TERASAWA Yuri

写真a

Affiliation

Faculty of Letters (Hiyoshi)

Position

Associate Professor

External Links
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Career 【 Display / hide 】

  • 2011.04
    -
    2014.03

    National Center of Neurology and Psychiatry, Department of Psychophysiology, 研究員

  • 2014.04
    -
    2019.03

    Keio University, Department of Psychology, Faculty of Literature, Assistant Professore

  • 2019.04
    -
    Present

    Keio University, Department of Psychology, Associate Professor

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Academic Background 【 Display / hide 】

  • 2001.04
    -
    2005.03

    Keio University, Faculty of Literature, Department of Psychology

    University, Graduated

  • 2005.04
    -
    2007.03

    Keio University, Graduate School of Human Relations, Department of Psychology

    Graduate School, Completed, Master's course

  • 2007.04
    -
    2010.03

    Keio University, Graduate School of Human Relations, Department of Psychology

    Graduate School, Withdrawal after completion of doctoral course requirements, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士(心理学), 慶應義塾大学, Coursework, 2013.02

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Research Areas 【 Display / hide 】

  • Humanities & Social Sciences / Experimental psychology

  • Life Science / Basic brain sciences

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Research Keywords 【 Display / hide 】

  • Interoception

  • Affective neuroscience

  • emotion

  • Neuropsychology

  • Cognitive neuroscience

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Books 【 Display / hide 】

  • The Neural Basis of Interoception

    Terasawa Y., Brewer R., Interoception A Comprehensive Guide, 2024.01

    　View Summary

    The underlying neural substrates of interoception have been a topic of research interest from the conceptualisation of interoception. In fact, many of the (multiple) definitions of interoception have drawn upon our understanding of neural pathways and brain regions in order to distinguish interoception from other forms of perception, and discriminate between separate facets of interoception. In this chapter, we review early and contemporary research on the neural substrates of interoception. We describe the neural and humoral pathways from peripheral sensors in the body (chemoreceptors, humoral receptors, specialised mechanoreceptors and free nerve endings) to the brain, for example via cranial nerves and spinal visceral afferents projecting to the brainstem. We then summarise the limbic and cortical regions involved in interoception, such as the thalamus, anterior insula and anterior cingulate cortex. We also discuss recent evidence regarding the integration of interoeptive information, and interactions between afferent and efferent signals at different points throughout the interoceptive neural networks. We end the chapter with a discussion of outstanding questions and priorities for future research.

  • Neurocognitive mechanisms of social anxiety and interoception

    Terasawa Y., Umeda S., Island of Reil (Insula) in the Human Brain: Anatomical, Functional, Clinical and Surgical Aspects, 2018.07

  • Island of Reil (Insula) in the Human Brain

    TERASAWA Yuri, UMEDA Satoshi, Springer, 2018.01

    Scope: Neurocognitive Mechanisms of Social Anxiety and Interoception

  • Memory in a Social Context

    Terasawa Yuri, Umeda Satoshi, Springer, 2017.12

    Scope: The impact of interoception on memory

    　View Summary

    <p>Using interoception as a keyword, this chapter has summarized how changes in the internal physical state are encoded and how the processing of interoceptive information affects the memory of episodes and events. Interoceptive information processing is discussed frequently in the context of emotion in psychology. On the other hand, research studies and literature that have examined its relation to episodic memory are rare. However, changes in the internal physical state exist at the foundation of various concepts that have examined its relationship with memory. To understand the relationship more precisely, we focused on the following issues in this chapter: emotional arousal and bodily responses; effects of bodily responses on memory encoding; judgment related to memories and bodily response; and insular cortex and memory consolidation. Throughout the chapter, we presented the possibility that change in the physical state itself plays a role in latently supporting the encoding and recollection process.</p>

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Papers 【 Display / hide 】

  • Paradoxical somatic information processing for interoception and anxiety in alexithymia

    Yuri Terasawa, Kentaro Oba, Yuki Motomura, Ruri Katsunuma, Hiroki Murakami, Yoshiya Moriguchi

