Kase, Yoshitaka



School of Medicine, Department of Physiology (Shinanomachi)




Yoshitaka Kase

Other Affiliation 【 Display / hide

  • 東京大学大学院, 医学系研究科, 加齢医学講座, 助教

Academic Degrees 【 Display / hide

  • 医学博士, The University of Tokyo, Coursework

Licenses and Qualifications 【 Display / hide

  • 医師免許

  • 薬剤師免許


Research Areas 【 Display / hide

  • Neurophysiology / General neuroscience

  • General physiology

  • General internal medicine (including psychosomatic medicine)

Research Keywords 【 Display / hide

  • 神経幹細胞、神経新生、再生医療、老化


Books 【 Display / hide

  • [九訂]介護支援専門員基本テキスト

    加瀬義高, 2021.06

Papers 【 Display / hide

  • Neurological pathogenesis of SARS-CoV-2 (COVID-19): from virological features to clinical symptoms

    Yoshitaka Kase, Hideyuki Okano

    Inflammation and Regeneration (Inflammation and Regeneration)  41 ( 15 ) 15 2021.05

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  1880-9693

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    Since the worldwide outbreak of coronavirus disease 2019 (COVID-19) in 2020, various research reports and case reports have been published. It has been found that COVID-19 causes not only respiratory disorders but also thrombosis and gastrointestinal disorders, central nervous system (CNS) disorders, and peripheral neuropathy. Compared to other disorders, there are low number of research reports and low number of summaries on COVID-19-related neural disorders. Therefore, focusing on neural disorders, we outline both basic research and clinical manifestations of COVID-19-related neural disorders.

  • Deteriorating anemia in an 86-year-old man was improved by prednisolone

    Kitago M, Kase Y, Iwata Y, Suwa Y, Tsuchiya H, Hanata N, Kojima T, Ogawa S, Fujio K, Akishita M

    geriatrics & gerontology international  2020.09

    Research paper (scientific journal), Accepted,  ISSN  1444-1586

  • Current understanding of adult neurogenesis in the mammalian brain: how does adult neurogenesis decrease with age?

    Kase Y, Shimazaki T, Okano H

    Inflammation and regeneration (Inflammation and Regeneration)  40 ( 1 ) 10 2020

    Accepted,  ISSN  1880-9693

     View Summary

    © 2020 The Author(s). Adult neurogenesis occurs throughout life in restricted brain regions in mammals. However, the number of neural stem cells (NSCs) that generate new neurons steadily decreases with age, resulting in a decrease in neurogenesis. Transplantation of mesenchymal cells or cultured NSCs has been studied as a promising treatment in models of several brain injuries including cerebral infarction and cerebral contusion. Considering the problems of host-versus-graft reactions and the tumorigenicity of transplanted cells, the mobilization of endogenous adult NSCs should be more feasible for the treatment of these brain injuries. However, the number of adult NSCs in the adult brain is limited, and their mitotic potential is low. Here, we outline what we know to date about why the number of NSCs and adult neurogenesis decrease with age. We also discuss issues applicable to regenerative medicine.

  • Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disorders.

    Kase Y, Okano H

    Inflammation and regeneration 40   32 2020

    Accepted,  ISSN  1880-9693

  • Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling

    Kase Y, Otsu K, Shimazaki T, Okano H

    Stem Cell Reports (Stem Cell Reports)  12 ( 6 ) 1313 - 1328 2019.05

    Research paper (scientific journal), Accepted,  ISSN  22136711

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    © 2019 The Author(s) Neurogenesis in specific brain regions in adult mammals decreases with age. Progressive reduction in the proliferation of neural stem and progenitor cells (NS/PCs) is a primary cause of this age-associated decline. However, the mechanism responsible for this reduction is poorly understood. We identify p38 MAPK as a key factor in the proliferation of neural progenitor cells (NPCs) in adult neurogenic niches. p38 expression in adult NS/PCs is downregulated during aging. Deletion of p38α in NS/PCs specifically reduces the proliferation of NPCs but not stem cells. Conversely, forced expression of p38α in NS/PCs in the aged mouse subventricular zone (SVZ) restores NPC proliferation and neurogenesis, and prevents age-dependent SVZ atrophy. We also found that p38 is necessary for suppressing the expression of Wnt antagonists DKK1 and SFRP3, which inhibit the proliferation of NPCs. Age-related reduction in p38 thus leads to decreased adult neurogenesis via downregulation of Wnt signaling. Kase et al. show that p38 expression in neural stem and progenitor cells (NS/PCs) in the adult brain decreases with aging. This reduction specifically causes proliferation defect in neural progenitor cells (NPCs), leading to the age-dependent decline of adult neurogenesis. Conversely, overexpression of p38α in NS/PCs in the aged brain restores NPC proliferation without exhaustion of neural stem cells.

