Kawano, Yoshinaga

写真a

Affiliation

School of Medicine, Department of Internal Medicine (Nephrology, Endocrinology and Metabolism) (Shinanomachi)

Position

Senior Assistant Professor (Non-tenured)/Assistant Professor (Non-tenured)

Profile 【 Display / hide

  • My main research interest is immunometabolism especially in intestinal immunity in the pathophysiology of insulin resistance. My master’s thesis is the role of Foxo1 in Macrophage in glucose metabolism. I clarified that Foxo1 in macrophage induced Ccr2 expression and deteriorated Visceral Adipose Tissue (VAT) inflammation and systemic Insulin resistance (Kawano Y et al. Diabetes. 2012). After graduate school, he became interested in gut immunity in HFD induced insulin resistance, because he found that pro-inflammatory macrophages infiltrate into colon earlier than into VAT. He currently reported that colonic pro-inflammatory macrophage could play important roles in the mechanism of HFD induced insulin resistance (Kawano Y et al. Cell metabolism. 2016)

Career 【 Display / hide

  • 2007.04
    -
    2009.03

    Residency: Keio University Hospital, JPN, Keio University Hospital, Residency

  • 2009.04
    -
    2013.03

    Fellowship: Keio University Hospital, JPN Division of Endocrinology, Metabolism, Nephrology, Keio University Hospital, JPN Division of Endocrinology, Metabolism, Nephrology, Fellowship

  • 2013.04
    -
    2016.03

    Assistant Professor, Keio University School of Medicine, JPN. Division of Endocrinology, Metabolism, Nephrology, Keio University School of Medicine, JPN. Division of Endocrinology, Metabolism, Nephrology, Assistant Professor

  • 2017.04
    -
    Present

    Designated Assistant Professor, Keio University School of Medicine, JPN. Division of Endocrinology, Metabolism, Nephrology, Keio University School of Medicine, JPN Division of Endocrinology, Metabolism, Nephrology, Designated Assistant Professor

Academic Background 【 Display / hide

  • 2002.04
    -
    2007.03

    Keio University School of Medicine,, Medicine

    Graduated, Other

  • 2009.04
    -
    2013.03

    Keio University School of Medicine. Graduate School Division of Endocrinology, Metabolism, Nephrology, Keio University School of Medicine. Graduate School

    Graduated, Doctoral course

Academic Degrees 【 Display / hide

  • M.D. (degree awarded date: 3/2007), Keio University School of Medicine, 2007.03

  • Ph.D. (degree awarded date: 3/2013), Keio University School of Medicine, Dissertation, 2013.03

    Kawano Y, Nakae J, Watanabe N, Fujisaka S, Iskandar K, Sekioka R, Hayashi Y, Tobe K, Kasuga M, Noda T, Yoshimura A, Onodera M, Itoh H. Loss of PDK1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance. Diabetes 61: 2012. 1935-48

Licenses and Qualifications 【 Display / hide

  • Medical License, 2007.03

  • • 2008 - Present Board certified member of the Japanese society of Internal Medicine, 2008

  • • 2012 - Present Board certified member of the Japan Diabetes Society

 

Research Areas 【 Display / hide

  • Life Science / Immunology

  • Life Science / Metabolism and endocrinology

Research Keywords 【 Display / hide

  • Insulin Resistance

  • Diabetes

  • Immuno-metabolism

  • Intestinal Immunity

Research Themes 【 Display / hide

  • Physiological roles of gut immunity in high fat diet induced insulin resistance, 

    2012
    -
    Present

  • 糖・エネルギー代謝における免疫細胞Foxoの役割, 

    2008
    -
    Present

 

Papers 【 Display / hide

  • Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-dependent Manner

    Kawano Y, Nakae J, Watanabe N, Kikuchi T, Tateya S, Tamori Y, Kaneko M, Abe T, Onodera M, Itoh H.

    Cell Metabolism, 24:2016, 295-310  2016

    Research paper (scientific journal)

  • Novel repressor regulates insulin sensitivity through interaction with Foxo1. 

    Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi S, Itoh H

    EMBO J.  2012

    Research paper (scientific journal)

  • Loss of PDK1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance.

    Kawano Y, Nakae J, Watanabe N, Fujisaka S, Iskandar K, Sekioka R, Hayashi Y, Tobe K, Kasuga M, Noda T, Yoshimura A, Onodera M, Itoh H.

    Diabetes  2012

    Research paper (scientific journal)

Papers, etc., Registered in KOARA 【 Display / hide

Presentations 【 Display / hide

  • Invited Presentator at the 38th Annual Meeting of Japan Society for the study of Obesity (2017)

    Kawano Yoshinaga

    2017

    Symposium, workshop panel (public)

Research Projects of Competitive Funds, etc. 【 Display / hide

  • • JSPS KAKENHI Grant Number JP16K19546

     

    No Setting

Awards 【 Display / hide

  • • 2015 Young Investigator’s Award of The Japan Endocrine Society

    2015

  • • 2015 Young Investigator’s Award of The Japan Society for the study of obesity

    2015

  • • 2015 Young Investigator’s Award of The Japan Society for the study of obesity

    2015

  • • 2015 Young Investigator’s Award of The Japan Endocrine Society

    2015

 

Courses Previously Taught 【 Display / hide

  • Internal Medicine

    Keio University School of Medicine

    2018.04
    -
    2019.03

  • Diabetology

    Keio University School of Medicine

    2018.04
    -
    2019.03

  • Medical Student Educator

    Keio University

    2016.04
    -
    2017.03

    Seminar, 40h

  • Medical Student Educator

    Keio University

    2015.04
    -
    2016.03

    Seminar, 40h, 100people

  • Medical Student Educator

    Keio University

    2014.04
    -
    2015.03

    Seminar, 40h

Educational Activities and Special Notes 【 Display / hide

  • Medical Student Educator. Best teacher award in Keio University School of Medicine 2014, 2015, 2016

    2014.04
    -
    2016.03

    , Special Affairs