellers (306 men and 622 women) were included in this study. The association between NAFLD and CAVI was examined using a multivariable regression model adjusted for confounders. Metabolites commonly associated with NAFLD and CAVI were investigated using linear mixed-effects models in which batch numbers of metabolite measurements were used as a random-effects variable, and false discovery rate-adjusted p-values were calculated. To determine the extent to which these metabolites mediated the association between NAFLD and CAVI, mediation analysis was conducted. RESULTS: NAFLD was positively associated with CAVI (coefficients [95% Confidence intervals (CI)]=0.23 [0.09-0.37]; p=0.001). A total of 10 metabolites were involved in NAFLD and CAVI, namely, branched-chain amino acids (BCAAs; valine, leucine, and isoleucine), aromatic amino acids (AAAs; tyrosine and tryptophan), alanine, proline, glutamic acid, glycerophosphorylcholine, and 4-methyl-2-oxopentanoate. Mediation analysis showed that BCAAs mediated more than 20% of the total effect in the association between NAFLD and CAVI. CONCLUSIONS: NAFLD was associated with a marker of atherosclerosis, and several metabolites related to insulin resistance, including BCAAs and AAAs, could be involved in the process by which NAFLD leads to atherosclerosis.

  • Reliability of Time-Series Plasma Metabolome Data over 6 Years in a Large-Scale Cohort Study

    Miyake A., Harada S., Sugiyama D., Matsumoto M., Hirata A., Miyagawa N., Toki R., Edagawa S., Kuwabara K., Okamura T., Sato A., Amano K., Hirayama A., Sugimoto M., Soga T., Tomita M., Arakawa K., Takebayashi T., Iida M.

    Metabolites 14 ( 1 )  2024.01

    　View Summary

    Studies examining long-term longitudinal metabolomic data and their reliability in large-scale populations are limited. Therefore, we aimed to evaluate the reliability of repeated measurements of plasma metabolites in a prospective cohort setting and to explore intra-individual concentration changes at three time points over a 6-year period. The study participants included 2999 individuals (1317 men and 1682 women) from the Tsuruoka Metabolomics Cohort Study, who participated in all three surveys—at baseline, 3 years, and 6 years. In each survey, 94 plasma metabolites were quantified for each individual and quality control (QC) sample. The coefficients of variation of QC, intraclass correlation coefficients, and change rates of QC were calculated for each metabolite, and their reliability was classified into three categories: excellent, fair to good, and poor. Seventy-six percent (71/94) of metabolites were classified as fair to good or better. Of the 39 metabolites grouped as excellent, 29 (74%) in men and 26 (67%) in women showed significant intra-individual changes over 6 years. Overall, our study demonstrated a high degree of reliability for repeated metabolome measurements. Many highly reliable metabolites showed significant changes over the 6-year period, suggesting that repeated longitudinal metabolome measurements are useful for epidemiological studies.

  • A population-based urinary and plasma metabolomics study of environmental exposure to cadmium

    Ishibashi Y., Harada S., Eitaki Y., Kurihara A., Kato S., Kuwabara K., Iida M., Hirata A., Sata M., Matsumoto M., Shibuki T., Okamura T., Sugiyama D., Sato A., Amano K., Hirayama A., Sugimoto M., Soga T., Tomita M., Takebayashi T.

    Environmental Health and Preventive Medicine 29 2024

    ISSN  1342078X

    　View Summary

    Background: The application of metabolomics-based profiles in environmental epidemiological studies is a promising approach to refine the process of health risk assessment. We aimed to identify potential metabolomics-based profiles in urine and plasma for the detection of relatively low-level cadmium (Cd) exposure in large population-based studies. Method: We analyzed 123 urinary metabolites and 94 plasma metabolites detected in fasting urine and plasma samples collected from 1,412 men and 2,022 women involved in the Tsuruoka Metabolomics Cohort Study. Regression analysis was performed for urinary N-acetyl-beta-D-glucosaminidase (NAG), plasma, and urinary metabolites as dependent variables, and urinary Cd (U-Cd, quartile) as an independent variable. The multivariable regression model included age, gender, systolic blood pressure, smoking, rice intake, BMI, glycated hemoglobin, low-density lipoprotein cholesterol, alcohol consumption, physical activity, educational history, dietary energy intake, urinary Na/K ratio, and uric acid. Pathway-network analysis was carried out to visualize the metabolite networks linked to Cd exposure. Result: Urinary NAG was positively associated with U-Cd, but not at lower concentrations (Q2). Among urinary metabolites in the total population, 45 metabolites showed associations with U-Cd in the unadjusted and adjusted models after adjusting for the multiplicity of comparison with FDR. There were 12 urinary metabolites which showed consistent associations between Cd exposure from Q2 to Q4. Among plasma metabolites, six cations and one anion were positively associated with U-Cd, whereas alanine, creatinine, and isoleucine were negatively associated with U-Cd. Our results were robust by statistical adjustment of various confounders. Pathway-network analysis revealed metabolites and upstream regulator changes associated with mitochondria (ACACB, UCP2, and metabolites related to the TCA cycle). Conclusion: These results suggested that U-Cd was associated with metabolites related to upstream mitochondrial dysfunction in a dose-dependent manner. Our data will help develop environmental Cd exposure profiles for human populations.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • A longitudinal study on metabolic profiling of menopause: a large-scale population-based cohort study in Japan

