KEIO RESEARCHERS INFORMATION SYSTEM

Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 2007.03

  Keio University, Graduate School, Division of Medical Science, Medical Science

  Graduate School, Completed, Master's course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士（医学）, 慶應義塾大学, Dissertation

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Digestive surgery (Digestive Organ Surgery)

Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Development of therapy for cancer stem cell targeting miRNA in esophageal squamous cell carcinoma

  Fukuda, Kazumasa

  科学研究費補助金研究成果報告書 2016

• The effect of the prorenin receptor blocker on sepsis in lipopolysaccharide induced rat model

  Fukuda, Kazumasa

  科学研究費補助金研究成果報告書 2015

• Identification and function analysis of cancer stem cell in esophageal cancer

  Fukuda, Kazumasa

  科学研究費補助金研究成果報告書 2013

• Establishment and characterization of cancer stem cell model using iPS technology

  Fukuda, Kazumasa

  科学研究費補助金研究成果報告書 2010

• Bone marrow derived cells may play an important role in "gastric cancer stem cell system"

  FUKUDA, KAZUMASA

  科学研究費補助金研究成果報告書 2008

Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Functional analysis of inflammation-inducing bacteria derived form oral microflora and immunoreactive T cells in gastrointestinal cancer

  2023.04

  -

  2026.03

  基盤研究(C), Principal investigator

• Development of therapy for cancer stem cell targeting miRNA in esophageal squamous cell carcinoma

  2014.04

  -

  2017.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  　View Summary

  In the present study, we investigated miRNA expression profile and function in CSC-like clones and serum derived from esophageal squamous cell carcinoma (ESCC) patients. The result exhibited common 67 miRNAs differentially expressed between CSC-like clones and their parent cell lines. The genes predicted to be targets of candidate miRNAs were chosen and analyzed using the database of miRNA.org site. miR-125a-5p has important roles in docetaxel resistance by regulating protein expression of the ICIS gene. Analysis of comprehensive expression of miRNA in serum was performed using the 3D-Gene system. Between lymph node metastasis group and non-metastasis group, 33 miRNAs significantly showed expression fluctuation. These findings suggest that it may be helpful to develop novel strategies for targeted therapies in ESCC patients.