    European Journal of Neuroscience (Wiley)  54 ( 11 ) 8052 - 8068 2021.11

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0953816X

    　View Summary

    The concept of alexithymia has garnered much attention in an attempt to understand the psychological mechanisms underlying the experience of feeling an emotion. In this study, we aimed to understand how the interoceptive processing in an emotional context relates to problems of alexithymia in recognizing self-emotions. Therefore, we prepared experimental conditions to induce emotional awareness based on interoceptive information. As such, we asked participants to be aware of interoception under an anxiety-generating situation anticipating pain, having them evaluate their subjective anxiety levels in this context. High alexithymia participants showed attenuated functional connectivity within their ‘interoception network’, particularly between the insula and the somatosensory areas when they focused on interoception. In contrast, they had enhanced functional connectivity between these regions when they focused on their anxiety about pain. Although access to somatic information is supposed to be more strongly activated while attending to interoception in the context of primary sensory processing, high alexithymia individuals were biased as this process was activated when they felt emotions, suggesting they recognize primitive and unprocessed bodily sensations as emotions. The paradoxical somatic information processing may reflect their brain function pathology for feeling emotions and their difficulty with context-dependent emotional control.

  • Effects of insular resection on interactions between cardiac interoception and emotion recognition

    Terasawa Y., Motomura K., Natsume A., Iijima K., Chalise L., Sugiura J., Yamamoto H., Koyama K., Wakabayashi T., Umeda S.

    Cortex (Cortex)  137   271 - 281 2021.04

    Accepted,  ISSN  00109452

    　View Summary

    The insular cortex is considered an important region for feeling emotions through interoception. Most studies that report the role of the insula in integrating interoception and emotion have used neuroimaging techniques such as functional magnetic resonance imaging (fMRI); however, there are limited neuropsychological studies. The effects of insular lesions on emotion and interoception have not been suitably investigated. In this study, we examined the role of the insular cortex in cardiac interoception and recognizing emotions from facial expressions by comparing them pre- and post-operatively in patients with glial tumors or brain metastases associated with the insular lobe. Although no significant difference in interoceptive accuracy was observed between the two phases, there were significant associations between the changes in interoceptive accuracy and sensitivity to expressions of anger and happiness. An increased error rate in the heartbeat counting task in the post-operation phase was associated with a decreased accuracy in recognizing anger and happiness. Since most patients had left insula lesions, generalizability of the findings to patients with right lesions is a future subject. To the best of our knowledge, this is the first study to examine the change in interoception and emotion after insular resection in humans. The study results indicate that removal of the insula affects the recognition of emotions such as anger and happiness through interoceptive processing.

  • Heartbeat evoked potentials reflect interoceptive awareness during an emotional situation

    Tanaka Y., Ito Y., Shibata M., Terasawa Y., Umeda S.

    Scientific Reports 15 ( 1 ) 8072 2025.12

    　View Summary

    Interoception, the ability to perceive internal bodily signals, involves various mental processes. This study investigated moments when individuals experienced a change in their interoceptive state. Interoception affects the subjective feelings of emotions. However, whether changes in interoceptive processing occur when visceral changes are perceived as interoceptive sensations remains unclear. This study examined the psychophysiological markers of perceptual changes in the interoceptive state using heartbeat evoked potentials (HEP). Emotional photos were viewed by participants who were asked whether they experienced changes in their interoceptive state. The results showed that the HEP amplitude increased when participants had subjective awareness of changes in their interoceptive state. Notably, the HEP amplitude did not correlate with individual differences in interoceptive accuracy measured by the heartbeat counting task. When individuals perceive changes in their interoceptive state, this perception is reflected in the HEP amplitude. Multiple aspects of interoception are related to the emotional recognition and conscious attention to changing bodily states.

  • Dynamic neural network modulation associated with rumination in major depressive disorder: a prospective observational comparative analysis of cognitive behavioral therapy and pharmacotherapy.

