Fukuda, Kazumasa

写真a

Affiliation

School of Medicine, Department of Surgery (General and Gastroenterological Surgery) (Shinanomachi)

Position

Assistant Professor/Senior Assistant Professor

External Links

Academic Background 【 Display / hide

  • 2007.03

    Keio University, Graduate School, Division of Medical Science, Medical Science

    Graduate School, Completed, Master's course

Academic Degrees 【 Display / hide

  • 博士(医学), 慶應義塾大学, Dissertation

 

Research Areas 【 Display / hide

  • Life Science / Digestive surgery (Digestive Organ Surgery)

 

Papers, etc., Registered in KOARA 【 Display / hide

Research Projects of Competitive Funds, etc. 【 Display / hide

  • Development of therapy for cancer stem cell targeting miRNA in esophageal squamous cell carcinoma

    2014.04
    -
    2017.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

     View Summary

    In the present study, we investigated miRNA expression profile and function in CSC-like clones and serum derived from esophageal squamous cell carcinoma (ESCC) patients. The result exhibited common 67 miRNAs differentially expressed between CSC-like clones and their parent cell lines. The genes predicted to be targets of candidate miRNAs were chosen and analyzed using the database of miRNA.org site. miR-125a-5p has important roles in docetaxel resistance by regulating protein expression of the ICIS gene. Analysis of comprehensive expression of miRNA in serum was performed using the 3D-Gene system. Between lymph node metastasis group and non-metastasis group, 33 miRNAs significantly showed expression fluctuation. These findings suggest that it may be helpful to develop novel strategies for targeted therapies in ESCC patients.