NAKAJIMA, Kazunori

写真a

Affiliation

School of Medicine, Department of Anatomy (Shinanomachi)

Position

Professor

E-mail Address

E-mail address

Related Websites

Contact Address

35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan

External Links

Career 【 Display / hide

  • 1988.05
    -
    1990.03

    Keio University Hospital, Department of Internal Medicine, Resident physician

  • 1994.04
    -
    1995.03

    the University of Tokyo (Professor Katsuhiko Mikoshiba), Postdoctoral Research Fellow of the Japan Society for the Promotion of Science

  • 1994.04
    -
    1995.03

    Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN), Molecular Neurobiology Laboratory (Chief Scientist: Dr. Katsuhiko Mikoshiba), Research Collaborative Advisor,

  • 1995.04
    -
    1998.08

    Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN), Molecular Neurobiology Laboratory, Research Scientist

  • 1996.02
    -
    1998.02

    St. Jude Children’s Research Hospital, Memphis, U.S.A., Department of Developmental Neurobiology (Chairman: Dr. Tom Curran), Visiting Scientist

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Academic Background 【 Display / hide

  • 1982.04
    -
    1988.03

    Keio University, School of Medicine

    University, Graduated

  • 1990.04
    -
    1994.03

    Osaka University, Graduate School, Division of Medicine, 生理系

    Graduate School, Graduated, Doctoral course

Academic Degrees 【 Display / hide

  • Ph.D., Osaka University, Coursework, 1994.03

Licenses and Qualifications 【 Display / hide

  • M.D., 1988.06

 

Research Areas 【 Display / hide

  • Developmental biology (Developmental neurobiology)

Research Keywords 【 Display / hide

  • 中枢神経系の組織構築機構

  • 神経細胞移動

  • 脳皮質形成機構

Research Themes 【 Display / hide

  • Mechanisms of cerebral cortical development, 

    2002.04
    -
    Present

 

Books 【 Display / hide

  • Comprehensive Developmental Neuroscience: Cellular Migration and Formation of Axons and Dendrites, 2nd Edition (Senior Editors-in-Chief: John Rubenstein, Pasko Rakic)

    Kanehiro Hayashi, Katsutoshi Sekine, Hidenori Tabata, and Kazunori Nakajima* (* is the corresponding author), Elsevier, 2020.05,  Page: 618

    Contact page: 289-304

  • ヒトの脳は、何が特別なのか?、『特別展 人体 神秘への挑戦』

    吉永怜史、仲嶋 一範, NHK・NHKプロモーション・朝日新聞社, 2018.03,  Page: 183

    Contact page: 172-176

  • 大脳皮質の層形成機構 、『再生医療シリーズ:脳神経系の再生医学 —発生と再生の融合的新展開—(井村裕夫・高橋淳 監修、河崎洋志 編集) 』

    仲嶋 一範, 診断と治療社 , 2015.01,  Page: 169

    Contact page: 60-65

  • ニューロンの移動と層および神経核の形成、『脳の発生学 ニューロンの誕生・分化・回路形成(宮田卓樹・山本亘彦 編)』

    仲嶋 一範, 化学同人, 2013.06

    Scope: 53-71

  • Cell polarity and initiation of migration (Chapter 12). Comprehensive Developmental Neuroscience: Cellular Migration and Formation of Neuronal Connections (J.L.R. Rubenstein, P. Rakic, ed.)

    Katsutoshi Sekine, Hidenori Tabata, and Kazunori Nakajima* (* is the corresponding author), Amsterdam, Academic Press, 2013.05,  Page: 1080

    Contact page: 231-244

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Papers 【 Display / hide

  • Reelin-Nrp1 interaction regulates neocortical dendrite development in a context-specific manner.

    Takao Kohno, Keisuke Ishii, Yuki Hirota, Takao Honda, Makoto Makino, Takahiko Kawasaki, Kazunori Nakajima, and Mitsuharu Hattori.

    J. Neurosci. 40 ( 43 ) 8248 - 8261 2020.10

    Research paper (scientific journal), Joint Work, Accepted

  • Two-photon voltage imaging of spontaneous activity from multiple neurons reveals network activity in brain tissue.

    Binglun Li, Mariya Chavarha, Yuho Kobayashi, Satoshi Yoshinaga, Kazunori Nakajima, Michael Z. Lin, and Takafumi Inoue

    iScience 23 ( 8 ) 101363 2020.08

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    Recording the electrical activity of multiple neurons simultaneously would greatly facilitate studies on the function of neuronal circuits. The combination of the fast scanning by random-access multiphoton microscopy (RAMP) and the latest two-photon-compatible high-performance fluorescent genetically encoded voltage indicators (GEVIs) has enabled action potential detection in deep layers in in vivo brain. However, neuron connectivity analysis on optically recorded action potentials from multiple neurons in brain tissue has yet to be achieved. With high expression of a two-photon-compatible GEVI, ASAP3, via in utero electroporation and RAMP, we achieved voltage recording of spontaneous activities from multiple neurons in brain slice. We provide evidence for the developmental changes in intralaminar horizontal connections in somatosensory cortex layer 2/3 with a greater sensitivity than calcium imaging. This method thus enables investigation of neuronal network connectivity at the cellular resolution in brain tissue.

