KEIO RESEARCHERS INFORMATION SYSTEM

Other Affiliation 【 Display / hide 】

Other Affiliation 【 Display / hide 】

• School of Medicine, Vice Dean

• Keio Information Technology Center, Deputy Director

• 教学マネジメント推進センター, Deputy Director

Career 【 Display / hide 】

Career 【 Display / hide 】

• 1991.04

  -

  1992.03

  慶應義塾大学病院内科研修医

• 1996.01

  -

  1998.12

  学術振興会特別研究員(PD)

• 1999.01

  -

  1999.06

  慶應義塾大学医学部助手（医学部）

• 1999.07

  -

  2002.03

  Division of Nephrology, University of Washington Research Fellow

• 2002.04

  -

  2007.03

  慶應義塾大学医学部腎臓内分泌代謝内科助手

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Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1991

  Keio University, School of Medicine

  University, Graduated

• 1996.03

  Keio University, Graduate School, Division of Medicine, 内科学

  Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士（医学）, Keio University, Coursework, 1996.03

Licenses and Qualifications 【 Display / hide 】

Licenses and Qualifications 【 Display / hide 】

• 医師免許, 1991.05

• 日本内科学会認定内科医, 1996.09

• 労働衛生コンサルタント（保健衛生）, 1998.06

• 日本腎臓学会腎臓専門医, 2003.04

• 日本透析医学会専門医, 2005.04

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Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Life Science / Nephrology (Nephrology)

• 医学教育学

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• 医学教育学

• electrolyte, acid-base disorder

Research Themes 【 Display / hide 】

Research Themes 【 Display / hide 】

• Interprofessional education, 

  2011.04

  -

  Present

• 医学教育学, 

  2011.04

  -

  Present

• electrolyte, acid-base disorder, 

  2002.04

  -

  Present

• development and induction of renal tubular cells, 

  2002.04

  -

  Present

Books 【 Display / hide 】

Books 【 Display / hide 】

• ハルペリン 病態から考える電解質異常

  Kamel S. Kamel、Mitchell L. Halperin著、門川俊明 翻訳, メディカルサイエンスインターナショナル, 2018.06

• なぜパターン認識だけで腎病理は読めないのか?

  MONKAWA TOSHIAKI, 医学書院, 2017.05

• 電解質輸液塾

  MONKAWA TOSHIAKI, 中外医学社, 2013.04

• レジデントのための血液透析患者マネジメント

  MONKAWA TOSHIAKI, 医学書院, 2011.06

• 研究留学術

  MONKAWA TOSHIAKI, 医歯薬出版, 2002.07

Papers 【 Display / hide 】

Papers 【 Display / hide 】

• Combining hemodialysis with peritoneal dialysis improves cognitive function: a three-case report

  Maruki T., Nakayama T., Morimoto K., Uchiyama K., Washida N., Mitsuno R., Tonomura S., Hama E.Y., Kusahana E., Yoshimoto N., Hishikawa A., Hagiwara A., Azegami T., Yoshino J., Monkawa T., Yoshida T., Yamaguchi S., Hayashi K.

  CEN Case Reports 13 ( 6 ) 517 - 521 2024.12

  　View Summary

  Chronic kidney disease (CKD) is associated with multiple complications, with recent scholarly attention underscoring cognitive impairment as a salient manifestation. Considering societal aging, preserving cognitive function has emerged as an urgent medical concern. Prolonged dialysis, encompassing hemodialysis (HD) and peritoneal dialysis (PD), has been associated with a decline in cognitive function. Here, we present the cases of three patients undergoing PD who exhibited a noticeable improvement in cognitive function upon the initiation of HD. One patient had exhibited mild cognitive decline, whereas the remaining two presented more severe impairment. Apart from a mild tendency for fluid retention, none of the three patients exhibited abnormalities in physical or imaging examinations. Evaluation using the Japanese version of the Montreal Cognitive Assessment (MoCA-J) yielded decreased scores across multiple domains, notably in executive and attention functions. However, after HD initiation, all patients demonstrated a marked enhancement in multiple MoCA-J parameters, accompanied by a significant improvement in subjective symptoms. Moreover, improvements in anemia and hypoalbuminemia were observed in all three patients, whereas consistent trends in other parameters were absent. These clinical observations suggest that the integration of HD into the therapeutic regimen of patients undergoing PD may enhance cognitive function, highlighting the contributory roles of hemoglobin and albumin in CKD-associated cognitive impairment.

