Details of a Researcher - Kinouchi, Kenichiro

Papers - Kinouchi, Kenichiro

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特集総排泄腔遺残症総排泄腔遺残症の術後遠隔期における問題とDSDセンターの意義

加藤源俊, 佐藤壮泰, 熊谷知子, 杉山祥基, 城崎浩司, 山岸徳子, 工藤裕実, 鈴木悠史, 佐藤温子, 市橋洋輔, 狩野元宏, 木内謙一郎, 木須伊織, 内田明花, 山田洋平, 佐々木掌子, 菊地俊暁, 鳴海覚志, 浅沼宏, 藤野明浩

小児外科 (東京医学社) 57 ( 11 ) 1179 - 1182 2025.11

Lead author, Last author, Corresponding author, ISSN 03856313

Effects of perirenal fat accumulation on cardiometabolic and renal functions and mineralocorticoid receptor activation in primary aldosteronism.

Ryunosuke Mitsuno, Toshifumi Nakamura, Kengo Nakamura, Kenji Kaneko, Daiki Kojima, Yosuke Mizutani, Yoshitake Yamada, Masahiro Jinzaki, Tatsuhiko Azegami, Takeshi Kanda, Kenichiro Kinouchi, Hiroshi Itoh, Jun Yoshino, Kaori Hayashi

Hypertension research : official journal of the Japanese Society of Hypertension 48 ( 12 ) 3244 - 3256 2025.10

Lead author, Last author, Corresponding author, Accepted, ISSN 0916-9636

Perirenal fat (PRF), an ectopic fat depot lying adjacent to kidneys, is a risk factor for cardiometabolic and renal dysfunctions in patients with obesity and type 2 diabetes. We aimed to investigate the involvement of PRF in the pathophysiology and treatment of primary aldosteronism (PA). To this end, we measured PRF volume by abdominal CT and evaluated the relationships among PRF volume, cardiometabolic and renin-angiotensin-aldosterone system (RAAS) parameters, and therapeutic response to mineralocorticoid receptor antagonist (MRA) treatment in well-phenotyped PA patients. In addition, we evaluated the effects of MRA treatment on inflammation and fibrosis, potential downstream targets of MR signaling, by analyzing PRF obtained from obese (db/db) mice. PRF volume (PRF%) and visceral fat volume (VFV) were associated with various cardiometabolic and renal risk markers and RAAS parameters, such as body mass index, creatinine, triglyceride, high-density lipoprotein cholesterol, uric acid, fasting glucose, C-reactive protein, 24-h urine aldosterone, and 24-h urine normetanephrine (all P < 0.05). PRF%, but not VFV, positively correlated with changes in systolic and diastolic blood pressure and initial estimated glomerular filtration rate (eGFR) fall following MRA treatment after adjusting for confounders (all P < 0.05). In addition, MRA treatment decreased PRF expression of markers of macrophage infiltration and fibrosis in db/db mice (all P < 0.05). In conclusion, our results suggest that PRF accumulation is involved in the mechanisms linking MR activation to cardiometabolic and renal dysfunctions in PA patients. Moreover, PRF could be not only a prognostic factor but also a new therapeutic target for MRA-resistant hypertension.

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Sodium-glucose co-transporter 2 inhibitor-induced increase in adenosine promotes lipolysis and weight reduction by activating reno-adipose autonomic neurocircuitry.

Aika Hagiwara, Shintaro Yamaguchi, Kazutoshi Miyashita, Kenichiro Kinouchi, Kaori Hayashi, Hiroshi Itoh

Hypertension research : official journal of the Japanese Society of Hypertension 48 ( 10 ) 2664 - 2676 2025.10

Lead author, Last author, Corresponding author, Accepted, ISSN 0916-9636

Sodium-glucose co-transporter 2 (SGLT2) inhibitors promote weight loss in patients with type 2 diabetes mellitus; however, the underlying mechanisms remain unknown. This study investigated the role of renal autonomic nerves in SGLT2 inhibitor-induced lipolysis and body weight reduction by utilizing the renal denervation technique. The results indicated that renal autonomic nerves mediated lipolysis in mice fed a high-fat diet following treatment with tofogliflozin, an SGLT2 inhibitor. The effect was attenuated by renal denervation or β3-adrenergic blockade. Metabolomic analysis revealed that treatment with tofogliflozin elevated renal adenosine, which in turn activated adipose sympathetic nerves, as evidenced by increased norepinephrine concentrations in adipose tissue, thereby promoting lipolysis. These findings uncover a novel reno-adipose neurocircuitry linking renal energy depletion to systemic fatty acid oxidation, providing insights into the sustained weight-reducing effects of SGLT2 inhibitors. A scheme illustrating SGLT2 inhibitor-induced activation of reno-adipose autonomic neurocircuitry, which promotes lipolysis and weight reduction.

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Vascular Endothelial NAMPT-Mediated NAD+ Biosynthesis Regulates Angiogenesis and Cardiometabolic Functions in Male Mice.

