Details of a Researcher - NAKAJIMA, Kazunori

Papers - NAKAJIMA, Kazunori

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Comprehensive analysis of immunoglobulin expression in the mouse brain from embryonic to adult stages.

Keiko Morimoto*, Hitomi Sano, Michiko Takahashi, Rikuo Takahashi, and Kazunori Nakajima*

J. Neuroinflammation, 22 ( 153 ) 2025.06

Research paper (scientific journal), Last author, Corresponding author, Accepted

Propagation of neuronal micronuclei regulates microglial characteristics.

Sarasa Yano, Natsu Asami, Yusuke Kishi, Ikuko Takeda, Hikari Kubotani, Yuki Hattori, Ayako Kitazawa, Kanehiro Hayashi, Ken-ichiro Kubo, Mai Saeki, Chihiro Maeda, Chihiro Hiraki, Rin-ichiro Teruya, Takumi Taketomi, Kaito Akiyama, Tomomi Okajima-Takahashi, Ban Sato, Hiroaki Wake, Yukiko Gotoh, Kazunori Nakajima, Takeshi Ichinohe, Takeshi Nagata, Tomoki Chiba, Fuminori Tsuruta*

Nat. Neurosci. 28 487 - 498 2025.01

Research paper (scientific journal), Accepted

Cadherin-6 controls neuronal migration during mouse neocortical development via an integrin-mediated pathway.

Yuki Hirota*, Rikaho Saito, Takao Honda, Hitomi Sano, Mayuko Hotta, Yukiko U. Inoue, Takayoshi Inoue, and Kazunori Nakajima*

FEBS J., in press 2025

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

De novo monoallelic Reelin missense variants cause dominant neuronal migration disorders via a dominant-negative mechanism

Martina Riva, Sofia Ferreira, Kotaro Hayashi, Yoann Saillour, Vera P. Medvedeva, Takao Honda, Kanehiro Hayashi, Claire Altersitz, Shahad Albadri, Marion Rosello, Julie Dang, Malo Serafini, Frédéric Causeret, Olivia J. Henry, Charles-Joris Roux, Céline Bellesme, Elena Freri, Dragana Josifova, Elena Parrini, Renzo Guerrini, Filippo Del Bene, Kazunori Nakajima, Nadia Bahi-Buisson, and Alessandra Pierani* (☆Filippo Del Bene, Kazunori Nakajima, and Nadia Bahi-Buisson contributed equally to this work)

J. Clin. Invest. 134 ( 16 ) e153097 2024.07

Research paper (scientific journal), Joint Work, Accepted

Maternal immunoglobulins are distributed in the offspring’s brain to support the maintenance of cortical interneurons in the postnatal period.

Keiko Morimoto*, Rikuo Takahashi, Goro Takahashi, Michio Miyajima, and Kazunori Nakajima*

(Inflamm. Regen.) 44 ( 24 ) 2024.05

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

Time-lapse imaging of migrating neurons and glial progenitors in embryonic mouse brain slices.

Hidenori Tabata, Koh-ichi Nagata, and Kazunori Nakajima

J. Vis. Exp 205 ( e66631 ) 1 - 12 2024.03

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

Migratory mode transition of astrocyte progenitors in the cerebral cortex: an intrinsic or extrinsic cell process?

Michio Miyajima, Hidenori Tabata, and Kazunori Nakajima

Neural Regen. Res. 19 ( 3 ) 471 - 472 2024.03

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

Interactions between neural cells and blood vessels in central nervous system development

Keiko Morimoto, Hidenori Tabata, Rikuo Takahashi, and Kazunori Nakajima

BioEssays 46 ( 3 ) e2300091 2024.03

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

Heterozygous Dab1 null mutation disrupts neocortical and hippocampal development.

Takao Honda, Yuki Hirota, and Kazunori Nakajima

eNeuro 10 ( 4 ) 2023.03

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

Access to Document (DOI)

A unique “reversed” migration of neurons in the developing claustrum.

Kota Oshima, Satoshi Yoshinaga, Ayako Kitazawa, Yuki Hirota, Kazunori Nakajima*, and Ken-ichiro Kubo*.

J. Neurosci 43 ( 5 ) 693 - 708 2023

Research paper (scientific journal), Joint Work, Corresponding author, Accepted

Dab1-deficient deep layer neurons prevent Dab1-deficient superficial layer neurons from entering the cortical plate.

Satoshi Yoshinaga, Takao Honda, Ken-ichiro Kubo, and Kazunori Nakajima

Neurosci. Res 180 23 - 35 2022.07

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

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Rhythmic activation of excitatory neurons in the mouse frontal cortex improves the prefrontal cortex-mediated cognitive function.

Debabrata Hazra, Satoshi Yoshinaga, Keitaro Yoshida, Norio Takata, Kenji F. Tanaka, Ken-ichiro Kubo, and Kazunori Nakajima

Cereb. Cortex 32 ( 23 ) 5243 - 5258 2022.02

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

TPT1 supports proliferation of neural stem/progenitor cells and brain tumor initiating cells regulated by Macrophage migration Inhibitory Factor (MIF).

Yukina Morimoto, Ayako Tokumitsu, Takefumi Sone, Yuki Hirota, Ryota Tamura, Ayuna Sakamoto, Kazunori Nakajima, Masahiro Toda, Yutaka Kawakami, Hideyuki Okano, and Shigeki Ohta.

Neurochem. Res. 47 2741 - 2756 2022

Research paper (scientific journal), Joint Work, Accepted

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Development of intensiometric indicators for visualizing N-cadherin interaction across cells.

Takashi Kanadome, Kanehiro Hayashi, Yusuke Seto, Mototsugu Eiraku, Kazunori Nakajima, Takeharu Nagai, and Tomoki Matsuda.

Commun. Biol 5 ( 1 ) 1065 2022

Research paper (scientific journal), Joint Work, Accepted

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Activation of sonic hedgehog signaling promotes differentiation of cortical layer 4 neurons via regulation of their cell positioning.

Koji Oishi, Kazunori Nakajima, and Jun Motoyama

J. Dev. Biol. 10 ( 4 ) 50 2022

Research paper (scientific journal), Joint Work, Accepted

Erratic and Blood Vessel-Guided Migration of Astrocyte Progenitors in the Cerebral Cortex.（Featured in “Editors’ Highlights” as one of the most exciting articles.）

Hidenori Tabata, Megumi Sasaki, Masakazu Agetsuma, Hitomi Sano, Yuki Hirota, Michio Miyajima, Kanehiro Hayashi, Takao Honda, Masashi Nishikawa, Yutaka Inaguma, Hidenori Ito, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Junichi Nabekura, Koh-ichi Nagata, and Kazunori Nakajima.

Nat. Commun. 13 6571 2022

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

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Comprehensive characterization of migration profiles of murine cerebral cortical neurons during development using FlashTag labeling.

Satoshi Yoshinaga, Minkyung Shin, Ayako Kitazawa, Kazuhiro Ishii, Masato Tanuma, Atsushi Kasai, Hitoshi Hashimoto, Ken-ichiro Kubo, and Kazunori Nakajima

iScience 24 ( 4 ) 102277 2021

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

Cerebellar foliation via non-uniform cell accumulation caused by fiber-guided migration of granular cells.

Hironori Takeda, Yoshitaka Kameo, Takahiro Yamaguchi, Kazunori Nakajima, and Taiji Adachi

J. Biomech. Sci. Eng. 16 ( 1 ) Paper No.20-00516 2021

Research paper (scientific journal), Joint Work, Accepted

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Reelin-Nrp1 interaction regulates neocortical dendrite development in a context-specific manner.

Takao Kohno, Keisuke Ishii, Yuki Hirota, Takao Honda, Makoto Makino, Takahiko Kawasaki, Kazunori Nakajima, and Mitsuharu Hattori.

J. Neurosci. 40 ( 43 ) 8248 - 8261 2020.10

Research paper (scientific journal), Joint Work, Accepted

Two-photon voltage imaging of spontaneous activity from multiple neurons reveals network activity in brain tissue.

Binglun Li, Mariya Chavarha, Yuho Kobayashi, Satoshi Yoshinaga, Kazunori Nakajima, Michael Z. Lin, and Takafumi Inoue

iScience 23 ( 8 ) 101363 2020.08

Research paper (scientific journal), Joint Work, Accepted

Recording the electrical activity of multiple neurons simultaneously would greatly facilitate studies on the function of neuronal circuits. The combination of the fast scanning by random-access multiphoton microscopy (RAMP) and the latest two-photon-compatible high-performance fluorescent genetically encoded voltage indicators (GEVIs) has enabled action potential detection in deep layers in in vivo brain. However, neuron connectivity analysis on optically recorded action potentials from multiple neurons in brain tissue has yet to be achieved. With high expression of a two-photon-compatible GEVI, ASAP3, via in utero electroporation and RAMP, we achieved voltage recording of spontaneous activities from multiple neurons in brain slice. We provide evidence for the developmental changes in intralaminar horizontal connections in somatosensory cortex layer 2/3 with a greater sensitivity than calcium imaging. This method thus enables investigation of neuronal network connectivity at the cellular resolution in brain tissue.

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VLDLR is not essential for Reelin-induced neuronal aggregation but suppresses neuronal invasion into the marginal zone.（Selected to appear as a Research Highlight）

Hirota, Y. ,Nakajima,K.

Development 147 ( 12 ) 189936 2020.06

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

Neuron-derived VEGF contributes to cortical and hippocampal development independently of VEGFR1/2-mediated neurotrophism.