    Katayama N, Shinagawa K, Hirano J, Kobayashi Y, Nakagawa A, Umeda S, Kamiya K, Tajima M, Amano M, Nogami W, Ihara S, Noda S, Terasawa Y, Kikuchi T, Mimura M, Uchida H

    Translational psychiatry 15 ( 1 ) 267 2025.08

  • Reduced sensory attenuation is related to aberrant interoceptive influences on intentional binding in schizophrenia

    Koreki A., Terasawa Y., Oi H., Mouri T., Takenaka A., Koizumi T., Onaya M., Yogarajah M., Critchley H., Nuruki A.

    Psychiatry and Clinical Neurosciences Reports 4 ( 2 ) e70106 2025.06

    　View Summary

    Aim: Schizophrenia (SZ) is characterized by abnormalities in self-representation, including an aberrant sense of agency (SoA). Experimentally observed abnormalities in force matching and intentional binding tasks suggest that the SoA in SZ is compromised at the implicit level. However, these task effects have been reported independently, leading to inconsistencies that complicate the understanding of SZ pathophysiology. Methods: Thirty-three patients with SZ and 37 nonclinical (healthy) controls (HCs) performed force matching and intentional binding tasks. The former task assessed sensory attenuation, while the latter evaluated an intentional binding effect, both measuring implicit levels of SoA. We previously observed that the cardiac phase (systole vs diastole) influences intentional binding. Therefore, we investigated the relationship between sensory attenuation and intentional binding, including this “cardiac effect,” which refers to the influence of cardiac interoceptive signals. Results: In SZ, significantly reduced sensory attenuation, a greater but nonsignificant intentional binding effect, and a significant opposite cardiac effect were observed compared with HCs. Sensory attenuation and intentional binding were significantly and positively correlated in the SZ group but not in the HC group. Across all participants, sensory attenuation correlated with the cardiac effect on intentional binding. This effect remained significant in the HC group but not in the SZ group. Conclusion: Group differences and task associations suggest shared mechanisms and pathophysiology in SZ, potentially involving impaired predictive processes and the failure of sensory attenuation. The cardiac effect may be explained by interoceptive sensory attenuation, and its failure could lead to a disturbed SoA in patients with SZ.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 内受容感覚を媒介とするアロスタシスと感情

    寺澤 悠理, 是木 明宏

    BRAIN and NERVE (医学書院)  75 ( 11 ) 1251 - 1257 2023.11

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author

  • 内受容感覚とアロスタシスからみた精神疾患

    是木 明宏, 寺澤 悠理

    BRAIN and NERVE (医学書院)  75 ( 11 ) 1245 - 1250 2023.11

    Article, review, commentary, editorial, etc. (scientific journal), Joint Work

  • Effects of insular resection on interactions between cardiac interoception and emotion recognition

    Yuri Terasawa and Kazuya Motomura and Atsushi Natsume and Kentaro Iijima and Lushun Chalise and Junko Sugiura and Hiroyasu Yamamoto and Kyohei Koyama and Toshihiko Wakabayashi and Satoshi Umeda

    Cortex (Elsevier {BV})  137   271 - 281 2021.02

    Article, review, commentary, editorial, etc. (scientific journal)

  • Interoception and Mental Health: A Roadmap

    Khalsa, S.S. and Adolphs, R. and Cameron, O.G. and Critchley, H.D. and Davenport, P.W. and Feinstein, J.S. and Feusner, J.D. and Garfinkel, S.N. and Lane, R.D. and Mehling, W.E. and Meuret, A.E. and Nemeroff, C.B. and Oppenheimer, S. and Petzschner, F.H. and Pollatos, O. and Rhudy, J.L. and Schramm, L.P. and Simmons, W.K. and Stein, M.B. and Stephan, K.E. and Van den Bergh, O. and Van Diest, I. and von Leupoldt, A. and Paulus, M.P. and Ainley, V. and Al Zoubi, O. and Aupperle, R. and Avery, J. and Baxter, L. and Benke, C. and Berner, L. and Bodurka, J. and Breese, E. and Brown, T. and Burrows, K. and Cha, Y.-H. and Clausen, A. and Cosgrove, K. and Deville, D. and Duncan, L. and Duquette, P. and Ekhtiari, H. and Fine, T. and Ford, B. and Garcia Cordero, I. and Gleghorn, D. and Guereca, Y. and Harrison, N.A. and Hassanpour, M. and Hechler, T. and Heller, A. and Hellman, N. and Herbert, B. and Jarrahi, B. and Kerr, K. and Kirlic, N. and Klabunde, M. and Kraynak, T. and Kriegsman, M. and Kroll, J. and Kuplicki, R. and Lapidus, R. and Le, T. and Hagen, K.L. and Mayeli, A. and Morris, A. and Naqvi, N. and Oldroyd, K. and Pan{\'e}-Farr{\'e}, C. and Phillips, R. and Poppa, T. and Potter, W. and Puhl, M. and Safron, A. and Sala, M. and Savitz, J. and Saxon, H. and Schoenhals, W. and Stanwell-Smith, C. and Teed, A. and Terasawa, Y. and Thompson, K. and Toups, M. and Umeda, S. and Upshaw, V. and Victor, T. and Wierenga, C. and Wohlrab, C. and Yeh, H.-W. and Yoris, A. and Zeidan, F. and Zotev, V. and Zucker, N.

    Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 3 ( 6 ) 501 - 513 2018

    ISSN  24519030 24519022

  • 感情認識における島皮質の機能

    TERASAWA Yuri

    神経心理学 30 ( 1 ) 61 - 68 2014.03

    Article, review, commentary, editorial, etc. (scientific journal)

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Presentations 【 Display / hide 】

  • TEMPORAL AND AFFECTIVE ORIENTATION OF THOUGHT IN DEPRESSION AND ANXIETY: AN ERP AND HEP STUDY

    Ito, Yuichi, Shibata, Midori, Tanaka, Yuto, Terasawa, Yuri, Umeda, Satoshi

    PSYCHOPHYSIOLOGY, 

    2017.12
    , 

    Poster presentation

  • FEELING CHANGES OF INTERNAL BODILY STATE DURING EMOTIONAL RECOGNITION: AN ERP AND HEP STUDY

    Tanaka, Yuto, Ito, Yuichi, Shibata, Midori, Terasawa, Yuri, Umeda, Satoshi

    PSYCHOPHYSIOLOGY, 

    2017.12
    , 

    Poster presentation

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • The influence of interoceptive abilities on emotion recognition

    2024.04
    -
    2028.03

    Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), No Setting

    　View Summary

    本研究では不安傾向やアレキシサイミア(失感情語症)傾向に着目し、感情の認識に内受容感覚(身体内部状態の知覚)の諸側面が及ぼす影響を検討し、因果関係の解明と効果的な介入方法の確立を目指す。感情認識と内受容感覚の関連性は、広く研究者の興味をひいてきた一方、内受容感覚の測定方法の信頼性・妥当性の問題や、複数の測定方法のそれぞれが何を測定対象にしているのか、という議論がないがしろにされた状況にある。不安やアレキシサイミアなどの感情認識傾向との関係性を把握した後に、それぞれの傾向と特に強く関連した内受容感覚の側面を変化させるトレーニングを実施し、その変化が感情認識に及ぼす影響を明らかにする。

  • 眼窩前頭皮質の自律神経機能解明：脳神経外科学・認知神経機能学からの統合的理解

    2024.04
    -
    2027.03

    Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), No Setting

    　View Summary

    この研究において、自律神経機能の同定と機能温存、経時的な機能回復を目的とした次世代型覚醒下手術法の確立を目標とする。また、自律神経系ネットワークの早期回復を目指し、脳腫瘍患者の術後の生命予後の改善のみならず、機能予後改善を図ることを主眼に置いた治療を行う。
    眼窩前頭皮質が自律神経と密接に関わることをヒトで検討できる脳神経外科学と、ヒトの感情や自律神経機能を多角的に捉えることができる認知神経科学が、分野融合型の共同研究を行うことは大変意義深いと考える。