Shotaro Kosugi, Shintaro Yamaguchi, Ken Nishioka, Taichi Nagahisa, Yasuhiro Watanabe, Daiki Kojima, Kenji Kaneko, Ryunosuke Mitsuno, Ran Nakamichi, Yoshinaga Kawano, Kenichiro Kinouchi, Koichiro Homma, Takeshi Kanda, Junichiro Irie, Kazutoshi Miyashita, Toshiaki Monkawa, Jun Yoshino, Hiroshi Itoh, Kaori Hayashi

Aging cell 24 ( 11 ) e70222 2025.09

Lead author, Last author, Corresponding author, Accepted, ISSN 1474-9718

Aging is associated with metabolic dysfunction and cardiovascular abnormalities. Defective nicotinamide adenine dinucleotide (NAD+) biosynthesis correlates with aging and aging-associated complications. However, the precise molecular mechanisms linking aging-associated NAD+ deficiency to cardiometabolic dysfunction remain unclear. Herein, we examined whether nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in NAD+ biosynthesis, influences vascular endothelial function and whole-body metabolic and hemodynamic homeostasis during aging. Vascular endothelial cell-specific Nampt knockout (VeNKO) mice fed a regular chow diet exhibited no cardiometabolic abnormalities, whereas male VeNKO mice fed a high-fat diet exhibited reduced angiogenesis, resulting in impaired subcutaneous adipogenesis, impaired glucose metabolism, and hemodynamic disturbances. Mechanistically, NAMPT loss attenuated NAD+-dependent deacetylase sirtuin-1 (SIRT1) and endothelial nitric oxide synthase (eNOS) signaling, impairing angiogenesis. Aged mice exhibited endothelial NAD+ depletion driven by an imbalance between NAMPT-mediated NAD+ biosynthesis and consumption, leading to impaired eNOS signaling and associated angiogenic and cardiometabolic dysfunction, similar to that observed in VeNKO mice. Nicotinamide mononucleotide administration replenished vascular endothelial NAD+ levels, improved angiogenesis, restored subcutaneous adipose tissue volume, and ameliorated aging-associated cardiometabolic dysfunction. Collectively, our findings provide mechanistic and therapeutic insights into vascular endothelial NAMPT-NAD+-SIRT1-eNOS signaling related to aging-associated cardiometabolic disorders.

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A systematic review to compare adrenalectomy and mineralocorticoid receptor antagonists in patients with unilateral primary aldosteronism.

Yuichi Yoshida, Kenichiro Kinouchi, Satoshi Nagai, Atsushi Sakima, Yoichi Takami, Hisatomi Arima, Kazutoshi Miyashita, Masashi Mukoyama

Hypertension research : official journal of the Japanese Society of Hypertension 48 ( 9 ) 2368 - 2375 2025.09

Lead author, Last author, Corresponding author, Accepted, ISSN 0916-9636

To date, no systematic review has examined whether adrenalectomy (ADX) or mineralocorticoid receptor antagonist (MRA) treatment is more effective in patients with unilateral primary aldosteronism (uPA). Comparing clinical and biochemical data before and after treatment, we performed a systematic review to determine whether either ADX or MRA treatment is superior to the other in patients with uPA. Article search was performed using the PubMed, Cochrane Library, and ICHUSHI electronic databases. A comparative analysis was performed when at least 3 articles were available in each outcome. The collected data were used to calculate the effect measures represented as mean difference (MD) or odds ratio (OR). Our search strategy identified 526 abstracts, of which 7 research papers were finally included in the analysis. ADX for uPA patients significantly reduced the incidence of cerebro-cardiovascular disease (OR 0.63 [95% confidence interval 0.46, 0.85]), lowered the systolic BP (-8.78 mmHg [-11.61, -5.95]), and increased the serum potassium levels (0.43 mmol/L [0.35, 0.51]) compared to MRAs. In conclusion, ADX is more effective than MRA treatment in patients with uPA, but with higher risk of increased serum potassium levels. Graphical abstract: ADX adrenalectomy, MRAs mineralocorticoid receptor antagonists, PA primary aldosteronism, SBP systolic blood pressure.

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131I-MIBG治療により遅発的に血糖値改善が得られた糖尿病合併褐色細胞腫の1例