  • Access to Document (DOI)

• Development of a validated assessment tool for medical students using simulated patients: an 8-year panel survey

  Haruta J., Nakajima R., Monkawa T.

  BMC Medical Education 24 ( 1 )  2024.12

  　View Summary

  Background: The use of simulated patients (SPs) to assess medical students’ clinical performance is gaining prominence, underscored by patient safety perspective. However, few reports have investigated the validity of such assessment. Here, we examined the validity and reliability of an assessment tool that serves as a standardized tool for SPs to assess medical students’ medical interview. Methods: This longitudinal survey was conducted at Keio University School of Medicine in Japan from 2014 to 2021. To establish content validity, the simulated patient assessment tool (SPAT) was developed by several medical education specialists from 2008 to 2013. A cohort of 36 SPs assessed the performance of 831 medical students in clinical practice medical interview sessions from April 2014 to December 2021. The assessment’s internal structure was analyzed using descriptive statistics (maximum, minimum, median, mean, and standard deviation) for the SPAT’s 13 item total scores. Structural validity was examined with exploratory factor analysis, and internal consistency with Cronbach’s alpha coefficients. The mean SPAT total scores across different SPs and scenarios were compared using one way analysis of variance (ANOVA). Convergent validity was determined by correlating SPAT with the post-clinical clerkship obstructive structured clinical examination (post-CC OSCE) total scores using Pearson’s correlation coefficient. Results: Of the 831 assessment sheets, 36 with missing values were excluded, leaving 795 for analysis. Thirty-five SPs, excluding one SP who quit in 2014, completed 795 assessments, for a response rate of 95.6%. Exploratory factor analysis revealed two factors, communication and physician performance. The overall Cronbach’s alpha coefficient was 0.929. Significant differences in SPAT total scores were observed across SPs and scenarios via one-way ANOVA. A moderate correlation (r =.212, p <.05) was found between SPAT and post-CC OSCE total scores, indicating convergent validity. Conclusions: Evidence for the validity of SPAT was examined. These findings may be useful in the standardization of SP assessment of the scenario-based clinical performance of medical students.

  • Access to Document (DOI)

• Efficacy of sucrose and povidone–iodine mixtures in peritoneal dialysis catheter exit-site care

  Nakayama T., Morimoto K., Uchiyama K., Washida N., Kusahana E., Hama E.Y., Mitsuno R., Tonomura S., Yoshimoto N., Hishikawa A., Hagiwara A., Azegami T., Yoshino J., Monkawa T., Yoshida T., Yamaguchi S., Hayashi K.

  BMC Nephrology 25 ( 1 )  2024.12

  　View Summary

  Background: Exit-site infection (ESI) is a common recurring complication in patients undergoing peritoneal dialysis (PD). Sucrose and povidone–iodine (SPI) mixtures, antimicrobial ointments that promote wound healing, have been used for the treatment of ulcers and burns, but their efficacy in exit–site care is still unclear. Methods: This single-center retrospective observational study included patients who underwent PD between May 2010 and June 2022 and presented with episodes of ESI. Patients were divided into SPI and non-SPI groups and followed up from initial ESI onset until PD cessation, death, transfer to another facility, or June 2023. Results: Among the 82 patients (mean age 62, [54–72] years), 23 were treated with SPI. The median follow-up duration was 39 months (range, 14–64), with an overall ESI incidence of 0.70 episodes per patient-year. Additionally, 43.1% of second and 25.6% of third ESI were caused by the same pathogen as the first. The log-rank test demonstrated significantly better second and third ESI-free survival in the SPI group than that in the non-SPI group (p < 0.01 and p < 0.01, respectively). In a Cox regression analysis, adjusting for potential confounders, SPI use was a significant predictor of decreased second and third ESI episodes (hazard ratio [HR], 0.22; 95% confidence interval [CI], 0.10–0.52 and HR, 0.22; 95%CI, 0.07–0.73, respectively). Conclusions: Our results showed that the use of SPI may be a promising option for preventing the incidence of ESI in patients with PD. Trial registration: This study was approved by the Keio University School of Medicine Ethics Committee (approval number 20231078) on August 28, 2023. Retrospectively registered.

  • Access to Document (DOI)

• The proteinuria selectivity index value predicts the remission of IgA nephropathy: a retrospective cohort study

  Mitsuno R., Nakayama T., Ito W., Maruki T., Nakamichi R., Adachi K., Yoshimoto N., Hishikawa A., Hagiwara A., Yamaguchi S., Monkawa T., Yoshino J., Hashiguchi A., Azegami T., Hayashi K.