    Atsuko Miyake*1*2, Miho Iida*2, Toru Takebayashi*2, Kouji Banno*1, Wataru Yamagami*1, Mamoru Tanaka*1

    第76回 日本産科婦人科学会学術講演会 (横浜) , 

    2024.04

  • 習慣的飲酒と尿メタボロームの関連：鶴岡メタボロームコホート研究

    原田 成, 飯田美穂, 宮川尚子, 平田あや, 松元美奈子,土岐了大, 枝川 峻, 岡村智教, 武林 亨

    第94回　日本衛生学会 (熊本) , 

    2024.03

  • 日本の地域住民における喫煙習慣の有無別の血清総ビリルビンと脳・心血管疾患発症との関連

    平田あや1、原田成1、飯田美穂1、宮川尚子1、松元美奈子1、土岐了大1、枝川俊1、三宅温子1、桑原和代1、杉山大典1,2、岡村智教1、武林亨1

    第34回　日本疫学会学術総会 (滋賀県大津市・びわ湖大津プリンスホテル) , 

    2024.01
    -
    2024.02
    , 

    日本疫学会

  • 日本人集団における血中アミノ酸濃度のゲノムワイド関連解析(GWAS)とそれを用いた疾患との関連研究

    土岐了大, 小島駿, 伏木蒼太郎, 原田成, 平田あや, 飯田美穂, 松元美奈子, 宮川尚子, 枝川竣, 三宅温子, 須藤洋一, 大桃秀樹, 山崎弥生, 岡村智教, 清水厚志, 武林亨

    第34回　日本疫学会学術総会 (滋賀県大津市・びわ湖大津プリンスホテル) , 

    2024.01
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    2024.02
    , 

    日本疫学会

  • Association of BMI at age 18 and subsequent infertility: Japan Nurses' Health Study

    Miho Iida1, Kunihiko Hayashi2, Yuki Ideno2, Kazue Nagai2, Yukiko Miyazaki3, Yasunori Sato1

    第34回　日本疫学会学術総会 (滋賀県大津市・びわ湖大津プリンスホテル) , 

    2024.01
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    2024.02
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    日本疫学会

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • ステロイドホルモン・プロファイリングを用いた女性健康実現のための地域コホート研究

    2019.04
    -
    Present

    文部科学省, 科学研究費助成事業（科研費）, 若手研究, No Setting, Principal investigator

    　View Summary

    近年、エイジングに伴う健康寿命延伸・QOL向上において、ステロイドホルモンが果たす役割の重要性が明らかになってきた。とくに高齢女性においては、更年期状態の把握以外に女性ホルモン濃度を測定する意義は乏しいとされてきたのに対し、閉経後の卵巣や副腎における性ホルモンやその前駆体の分泌が明らかとなり、これらの網羅的なプロファイルと認知機能低下、フレイルや動脈硬化性疾患、骨粗鬆症等との関連について検証する意義は大きい。
    本研究では、高齢女性の健康状態やQOLに関連する代謝プロファイル・ステロイドホルモンプロファイルを明らかにし、女性の健康寿命・QOL向上に繋げることを目的とする。

  • メタボロミクス疫学による個別か女性予防医療研究：更年期障害の客観的評価指標の探索と疾患発症予測の検討

    2018.10
    -
    2019.09

    大和証券ヘルス財団, 平成30年度（第45回）調査研究助成, 中高年・高齢者のための予防医学・臨床医学、並びに医療に関する調査研究, No Setting, Principal investigator

    　View Summary

    女性活躍社会の実現は，多様性を尊重する世界の潮流となっている。人口減少社会を迎えるわが国においても，2020年までに指導的地位に女性が占める割合を30％程度とする目標が掲げられている．一方で，社会において指導的地位を担う可能性が高い40-50代女性において，更年期障害を有する女性の労働能力の低下は，更年期障害なしの場合の8.4倍にも及ぶことが示されている．更年期障害は，軽症のものも含めると全女性の半数以上が経験するが，エストロゲン分泌低下の直接的影響を受ける血管運動神経系症状（例：ほてり，発汗）と，心理・社会的背景の変化に基づくエストロゲン低下を介さない精神神経系／運動神経系症状（例：抑うつ，めまい）の両者が複合的に絡み合い多彩な表現型を示すことから，さまざまな状態に応じて診断・治療の最適化を図る個別化予防医療の対象疾患として重要である.
    体内の代謝プロファイルを網羅的に評価することのできる手法であるメタボロミクスは，遺伝子-環境相互作用の結果を鋭敏に反映する手法として，疾患バイオマーカー探索から薬剤開発まで広く用いられつつある.そこで本研究では，地域在住の更年期女性を対象に，既存の各種ホルモン値に加え血中メタボロームを網羅的に測定し，更年期障害のメタボロームプロファイリングを通じて，更年期障害の客観的評価法を見出すことを目的とする．また，更年期障害を有する女性は将来心血管疾患を発症するリスクが高いことが報告されており，大規模疫学研究データを用いて，将来的な疾患発症予測に関する検証を第二の目的とする．
    更年期障害は社会的に広く認知されかつ治療法もおおむね確立しているにも関わらず，本邦における更年期女性の医療機関受診率やホルモン補充療法の普及率は低い．その背景には，ホルモン値測定による卵巣機能の評価は診断の参考になるが，症状の感じ方・現れ方に個人差が大きく主観的であり，実地臨床において客観的判断が難しいとの課題がある.本研究により更年期女性の健康課題に対して従来とは異なる新しい発想のアプローチを行うことで，更年期症状の客観的評価や将来の疾患発症に対する早期介入が可能となり，一人でも多くの女性のより良い生涯と日本の男女共同参画社会実現の一助となることが期待される．