中村俊文, 川野義長, 水谷洋佑, 木内謙一郎, 林香

日本内科学会関東地方会 (日本内科学会-関東地方会) 705回 np27 - np27 2025.06

Lead author, Last author, Corresponding author

甲状腺癌術前CT検査で偶発的に発見された巨大下垂体腫瘍を伴う先端巨大症の一例

小宮山紘史, 中村俊文, 水谷洋佑, 木内謙一郎, 植田良, 林香

日本内分泌学会雑誌 ((一社)日本内分泌学会) 101 ( 1 ) 390 - 390 2025.05

Lead author, Last author, Corresponding author, ISSN 0029-0661

下垂体卒中を合併した先端巨大症の一例

神戸理紗, 水谷洋佑, 中村俊文, 木内謙一郎, 植田良, 林香

日本内分泌学会雑誌 ((一社)日本内分泌学会) 101 ( 1 ) 368 - 368 2025.05

Lead author, Last author, Corresponding author, ISSN 0029-0661

副腎静脈サンプリングおよびアドステロールシンチグラフィにより治療方針を検討したPPNADの1例

吉岡桜子, 中村俊文, 水谷洋佑, 木内謙一郎, 田村全, 中塚誠之, 武田利和, 林香

日本内分泌学会雑誌 ((一社)日本内分泌学会) 101 ( 1 ) 308 - 308 2025.05

Lead author, Last author, Corresponding author, ISSN 0029-0661

右側腹部痛を契機に診断された、ACTH抑制がみられなかったCushing症候群を伴う副腎癌の1例

田倉裕介, 木内謙一郎, 中村俊文, 水谷洋佑, 武田利和, 林香

日本内分泌学会雑誌 ((一社)日本内分泌学会) 101 ( 1 ) 388 - 388 2025.05

Lead author, Last author, Corresponding author, ISSN 0029-0661

Endocrinology in maternal-fetal synchronization and developmental origins of susceptibility to metabolic diseases

Kenichiro Kinouchi, Hiroshi Itoh

Endocrine Journal 2025

Lead author, Last author, Corresponding author, Accepted, ISSN 0918-8959

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On the imperative of including 24-h and longitudinal multidimensional physiological phenotyping in rodent models of sleep apnea

Gaucher, J., Vial, G., Bouyon, S., Brian?on-Marjollet, A., Faury, G., Arnaud, C., Bailly, S., Tamisier, R., Kinouchi, K., Baldi, P., Gozal, D., P{\'e}pin, J.-L.

Sleep Medicine 127 133 - 137 2025

Lead author, Last author, Corresponding author, ISSN 1878-5506

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造影CT検査では同定困難であったインスリノーマの1例

大曽根史織, 木内謙一郎, 浅井愛未, 水谷洋佑, 中村俊文, 田村全, 中塚誠之, 北郷実, 林香

日本内分泌学会雑誌 ((一社)日本内分泌学会) 100 ( 2 ) 626 - 626 2024.10

Lead author, Last author, Corresponding author, ISSN 0029-0661

ACTH依存性にテストステロン産生を来した副腎機能低下症の一例

浅井愛未, 中村俊文, 水谷洋佑, 木内謙一郎, 小林佐紀子, 石井智弘, 林香

日本内分泌学会雑誌 ((一社)日本内分泌学会) 100 ( 2 ) 604 - 604 2024.10

Lead author, Last author, Corresponding author, ISSN 0029-0661

低Ca血症の精査で診断に至った偽性副甲状腺機能低下症の1例

三角昂之, 木内謙一郎, 水谷洋佑, 中村俊文, 石井智弘, 林香

日本内分泌学会雑誌 ((一社)日本内分泌学会) 100 ( 2 ) 620 - 620 2024.10

Lead author, Last author, Corresponding author, ISSN 0029-0661

COVID-19に両側副腎出血を続発した抗リン脂質抗体症候群の1例

豊浦文, 中村俊文, 水谷洋佑, 木内謙一郎, 林侑太朗, 林香

日本内分泌学会雑誌 ((一社)日本内分泌学会) 100 ( 2 ) 645 - 645 2024.10

Lead author, Last author, Corresponding author, ISSN 0029-0661

原発性アルドステロン症における腎周囲脂肪蓄積の臨床的意義

満野竜ノ介, 中村俊文, 金子賢司, 児島大輝, 中村健吾, 水谷洋佑, 山田祥岳, 畔上達彦, 神田武志, 木内謙一郎, 吉野純, 林香

日本内分泌学会雑誌 ((一社)日本内分泌学会) 100 ( 2 ) 642 - 642 2024.10

Lead author, Last author, Corresponding author, ISSN 0029-0661

造影剤アレルギーのため炭酸ガス造影とcone beam CTで副腎静脈サンプリングを行った原発性アルドステロン症の一例

吉岡桜子, 木内謙一郎, 中村俊文, 水谷洋佑, 小林佐紀子, 乃村元子, 中塚誠之, 田村全, 林香

日本内分泌学会雑誌 ((一社)日本内分泌学会) 100 ( 1 ) 392 - 392 2024.05

Lead author, Last author, Corresponding author, ISSN 0029-0661

オシロドロスタット投与により病勢のコントロールが得られたクッシング病の一例

増田佳奈子, 木内謙一郎, 中村俊文, 水谷洋佑, 小林佐紀子, 乃村元子, 伊藤裕, 林香

日本内分泌学会雑誌 ((一社)日本内分泌学会) 100 ( 1 ) 370 - 370 2024.05

Lead author, Last author, Corresponding author, ISSN 0029-0661

保険収載後に施行したラジオ波焼灼術で奏功が確認されたアルドステロン産生腺腫の1例

三角昂之, 中村俊文, 水谷洋佑, 木内謙一郎, 小林佐紀子, 中塚誠之, 田村全, 林香

日本内分泌学会雑誌 ((一社)日本内分泌学会) 100 ( 1 ) 424 - 424 2024.05

Lead author, Last author, Corresponding author, ISSN 0029-0661

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