Details of a Researcher - Kinouchi, Kenichiro

Papers - Kinouchi, Kenichiro

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SP037SIGNIFICANCE OF EPIGENETIC MODIFICATION IN THE KIDNEY FOR THE ONSET AND PERSISTENCE OF HYPERTENSION AFTER TRANSIENT SALT LOADING IN MICE

Sho Endo, Kentaro Fujii, Masaki Ryuzaki, Kenichiro Kinouchi, Aika Hagiwara, Masaaki Sato, Asuka Uto, Kazutoshi Miyashita, Hiroyuki Inoue, Hiroshi Itoh

Nephrology Dialysis Transplantation (Oxford University Press (OUP)) 34 2019.06

Lead author, Last author, Corresponding author, ISSN 09310509

SP039HYPERTENSION-RELATED PROTEIN DEACETYLASE SIRT3 AFFECTS BLOOD PRESSURE THROUGH REGULATION OF INTESTINAL SALT ABSORPTION IN MICE

Kenichiro Kinouchi, Masaki Ryuzaki, Asuka Uto, Masaaki Sato, Kentaro Fujii, Sho Endo, Kazutoshi Miyashita, Hiroshi Itoh, Hiroyuki Inoue

Nephrology Dialysis Transplantation (Oxford University Press (OUP)) 34 2019.06

Lead author, Last author, Corresponding author, ISSN 09310509

DISTRIBUTION OF ADENOSINE IN THE KISNEY DETERMINES LOCAL VASCULAR TONE VIA A2B ACTIVATION AND AFFECTS RENO-PROTECTION AGAINST ACUTE ISCHEMIA IN MICE

Kentaro, F; Kazutoshi, M; Akiko, K; Masaaki, S; Aika, H; Hiroyuki, I; Masaki, R; Sho, E; Asuka, U; Kenichiro, K; Makoto, S; Hiroshi, I

NEPHROLOGY DIALYSIS TRANSPLANTATION 34 2019.06

Lead author, Last author, Corresponding author, ISSN 0931-0509

BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis.

Welz PS, Zinna VM, Symeonidi A, Koronowski KB, Kinouchi K, Smith JG, Guillén IM, Castellanos A, Furrow S, Aragón F, Crainiciuc G, Prats N, Caballero JM, Hidalgo A, Sassone-Corsi P, Benitah SA

Cell 177 ( 6 ) 1436 - 1447.e12 2019.05

Lead author, Last author, Corresponding author, ISSN 0092-8674

Access to Document (DOI)

BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis

Patrick-Simon Welz, Valentina M. Zinna, Aikaterini Symeonidi, Kevin B. Koronowski, Kenichiro Kinouchi, Jacob G. Smith, Inés Marín Guillén, Andrés Castellanos, Stephen Furrow, Ferrán Aragón, Georgiana Crainiciuc, Neus Prats, Juan Martín Caballero, Andrés Hidalgo, Paolo Sassone-Corsi, Salvador Aznar Benitah

Cell (Elsevier BV) 177 ( 6 ) 1436 - 1447.e12 2019.05

Lead author, Last author, Corresponding author, ISSN 00928674

Nutrient-sensitive transcription factors TFEB and TFE3 couple autophagy and metabolism to the peripheral clock.

Pastore N, Vainshtein A, Herz NJ, Huynh T, Brunetti L, Klisch TJ, Mutarelli M, Annunziata P, Kinouchi K, Brunetti-Pierri N, Sassone-Corsi P, Ballabio A

The EMBO journal (Springer Science and Business Media LLC) 38 ( 12 ) e101347 2019.05

Lead author, Last author, Corresponding author, Accepted, ISSN 0261-4189

Light Entrains Diurnal Changes in Insulin Sensitivity of Skeletal Muscle via Ventromedial Hypothalamic Neurons.

Aras E, Ramadori G, Kinouchi K, Liu Y, Ioris RM, Brenachot X, Ljubicic S, Veyrat-Durebex C, Mannucci S, Galié M, Baldi P, Sassone-Corsi P, Coppari R

Cell reports (Elsevier BV) 27 ( 8 ) 2385 - 2398.e3 2019.05

Lead author, Last author, Corresponding author, Accepted, ISSN 22111247

Defining the Independence of the Liver Circadian Clock.

Koronowski KB, Kinouchi K, Welz PS, Smith JG, Zinna VM, Shi J, Samad M, Chen S, Magnan CN, Kinchen JM, Li W, Baldi P, Benitah SA, Sassone-Corsi P

Cell (Elsevier BV) 177 ( 6 ) 1448 - 1462.e14 2019.05

Lead author, Last author, Corresponding author, Accepted, ISSN 0092-8674

BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis.