  • Integration of genomics and metabolomics for prevention of menopausal disorders

    2021.04
    -
    2023.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists , Principal investigator

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Awards 【 Display / hide 】

  • The 90th Annual Meeting of Japanese Society for Hygiene, Young Investigator Award

    2022.03, Japanese Society for Hygiene, 閉経後女性の代謝プロファイルに対する出産経験の影響：鶴岡メタボロームコホート研究

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • 2017 JSOG Best Paper Award (Women's Health section)

    2017.04, Japan Society of Obstetrics and Gynecology (JSOG), 閉経後女性におけるメタボリック症候群の血漿メタボローム・プロファイリング

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • The 30th annual meeting of the Japan Society for Menopause and Women’s Health Best Presentation Award

    2015.11, Japan Society for Menopause and Women’s Health (JMWH), 閉経後女性におけるメタボリック症候群の血漿メタボローム解析：鶴岡メタボロームコホート研究

    Type of Award： Award from Japanese society, conference, symposium, etc.

  • Kameda Medican Center, The Best Resident Award (22nd)

    2010.03

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Courses Taught 【 Display / hide 】

  • PUBLIC HEALTH 2 (ADVANCED)

    2024

  • PUBLIC HEALTH 1 (BASIC)

    2024

  • EPIDEMIOLOGY AND PREVENTIVE MEDICINE

    2024

  • ENVIRONMENTAL AND OCCUPATIONAL HEALTH

    2024

  • 臨床疫学

    2024, Postgraduate, Lecture

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Courses Previously Taught 【 Display / hide 】

  • 医学統計・医療情報

    Keio University

    2018.04
    -
    2019.03
    , 

    Seminar, Lecturer outside of Keio, 3h, 110people

  • 自主学習

    Keio University

    2018.04
    -
    2019.03
    , 

    Seminar, Lecturer outside of Keio, 3h, 5people

  • 医学統計・医療情報

    慶應義塾大学医学部

    2018.04
    -
    2019.03

  • 公衆衛生学

    慶應義塾大学医学部

    2018.04
    -
    2019.03

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Educational Activities and Special Notes 【 Display / hide 】

  • 自主学習

    2019.04
    -
    2019.11

    , Lecture at Education Method and Practice

  • 公衆衛生学調査研究

    2018.10
    -
    2018.11

    , Special Affairs

  • 医学統計・医療情報

    2018.09
    -
    2018.11

    , Special Affairs

  • 自主学習

    2018.04
    -
    2018.11

    , Lecture at Education Method and Practice

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Social Activities 【 Display / hide 】

  • 生理に伴う不調への対処と学校における啓発の必要性

    NPO法人日本トイレ研究所, 中学・高校向け授業 「みんなで知ろう 生理に伴う不調とケア」 研修会, 

    , 
    2024.08

  • 月経による健康課題と職場でできること

    NPO法人日本トイレ研究所, 第73回トイレラボ勉強会, 

    , 
    2024.04

  • 働く女性の健康課題解決へー企業は何をするべきか

    佐賀県、女性の活躍推進佐賀県会議, 働く女性のこころとからだケアセミナー, 

    , 
    2024.01

  • 男性も女性も知っておきたい女性の健康についてー妊娠・出産ー

    経済産業省, 教えよう！ココロ＆カラダ　厚生企画室勉強会, 

    , 
    2023.12

  • 女性特有のからだの悩みとその対応について学ぼう

    日産自動車（株）横浜工場 安全健康管理課, 管理・監督者向けセミナー「女性の活躍と健康」, 

    , 
    2023.11

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Media Coverage 【 Display / hide 】

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Committee Experiences 【 Display / hide 】

  • 2021.04
    -
    Present

    世話人, 日本産業衛生学会 就労女性健康研究会

  • 2020.11
    -
    Present

    代議員, 日本産業衛生学会

  • 2018.09
    -
    Present

    食養委員, 慶應義塾大学病院食養委員会

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