  • VLDLR is not essential for Reelin-induced neuronal aggregation but suppresses neuronal invasion into the marginal zone.(Selected to appear as a Research Highlight)

    Hirota, Y. ,Nakajima,K.

    Development 147 ( 12 ) 189936 2020.06

    Research paper (scientific journal), Joint Work, Accepted

  • Neuron-derived VEGF contributes to cortical and hippocampal development independently of VEGFR1/2-mediated neurotrophism.

    Keisuke Okabe, Hugh Fukada, Ikue Tai-Nagara, Tomofumi Ando, Takao Honda, Kazunori Nakajima, Norihiko Takeda, Guo-Hua Fong, Masatsugu Ema, and Yoshiaki Kubota

    Dev. Biol. (Dev. Biol.)  459 ( 2 ) 65 - 71 2020.03

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  00121606

     View Summary

    © 2019 The Authors Vascular endothelial growth factor (VEGF) is a potent mitogen critical for angiogenesis and organogenesis. Deletion or inhibition of VEGF during development not only profoundly suppresses vascular outgrowth, but significantly affects the development and function of various organs. In the brain, VEGF is thought to not only promote vascular growth, but also directly act on neurons as a neurotrophic factor by activating VEGF receptors. In the present study, we demonstrated that deletion of VEGF using hGfap-Cre line, which recombines genes specifically in cortical and hippocampal neurons, severely impaired brain organization and vascularization of these regions. The mutant mice had motor deficits, with lethality around the time of weaning. Multiple reporter lines indicated that VEGF was highly expressed in neurons, but that its cognate receptors, VEGFR1 and 2 were exclusive to endothelial cells in the brain. In accordance, mice lacking neuronal VEGFR1 and VEGFR2 did not exhibit neuronal deformities or lethality. Taken together, our data suggest that neuron-derived VEGF contributes to cortical and hippocampal development likely through angiogenesis independently of direct neurotrophic effects mediated by VEGFR1 and 2.

  • The secreted glycoprotein Reelin suppresses the proliferation and regulates the distribution of oligodendrocyte progenitor cells in the embryonic neocortex.

    Himari Ogino, Tsuzumi Nakajima, Yuki Hirota, Kohki Toriuchi, Mineyoshi Aoyama, Kazunori Nakajima, and Mitsuharu Hattori.

    J. Neurosci.  2020

    Research paper (scientific journal), Joint Work, Accepted

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • 精神神経疾患の関連分子が神経細胞を正しく配置させるしくみを発見

    廣田ゆき、仲嶋一範

    KOMPAS「慶應発サイエンス」  2020.09

    Introduction and explanation (others)

  • 精神神経疾患に関わるタンパク質「リーリン」 – 受容体を使い分けて神経細胞の”集合”と”整列”を制御する分子(研究コラム)

    廣田ゆき、仲嶋一範

    academist Journal  2020.08

    Introduction and explanation (others)

  • Timing and shaping mechanisms of neural development.

    Ryoichiro Kageyama and Kazunori Nakajima

    Neurosci. Res. (Neuroscience Research)  138   1 - 2 2019.01

    Introduction and explanation (scientific journal), Joint Work,  ISSN  01680102

  • 精神科医でもある大学院生が行っている神経発生研究

    吉永怜史、久保健一郎、仲嶋一範

    日本生物学的精神医学会誌 30 ( 3 ) 120 - 125 2019

    Introduction and explanation (scientific journal)

  • プレプレート

    石井一裕 仲嶋 一範

    脳科学辞典  2018.08

    Introduction and explanation (scientific journal), Joint Work

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Presentations 【 Display / hide

  • マウス大脳新皮質錐体細胞との比較による海馬CA1錐体細胞の移動制御要因の解明

    北澤彩子、大石康二、吉永怜史、シンミンギョン、林周宏、久保健一郎、仲嶋一範

    2020.10, Oral Presentation(general)

  • VLDLR controls the positioning of pyramidal neurons by suppressing neuronal invasion into the marginal zone, rather than by promoting neuronal aggregation, during neocortical development

    廣田ゆき、仲嶋一範

    第63回日本神経化学会大会合同大会、いちょうホール(東京都八王子市), 2020.09, Poster (general)

  • Analysis of extrinsic signals for layer 4 subtype specification in the neocortex

    長谷川紘之,大石康二,山本亘彦,仲嶋一範

    第43回日本神経科学大会 (神戸コンベンションセンター(兵庫県神戸市)<オンライン/誌上開催に変更>) , 2020.07, Poster (general)

  • Two-photon voltage imaging of spontaneous activity from multiple neurons reveals network activity in brain tissue

    Binglun Li, Mariya Chavarha, Yuho Kobayashi, Satoshi Yoshinaga, Kazunori Nakajima, Michael Z. Lin, Takafumi Inoue

    第43回日本神経科学大会 (神戸コンベンションセンター(兵庫県神戸市)<オンライン/誌上開催に変更>) , 2020.07, Poster (general)