  Renal Failure 46 ( 2 )  2024

  ISSN  0886022X

  　View Summary

  IgA nephropathy (IgAN) is the most common type of primary glomerulonephritis worldwide and leads to end-stage kidney disease. The proteinuria selectivity index (PSI) has been used to assess the prognosis in nephrotic syndrome, but its predictive value in patients with IgAN remains unclear. This single-center retrospective cohort study included patients who diagnosed with IgAN between March 2012 and March 2020. The PSI was calculated at the time of kidney biopsy. Patients were followed up from the time of kidney biopsy to kidney replacement therapy, death, transfer to another facility, or study completion. Ninety-four patients with a median age of 51 years were enrolled and divided according to the cutoff value of PSI determined by the receiver operating characteristic curve analysis into low-PSI (PSI <0.243, n = 39) and high-PSI groups (PSI ≥0.243, n = 55). The median follow-up duration was 70 months. Rates of remission of proteinuria and survival without a two-fold increase in serum creatinine were significantly better in the low-PSI group (both p < 0.01, log-rank test). Cox regression analysis showed that a low PSI was significantly associated with an increased likelihood of remission of proteinuria and hematuria (hazard ratio [HR] 1.96; 95% confidence interval [CI] 1.02–3.85 and HR 1.75; 95% CI 1.01–3.13, respectively), and a decreased risk of a two-fold increase in serum creatinine (HR 0.10; 95% CI 0.01–0.81). In conclusion, The PSI could have the potential to support the assessment of the prognosis of IgAN, in addition to established prognostic markers, by reflecting the overall glomerular permeability.

  • Access to Document (DOI)

• RECURRENT AND VIRTUAL EDUCATION FOR ALL DISCIPLINES AND OCCUPATIONS IN THE ALLERGY REALM：A SURVEY OF THE PARTICIPANTS FROM THE INITIATIVE 'OUTREACH LECTURES' TO CREATE EDUCATIONAL OPPORTUNITIES

  Masaki K., Sakashita M., Ogawa Y., Inomata T., Kainuma K., Kan-O K., Sato S., Tamari M., Nakajima S., Morita H., Kurashima Y., Futamura M., Takahashi K., Haruta J., Hyakutake M., Monkawa T., Ishizuka T., Imoto Y., Oyama N., Kanzaki S., Kidoguchi M., Fukushima A., Fukunaga K., Fujieda S., Yasutomi M., Adachi T.

  Japanese Journal of Allergology 73 ( 4 ) 329 - 339 2024

  ISSN  00214884

  　View Summary

  Background: In the enhancement of allergy care involving multidisciplinary and multiple medical departments, there is a perceived need for education that targets not only specialists but also non-specialists. However, research on the need for and methods of such education remains inadequate. Objective: To design a remote allergy care education program for all medical practitioners and to validate its necessity and utility. Methods: The Empowering Next Generation Allergist/immunologist toward Global Excellence Task Force (ENGAGE-TF), supported by the Japanese Society of Allergology, initiated a virtual educational program called 'Outreach Lectures' in collaboration with Keio University and Fukui University. This initiative was widely promoted through social media and various institutions, and a survey was conducted through its mailing list. Results: 1139 responses were obtained. More than half were physicians from non-allergy specialties, representing a diverse range of healthcare professions. Over 70% expressed being 'very satisfied, ' and over 60% found the difficulty level 'appropriate. ' Free-form feedback revealed differences in learning focus based on profession and learning approach based on years of experience. Conclusion: The high participation rate (90%) of non-specialist physicians underscores the demand for addressing allergic conditions in primary care. The effectiveness of virtual/recurrent education, particularly for healthcare professionals with over 11 years of experience, was implied. Further follow-up investigation focusing on quantitative and objective assessment of educational effectiveness is indispensable.