Welz PS, Zinna VM, Symeonidi A, Koronowski KB, Kinouchi K, Smith JG, Guillén IM, Castellanos A, Furrow S, Aragón F, Crainiciuc G, Prats N, Benitah SA

Cell 177 ( 6 ) 1436 - 1447.e12 2019.05

Lead author, Last author, Corresponding author, Accepted, ISSN 0092-8674

Access to Document (DOI)

Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle.

Kinouchi K, Magnan C, Ceglia N, Liu Y, Cervantes M, Pastore N, Huynh T, Ballabio A, Baldi P, Masri S, Sassone-Corsi P

Cell reports (Elsevier BV) 25 ( 12 ) 3299 - 3314.e6 2018.12

Lead author, Last author, Corresponding author, Accepted, ISSN 22111247

Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks.

Dyar KA, Lutter D, Artati A, Ceglia NJ, Liu Y, Armenta D, Jastroch M, Schneider S, de Mateo S, Cervantes M, Abbondante S, Tognini P, Orozco-Solis R, Sassone-Corsi P

Cell (Elsevier BV) 174 ( 6 ) 1571 - 1585.e11 2018.09

Lead author, Last author, Corresponding author, Accepted, ISSN 0092-8674

Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis

Selma Masri, Thales Papagiannakopoulos, Kenichiro Kinouchi, Yu Liu, Marlene Cervantes, Pierre Baldi, Tyler Jacks, Paolo Sassone-Corsi

CELL (Elsevier BV) 165 ( 4 ) 896 - 909 2016.05

Lead author, Last author, Corresponding author, Accepted, ISSN 0092-8674

Circadian clocks, epigenetics, and cancer

Selma Masri, Kenichiro Kinouchi, Paolo Sassone-Corsi

CURRENT OPINION IN ONCOLOGY (Ovid Technologies (Wolters Kluwer Health)) 27 ( 1 ) 50 - 56 2015.01

Lead author, Last author, Corresponding author, Accepted, ISSN 1040-8746

Significant roles of the (pro)renin receptor in integrity of vascular smooth muscle cells

Asako Kurauchi-Mito, Atsuhiro Ichihara, Kanako Bokuda, Mariyo Sakoda, Kenichiro Kinouchi, Tomonori Yaguchi, Taketo Yamada, Ge-Hong Sun-Wada, Yoh Wada, Hiroshi Itoh

Hypertension Research (Japanese Society of Hypertension) 37 ( 9 ) 830 - 835 2014.09

Lead author, Last author, Corresponding author, ISSN 1348-4214

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Significant roles of the (pro)renin receptor in integrity of vascular smooth muscle cells

Asako Kurauchi-Mito, Atsuhiro Ichihara, Kanako Bokuda, Mariyo Sakoda, Kenichiro Kinouchi, Tomonori Yaguchi, Taketo Yamada, Ge-Hong Sun-Wada, Yoh Wada, Hiroshi Itoh

HYPERTENSION RESEARCH 37 ( 9 ) 830 - 835 2014.09

Lead author, Last author, Corresponding author, Accepted, ISSN 0916-9636

Access to Document (DOI)

Significant roles of the (pro)renin receptor in integrity of vascular smooth muscle cells.

Kurauchi-Mito A, Ichihara A, Bokuda K, Sakoda M, Kinouchi K, Yaguchi T, Yamada T, Sun-Wada GH, Wada Y, Itoh H

Hypertension research : official journal of the Japanese Society of Hypertension 37 ( 9 ) 830 - 5 2014.09

Lead author, Last author, Corresponding author, ISSN 0916-9636

Access to Document (DOI)

Significant roles of the (pro)renin receptor in integrity of vascular smooth muscle cells

Asako Kurauchi-Mito, Atsuhiro Ichihara, Kanako Bokuda, Mariyo Sakoda, Kenichiro Kinouchi, Tomonori Yaguchi, Taketo Yamada, Ge-Hong Sun-Wada, Yoh Wada, Hiroshi Itoh

Hypertension Research (Springer Science and Business Media LLC) 37 ( 9 ) 830 - 835 2014.05

