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Affiliation
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School of Medicine, Department of Internal Medicine (Nephrology, Endocrinology and Metabolism) (Shinanomachi)
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Position
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Assistant Professor/Senior Assistant Professor
Kawano, Yoshinaga
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Profile 【 Display / hide 】
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My main research interest is immunometabolism especially in intestinal immunity in the pathophysiology of insulin resistance. My master’s thesis is the role of Foxo1 in Macrophage in glucose metabolism. I clarified that Foxo1 in macrophage induced Ccr2 expression and deteriorated Visceral Adipose Tissue (VAT) inflammation and systemic Insulin resistance (Kawano Y et al. Diabetes. 2012). After graduate school, he became interested in gut immunity in HFD induced insulin resistance, because he found that pro-inflammatory macrophages infiltrate into colon earlier than into VAT. He currently reported that colonic pro-inflammatory macrophage could play important roles in the mechanism of HFD induced insulin resistance (Kawano Y et al. Cell metabolism. 2016)
Career 【 Display / hide 】
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2007.04-2009.03
Residency: Keio University Hospital, JPN, Keio University Hospital, Residency
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2009.04-2013.03
Fellowship: Keio University Hospital, JPN Division of Endocrinology, Metabolism, Nephrology, Keio University Hospital, JPN Division of Endocrinology, Metabolism, Nephrology, Fellowship
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2013.04-2016.03
Assistant Professor, Keio University School of Medicine, JPN. Division of Endocrinology, Metabolism, Nephrology, Keio University School of Medicine, JPN. Division of Endocrinology, Metabolism, Nephrology, Assistant Professor
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2017.04-Present
Designated Assistant Professor, Keio University School of Medicine, JPN. Division of Endocrinology, Metabolism, Nephrology, Keio University School of Medicine, JPN Division of Endocrinology, Metabolism, Nephrology, Designated Assistant Professor
Academic Background 【 Display / hide 】
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2002.04-2007.03
Keio University School of Medicine,, Medicine
Graduated, Other
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2009.04-2013.03
Keio University School of Medicine. Graduate School Division of Endocrinology, Metabolism, Nephrology, Keio University School of Medicine. Graduate School
Graduated, Doctoral course
Academic Degrees 【 Display / hide 】
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M.D. (degree awarded date: 3/2007), Keio University School of Medicine, 2007.03
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Ph.D. (degree awarded date: 3/2013), Keio University School of Medicine, Dissertation, 2013.03
Kawano Y, Nakae J, Watanabe N, Fujisaka S, Iskandar K, Sekioka R, Hayashi Y, Tobe K, Kasuga M, Noda T, Yoshimura A, Onodera M, Itoh H. Loss of PDK1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance. Diabetes 61: 2012. 1935-48
Licenses and Qualifications 【 Display / hide 】
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Medical License, 2007.03
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• 2008 - Present Board certified member of the Japanese society of Internal Medicine, 2008
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• 2012 - Present Board certified member of the Japan Diabetes Society
Research Areas 【 Display / hide 】
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Life Science / Immunology
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Life Science / Metabolism and endocrinology
Research Keywords 【 Display / hide 】
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Insulin Resistance
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Diabetes
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Immuno-metabolism
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Intestinal Immunity
Research Themes 【 Display / hide 】
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Physiological roles of gut immunity in high fat diet induced insulin resistance,
2012-Present -
糖・エネルギー代謝における免疫細胞Foxoの役割,
2008-Present
Papers 【 Display / hide 】
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Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-dependent Manner
Kawano Y, Nakae J, Watanabe N, Kikuchi T, Tateya S, Tamori Y, Kaneko M, Abe T, Onodera M, Itoh H.
Cell Metabolism, 24:2016, 295-310 2016
Research paper (scientific journal)
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Novel repressor regulates insulin sensitivity through interaction with Foxo1.
Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi S, Itoh H
EMBO J. 2012
Research paper (scientific journal)
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Loss of PDK1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance.
Kawano Y, Nakae J, Watanabe N, Fujisaka S, Iskandar K, Sekioka R, Hayashi Y, Tobe K, Kasuga M, Noda T, Yoshimura A, Onodera M, Itoh H.
Diabetes 2012
Research paper (scientific journal)
Papers, etc., Registered in KOARA 【 Display / hide 】
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The physiological roles of intestinal immunity in high fat diet induced insulin resistance
Kawano, Yoshinaga
科学研究費補助金研究成果報告書 2017
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Physiological roles of intestinal macrophage Foxo1 in HFD-induced insulin resistance
Kawano, Yoshinaga
科学研究費補助金研究成果報告書 2015
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Kawano, Yoshinaga
科学研究費補助金研究成果報告書 2012
Presentations 【 Display / hide 】
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Invited Presentator at the 38th Annual Meeting of Japan Society for the study of Obesity (2017)
Kawano Yoshinaga
2017,Symposium, workshop panel (public)
Research Projects of Competitive Funds, etc. 【 Display / hide 】
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Dietary sugar disrupt the commensal gut immune system leading to metabolic disorders
2024.04-2027.03基盤研究(C), Principal investigator
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• JSPS KAKENHI Grant Number JP16K19546
No Setting
Awards 【 Display / hide 】
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• 2015 Young Investigator’s Award of The Japan Endocrine Society
2015
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• 2015 Young Investigator’s Award of The Japan Society for the study of obesity
2015
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• 2015 Young Investigator’s Award of The Japan Society for the study of obesity
2015
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• 2015 Young Investigator’s Award of The Japan Endocrine Society
2015
Courses Previously Taught 【 Display / hide 】
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Internal Medicine
Keio University School of Medicine
2018.04-2019.03 -
Diabetology
Keio University School of Medicine
2018.04-2019.03 -
Medical Student Educator
Keio University
2016.04-2017.03,Seminar, 40h
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Medical Student Educator
Keio University
2015.04-2016.03,Seminar, 40h, 100people
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Medical Student Educator
Keio University
2014.04-2015.03,Seminar, 40h
Educational Activities and Special Notes 【 Display / hide 】
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Medical Student Educator. Best teacher award in Keio University School of Medicine 2014, 2015, 2016
2014.04-2016.03, Special Affairs