Papers - NAKAJIMA, Kazunori

Comprehensive analysis of immunoglobulin expression in the mouse brain from embryonic to adult stages.

Keiko Morimoto*, Hitomi Sano, Michiko Takahashi, Rikuo Takahashi, and Kazunori Nakajima*

J. Neuroinflammation, 22 ( 153 )  2025.06

Research paper (scientific journal), Last author, Corresponding author, Accepted

Propagation of neuronal micronuclei regulates microglial characteristics.

Sarasa Yano, Natsu Asami, Yusuke Kishi, Ikuko Takeda, Hikari Kubotani, Yuki Hattori, Ayako Kitazawa, Kanehiro Hayashi, Ken-ichiro Kubo, Mai Saeki, Chihiro Maeda, Chihiro Hiraki, Rin-ichiro Teruya, Takumi Taketomi, Kaito Akiyama, Tomomi Okajima-Takahashi, Ban Sato, Hiroaki Wake, Yukiko Gotoh, Kazunori Nakajima, Takeshi Ichinohe, Takeshi Nagata, Tomoki Chiba, Fuminori Tsuruta*

Nat. Neurosci. 28   487 - 498 2025.01

Research paper (scientific journal), Accepted

Cadherin-6 controls neuronal migration during mouse neocortical development via an integrin-mediated pathway.

Yuki Hirota*, Rikaho Saito, Takao Honda, Hitomi Sano, Mayuko Hotta, Yukiko U. Inoue, Takayoshi Inoue, and Kazunori Nakajima*

FEBS J.,  in press 2025

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

De novo monoallelic Reelin missense variants cause dominant neuronal migration disorders via a dominant-negative mechanism

Martina Riva, Sofia Ferreira, Kotaro Hayashi, Yoann Saillour, Vera P. Medvedeva, Takao Honda, Kanehiro Hayashi, Claire Altersitz, Shahad Albadri, Marion Rosello, Julie Dang, Malo Serafini, Frédéric Causeret, Olivia J. Henry, Charles-Joris Roux, Céline Bellesme, Elena Freri, Dragana Josifova, Elena Parrini, Renzo Guerrini, Filippo Del Bene, Kazunori Nakajima, Nadia Bahi-Buisson, and Alessandra Pierani* (☆Filippo Del Bene, Kazunori Nakajima, and Nadia Bahi-Buisson contributed equally to this work)

J. Clin. Invest. 134 ( 16 ) e153097 2024.07

Research paper (scientific journal), Joint Work, Accepted

Maternal immunoglobulins are distributed in the offspring’s brain to support the maintenance of cortical interneurons in the postnatal period.

Keiko Morimoto*, Rikuo Takahashi, Goro Takahashi, Michio Miyajima, and Kazunori Nakajima*

(Inflamm. Regen.)  44 ( 24 )  2024.05

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

Time-lapse imaging of migrating neurons and glial progenitors in embryonic mouse brain slices.

Hidenori Tabata, Koh-ichi Nagata, and Kazunori Nakajima

J. Vis. Exp 205 ( e66631 ) 1 - 12 2024.03

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

Migratory mode transition of astrocyte progenitors in the cerebral cortex: an intrinsic or extrinsic cell process?

Michio Miyajima, Hidenori Tabata, and Kazunori Nakajima

Neural Regen. Res. 19 ( 3 ) 471 - 472 2024.03

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

Interactions between neural cells and blood vessels in central nervous system development

Keiko Morimoto, Hidenori Tabata, Rikuo Takahashi, and Kazunori Nakajima

BioEssays 46 ( 3 ) e2300091 2024.03

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

Heterozygous Dab1 null mutation disrupts neocortical and hippocampal development.

Takao Honda, Yuki Hirota, and Kazunori Nakajima

eNeuro 10 ( 4 )  2023.03

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

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A unique “reversed” migration of neurons in the developing claustrum.

Kota Oshima, Satoshi Yoshinaga, Ayako Kitazawa, Yuki Hirota, Kazunori Nakajima*, and Ken-ichiro Kubo*.

J. Neurosci 43 ( 5 ) 693 - 708 2023

Research paper (scientific journal), Joint Work, Corresponding author, Accepted

Dab1-deficient deep layer neurons prevent Dab1-deficient superficial layer neurons from entering the cortical plate.

Satoshi Yoshinaga, Takao Honda, Ken-ichiro Kubo, and Kazunori Nakajima

Neurosci. Res 180   23 - 35 2022.07

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

• Access to Document (DOI)

Rhythmic activation of excitatory neurons in the mouse frontal cortex improves the prefrontal cortex-mediated cognitive function.