Keisuke Okabe, Hugh Fukada, Ikue Tai-Nagara, Tomofumi Ando, Takao Honda, Kazunori Nakajima, Norihiko Takeda, Guo-Hua Fong, Masatsugu Ema, and Yoshiaki Kubota

Dev. Biol. (Dev. Biol.) 459 ( 2 ) 65 - 71 2020.03

Research paper (scientific journal), Joint Work, Accepted, ISSN 00121606

© 2019 The Authors Vascular endothelial growth factor (VEGF) is a potent mitogen critical for angiogenesis and organogenesis. Deletion or inhibition of VEGF during development not only profoundly suppresses vascular outgrowth, but significantly affects the development and function of various organs. In the brain, VEGF is thought to not only promote vascular growth, but also directly act on neurons as a neurotrophic factor by activating VEGF receptors. In the present study, we demonstrated that deletion of VEGF using hGfap-Cre line, which recombines genes specifically in cortical and hippocampal neurons, severely impaired brain organization and vascularization of these regions. The mutant mice had motor deficits, with lethality around the time of weaning. Multiple reporter lines indicated that VEGF was highly expressed in neurons, but that its cognate receptors, VEGFR1 and 2 were exclusive to endothelial cells in the brain. In accordance, mice lacking neuronal VEGFR1 and VEGFR2 did not exhibit neuronal deformities or lethality. Taken together, our data suggest that neuron-derived VEGF contributes to cortical and hippocampal development likely through angiogenesis independently of direct neurotrophic effects mediated by VEGFR1 and 2.

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The secreted glycoprotein Reelin suppresses the proliferation and regulates the distribution of oligodendrocyte progenitor cells in the embryonic neocortex.

Himari Ogino, Tsuzumi Nakajima, Yuki Hirota, Kohki Toriuchi, Mineyoshi Aoyama, Kazunori Nakajima, and Mitsuharu Hattori.

J. Neurosci. 40 ( 40 ) 7625 - 7636 2020

Research paper (scientific journal), Joint Work, Accepted

Drebrin-like (Dbnl) controls neuronal migration via regulating N-cadherin expression in the developing cerebral cortex

Seika Inoue, Kanehiro Hayashi, Kyota Fujita, Kazuhiko Tagawa, Hitoshi Okazawa, Ken-ichiro Kubo, and Kazunori Nakajima* (*corresponding author)

J. Neurosci. (Journal of Neuroscience) 39 ( 4 ) 678 - 691 2019.01

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted, ISSN 02706474

© 2019 the authors. The actin cytoskeleton is crucial for neuronal migration in the mammalian developing cerebral cortex. The adaptor protein Drebrin-like (Dbnl) plays important roles in reorganization of the actin cytoskeleton, dendrite formation, and endocytosis by interacting with F-actin, cobl, and dynamin. Although Dbnl is known to be expressed in the brain, the functions of this molecule during brain development are largely unknown. In this study, to examine the roles of Dbnl in the developing cerebral cortex, we conducted experiments using mice of both sexes with knockdown of Dbnl, effected by in utero electroporation, in the migrating neurons of the embryonic cortex. Time-lapse imaging of the Dbnl-knockdown neurons revealed that the presence of Dbnl is a prerequisite for appropriate formation of processes in the multipolar neurons in the multipolar cell accumulation zone or the deep part of the subventricular zone, and for neuronal polarization and entry into the cortical plate. We found that Dbnl knockdown decreased the amount of N-cadherin protein expressed on the plasma membrane of the cortical neurons. The defect in neuronal migration caused by Dbnl knockdown was rescued by moderate overexpression of N-cadherin and αN-catenin or by transfection of the phospho-mimic form(Y337E, Y347E), but not the phospho-resistant form(Y337F, Y347F), of Dbnl. These results suggest that Dbnl controls neuronal migration, neuronal multipolar morphology, and cell polarity in the developing cerebral cortex via regulating N-cadherin expression.

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Both excitatory and inhibitory neurons transiently form clusters at the outermost region of the developing mammalian cerebral neocortex

Minkyung Shin, Ayako Kitazawa, Satoshi Yoshinaga, Kanehiro Hayashi, Yukio Hirata, Colette Dehay, Ken-ichiro Kubo*, and Kazunori Nakajima* (*corresponding authors)(M. Shin and A. Kitazawa are co-first authors)

J. Comp. Neurol. (Journal of Comparative Neurology) 527 ( 10 ) 1577 - 1597 2019

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted, ISSN 00219967

© 2019 Wiley Periodicals, Inc. During development of the mammalian cerebral neocortex, postmitotic excitatory neurons migrate toward the outermost region of the neocortex. We previously reported that this outermost region is composed of densely packed relatively immature neurons; we named this region, which is observed during the late stage of mouse neocortical development, the “primitive cortical zone (PCZ).” Here, we report that postmigratory immature neurons spend about 1–1.5 days in the PCZ. An electron microscopic analysis showed that the neurons in the PCZ tend to be in direct contact with each other, mostly in a radial direction, forming “primitive neuronal clusters” with a height of 3–7 cells and a width of 1–2 cells. A time-course analysis of fluorescently labeled neurons revealed that the neurons took their positions within the primitive clusters in an inside-out manner. The neurons initially participated in the superficial part of the clusters, gradually shifted their relative positions downward, and then left the clusters at the bottom of this structure. GABAergic inhibitory interneurons were also found within the primitive clusters in the developing mouse neocortex, suggesting that some clusters are composed of both excitatory neurons and inhibitory interneurons. Similar clusters were also observed in the outermost region of embryonic day (E) 78 cynomolgus monkey occipital cortex and 23 gestational week (GW) human neocortices. In the primate neocortices, including human, the presumptive primitive clusters seemed to expand in the radial direction more than that observed in mice, which might contribute to the functional integrity of the primate neocortex.

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Role of the immune system in the development of the central nervous system.

Keiko Morimoto and Kazunori Nakajima* (*corresponding author)

Front. Neurosci. (Frontiers in Neuroscience) 13 2019

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted, ISSN 16624548

© Copyright © 2019 Morimoto and Nakajima. The central nervous system (CNS) and the immune system are both intricate and highly organized systems that regulate the entire body, with both sharing certain common features in developmental mechanisms and operational modes. It is known that innate immunity-related molecules, such as cytokines, toll-like receptors, the complement family, and acquired immunity-related molecules, such as the major histocompatibility complex and antibody receptors, are also expressed in the brain and play important roles in brain development. Moreover, although the brain has previously been regarded as an immune-privileged site, it is known to contain lymphatic vessels. Not only microglia but also lymphocytes regulate cognition and play a vital role in the formation of neuronal circuits. This review provides an overview of the function of immune cells and immune molecules in the CNS, with particular emphasis on their effect on neural developmental processes.

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Subtype specification of cerebral cortical neurons in their immature stages.

Koji Oishi* and Kazunori Nakajima* (* are the corresponding authors)

Neurochem. Res. (Neurochemical Research) 43 ( 1 ) 238 - 244 2018.01

Research paper (scientific journal), Joint Work, Accepted, ISSN 03643190

© 2017, Springer Science+Business Media, LLC, part of Springer Nature. The diversification of neuronal subtypes during corticogenesis is fundamental to the establishment of the complex cortical structure. Although subtype specification has been assumed to occur in neural progenitor cells, increasing evidence has begun to reveal the plasticity of subtype determination in immature neurons. Here, we summarize recent findings regarding the regulation of subtype specification during later periods of neuronal differentiation, such as the post-mitotic and post-migratory stages. We also discuss thalamocortical axons as an extra-cortical cue that provides information on the subtype determination of immature cortical neurons.

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ApoER2 controls not only neuronal migration in the intermediate zone, but also termination of migration in the developing cerebral cortex. (Featured on the cover)

Yuki Hirota, Ken-ichiro Kubo, Takahiro Fujino, Tokuo T. Yamamoto, and Kazunori Nakajima* (* is the corresponding author)

Cereb. Cortex (Cerebral Cortex) 28 ( 1 ) 238 - 244 2018.01

Research paper (scientific journal), Joint Work, Accepted, ISSN 10473211

© The Author 2016. Published by Oxford University Press. All rights reserved. Neuronal migration contributes to the establishment of mammalian brain. The extracellular protein Reelin sends signals to various downstream molecules by binding to its receptors, the apolipoprotein E receptor 2 (ApoER2) and very low-density lipoprotein receptor and exerts essential roles in the neuronal migration and formation of the layered neocortex. However, the cellular and molecular functions of Reelin signaling in the cortical development are not yet fully understood. Here, to gain insight into the role of Reelin signaling during cortical development, we examined the migratory behavior of Apoer2-deficient neurons in the developing brain. Stage-specific labeling of newborn neurons revealed that the neurons ectopically invaded the marginal zone (MZ) and that neuronal migration of both early- and late-born neurons was disrupted in the intermediate zone (IZ) in the Apoer2 KO mice. Rescue experiments showed that ApoER2 functions both in cell-autonomous and noncell-autonomous manners, that Rap1, integrin, and Akt are involved in the termination of migration beneath the MZ, and that Akt also controls neuronal migration in the IZ downstream of ApoER2. These data indicate that ApoER2 controls multiple processes in neuronal migration, including the early stage of radial migration and termination of migration beneath the MZ in the developing neocortex.

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Enhanced expression of Pafah1b1 causes over-migration of cerebral cortical neurons into the marginal zone.

