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Affiliation
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School of Medicine, Department of Physiology (Shinanomachi)
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Position
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Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)
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Maeda, Sumihiro
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In 2001, I joined the laboratory for Alzheimer’s disease (AD) at RIKEN Institute and started my PhD works on tau protein. During my doctoral thesis, I found an oligomeric species of tau aggregate in in vitro and purified tau oligomers from AD brain, which was the first purification of oligomeric species from human brains. After I finished my doctoral thesis in 2006, I obtained a post-doc position in the same laboratory to translate my findings into therapies. To find therapeutic targets, we searched two kinds of molecules: (1) aggregation inhibitors to disrupt the aggregation of tau and (2) probes for tau oligomer to use for diagnosis before the onset of AD. In 2008 I joined the laboratory of Dr. Lennart Mucke at the Gladstone Institute of Neurological Disease. I studied the pathogenesis of A152T human tau variant (hTau-A152T) that is genetically linked to AD for the first time and found that hTau-A152T could induce epileptic activity independent of tau aggregation. In 2016, I was appointed instructor at Keio university school of medicine and launched some projects to study the pathogenesis of tau protein using iPSC-derived neurons.
RIKEN, Brain Science Institute, Laboratory for Alzheimer's Disease, Junior research associate
RIKEN, Brain Science Institute, Laboratory for Alzheimer's Disease, Post-doctoral fellow
The J. David Gladstone Institutes, Gladstone Institute of Neurological Disease, Post-doctoral fellow
The J. David Gladstone Institutes, Gladstone Institute of Neurological Disease, Research scientist
Keio University, School of Medicine, Physiology Department, Instructor
Tokyo Institute of Technology, Department of Life Science and Technology, 分子生命科学専攻
Japan, University, Graduated, Master's course
Tokyo Institute of Technology, Department of Life Science and Technology, 分子生命科学専攻
Japan, University, Graduated, Doctoral course
Ph. D., Tokyo Institute of Technology, 2006.03
顆粒状凝集体を介したタウ線維形成:タウ線維中間体の同定
Neurophysiology / General neuroscience
Nerve anatomy/Neuropathology
Molecular biology
Molecular biology
Pathological medical chemistry
iPS cells
Epilepsy
Epilepsy
Alzheimer's disease
Tau protein
Neuronal levels and sequence of tau modulate the power of brain rhythms
Das M., Maeda S., Hu B., Yu G., Guo W., Lopez I., Yu X., Tai C., Wang X., Mucke L.
Neurobiology of Disease (Neurobiology of Disease) 117 181 - 188 2018.09
ISSN 09699961
Maeda S., Sato Y., Takashima A.
Neurobiology of Aging (Neurobiology of Aging) 69 26 - 32 2018.09
ISSN 01974580
Tau Phosphorylation-Much More than a Biomarker
Maeda, Sumihiro, Mucke, Lennart
NEURON 92 ( 2 ) 265 - 267 2016.10
Research paper (scientific journal), ISSN 0896-6273
Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice
Maeda, Sumihiro, Djukic, Biljana, Taneja, Praveen, Yu, Gui-Qiu, Lo, Iris, Davis, Allyson, Craft, Ryan, Guo, Weikun, Wang, Xin, Kim, Daniel, Ponnusamy, Ravikumar, Gill, T. Michael, Masliah, Eliezer, Mucke, Lennart
EMBO REPORTS 17 ( 4 ) 530 - 551 2016.04
Research paper (scientific journal), ISSN 1469-221X
Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups
Soeda, Yoshiyuki, Yoshikawa, Misato, Almeida, Osborne F. X., Sumioka, Akio, Maeda, Sumihiro, Osada, Hiroyuki, Kondoh, Yasumitsu, Saito, Akiko, Miyasaka, Tomohiro, Kimura, Tetsuya, Suzuki, Masaaki, Koyama, Hiroko, Yoshiike, Yuji, Sugimoto, Hachiro, Ihara, Yasuo, Takashima, Akihiko
NATURE COMMUNICATIONS 6 530 - 551 2015.12
Research paper (scientific journal), ISSN 2041-1723
Maeda, Sumihiro
科学研究費補助金研究成果報告書 2018
Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration.
MAEDA Sumihiro
Curr Alzheimer Res 5 ( 6 ) 591 - 598 2008
Introduction and explanation (scientific journal), Joint Work
神経原線維変化形成機構
MAEDA Sumihiro
Dementia Japan (日本認知症学会) 20 ( 3 ) 262 - 270 2006.12
Introduction and explanation (scientific journal), Joint Work
Mechanism of Neurofibrillary Tangle Formation: Tau Accumulation and Fibril Formation
MAEDA Sumihiro
Alzheimer's association 2004
Introduction and explanation (scientific journal), Joint Work
Epileptic activity caused by soluble tau species
MAEDA Sumihiro
タウ研究会2017, 2017.08, Symposium, Workshop, Panelist (public offering), タウ研究会 運営委員会
Aggregation-dependent and –independent pathogenesis of tau protein
MAEDA Sumihiro
Summer school for 2017, 2017, Public discourse, seminar, tutorial, course, lecture and others
Analysis of network dysfunction in hTau-A152T transgenic mice identifies potential new biomarker and opportunity for therapeutic intervention
MAEDA Sumihiro
Society for Neuroscience annual meeting, 2016, Poster (general)
タウオリゴマー
MAEDA Sumihiro
日本認知症学会 学術集会, 2015, Symposium, Workshop, Panelist (public offering)
Behavioral, Synaptic, and Neuropathological Changes Caused by A152T Human Tau without Mature Tau Aggregates
MAEDA Sumihiro
2015, Public discourse, seminar, tutorial, course, lecture and others
ヒトiPS、線維芽細胞から直接誘導された神経細細胞におけるタウタンパク質の解析
文部科学省, Grant-in-Aid for Scientific Research, Sumihiro Maeda, Research grant, Principal Investigator
神経原線維変化形成機構
文部科学省, Grant-in-Aid for Scientific Research, Akihiko Takashima, Co-investigator
タウ凝集阻害剤の検索と評価
MEXT, Grant-in-Aid for Scientific Research, Sumihiro Maeda, Research grant, Principal Investigator
Career advancement award
2014, The J. David Gladstone Institute
Poster presentation award (1st)
2013, The J. David Gladstone Institute
Scientific leadership award
2012, The J. David Gladstone Institute
Poster presentation award (3rd)
2012, The J. David Gladstone Institute
Excellent paper award
2006, Neuroscience Research
PHYSIOLOGY 2
2020
LECTURE SERIES, INTERNAL MEDICINE (NEUROLOGY)
2020
PHYSIOLOGY 2
2019
再生・遺伝子の科学
Keio University, 2017, Autumn Semester, Other, Lecture, Lecturer outside of Keio, 40people
Alzheimer's disease, Tau protein
尿生成
Keio University, 2017, Autumn Semester, General education subject, Laboratory work/practical work/exercise, Outside own faculty (within Keio), 120people
自主学習プログラム
Keio University, 2017, Spring Semester, Other, Laboratory work/practical work/exercise, 10h, 2people
日本神経科学会,
Society for Neuroscience,
日本認知症学会,