  • Access to Document (DOI)

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Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Master regulatory factors for regeneration and EMT of kidney tubular cells

  Monkawa, Toshiaki

  科学研究費補助金研究成果報告書 2017

• The direct differentiation method of renal tubular cells by master transcription factors identified from TF-inducible human ES bank

  Monkawa, Toshiaki

  科学研究費補助金研究成果報告書 2015

• An investigation of mechanism of progression of kidney disease using renal tubular cells differentiated from ES/iPS cells

  Monkawa, Toshiaki

  科学研究費補助金研究成果報告書 2014

• Mechanism of regeneration of renal tubular cells and differentiation from ES and iPS cells to renal tubular cells

  Monkawa, Toshiaki

  科学研究費補助金研究成果報告書 2011

Presentations 【 Display / hide 】

Presentations 【 Display / hide 】

• 慶應義塾大学における海外施設での臨床実習プログラム

  MONKAWA TOSHIAKI

  第49回日本教育学会大会, 

  2017.08

  , 

  Oral presentation (general)

• もう一度やり直す腎生理

  MONKAWA TOSHIAKI

  第46回日本腎臓学会東部学術大会, 

  2016.10

  , 

  Symposium, workshop panel (public)

• タブレット端末iPad配付と教学システムのデジタル化

  MONKAWA TOSHIAKI

  第48回日本教育学会大会, 

  2016.07

  , 

  Oral presentation (general)

• 腎臓専門医制度 腎臓専門医(内科)のカリキュラム

  MONKAWA TOSHIAKI

  第59回日本腎臓学会学術大会, 

  2016.06

  , 

  Symposium, workshop panel (public)

• K代謝異常

  MONKAWA TOSHIAKI

  第25回臨床内分泌代謝アップデート, 

  2015.11

  , 

  Symposium, workshop panel (nominated)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Master regulatory factors for regeneration and EMT of kidney tubular cells

  2015.04

  -

  2018.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

Awards 【 Display / hide 】

Awards 【 Display / hide 】

• Best Teacher

  2015.03, Keio University School of Medicine

• 日本内科学会奨励賞

  MONKAWA TOSHIAKI, 2004.04, 日本内科学会

  Type of Award： Award from Japanese society, conference, symposium, etc.

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• SYMPTOMATOLOGY

  2024

• PHARMACOLOGY FOR NURSING AND HEALTH CARE

  2024

• PATHOPHYSIOLOGY AND CLINICAL ASSESSMENT

  2024

• PATHOPHYSIOLOGICAL ISSUES IN CHRONIC CARE

  2024

• MEDICAL PROFESSIONALISM 4

  2024

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Courses Previously Taught 【 Display / hide 】

Courses Previously Taught 【 Display / hide 】

• 地域基盤型臨床実習

  Keio University

  2017.04

  -

  2018.03

  , 

  Full academic year, Laboratory work/practical work/exercise, Within own ｆaculty, 110people

• 選択臨床実習

  Keio University

  2017.04

  -

  2018.03

  , 

  Full academic year, Laboratory work/practical work/exercise

• 診断学実習

  Keio University

  2017.04

  -

  2018.03

  , 

  Full academic year, Laboratory work/practical work/exercise, Within own ｆaculty

• MEDICAL PROFESSIONALISM 4

  Keio University

  2015.04

  -

  2016.03

  , 

  Full academic year, Laboratory work/practical work/exercise, Within own ｆaculty, 118people

• CLINICAL REASONING

  Keio University

  2015.04

  -

  2016.03

  , 

  Full academic year, Laboratory work/practical work/exercise, Within own ｆaculty, 118people

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Educational Activities and Special Notes 【 Display / hide 】

Educational Activities and Special Notes 【 Display / hide 】

• なぜパターン認識だけで腎病理は読めないのか?

  2017.05

  , Development of Textbook and Teaching Material

• Denkaishitsu-Yueki-Juku

  2013.04

  , Development of Textbook and Teaching Material

• Management of hemodialysis patient for residents

  2011.06

  , Development of Textbook and Teaching Material

• Interprofessional education at Keio University

  2011.04

  -

  Present

  , Special Affairs

Social Activities 【 Display / hide 】

Social Activities 【 Display / hide 】

• 医学中央雑誌

  2010

  -

  Present

• 医学のあゆみ

  2007

  -

  Present

Memberships in Academic Societies 【 Display / hide 】

Memberships in Academic Societies 【 Display / hide 】

• 日本腎臓学会, 

  1995.11

  -

  Present

• 日本透析医学会

  　

• 日本内科学会

  　

• 日本医学教育学会, 

  2008

  -

  Present

Committee Experiences 【 Display / hide 】

Committee Experiences 【 Display / hide 】

• 2024.07

  -

  Present

  理事, 日本医学教育学会

• 2020.06

  -

  Present

  理事, 日本腎臓学会

• 1995.11

  -

  Present

  評議員, 日本腎臓学会

• 2008

  -

  Present

  representative, 日本医学教育学会

• 2010

  -

  Present

  Editor, 医学中央雑誌

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