Kei-ichi Katayama, Kanehiro Hayashi, Seika Inoue, Kazushige Sakaguchi, and Kazunori Nakajima* (* is the corresponding author)

Brain Struct. Funct. 222 ( 9 ) 4283 - 4291 2017.12

Research paper (scientific journal), Joint Work, Accepted

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CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations.

Hironobu Okuno，Francois Renault Mihara, Shigeki Ohta, Kimiko Fukuda, Kenji Kurosawa, Wado Akamatsu, Tsukasa Sanosaka, Jun Kohyama, Kanehiro Hayashi, Kazunori Nakajima, Takao Takahashi, Joanna Wysocka, Kenjiro Kosaki, and Hideyuki Okano

eLife 6 ( e21114 ) 2017.11

Research paper (scientific journal), Joint Work, Accepted

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Dendritic homeostasis disruption in a novel frontotemporal dementia mouse model expressing cytoplasmic fused in sarcoma.

Gen Shiihashi, Daisuke Ito, Itaru Arai, Yuki Kobayashi, Kanehiro Hayashi, Shintaro Otsuka, Kazunori Nakajima, Michisuke Yuzaki, Shigeyoshi Itohara, and Norihiro Suzuki

EBioMedicine 24 102 - 115 2017.10

Research paper (scientific journal), Joint Work, Accepted

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Impaired dendritic growth and positioning of cortical pyramidal neurons by activation of aryl hydrocarbon receptor signaling in the developing mouse.

Eiki Kimura, Ken-ichiro Kubo, Toshihiro Endo, Wenting Ling, Kazunori Nakajima, Masaki Kakeyama, and Chiharu Tohyama

PLoS One 12 ( 8 ) e0183497 2017.08

Research paper (scientific journal), Joint Work, Accepted

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Association of impaired neuronal migration with cognitive deficits in extremely preterm infants

Ken-ichiro Kubo*, Kimiko Deguchi, Taku Nagai, Yukiko Ito, Keitaro Yoshida, Toshihiro Endo, Seico Benner, Wei Shan, Ayako Kitazawa, Michihiko Aramaki, Kazuhiro Ishii, Minkyung Shin, Yuki Matsunaga, Kanehiro Hayashi, Masaki Kakeyama, Chiharu Tohyama, Kenji F. Tanaka, Kohichi Tanaka, Sachio Takashima, Masahiro Nakayama, Masayuki Itoh, Yukio Hirata, Barbara Antalffy, Dawna D. Armstrong, Kiyofumi Yamada, Ken Inoue*, and Kazunori Nakajima* (* are the co-corresponding authors)(K. Kubo and K. Deguchi are co-first authors)

JCI Insight, 2 ( 10,e88609 ) 2017.05

Research paper (scientific journal), Joint Work, Accepted

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A crossroad of neuronal diversity to build circuitry.

Satoshi Yoshinaga and Kazunori Nakajima* (*corresponding author)

Science 356 ( 6336 ) 376 - 377 2017.04

Research paper (scientific journal), Joint Work

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Control of neuronal migration and aggregation by Reelin signaling in the developing cerebral cortex.

Yuki Hirota and Kazunori Nakajima* (* is the corresponding author)

Front. Cell Dev. Biol. 5 ( 40 ) 2017.04

Research paper (scientific journal), Joint Work, Accepted

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Reelin transiently promotes N-cadherin-dependent neuronal adhesion during mouse cortical development.

Yuki Matsunaga, Mariko Noda, Hideki Murakawa, Kanehiro Hayashi, Arata Nagasaka, Seika Inoue, Takaki Miyata, Takashi Miura, Ken-ichiro Kubo, and Kazunori Nakajima* (* is the corresponding author)(Y. Matsunaga and M. Noda are co-first authors)

Proc. Natl. Acad. Sci. U.S.A. 114 ( 8 ) 2048 - 2053 2017.02

Research paper (scientific journal), Joint Work, Accepted

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Excessive activation of AhR signaling disrupts neuronal migration in the hippocampal CA1 region in the developing mouse.

Eiki Kimura, Ken-ichiro Kubo, Toshihiro Endo, Kazunori Nakajima, Masaki Kakeyama, and Chiharu Tohyama

J. Toxicol. Sci. 42 ( 1 ) 25 - 30 2017.02

Research paper (scientific journal), Joint Work, Accepted

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DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia.

Minae Niwa, Tyler Cash-Padgett, Ken-Ichiro Kubo, Atsushi Saito, Kazuhiro Ishii, Akiko Sumitomo, Yu Taniguchi, Koko Ishizuka, Hanna Jaaro-Peled, Toshifumi Tomoda, Kazunori Nakajima, Akira Sawa, and Atsushi Kamiya

Mol. Psychiatry 21 ( 11 ) 1488 - 1489 2016.11

Research paper (scientific journal), Accepted

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Reelin and neuropsychiatric disorders.

Kazuhiro Ishii, Ken-ichiro Kubo, and Kazunori Nakajima* (* is the corresponding author)

Front. Cell. Neurosci. 10 ( 229 ) 2016.10

Research paper (scientific journal), Joint Work, Accepted

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ADP ribosylation factor 6 regulates neuronal migration in the developing cerebral cortex through FIP3/Arfophilin-1-dependent endosomal trafficking of N-cadherin.

Yoshinobu Hara, Masahiro Fukaya, Kanehiro Hayashi, Takeshi Kawauchi, Kazunori Nakajima, and Hiroyuki Sakagami.

eNeuro 3 ( (4) e0148 ) 1 - 20 2016.08

Research paper (scientific journal), Joint Work, Accepted

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The mitotic tensegrity guardian tau protects mammary epithelia from katanin-like1-induced aneuploidy

Haruka Sudo and Kazunori Nakajima

Oncotarget 7 ( 33 ) 53712 - 53734 2016.08

Research paper (scientific journal), Joint Work, Accepted

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Proper level of cytosolic Disabled-1, which is regulated by dual nuclear translocation pathways, is important for cortical neuronal migration. (Featured on the cover)

Takao Honda and Kazunori Nakajima* (* is the corresponding author)

Cereb. Cortex 26 ( 7 ) 3219 - 3236 2016.07

Research paper (scientific journal), Joint Work, Accepted

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The PDK1-Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex.

Yasuhiro Itoh, Maiko Higuchi, Koji Oishi, Yusuke Kishi, Tomohiko Okazaki, Hiroshi Sakai, Takaki Miyata, Kazunori Nakajima, and Yukiko Gotoh

Proc. Natl. Acad. Sci. U.S.A. 113 ( 21 ) E2955 - 2964 2016.05

Research paper (scientific journal), Joint Work, Accepted

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SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex.

Stephanie Tankou, Kazuhiro Ishii, Christina Elliott, Krishna C. Yalla, Jon P. Day, Keiko Furukori, Ken-ichiro Kubo, Nicholas J. Brandon, Qiyi Tang, Gary Hayward, Kazunori Nakajima, Miles D. Houslay, Atsushi Kamiya, George Baillie, Koko Ishizuka, and Akira Sawa

Mol. Neuropsychiatry 2 ( 1 ) 20 - 27 2016.05

Research paper (scientific journal), Joint Work, Accepted

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Mutually repressive interaction between Brn1/2 and Rorb contributes to establishment of neocortical layer 2/3 and layer 4.

Koji Oishi*, Michihiko Aramaki, and Kazunori Nakajima* (* are the corresponding authors)

Proc. Natl. Acad. Sci. U.S.A 113 ( 12 ) 3371 - 3376 2016.03

Research paper (scientific journal), Joint Work, Accepted

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In utero bisphenol A exposure induces abnormal neuronal migration in the cerebral cortex of mice.

Wenting Ling, Toshihiro Endo, Ken-ichiro Kubo, Masaki Kakeyama, Kazunori Nakajima and Chiharu Tohyama

Front. Endocrinol 7 ( 7 ) 2016.02

Research paper (scientific journal), Joint Work, Accepted

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Identity of neocortical layer 4 neurons is specified through correct positioning into the cortex.

Koji Oishi*, Nao Nakagawa, Kashiko Tachikawa, Shinji Sasaki, Michihiko Aramaki, Shinji Hirano, Nobuhiko Yamamoto, Yumiko Yoshimura, and Kazunori Nakajima* (* are the corresponding authors)

eLife 5 ( e10907 ) 1 - 26 2016.02

Research paper (scientific journal), Joint Work, Accepted

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Developmental origin of abnormal dendritic growth in the mouse brain induced by in utero disruption of aryl hydrocarbon receptor signaling.

Eiki Kimura, Ken-ichiro Kubo, Chieri Matsuyoshi, Seico Benner, Mayuko Hosokawa, Toshihiro Endo, Wenting Ling, Masanobu Kohda, Kazuhito Yokoyama, Kazunori Nakajima, Masaki Kakeyama, and Chiharu Tohyama

Neurotoxicol. Teratol 52 ( Pt A ) 42 - 50 2015.10

Research paper (scientific journal), Joint Work, Accepted

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Neuronal heterotopias affect the activities of distant brain areas and lead to behavioral deficits.