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Reviews, Commentaries, etc. 【 Display / hide

  • COVID-19の中枢神経系への影響

    加瀬 義高, 岡野 栄之

    Depression Strategy ((株)先端医学社)  11 ( 2 ) 4 - 7 2021.06

    Other article, Joint Work,  ISSN  2186-2575

  • 老年症候群によるポリファーマシーに対し入院精査により減薬を達成した1例

    宮脇 正次, 大澤 一太, 岩田 裕子, 加瀬 義高, 原田 さおり, 小島 太郎, 小川 純人, 秋下 雅弘

    日本老年医学会雑誌 ((一社)日本老年医学会)  57 ( 4 ) 501 - 501 2020.10

    Other article, Joint Work,  ISSN  0300-9173

  • 貧血から顕微鏡的多発血管炎(MPA)の診断、治療に至った高齢男性の1例

    北郷 萌, 岩田 裕子, 加瀬 義高, 小島 太郎, 小川 純人, 秋下 雅弘, 諏訪 雄一, 土屋 遥香, 花田 徳大, 藤尾 圭志

    日本老年医学会雑誌 ((一社)日本老年医学会)  57 ( 4 ) 528 - 528 2020.10

    Other article, Joint Work,  ISSN  0300-9173

  • 成体の神経新生における老化に関連した低下に対するp38のWntシグナル伝達調節を介した保護的役割(Preventive Role of p38 Against Age-related Decline in Adult Neurogenesis via Modulation of Wnt Signaling)

    加瀬 義高, 島崎 琢也, 岡野 栄之

    日本抗加齢医学会総会プログラム・抄録集 ((一社)日本抗加齢医学会)  19回   236 - 236 2019.06

    Other article, Joint Work

  • Improvement in polypharmacy and medication regimen complexity among older inpatients with dementia in a geriatric ward

    Kase Y., Hattori Y., Umeda-Kameyama Y., Kojima T., Ogawa S., Akishita M.

    Geriatrics and Gerontology International (Geriatrics and Gerontology International)  19 ( 5 ) 461 - 462 2019.05

    ISSN  14441586

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Presentations 【 Display / hide

  • ウイルス毒性増悪因子としてのCCN family member 1 の COVID-19 関連神経障害への関与


    第12回 日本CCNファミリー研究会, 2021.09, Symposium, Workshop, Panelist (nomination)


    ISSCR 2021 Annual Meeting, to be held virtually from 21 June - 26 June, 2021., 2021.07

  • 新規ゲノム編集手法の開発と glioblastoma 治療への応用

    岡野雄士, 加瀬義高, 吉田哲, 久松大介, 岡野栄之

    新規ゲノム編集手法の開発と glioblastoma 治療への応用, 2021.07, Oral Presentation(general)

  • Expression of ACE2 and a viral virulence-regulating factor CCN family member 1: implications for COVID-19-related CNS disorders

    第42回日本炎症・再生医学会, 2021.07, Oral Presentation(general)

  • Preventive Role of p38 Against Age-related Decline in Adult Neurogenesis via Modulation of Wnt Signaling


    第40回日本炎症・再生医学会, 2019.07, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 障害海馬での神経幹細胞の枯渇を招かない長期的な神経再生の基礎的研究


    Keio University, 加瀬義高, Grant-in-Aid for Early-Career Scientists, Other, Principal Investigator

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Awards 【 Display / hide

  • 優秀発表賞

    2021.10, 第64回日本神経化学会大会, ヒトのニューロンにおける神経突起伸長メカニズムの解明と神経突起伸長化合物の探索

    Type of Award: Awards of National Conference, Council and Symposium

  • 優秀演題賞

    Yoshitaka Kase, 2020.07, 第41回日本炎症・再生医学会, γ-secretase inhibitors enhance the neurite growth via modulation of p38 MAPK activation

    Type of Award: Awards of National Conference, Council and Symposium

  • 優秀演題賞

    2019.07, 第42回日本神経科学大会/第62回日本神経化学会大会/ NEURO2019

    Type of Award: Awards of National Conference, Council and Symposium

  • 優秀演題賞

    2019.07, 日本炎症・再生医学会

    Type of Award: Awards of National Conference, Council and Symposium

  • Poster Teasers

    2019.03, ES細胞由来神経幹細胞分化運命メカニズムの解析

    Type of Award: Awards of National Conference, Council and Symposium

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Courses Previously Taught 【 Display / hide

  • 老年医学 高齢者の臨床(認知症とその対応)

    首都大学東京, 2018

  • PBLチュートリアル教育

    東京大学, 2018

  • 老年医学 

    国立障害者リハビリテーションセンター学院, 2018

Educational Activities and Special Notes 【 Display / hide

  • Global science campus


    , Special Affairs

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Memberships in Academic Societies 【 Display / hide

  • 日本脳卒中学会, 

  • 日本炎症・再生医学会, 

  • 日本神経化学会, 

  • 日本抗加齢医学会, 

  • 日本再生医療学会, 


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