Tai, Ikue

写真a

Affiliation

School of Medicine, Department of Anatomy (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor
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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • リンパ管機能の維持におけるがん抑制遺伝子Folliculinの役割

    2022.04
    -
    2025.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 基盤研究(C), Principal investigator

  • Role of Tspan18 in the intracellular trafficking of VEGF receptor

    2019.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • 4回膜貫通タンパク質Tspan18を介した血管形成機能の解明

    2017.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Principal investigator

  • Tetraspanins regulate the formation of mature blood vessels

    2015.04
    -
    2017.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Principal investigator

    　View Summary

    Tetraspanins (Tspans) are membrane-anchored molecules with 4 transmembrane regions, which promote clustering of other membranous proteins by forming “tetraspanin-enriched microdomain”. Integrins and Immunoglobulin superfamily proteins have been identified as their binding proteins, and thus Tspans are thought to modulate the signal transduction associated with these molecules. However, the function of tetraspanins in vascular development has not been understood well. Here, we found some Tspans are expressed in endothelial cells, especially those in mature (arterial and venous) vessels. Conventional or endothelial-specific knockout of Tspan showed a significant reduction in the number of arterioles and venules and reduced radial vascular growth. In vitro data suggest that Tspan directly interacts with other membrane proteins involved in angiogenesis. Overall, Tspan might regulate the formation of arterioles and venules by clustering other membrane proteins.

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Courses Taught 【 Display / hide 】

  • HISTOLOGY

    2024

  • HISTOLOGY

    2023

  • HISTOLOGY

    2022

  • HISTOLOGY

    2021

  • HISTOLOGY

    2020

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