Kazuhiro Ishii, Ken-ichiro Kubo, Toshihiro Endo, Keitaro Yoshida, Seico Benner, Yukiko Ito, Hidenori Aizawa, Michihiko Aramaki, Akihiro Yamanaka, Kohichi Tanaka, Norio Takata, Kenji F. Tanaka, Masaru Mimura, Chiharu Tohyama, Masaki Kakeyama*, and Kazunori Nakajima* (* are the corresponding authors)(K. Ishii and K. Kubo are co-first authors)

J. Neurosci. 35 ( 36 ) 12432 - 12445 2015.09

Research paper (scientific journal), Joint Work, Accepted

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Analysis of cardiomyocyte movement in the developing murine heart

Hisayuki Hashimoto, Shinsuke Yuasa, Hidenori Tabata, Tomohisa Seki, Shugo Tohyama, Nozomi Hayashiji, Fumiyuki Hattori, Dai Kusumoto, Akira Kunitomi, Makoto Takei, Shin Kashimura, Gakuto Yozu, Masaya Shimojima, Chikaaki Motoda, Naoto Muraoka, Kazunori Nakajima, Asako Sakaue-Sawano, Atsushi Miyawaki, and Keiichi Fukuda

Biochem. Biophys. Res. Commun. 464 ( 4 ) 1000 - 1007 2015.09

Research paper (scientific journal), Joint Work, Accepted

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The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain.

Shigeaki Kanatani, Takao Honda, Michihiko Aramaki, Kanehiro Hayashi, Ken-ichiro Kubo, Mami Ishida, Daisuke H. Tanaka, Takeshi Kawauchi, Katsutoshi Sekine, Sayaka Kusuzawa, Takahiko Kawasaki, Tatsumi Hirata, Hidenori Tabata, Per Uhlén, and Kazunori Nakajima* (* is the corresponding author)

Proc. Natl. Acad. Sci. U.S.A. 112 ( 36 ) E4985 - 4994 2015.09

Research paper (scientific journal), Joint Work, Accepted

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Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons.

Sonja Rakić, Shigeaki Kanatani, David Hunt, Clare Faux, Anna Cariboni, Francesca Chiara, Shabana Khan, Olivia Wansbury, Beatrice Howard, Kazunori Nakajima, Margareta Nikolić, and John G. Parnavelas

Cereb. Cortex 25 ( 4 ) 991 - 1003 2015.04

Research paper (scientific journal), Joint Work, Accepted

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Cellular dynamics of neuronal migration in the hippocampus

Kanehiro Hayashi, Ken-ichiro Kubo, Ayako Kitazawa, and Kazunori Nakajima* (* is the corresponding author)

Front. Neurosci. 9 ( Article 135 ) 2015.04

Research paper (scientific journal), Joint Work, Accepted

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Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS.

Mai Yamakawa, Daisuke Ito, Takao Honda, Ken-ichiro Kubo, Mariko Noda, Kazunori Nakajima, and Norihiro Suzuki

Hum. Mol. Genet. 24 ( 6 ) 1630 - 1645 2015.03

Research paper (scientific journal), Joint Work, Accepted

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Importance of Reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis

Takao Kohno, Takao Honda, Ken-ichiro Kubo, Yoshimi Nakano, Ayaka Tsuchiya, Tatsuro Murakami, Hideyuki Banno, Kazunori Nakajima* and Mitsuharu Hattori* (* contributed equally to this work and are the corresponding authors) (T. Kohno, T. Honda, and K. Kubo are co-first authors)

J. Neurosci. (J. Neurosci.) 35 ( 11 ) 4776 - 4787 2015.03

Research paper (scientific journal), Joint Work, Accepted

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Reelin receptors ApoER2 and VLDLR are expressed in distinct spatio-temporal patterns in developing mouse cerebral cortex

Yuki Hirota, Ken-ichiro Kubo, Kei-ichi Katayama, Takao Honda, Takahiro Fujino, Tokuo T. Yamamoto, and Kazunori Nakajima* (* is the corresponding author)

J. Comp. Neurol., in press. 523 ( 3 ) 463 - 478 2015.02

Research paper (scientific journal), Joint Work, Accepted

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Reelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits.

Kazuhiro Ishii, Taku Nagai, Yuki Hirota, Mariko Noda, Toshitaka Nabeshima, Kiyofumi Yamada, Ken-ichiro Kubo*, and Kazunori Nakajima* (* are the corresponding authors) (K. Ishii, T. Nagai, and Y. Hirota are co-first authors)

Neurosci. Res. 96 30 - 36 2015.01

Research paper (scientific journal), Joint Work, Accepted

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Cdk5 and its substrates, Dcx and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons

Yoshiaki V. Nishimura, Mima Shikanai, Mikio Hoshino, Toshio Ohshima, Yo-ichi Nabeshima, Ken-ichi Mizutani, Koh-ichi Nagata, Kazunori Nakajima, and Takeshi Kawauchi.

Development 141 ( 18 ) 3540 - 3550 2014.09

Research paper (scientific journal), Joint Work, Accepted

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How does Reelin control neuronal migration and layer formation in the developing mammalian neocortex?

Katsutoshi Sekine, Ken-ichiro Kubo, and Kazunori Nakajima* (* is the corresponding author)

Neurosci. Res. 86 ( September ) 50 - 58 2014.09

Research paper (scientific journal), Joint Work, Accepted

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Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte

Hisayuki Hashimoto, Shinsuke Yuasa, HidenoriTabata, Shugo Tohyama, Nozomi Hayashiji, Fumiyuki Hattori, NaotoMuraoka, Toru Egashira, Shinichiro Okata, Kojiro Yae, Tomohisa Seki, Takahiko Nishiyama, Kazunori Nakajima, Asako Sakaue-Sawano, Atsushi Miyawaki, and Keiichi Fukuda

J. Mol. Cell. Cardiol. 72 241 - 249 2014.07

Research paper (scientific journal), Joint Work, Accepted

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Hippocampal pyramidal neurons switch from a multipolar migration mode to a novel “climbing” migration mode during development.

Ayako Kitazawa, Ken-ichiro Kubo, Kanehiro Hayashi, Yuki Matsunaga, Kazuhiro Ishii, and Kazunori Nakajima* (* is the corresponding author) (A. Kitazawa, K. Kubo, and K. Hayashi are co-first authors)

J. Neurosci. 34 ( 4 ) 1115 - 1126 2014.01

Research paper (scientific journal), Joint Work, Accepted

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DISC1: a key lead in studying cortical development and associated brain disorders.

Soumya Narayan, Kazunori Nakajima, and Akira Sawa

The Neuroscientist 19 ( 5 ) 451 - 464 2013.10

Research paper (scientific journal), Joint Work, Accepted

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TAG-1–assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding.

Mayumi Okamoto, Takashi Namba, Tomoyasu Shinoda, Takefumi Kondo, Tadashi Watanabe, Yasuhiro Inoue, Kosei Takeuchi, Yukiko Enomoto, Kumiko Ota, Kanako Oda, Yoshino Wada, Ken Sagou, Kanako Saito, Akira Sakakibara, Ayano Kawaguchi, Kazunori Nakajima, Taiji Adachi, Toshihiko Fujimori, Masahiro Ueda, Shigeo Hayashi, Kozo Kaibuchi, and Takaki Miyata

Nat. Neurosci. 16 ( 11 ) 1556 - 1566 2013.09

Research paper (scientific journal), Joint Work, Accepted

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Screening for candidate genes involved in the production of mouse subventricular zone proliferative cells and an estimation of their changes in evolutionary pressure during primate evolution.

Hidenori Tabata*, Hachiya Tsuyoshi, Koh-ichi Nagata, Yasubumi Sakakibara, and Kazunori Nakajima* (* are the corresponding authors)

Front. Neuroanat. (Frontiers) 7 ( 24 ) 2013.07

Research paper (scientific journal), Joint Work, Accepted

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Robo1 regulates the migration and laminar distribution of upper-layer pyramidal neurons of the cerebral cortex.

Yuko Gonda, William D. Andrews, Hidenori Tabata, Takashi Namba, John G. Parnavelas, Kazunori Nakajima, Shinichi Kohsaka, Carina Hanashima and Shigeo Uchino

Cereb. Cortex 23 ( 6 ) 1495 - 1508 2013.06

Research paper (scientific journal), Joint Work, Accepted

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Cortical excitatory neurons become protected from cell division during neurogenesis in an Rb family-dependent manner.

Mio Oshikawa, Kei Okada, Kazunori Nakajima and Itsuki Ajioka

Development 140 ( 11 ) 2310 - 2320 2013.06

Research paper (scientific journal), Joint Work, Accepted

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Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors, ApoER2 and VLDLR, in neurons.

Takahiro Fuchigami, Yutaka Sato1, Yuya Tomita1, Tetsuya Takano, Shin-ya Miyauchi, Yukinori Tsuchiya, Taro Saito, Ken-ichiro Kubo, Kazunori Nakajima, Mitsunori Fukuda, Mitsuharu Hattori, and Shin-ichi Hisanaga

Genes to Cells 18 ( 5 ) 410 - 424 2013.05

Research paper (scientific journal), Joint Work, Accepted

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RP58 regulates the multipolar-bipolar transition of newborn neurons in the developing cerebral cortex.

Chiaki Ohtaka-Maruyama, Shinobu Hirai, Akiko Miwa, Julian lk-Tsen Heng, Hiroshi Shitara, Rie Ishii, Choji Taya, Hitoshi Kawano, Masataka Kasai, Kazunori Nakajima, and Haruo Okado

Cell Reports 3 ( 2 ) 1 - 14 2013.02

Research paper (scientific journal), Joint Work, Accepted

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Axon guidance mechanisms for establishment of callosal connections.