  • Analysis of HA-tagged-Dab1-expressing mice using CRISPR/Cas9-mediated genome editing

    本田岳夫,宮川拓,仲嶋一範

    第43回日本神経科学大会 (神戸コンベンションセンター(兵庫県神戸市)<オンライン/誌上開催に変更>) , 2020.07, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 場との連携による脳細胞の動態制御機構

    2016
    -
    Present

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Kazunori Nakajima, Grant-in-Aid for Scientific Research

  • 成熟した大脳皮質神経細胞のサブタイプを生体内で人為的に転換させる試み

    2018
    -
    Present

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Kazunori Nakajima, Grant-in-Aid for Challenging Exploratory Research, Principal Investigator

  • 脳皮質の構築機構の解明

    2020.08
    -
    2025.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 仲嶋 一範, Grant-in-Aid for Scientific Research (S), Principal Investigator

  • 発生期の脳に免疫関連分子が存在するのはなぜか?

    2020.07
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 仲嶋 一範, Grant-in-Aid for Challenging Research (Exploratory), Principal Investigator

  • 大脳皮質構造の形成機構

    2019
    -
    Present

    慶應義塾福澤基金委員会, 福澤基金研究補助, Kazunori Nakajima, Other, Principal Investigator

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Awards 【 Display / hide

  • Outstanding teacher award

    2019

  • 第29回(2012年度)井上学術賞

    Kazunori Nakajima, 2013.02, 井上科学振興財団, 大脳皮質の発生・分化機構

    Type of Award: Awards of Publisher, Newspaper Company and Foundation.  Country: Japan

  • 第5回上田英雄賞

    2001.04, 東京慈恵会医科大学やよい会, 脳神経細胞の配置決定のメカニズム

    Type of Award: Other Awards.  Country: 日本

  • The Award for Distinguished Young Investigator

    Kazunori Nakajima, 2000.10, Japanese Society for Neurochemistry, 脳皮質形成のメカニズム

    Type of Award: Awards of National Conference, Council and Symposium

 

Courses Taught 【 Display / hide

  • 神経解剖学

    2019

  • EMBRYOLOGY

    2019

  • 肉眼解剖学

    2019

  • 骨学

    2019

  • 自主学習

    2019

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Courses Previously Taught 【 Display / hide

  • 生物科学特別講義Ⅱ

    東京大学理学部生物学科, 2020

  • 分子細胞生物学(MCB)

    慶応義塾大学医学部, 2020

  • 生物学特論

    慶応義塾大学医学部, 2020

  • 自主学習

    慶応義塾大学医学部, 2020

  • 骨学

    慶応義塾大学医学部, 2020

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Educational Activities and Special Notes 【 Display / hide

  • 2020年 慶應義塾大学医学教育貢献賞(Outstanding teacher award)

    2020
    -
    Present

     View Details

    多数回受賞のため、2020年に新設された医学教育貢献賞を受賞し、以後ベスト・ティーチャー賞の表彰対象外となった。


  • 第15回慶應義塾大学医学部ベスト・ティーチャー賞

    2019

  • 第14回慶應義塾大学医学部ベスト・ティーチャー賞

    2018

    , Device of Educational Contents

  • 第13回慶應義塾大学医学部ベスト・ティーチャー賞

    2017

    , Device of Educational Contents

  • 第12回慶應義塾大学医学部ベスト・ティーチャー賞

    2016

    , Device of Educational Contents

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Social Activities 【 Display / hide

  • 第42回四谷祭(慶應義塾大学信濃町キャンパス学園祭)にて一般向け研究室ツアー

    2019.11
  • 第41回四谷祭(慶應義塾大学信濃町キャンパス学園祭)にて一般向け研究室ツアー

    2018.11
  • 特別展「人体 ―神秘への挑戦―」(国立科学博物館)にて脳に関する展示に協力

    国立科学博物館、NHK、NHKプロモーション、朝日新聞社

    2018.03
    -
    2018.06
  • 第40回四谷祭(慶應義塾大学信濃町キャンパス学園祭)にて一般向け研究室ツアー

    2017.11
  • 慶應義塾大学医学部解剖学教室仲嶋研究室オープンラボ2017

    2017.08

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Memberships in Academic Societies 【 Display / hide

  • 日本発生生物学会

     
  • 日本解剖学会

     
  • 日本分子生物学会

     
  • 日本神経科学学会

     
  • Society for Neuroscience

     

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Committee Experiences 【 Display / hide

  • 2002.06
    -
    Present

    Editorial Advisory Board Member, The Keio Journal of Medicine

  • 2002.12
    -
    2005.12

    Editorial Board Member, Developmental Brain Research (Elsevier)

  • 2004.01
    -
    2011.07

    Editorial Board Member, Molecular and Cellular Biochemistry

  • 2009.01
    -
    Present

    Review Editor, Frontiers in Neuroanatomy

  • 2009.07
    -
    2014.04

    Review Editor for Specialty Section Neurogenesis, Frontiers in Neuroscience

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