Debabrata Hazra, Satoshi Yoshinaga, Keitaro Yoshida, Norio Takata, Kenji F. Tanaka, Ken-ichiro Kubo, and Kazunori Nakajima

Cereb. Cortex 32 ( 23 ) 5243 - 5258 2022.02

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

TPT1 supports proliferation of neural stem/progenitor cells and brain tumor initiating cells regulated by Macrophage migration Inhibitory Factor (MIF).

Yukina Morimoto, Ayako Tokumitsu, Takefumi Sone, Yuki Hirota, Ryota Tamura, Ayuna Sakamoto, Kazunori Nakajima, Masahiro Toda, Yutaka Kawakami, Hideyuki Okano, and Shigeki Ohta.

Neurochem. Res. 47   2741 - 2756 2022

Research paper (scientific journal), Joint Work, Accepted

• Access to Document (DOI)

Development of intensiometric indicators for visualizing N-cadherin interaction across cells.

Takashi Kanadome, Kanehiro Hayashi, Yusuke Seto, Mototsugu Eiraku, Kazunori Nakajima, Takeharu Nagai, and Tomoki Matsuda.

Commun. Biol 5 ( 1 ) 1065 2022

Research paper (scientific journal), Joint Work, Accepted

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Activation of sonic hedgehog signaling promotes differentiation of cortical layer 4 neurons via regulation of their cell positioning.

Koji Oishi, Kazunori Nakajima, and Jun Motoyama

J. Dev. Biol. 10 ( 4 ) 50 2022

Research paper (scientific journal), Joint Work, Accepted

Erratic and Blood Vessel-Guided Migration of Astrocyte Progenitors in the Cerebral Cortex.（Featured in “Editors’ Highlights” as one of the most exciting articles.）

Hidenori Tabata, Megumi Sasaki, Masakazu Agetsuma, Hitomi Sano, Yuki Hirota, Michio Miyajima, Kanehiro Hayashi, Takao Honda, Masashi Nishikawa, Yutaka Inaguma, Hidenori Ito, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Junichi Nabekura, Koh-ichi Nagata, and Kazunori Nakajima.

Nat. Commun. 13   6571 2022

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

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Comprehensive characterization of migration profiles of murine cerebral cortical neurons during development using FlashTag labeling.

Satoshi Yoshinaga, Minkyung Shin, Ayako Kitazawa, Kazuhiro Ishii, Masato Tanuma, Atsushi Kasai, Hitoshi Hashimoto, Ken-ichiro Kubo, and Kazunori Nakajima

iScience 24 ( 4 ) 102277 2021

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted

Cerebellar foliation via non-uniform cell accumulation caused by fiber-guided migration of granular cells.

Hironori Takeda, Yoshitaka Kameo, Takahiro Yamaguchi, Kazunori Nakajima, and Taiji Adachi

J. Biomech. Sci. Eng. 16 ( 1 ) Paper No.20-00516 2021

Research paper (scientific journal), Joint Work, Accepted

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Reelin-Nrp1 interaction regulates neocortical dendrite development in a context-specific manner.

Takao Kohno, Keisuke Ishii, Yuki Hirota, Takao Honda, Makoto Makino, Takahiko Kawasaki, Kazunori Nakajima, and Mitsuharu Hattori.

J. Neurosci. 40 ( 43 ) 8248 - 8261 2020.10

Research paper (scientific journal), Joint Work, Accepted

Two-photon voltage imaging of spontaneous activity from multiple neurons reveals network activity in brain tissue.

Binglun Li, Mariya Chavarha, Yuho Kobayashi, Satoshi Yoshinaga, Kazunori Nakajima, Michael Z. Lin, and Takafumi Inoue

iScience 23 ( 8 ) 101363 2020.08

Research paper (scientific journal), Joint Work, Accepted

　View Summary

Recording the electrical activity of multiple neurons simultaneously would greatly facilitate studies on the function of neuronal circuits. The combination of the fast scanning by random-access multiphoton microscopy (RAMP) and the latest two-photon-compatible high-performance fluorescent genetically encoded voltage indicators (GEVIs) has enabled action potential detection in deep layers in in vivo brain. However, neuron connectivity analysis on optically recorded action potentials from multiple neurons in brain tissue has yet to be achieved. With high expression of a two-photon-compatible GEVI, ASAP3, via in utero electroporation and RAMP, we achieved voltage recording of spontaneous activities from multiple neurons in brain slice. We provide evidence for the developmental changes in intralaminar horizontal connections in somatosensory cortex layer 2/3 with a greater sensitivity than calcium imaging. This method thus enables investigation of neuronal network connectivity at the cellular resolution in brain tissue.

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