Mitsuaki Nishikimi, Koji Oishi*, and Kazunori Nakajima* (* are the corresponding authors)

Special Issue: “Physiology and Plasticity of Interhemispheric Connections” Neural Plast. (Neural Plasticity) 2013 Article ID 149060 (7 pages) 2013.02

Research paper (scientific journal), Joint Work, Accepted

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Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin α5β1

Katsutoshi Sekine, Takeshi Kawauchi, Ken-ichiro Kubo, Takao Honda, Joachim Herz, Mitsuharu Hattori, Tatsuo Kinashi, and Kazunori Nakajima* (* is the corresponding author)

Neuron 76 ( 2 ) 353 - 369 2012.10

Research paper (scientific journal), Joint Work, Accepted

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A phosphatidylinositol lipids system, Lamellipodin and Ena/VASP regulate dynamic morphology of multipolar migrating cells in the developing cerebral cortex.

Satoshi Yoshinaga, Takahiro Ohkubo, Shinji Sasaki, Mutsuo Nuriya, Yukino Ogawa, Masato Yasui, Hidenori Tabata*, and Kazunori Nakajima* (* are the corresponding authors)

J. Neurosci., 32 ( 34 ) 11643 - 11656 2012.08

Research paper (scientific journal), Joint Work, Accepted

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Leucine-rich glioma inactivated 1 (Lgi1), an epilepsy-related secreted protein, has a nuclear localization signal and localizes both to the cytoplasm and nucleus of the caudal ganglionic eminence neurons.

Sayaka Kusuzawa, Takao Honda, Yuko Fukata, Masaki Fukata, Shigeaki Kanatani, Daisuke H. Tanaka, Kazunori Nakajima* (* is the corresponding author)

Eur. J. Neurosci., 36 ( 3 ) 2284 - 2292 2012.08

Research paper (scientific journal), Joint Work, Accepted

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Involvement of mGluR5-signaling in activity-related proliferation of adult hippocampal neural stem cells.

Rokuya Nochi, Tomomasa Kato, Jun Kaneko, Yoshie Itou, Hiroshi Kuribayashi, Satoshi Fukuda, Yasushi Terazono, Ayumu Matani, Shigeaki Kanatani, Kazunori Nakajima and Tatsuhiro Hisatsune

Eur. J. Neurosci. 36 ( 3 ) 2273 - 2283 2012.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Migratory pathways of GABAergic interneurons when they enter the neocortex.

Daisuke H. Tanaka*, Kazunori Nakajima* (* are the corresponding authors)

Eur. J. Neurosci. 35 ( 11 ) 1655 - 1660 2012.06

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

GABAergic interneuron migration and the evolution of the neocortex.

Daisuke H. Tanaka*, Kazunori Nakajima* (* are the corresponding authors)

Dev. Growth Differ. 54 ( 3 ) 366 - 372 2012.04

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Cytoarchitecture of mouse and human subventricular zone in developing cerebral neocortex.

Hidenori Tabata*, Satoshi Yoshinaga, and Kazunori Nakajima* (* are the corresponding authors)

Exp. Brain Res. 216 ( 2 ) 161 - 168 2012.01

Research paper (scientific journal), Joint Work, Accepted

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Segregation and pathfinding of callosal axons through EphA3 signaling. (Featured in “This Week in The Journal”)

Mitsuaki Nishikimi, Koji Oishi*, Hidenori Tabata, Kenichi Torii and Kazunori Nakajima* (* are the corresponding authors)

J. Neurosci. 31 ( 45 ) 16251 - 16260 2011.11

Research paper (scientific journal), Joint Work, Accepted

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GABAergic precursor transplantation into the prefrontal cortex prevents phencyclidine-induced cognitive deficits.

Daisuke H. Tanaka, Kazuya Toriumi, Ken-ichiro Kubo, Toshitaka Nabeshima*, and Kazunori Nakajima* (* are the corresponding authors)

J. Neurosci. 31 ( 40 ) 14116 - 14125 2011.10

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Basement membrane-like matrix sponge for the three-dimensional proliferation culture of differentiated retinal horizontal interneurons.

Itsuki Ajioka, Shizuko Ichinose, Kazunori Nakajima, and Hidehiro Mizusawa

Biomaterials 32 ( 25 ) 5765 - 5772 2011.09

Research paper (scientific journal), Joint Work, Accepted

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Laminar and areal expression of Unc5d and its role in cortical cell survival.

Makoto Takemoto, Yuki Hattori, Hong Zhao, Haruka Sato, Atsushi Tamada, Shinji Sasaki, Kazunori Nakajima and Nobuhiko Yamamoto

Cereb. Cortex 21 ( 8 ) 1925 - 1934 2011.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Reelin inhibits migration of sympathetic preganglionic neurons in the spinal cord of the chick.

Yee Ping Yip, Guangdou Zhou, Ken-ichiro Kubo, Kazunori Nakajima, and Joseph W. Yip

J. Comp. Neurol. 519 ( 10 ) 1970 - 1978 2011.07

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Regulation of cortical neuron migration by the Reelin signaling pathway.

Takao Honda, Kazuma Kobayashi, Katsuhiko Mikoshiba, and Kazunori Nakajima* (* is the corresponding author)

Neurochem. Res. 36 ( 7 ) 1270 - 1279 2011.07

Research paper (scientific journal), Joint Work

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The outermost region of the developing cortical plate is crucial for both the switch of the radial migration mode and the Dab1-dependent “inside-out” lamination in the neocortex. (Featured on the cover)

Katsutoshi Sekine, Takao Honda, Takeshi Kawauchi, Ken-ichiro Kubo, and Kazunori Nakajima* (* is the corresponding author)

J. Neurosci. 31 ( 25 ) 9426 - 9439 2011.06

Research paper (scientific journal), Joint Work, Accepted

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Disrupted-in-Schizophrenia-1 (Disc1) is necessary for migration of the pyramidal neurons during mouse hippocampal development.

Kenji Tomita, Ken-ichiro Kubo, Kazuhiro Ishii, and Kazunori Nakajima* (* is the corresponding author) (K. Tomita and K. Kubo are co-first authors)

Hum. Mol. Genet., in press. 20 ( 14 ) 2834 - 2845 2011.06

Research paper (scientific journal), Joint Work, Accepted

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DISC1-dependent switch from progenitor proliferation to migration in the developing cortex.

Koko Ishizuka, Atsushi Kamiya, Edwin C. Oh, Hiroaki Kanki, Saurav Seshadri, Jon F. Robinson, Hannah Murdoch, Allan J. Dunlop, Ken-ichiro Kubo,Keiko Furukori, Beverly Huang, Mariela Zeledon, Akiko Hayashi-Takagi, Hideyuki Okano, Kazunori Nakajima, Miles D. Houslay, Nicholas Katsanis, and Akira Sawa

Nature 473 ( 7345 ) 92 - 96 2011.05

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

N-Cadherin regulates radial glial fiber-dependent migration of cortical locomoting neurons.

Mima Shikanai, Kazunori Nakajima and Takeshi Kawauchi

Communicative & Integrative Biology 4 ( 3 ) 326 - 330 2011.05

Research paper (scientific journal), Joint Work, Accepted

Changes in cortical interneuron migration contribute to the evolution of the neocortex.

Daisuke H. Tanaka*, Ryo Oiwa, Erika Sasaki, and Kazunori Nakajima* (* are the corresponding authors)

Proc. Natl. Acad. Sci. U.S.A. 108 ( 19 ) 8015 - 8020 2011.05

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

PDK1-Foxo1 in Agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure.

Yongheng Cao, Masanori Nakata, Shiki Okamoto, Eisuke Takano, Toshihiko Yada, Yasuhiko Minokoshi, Yukio Hirata, Kazunori Nakajima, Kristy Iskandar, Yoshitake Hayashi, Wataru Ogawa, Gregory S. Barsh, Hiroshi Hosoda, Kenji Kangawa, Hiroshi Itoh, Tetsuo Noda, Masato Kasuga, and Jun Nakae

PLoS ONE 6 ( 4 ) e18324 2011.04

Research paper (scientific journal), Joint Work, Accepted, ISSN 0037-1017

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Neural crest-derived stem cells migrate and differentiate into cardiomyocytes after myocardial infarction.

Yuichi Tamura, Keisuke Matsumura, Motoaki Sano , Hidenori Tabata, Kensuke Kimura, Masaki Ieda, Takahide Arai, Yohei Ohno, Hideaki Kanazawa, Shinsuke Yuasa, Ruri Kaneda, Shinji Makino, Kazunori Nakajima, Hideyuki Okano, and Keiichi Fukuda

Arterioscler. Thromb. Vasc. Biol. 31 ( 3 ) 582 - 589 2011.03

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Cellular composition and organization of the subventricular zone and rostral migratory stream in the adult and neonatal common marmoset brain.

Kazunobu Sawamoto, Yuki Hirota, Clara Alfaro-Cervello, MarioSoriano-Navarro, Xiaoping He, Yoshika Hayakawa-Yano, Masayuki Yamada, Keigo Hikishima, Hidenori Tabata, Akio Iwanami, Kazunori Nakajima, Yoshiaki Toyama, Toshio Itoh, Arturo Alvarez-Buylla, Jose Manuel Garcia-Verdugo,and Hideyuki Okano(K. Sawamoto, Y. Hirota, C. Alfaro-Cervello, M. Soriano-Navarro contributed equally to this work)

J. Comp. Neurol. 519 ( 4 ) 690 - 713 2011.01

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

CXCR4 is required for proper regional and laminar distribution of cortical somatostatin-, calretinin- and neuropeptide Y-expressing GABAergic interneurons.