Lead author, Last author, Corresponding author, ISSN 09169636

The (pro)renin receptor ((P)RR) is known to play an important role in the pathogenesis of vascular complications in diabetes mellitus and hypertension through its function in activating the local renin-angiotensin system. Recent studies have shown that the (P)RR is an accessory protein of the vacuolar H(+)-ATPase, suggesting a more fundamental and developmental function. In this study, smooth muscle cell-specific (P)RR/Atp6ap2 conditional knockout mice were generated. Smooth muscle cell-specific ablation of the (P)RR resulted in nonatherogenic sclerosis in the abdominal aorta. The deletion of the (P)RR did not affect ambulatory blood pressure levels. In cultured murine vascular smooth muscle cells (VSMCs), ablation of the (P)RR suppressed the expression of the Vo subunit c of the vacuolar H(+)-ATPase and impaired the cell recycling system, leading to autophagic cell death. In addition, loss of the (P)RR in VSMCs induced the expression of monocyte chemotactic protein-1 and interleukin-6 mRNAs. These results suggest that the (P)RR is essential for cell survival and downregulation of vascular inflammation in murine VSMCs through maintaining normal function of the vacuolar H(+)-ATPase.

The role of individual domains and the significance of shedding of ATP6AP2/(pro)renin receptor in vacuolar H+-ATPase biogenesis

Kenichiro Kinouchi, Atsuhiro Ichihara, Motoaki Sano, Ge-Hong Sun-Wada, Yoh Wada, Hiroki Ochi, Toru Fukuda, Kanako Bokuda, Hideaki Kurosawa, Naohiro Yoshida, Shu Takeda, Keiichi Fukuda, Hiroshi Itoh

PLoS ONE (Public Library of Science (PLoS)) 8 ( 11 ) e78603 2013.11

Lead author, Last author, Corresponding author, Accepted, ISSN 1932-6203

The ATPase 6 accessory protein 2 (ATP6AP2)/(pro)renin receptor (PRR) is essential for the biogenesis of active vacuolar H(+)-ATPase (V-ATPase). Genetic deletion of ATP6AP2/PRR causes V-ATPase dysfunction and compromises vesicular acidification. Here, we characterized the domains of ATP6AP2/PRR involved in active V-ATPase biogenesis. Three forms of ATP6AP2/PRR were found intracellularly: full-length protein and the N- and C-terminal fragments of furin cleavage products, with the N-terminal fragment secreted extracellularly. Genetic deletion of ATP6AP2/PRR did not affect the protein stability of V-ATPase subunits. The extracellular domain (ECD) and transmembrane domain (TM) of ATP6AP2/PRR were indispensable for the biogenesis of active V-ATPase. A deletion mutant of ATP6AP2/PRR, which lacks exon 4-encoded amino acids inside the ECD (Δ4M) and causes X-linked mental retardation Hedera type (MRXSH) and X-linked parkinsonism with spasticity (XPDS) in humans, was defective as a V-ATPase-associated protein. Prorenin had no effect on the biogenesis of active V-ATPase. The cleavage of ATP6AP2/PRR by furin seemed also dispensable for the biogenesis of active V-ATPase. We conclude that the N-terminal ECD of ATP6AP2/PRR, which is also involved in binding to prorenin or renin, is required for the biogenesis of active V-ATPase. The V-ATPase assembly occurs prior to its delivery to the trans-Golgi network and hence shedding of ATP6AP2/PRR would not affect the biogenesis of active V-ATPase.

Effects of Adding Ezetimibe to Fluvastatin on Kidney Function in Patients with Hypercholesterolemia: a Randomized Control Trial

Kenichiro Kinouchi, Atsuhiro Ichihara, Kanako Bokuda, Satoshi Morimoto, Hiroshi Itoh

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 20 ( 3 ) 245 - 256 2013

Lead author, Last author, Corresponding author, Accepted, ISSN 1340-3478

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Current knowledge of (pro)renin receptor as an accessory protein of vacuolar H+-ATPase

Atsuhiro Ichihara, Kenichiro Kinouchi

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (SAGE Publications) 12 ( 4 ) 638 - 640 2011.12

Lead author, Last author, Corresponding author, Accepted, ISSN 1470-3203

<jats:p> The (pro)renin receptor (P)RR is a receptor for renin and prorenin, not only allowing local production of angiotensin I from angiotensinogen, but also inducing intracellular signaling. Intriguingly, (P)RR is also called ATP6AP2 because a (P)RR fragment was demonstrated to be associated with vacuolar-type H+-ATPase (V-ATPase), which is of importance for the maintenance of intracellular pH. Recent studies implicate that deletion of (P)RR results in the dysfunction of V-ATPase, suggesting that the (P)RR is essential for its role as a proton pump. Furthermore, the novel function of (P)RR as an adaptor protein between the Wnt receptor complex and the V-ATPase was discovered. Thus, (P)RR is a multi-functional molecule with functions beyond renin and prorenin. This review focuses on the current knowledge and issues of (P)RR and V-ATPase. </jats:p>

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