Daisuke H. Tanaka, Sakae Mikami, Takashi Nagasawa, Jun-ichi Miyazaki, Kazunori Nakajima and Fujio Murakami

Cereb. Cortex 20 ( 12 ) 2810 - 2817 2010.11

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi.

Ken-ichiro Kubo, Kenji Tomita, Asuka Uto, Keisuke Kuroda, Saurav Seshadri, Jared S. Cohen, Kozo Kaibuchi, Atsushi Kamiya*, Kazunori Nakajima* (* are the corresponding authors)(K. Kubo and K. Tomita are co-first authors)

Biochem. Biophys. Res. Commun. 400 ( 4 ) 631 - 637 2010.10

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Ectopic Reelin induces neuronal aggregation with a normal birthdate-dependent "inside-out" alignment in the developing neocortex. (Featured on the cover) (Featured in “This Week in The Journal” http://www.jneurosci.org/cgi/content/full/30/33/i)

Ken-ichiro Kubo, Takao Honda, Kenji Tomita, Katsutoshi Sekine, Kazuhiro Ishii, Asuka Uto, Kazuma Kobayashi, Hidenori Tabata, Kazunori Nakajima* (* is the corresponding author)

J. Neurosci. 30 ( 33 ) 10953 - 10966 2010.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Inhibition of N-methyl-d-aspartate receptor activity resulted in aberrant neuronal migration caused by delayed morphological development in the mouse neocortex.

Shigeo Uchino, Takae Hirasawa, Hidenori Tabata, Yuko Gonda, Chikako Waga, Yumiko Ondo, Kazunori Nakajima, Rand Shinichi Kohsaka (S. Uchino, T. Hirasawa, and H. Tabata are co-first authors.)

Neuroscience 169 ( 2 ) 609 - 618 2010.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-Cadherin trafficking.

Takeshi Kawauchi, Katsutoshi Sekine, Mima Shikanai, Kaori Chihama, Kenji Tomita, Ken-ichiro Kubo, Kazunori Nakajima, Yo-ichi Nabeshima, and Mikio Hoshino

Neuron 67 ( 4 ) 588 - 602 2010.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits.

Minae Niwa, Atsushi Kamiya, Rina Murai, Ken-ichiro Kubo, Aaron J Gruber, Kenji Tomita, Lingling Lu, Shuta Tomisato, Hanna Jaaro-Peled, Saurav Seshadri, Hideki Hiyama, Beverly Huang, Kazuhisa Kohda, Yukihiro Noda, Patricio O’Donnell, Kazunori Nakajima, Akira Sawa, and Toshitaka Nabeshima

Neuron 65 ( 4 ) 480 - 489 2010.02

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Dissecting the factors involved in the locomotion mode of neuronal migration in the developing cerebral cortex.

Yoshiaki V. Nishimura, Katsutoshi Sekine, Kaori Chihama, Kazunori Nakajima, Mikio Hoshino, Yo-ichi Nabeshima, and Takeshi Kawauchi

J. Biol. Chem. 285 ( 8 ) 5878 - 5887 2010.02

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Role of dual leucine zipper-bearing kinase (DLK/MUK/ZPK) in axonal growth.

Kaoru Eto, Takeshi Kawauchi, Makiko Osawa, Hidenori Tabata*, and Kazunori Nakajima* (* are the corresponding authors)

Neurosci. Res. 66 37 - 45 2010.01

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1.

Koji Oishi, Kenji Watatani, Yasuhiro Itoh, Hideyuki Okano, François Guillemot, Kazunori Nakajima, and Yukiko Gotoh

Proc. Natl. Acad. Sci. U.S.A. 106 ( 31 ) 13064 - 13069 2009.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Differences of migratory behavior between direct progeny of apical progenitors and basal progenitors in the developing cerebral cortex.

Hidenori Tabata, Shigeaki Kanatani, and Kazunori Nakajima* (* is the corresponding author)

Cereb. Cortex 19 ( 9 ) 2092 - 2105 2009.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Downregulation of functional Reelin receptors in projection neurons implys that primary Reelin action occurs at early/pre-migratory stages.

Takayuki Uchida, Atsushi Baba, F. Javier Pérez-Martínez, Terumasa Hibi, Takaki Miyata, Juan M. Luque, Kazunori Nakajima, and Mitsuharu Hattori

J. Neurosci. 29 ( 34 ) 10653 - 10662 2009.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

The transcriptional repressor RP58 is crucial for proper cell-division patterning and neuronal survival in the developing cortex.

Haruo Okado, Chiaki Ohtaka-Maruyama, Yoshinobu Sugitani, Yuko Fukuda, Reiko Ishida, Shinobu Hirai, Akiko Miwa, Akiyo Takahashi, Katsunori Aoki, Keijo Mochida, Osamu Suzuki, Takao Honda, Kazunori Nakajima, Masaharu Ogawa, Toshio Terashima, Junichiro Matsuda, Hitoshi Kawano, and Masataka Kasai

Dev. Biol. 331 ( 2 ) 140 - 151 2009.07

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Neurogenesis

Koji Oishi and Kazunori Nakajima* (* is the corresponding author)

Encyclopedia of Neuroscience (Editors: Marc D. Binder, Nobutaka Hirokawa and Uwe Windhorst) (Springer-Verlag Berlin Heidelberg) 2673 - 2676 2009.01

Research paper (scientific journal), Joint Work

COUP-TFII is preferentially expressed in the caudal ganglionic eminence and is involved in the caudal migratory stream

Shigeaki Kanatani, Masato Yozu, Hidenori Tabata, and Kazunori Nakajima* (* is the corresponding author)

J. Neurosci. 28 ( 50 ) 13582 - 13591 2008.12

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses.

Atsushi Kamiya, Perciliz L. Tan, Ken-ichiro Kubo, Caitlin Engelhard, Koko Ishizuka, Akiharu Kubo, Sachiko Tsukita, Ann E. Pulver, Kazunori Nakajima, Nicola G. Cascella, Nicholas Katsanis, and Akira Sawa

Arch. Gen. Psychiatry 65 ( 9 ) 996 - 1006 2008.09

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

The cortical subventricular zone-specific molecule Svet1 is part of the nuclear RNA coded by the putative Netrin receptor gene Unc5d and is expressed in multipolar migrating cells.

Shinji Sasaki, Hidenori Tabata, Kashiko Tachikawa and Kazunori Nakajima* (* is the corresponding author)

Mol. Cell. Neurosci. 38 ( 4 ) 474 - 483 2008.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Labeling embryonic mouse central nervous system cells by in utero electroporation

Hidenori Tabata and Kazunori Nakajima* (* is the corresponding author)

Develop. Growth Differ. 50 ( 6 ) 507 - 511 2008.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Cell-autonomous roles of ARX in cell proliferation and neuronal migration during corticogenesis.

Gaëlle Friocourt, Shigeaki Kanatani, Hidenori Tabata, Masato Yozu, Takao Takahashi, Mary Antypa, Odile Raguénès, Jamel Chelly, Claude Férec, Kazunori Nakajima, and John G. Parnavelas (G. Friocourt and S. Kanatani are co-first authors.)

J. Neurosci. 28 ( 22 ) 5794 - 5805 2008.05

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Time constraints and positional cues in the developing cerebellum regulate Purkinje cell placement in the cortical architecture.

Barbara Carletti, Ian M Williams, Ketty Leto, Kazunori Nakajima, Lorenzo Magrassi, and Ferdinando Rossi

Dev. Biol. 317 ( 1 ) 147 - 160 2008.05

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex.

Kashiko Tachikawa, Shinji Sasaki, Takuya Maeda, and Kazunori Nakajima* (* is the corresponding author)

Neurosci. Res. 60 ( 2 ) 135 - 146 2008.02

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Migratory behavior of presumptive interneurons is affected by AMPA receptor activation in slice cultures of embryonic mouse neocortex.

Masato Yozu, Hidenori Tabata, Norbert Koenig*, and Kazunori Nakajima* (* are the corresponding authors)

Dev. Neurosci. 30 ( 1-3 ) 105 - 116 2008.01

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Regulation of the interaction of Disabled-1 with CIN85 by phosphorylation with Cyclin-dependent kinase 5.

Yutaka Sato, Masato Taoka, Nami Sugiyama, Kenichiro Kubo, Takahiro Fuchigami, Akiko Asada, Taro Saito,Kazunori Nakajima, Toshiaki Isobe, and Shin-ichi Hisanaga

Genes to Cells 12 ( 12 ) 1315 - 1327 2007.12

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Computational cell model based on autonomous cell movement regulated by cell-cell signalling successfully recapitulates the “inside and outside” pattern of cell sorting.

Takuya T Maeda, Itsuki Ajioka, and Kazunori Nakajima* (* is the corresponding author)

BMC Syst. Biol. 1 ( 43 ) 1 - 16 2007.09

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Control of tangential/non-radial migration of neurons in the developing cerebral cortex

Kazunori Nakajima* (* is the corresponding author)

Neurochem. Int. 51 ( 2-4 ) 121 - 131 2007.09

Research paper (scientific journal), Accepted

Access to Document (DOI)

The extremely conserved C-terminal region of Reelin is not necessary for secretion but is required for efficient activation of downstream signaling.

Yoshimi Nakano, Takao Kohno, Terumasa Hibi, Shiori Kohno, Atsushi Baba, Katsuhiko Mikoshiba, Kazunori Nakajima, and Mitsuharu Hattori.

J. Biol. Chem. 282 ( 28 ) 20544 - 20552 2007.07

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex.

Toshio Ohshima, Motoyuki Hirasawa, Hidenori Tabata, Tetsuji Mutoh, Tomoko Adachi, Hiromi Suzuki, Keiko Saruta, Takuji Iwasato, Shigeyoshi Itohara, Mitsuhiro Hashimoto, Kazunori Nakajima, Masaharu Ogawa, Ashok B. Kulkarni and Katsuhiko Mikoshiba.

Development 134 ( 12 ) 2273 - 2282 2007.06

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Expression profiles of Insulin-like growth factor binding protein-like 1 in the developing mouse forebrain

Yuko Gonda, Hitoshi Sakurai, Yukio Hirata, Hidenori Tabata, Itsuki Ajioka, and Kazunori Nakajima* (* is the corresponding author)

Gene Expr. Patterns 7 ( 4 ) 431 - 440 2007.02

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Mouse Disabled1 (DAB1) is a nucleocytoplasmic shuttling protein

Takao Honda and Kazunori Nakajima* (* is the corresponding author)

J. Biol. Chem. 281 ( 50 ) 38951 - 38965 2006.12

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Large-scale correlation of DNA accession numbers to the cDNAs in the FANTOM full-length mouse cDNA clone set

Itsuki Ajioka, Takuya Maeda, and Kazunori Nakajima* (* is the corresponding author)

Keio J. Med. 55 ( 3 ) 107 - 110 2006.09

Research paper (scientific journal), Joint Work, Accepted, ISSN 0022-9717

Identification of ventricular-side-enriched molecules regulated in a stage-dependent manner during cerebral cortical development

Itsuki Ajioka, Takuya Maeda, and Kazunori Nakajima* (* is the corresponding author)

Eur. J. Neurosci. 23 ( 2 ) 296 - 308 2006.01

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development.

Atsushi Kamiya, Ken-ichiro Kubo, Toshifumi Tomoda, Manabu Takaki, Richard Youn, Yuji Ozeki, Naoya Sawamura, Una Park, Chikako Kudo, Masako Okawa, Christopher A. Ross, Mary E. Hatten, Kazunori Nakajima, and Akira Sawa

Nat. Cell Biol. 7 ( 12 ) 1167 - 1178 2005.12

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Switching of α-catenin from αE-catenin in the cortical ventricular zone to αN-catenin II in the intermediate zone. (Featured on the cover)

Itsuki Ajioka and Kazunori Nakajima* (* is the corresponding author)

Dev. Brain Res. 160 ( 1 ) 106 - 111 2005.09

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

The caudal migratory stream: a novel migratory stream of interneurons derived from the caudal ganglionic eminence in the developing mouse forebrain. (Featured on the cover)

Masato Yozu, Hidenori Tabata, and Kazunori Nakajima* (* is the corresponding author)

J. Neurosci. 25 ( 31 ) 7268 - 7277 2005.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Birth-date-dependent segregation of the mouse cerebral cortical neurons in reaggregation cultures

Itsuki Ajioka and Kazunori Nakajima* (* is the corresponding author)

Eur. J. Neurosci. 22 ( 2 ) 331 - 342 2005.07

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Expression profiles of EphA3 at both the RNA and protein level in the developing mammalian forebrain.

Chikako Kudo, Itsuki Ajioka, Yukio Hirata, and Kazunori Nakajima* (* is the corresponding author)

J. Comp. Neurol. 487 ( 3 ) 255 - 269 2005.07

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Neuronal migration in cortical development

Shigeaki Kanatani, Hidenori Tabata, and Kazunori Nakajima* (* is the corresponding author)

J. Child Neurol. 20 ( 4 ) 274 - 279 2005.04

Research paper (scientific journal), Accepted

Access to Document (DOI)

Birth-date dependent alignment of GABAergic neurons occurs in a different pattern from that of non-GABAergic neurons in the developing mouse visual cortex. (Featured on the cover)

Masato Yozu, Hidenori Tabata, and Kazunori Nakajima* (* is the corresponding author)

Neurosci. Res. 49 ( 4 ) 395 - 403 2004.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

The Wnt/β-catenin pathway directs neuronal differentiation of cortical neural precursor cells

Yusuke Hirabayashi, Yasuhiro Itoh, Hidenori Tabata, Kazunori Nakajima, Tetsu Akiyama, Norihisa Masuyama and Yukiko Gotoh

Development 131 ( 12 ) 2791 - 2801 2004.05

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Components of the Reelin signaling pathway are expressed in the spinal cord.

Yee Ping Yip, Christine Capriotti, Susan Magdaleno, David Benhayon, Tom Curran, Kazunori Nakajima, and Joseph W. Yip.

J. Comp. Neurol. 470 ( 2 ) 210 - 219 2004.03

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

神経発達とその障害：皮質構造形成の分子メカニズムと統合失調症

久保健一郎、仲嶋一範

医学のあゆみ 208 ( 3 ) 127 - 132 2004.01

Research paper (scientific journal), Joint Work

Multipolar migration: the third mode of radial neuronal migration in the developing cerebral cortex

Hidenori Tabata and Kazunori Nakajima* (* is the corresponding author)

J. Neurosci. 23 ( 31 ) 9996 - 10001 2003.11

Research paper (scientific journal), Joint Work, Accepted, ISSN 1529-2401

Access to Document (DOI)

Segregation and coactivation of developing neocortical layer 1 neurons. (Featured on the cover)

Takeshi Soda, Ryo Nakashima, Dai Watanabe, Kazunori Nakajima, Ira Pastan, and Shigetada Nakanishi

J. Neurosci. 23 ( 15 ) 6272 - 6279 2003.07

Research paper (scientific journal), Single Work, Accepted

Cellular and molecular mechanisms of neuronal migration in neocortical development

Takao Honda, Hidenori Tabata, and Kazunori Nakajima* (* is the corresponding author)

Sem. in Cell & Develop. Biol. 14 ( 3 ) 169 - 174 2003.06

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Cell and molecular mechanisms that control cortical layer formation in the brain

Ken-ichiro Kubo and Kazunori Nakajima* (* is the corresponding author)

Keio J. Med. 52 ( 1 ) 8 - 20 2003.03

Research paper (scientific journal), Joint Work, Accepted

Neurons tend to stop migration and differentiate along the cortical internal plexiform zones in the Reelin signal-deficient mice

Hidenori Tabata and Kazunori Nakajima* (* is the corresponding author)

J. Neurosci. Res. 69 ( 6 ) 723 - 730 2002.09

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Secreted Reelin molecules form homodimers

Ken-ichiro Kubo, Katsuhiko Mikoshiba, and Kazunori Nakajima* (* is the corresponding author)

Neurosci. Res. 43 ( 4 ) 381 - 388 2002.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Efficient in utero gene transfer system to the developing mouse brains using electroporation: Visualization of neuronal migration in the developing cortex.

Hidenori Tabata and Kazunori Nakajima* (* is the corresponding author)

Neuroscience 103 ( 4 ) 865 - 872 2001.01

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody.

Naoko Utsunomiya-Tate, Ken-ichiro Kubo, Shin-ichi Tate, Masatsune Kainosho, Eisaku Katayama, Kazunori Nakajima* and Katsuhiko Mikoshiba (* is the corresponding author)

Proc. Natl. Acad. Sci. U.S.A. 97 ( 17 ) 9729 - 9734 2000.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Reelin controls position of autonomic neurons in the spinal cord.

Joseph W. Yip, Yee Ping L. Yip, Kazunori Nakajima and Christine Capriotti

Proc. Natl. Acad. Sci. U.S.A. 97 ( 15 ) 8612 - 8616 2000.07

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

The disabled 1 gene is disrupted by a replacement with L1 fragment in yotari mice.

Toshio Kojima, Kazunori Nakajima* and Katsuhiko Mikoshiba (* is the corresponding author)

Mol. Brain Res. 75 ( 1 ) 121 - 127 2000.01

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Development of the mouse model dramatype for human clinical benefit

Kazunori Nakajima

Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of 1999 US/Japan Conference (National Academy Press, Washington, D.C.) 132 - 136 2000

Research paper (international conference proceedings), Single Work

Thyroid hormone regulates reelin and dab1 expression during brain development.

Manuel Alvarez-Dolado, Monica Ruiz, Jose A. del Rio, Soledad Alcantara, Ferran Burgaya, Michael Sheldon, Kazunori Nakajima, Juan Bernal, Brian W. Howell, Tom Curran, Eduardo Soriano, and Alberto Munoz

J. Neurosci. 19 ( 16 ) 6979 - 6993 1999.08

Research paper (scientific journal), Joint Work, Accepted

Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice.

S. Hossein Fatemi, Effat-Sadat Emamian, David Kist, Robert W. Sidwell, Kazunori Nakajima, Pervez Akhter, Anna Shier, Soheil Sheikh, and K. Bailey

Molecular Psychiatry 4 ( 2 ) 145 - 154 1999.03

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Reelin regulates the development and synaptogenesis of the layer-specific entorhino-hippocampal connections.

Victor Borrell, Jose A. Del Rio, Soledad Alcantara, Michele Derer, Albert Martinez, Gabriella D'Arcangelo, Kazunori Nakajima, Katsuhiko Mikoshiba, Paul Derer, Tom Curran, and Eduardo Soriano

J. Neurosci. 19 ( 04 ) 1345 - 1358 1999.02

Research paper (scientific journal), Joint Work, Accepted

Molecular mechanism involved in neural induction and neuronal fate determination

Katsuhiko Mikoshiba, Jun Aruga, Takeharu Nagai, Katsunori Nakata, Kazunori Nakajima, Takaki Miyata, and Masaharu Ogawa

Proceedings of the International Workshop 1999, Neuronal Precursor Cell Biology and Application for Treatment of Inborn Error of Metabolism 168 - 183 1999

Research paper (international conference proceedings), Joint Work

Reelin/CR-50 and the formation of cortical layers

Masaharu Ogawa, Takaki Miyata, Kazunori Nakajima, Katsuhiko Mikoshiba

Neural Development 115 - 116 1999

Research paper (international conference proceedings), Joint Work

Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain.

Dennis S. Rice, Michael Sheldon, Gabriella D'Arcangelo, Kazunori Nakajima, Dan Goldowitz, and Tom Curran

Development 125 ( 18 ) 3719 - 3729 1998.09

Research paper (scientific journal), Joint Work, Accepted

A novel neurological mutation of mouse, yotari, which exhibits reeler-like phenotype but expresses CR-50 antigen/Reelin.

Hiroyuki Yoneshima, Eiichiro Nagata, Mineo Matsumoto, Maki Yamada, Kazunori Nakajima, Takaki Miyata, Masaharu Ogawa, and Katsuhiko Mikoshiba

Neurosci. Res. 29 ( 3 ) 217 - 233 1997.11

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

A truncated Reelin protein is produced but not secreted in the "Orleans" reeler mutation (Relnrl-Orl).

Vinciane de Bergeyck*, Kazunori Nakajima*, C. Lambert de Rouvroit, B. Naerhuyzen, Andre M. Goffinet, Takaki Miyata, Masaharu Ogawa, and Katsuhiko Mikoshiba (* are the co-first authors/corresponding authors)

Mol. Brain Res 50 ( 1-2 ) 85 - 90 1997.10

Research paper (scientific journal), Joint Work, Accepted

Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice.

Michael Sheldon, Dennis Rice, Gabriella D'Arcangelo, Hiroyuki Yoneshima, Kazunori Nakajima, Katsuhiko Mikoshiba, Brian W. Howell, Jonathan A. Cooper, Dan Goldowitz, and Tom Curran

Nature 389 ( 6652 ) 730 - 733 1997.10

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Disruption of hippocampal development in vivo by CR-50, a monoclonal antibody against Reelin.

Kazunori Nakajima*, Katsuhiko Mikoshiba, Takaki Miyata, Chikako Kudo, and Masaharu Ogawa (* is the corresponding author)

Proc. Natl. Acad. Sci. U.S.A. 94 ( 15 ) 8196 - 8201 1997.07

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Regulation of Purkinje cell alignment by Reelin as revealed with CR-50 antibody.

Takaki Miyata, Kazunori Nakajima, Katsuhiko Mikoshiba, and Masaharu Ogawa

J. Neurosci. 17 ( 10 ) 3599 - 3609 1997.05

Research paper (scientific journal), Joint Work, Accepted

Astrocytic lineage analysis by detection of GFAP promoter activity in vitro

Noriyuki Morita, Kensuke Nakahira, Hiroko Baba, Hiromi Akita, Tatsuro Kumada, Masaharu Ogawa, Kazunori Nakajima, Mitsuhiro Kawata, Katsuhiko Mikoshiba, and Kazuhiro Ikenaka

Dev. Neurosci. 19 ( 2 ) 210 - 218 1997.01

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

A role for Cajal-Retzius cells and reelin in the development of hippocampal connections.

Jose A. Del Rio, Bernd Heimrich, Victor Borrell, Eckart Foerster, Alexander Drakew, Soledad Alcantara, Kazunori Nakajima, Takaki Miyata, Masaharu Ogawa, Katsuhiko Mikoshiba, Paul Derer, Michael Frotscher, and Eduardo Soriano

Nature 385 ( 6611 ) 70 - 74 1997.01

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody.

Gabriella D'Arcangelo, Kazunori Nakajima, Takaki Miyata, Masaharu Ogawa, Katsuhiko Mikoshiba, and Tom Curran

J. Neurosci. 17 ( 1 ) 23 - 31 1997.01

Research paper (scientific journal), Joint Work, Accepted

Distribution of a reeler gene-associated antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice.

Takaki Miyata, Kazunori Nakajima, Jun Aruga, Seiichi Takahashi, Kazuhiro Ikenaka, Katsuhiko Mikoshiba, and Masaharu Ogawa

J. Comp. Neurol. 372 ( 2 ) 215 - 228 1996.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell.

Shin-ichi Sakakibara, Takao Imai, Kayoko Hamaguchi, Masataka Okabe, Jun Aruga, Kazunori Nakajima, Daisuke Yasutomi, Takashi Nagata, Yasuyuki Kurihara, Seiichi Uesugi, Takaki Miyata, Masaharu Ogawa, Katsuhiko Mikoshiba, and Hideyuki Okano

Dev. Biol. 176 ( 2 ) 230 - 242 1996.06

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons.

Masaharu Ogawa, Takaki Miyata, Kazunori Nakajima, Kenichi Yagyu, Masahiro Seike, Kazuhiro Ikenaka, Hiroshi Yamamoto, and Katsuhiko Mikoshiba

Neuron 14 ( 5 ) 899 - 912 1995.05

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene.

Tetsushi Kagawa, Kazuhiro Ikenaka, Yoshiro Inoue, Shigeki Kuriyama, Tadasu Tsujii, Junji Nakao, Kazunori Nakajima, Jun Aruga, Hideyuki Okano, and Katsuhiko Mikoshiba

Neuron 13 ( 2 ) 427 - 442 1994.08

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Migration of genetically labeled glioma cells after implantation into murine brain.

Masanobu Yamada, Keiji Shimizu, Yasuyoshi Miyao, Toru Hayakawa, Kazunori Nakajima, Kensuke Nakahira, Hidemitsu Nakagawa, Katsuhiko Mikoshiba, and Kazuhiro Ikenaka

J. Neurosci. Res. 38 ( 4 ) 415 - 423 1994.07

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Selective expression of foreign genes in glioma cells: use of the mouse myelin basic protein gene promoter to direct toxic gene expression.

Yasuyoshi Miyao, Keiji Shimizu, S. Moriuchi, Masanobu Yamada, Kensuke Nakahira, Kazunori Nakajima, Junji Nakao, Shigeki Kuriyama, Tadasu Tsujii, Katsuhiko Mikoshiba, Toru Hayakawa, and Kazuhiro Ikenaka

J. Neurosci. Res. 36 ( 4 ) 472 - 479 1993.11

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Novel isoforms of mouse myelin basic protein predominantly expressed in embryonic stage.

Kazunori Nakajima, Kazuhiro Ikenaka, Tetsushi Kagawa, Jun Aruga, Junji Nakao, Kensuke Nakahira, Chiyo Shiota, Seung U. Kim, and Katsuhiko Mikoshiba

J. Neurochem. 60 ( 4 ) 1554 - 1563 1993.04

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

An improved retroviral vector for assaying promoter activity. Analysis of promoter interference in pIP211 vector

Kazunori Nakajima, Kazuhiro Ikenaka, Kensuke Nakahira, Noriyuki Morita, and Katsuhiko Mikoshiba

FEBS Lett. 315 ( 2 ) 129 - 133 1993.01

Research paper (scientific journal), Joint Work, Accepted

Access to Document (DOI)

Retrovirus-mediated gene transfer targeted to malignant glioma cells in murine brain.

Masanobu Yamada, Keiji Shimizu, Yasuyoshi Miyao, Toru Hayakawa, Kazuhiro Ikenaka, Kensuke Nakahira, Kazunori Nakajima, Tetsushi Kagawa, and Katsuhiko Mikoshiba

Jpn. J. Cancer Res. 83 ( 12 ) 1244 - 1247 1992.12

Research paper (scientific journal), Joint Work, Accepted

胎生期に発現するミエリン塩基性蛋白質の新しいアイソフォームの発見

仲嶋一範、池中一裕、鹿川哲史、有賀純、中尾純治、中平健祐、塩田千代、S. U. Kim、御子柴克彦

神経化学 31 ( 01 ) 418 - 419 1992.09

Research paper (scientific journal), Joint Work, ISSN 0037-3796

Detection of brain-specific gene expression in brain cells in primary culture: a novel promoter assay based on the use of a retrovirus vector. (Featured on the cover)

Kazuhiro Ikenaka, Kensuke Nakahira, Kazunori Nakajima, Ichiro Fujimoto, Tetsushi Kagawa, Masaharu Ogawa, and Katsuhiko Mikoshiba

The New Biologist 4 ( 1 ) 53 - 60 1992.01

Research paper (scientific journal), Joint Work, Accepted

癌の遺伝子治療に関する研究

栗山茂樹、山田正信、鹿川哲史、吉川正英、仲嶋一範、宮尾泰慶、清水恵司、辻井正、早川徹、御子柴克彦、池中一裕

飯能医化学シンポジウム 2 21 - 25 1992

Research paper (other academic), Joint Work

A rare case of female with liver cirrhosis and erythroblastic hypoplasia.

Hiromasa Ishii, Toshiko Fujisawa, Kazunori Nakajima, Toshio Morizane, Yasuo Ikeda, Yonosuke Watanabe, Toshimi Sato, Yoshio Mizuno, and Masaharu Tsuchiya

Keio J. Med. 39 ( 1 ) 32 - 46 1990.03

Research paper (scientific journal), Joint Work, Accepted

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