  • 気圧変化に伴う自律神経の応答と気分の揺らぎに関する認知神経科学研究

    2022.06
    -
    2026.03

    Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Pioneering), No Setting

    　View Summary

    我が国では気分障害の患者数が非常に多く，その原因となるメカニズム解明が求められている．実際，さまざまな療法では症状の改善が見られない「ノンリスポンダー」も一定数含まれる．その背景には，自律神経の応答性に個人差がある点，および自らの心臓の動きなどの自律神経活動の変化をどれだけ正確に感じ取ることができるかを示す指標である「内受容感覚」にも個人差がある点が関与している．また生活環境内には，気圧の変化など，自律神経活動を大きく作用する要因がある．そこで本研究では，気圧変化が気分変化とどのような関係にあるかについて，「心ー脳ー身体ー環境」の4者関係の複雑なメカニズム解明を通して明らかにする予定である．
    本研究は，精神疾患における気分のゆらぎと身体化の原因について，生活環境要因と心理的要因の効果を統合的に分析することを目的としている．気分の揺らぎはさまざまな原因によって起こる上に，身体化の背景には非常に複雑な要因が関わるため，身体生理機能・中枢神経機能に加え，主観的指標・客観的指標の両者を用いた心理的機能に着目する必要がある．今年度は，気圧の変化およびそれに対する内受容感覚に着目した実験を実施した．具体的には，身体化のなかでも慢性疼痛に深く関与されると考えられる気圧変化の影響について，健常者および身体症状症の症例を対象とした研究を実施した．特に，さまざまな部位に痛みが生じている患者に対して，複数の質問紙による主観報告を確認し，意思決定や感情処理のバイアスかあるか，痛み閾値に特殊性が見出されるか，痛みの感じ方に違いはあるか，などの側面について徹底的な解析を行い，さらに気圧変化時の自律神経動態について詳しく調べた．また自律神経に変化が生じていない状態および生じている状態における内受容感覚を詳細に調べ，主観・客観の両側面から多角的な実験データが取得できた．正確な感知が困難である気圧の変化に対する予測的反応性に着目し，自律神経の反応性をパターン別に分析し，それらの違いがどのような要因によって説明できるかを統合的に解析した．今後も，この実験と解析を継続し，総合的な観点から気分のゆらぎや痛みが生起されるメカニズムについて調べる．
    身体症状症研究については，当初，倫理審査審査に時間を要していたが，今年度は順調にリクルートが進み，順調なデータの取得ができている．臨床研究はさまざまな要因によって実験が計画通りに進まないことが多いが，本研究はその点では非常に順調に実験が進められており，データ解析も計画通りに進行している．このペースで次年度の研究も進める予定である．今後は対照となる健常者の実験も同時並行で進めることで，研究の遅れが出ないように工夫する．
    上述のとおり，本研究の遂行は順調であり，今後は患者群に加え，健常群対象の実験も同時並行で進める予定である．データが安定している部分については，積極的に学会での発表などを行い，専門家の意見を広く取り入れ，データの解釈に活かしていく予定である．

  • Investigating the autonomic nervous system function associated with the insular cortex using awake brain mapping

    2021.04
    -
    2024.03

    Nagoya University, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), No Setting

    　View Summary

    本研究では、倫理委員会の承認を得て、島回摘出により自律神経機能がどのように変化するかを解析する。さらに、覚醒下手術中に島皮質を直接刺激し、心電図、心拍数、血圧変化の測定、さらに心拍検出課題を行うことで、島皮質における自律神経機能活動の神経基盤を解明し、自律神経機能の同定と機能温存、経時的な機能回復を目的とした次世代型覚醒下手術法の確立を目標とする。
    島皮質が自律神経と密接に関わることをヒトで検討できる脳神経外科学と、ヒトの感情や自律神経機能を多角的に捉えることができる認知神経科学が、分野融合型の共同研究を行うことは大変意義深いと考える。

  • Somatic symptoms and distortions of emotion and thought: Cognitive neuroscientific approach

    2020.04
    -
    2023.03

    Keio University, Grants-in-Aid for Scientific Research, Umeda Satoshi, Grant-in-Aid for Scientific Research (A), No Setting

    　View Summary

    Somatic symptoms disorder, in which patients complain of pain and other physical symptoms even though there are no obvious symptoms of physical disease, actually occurs in a considerable number of cases, and certain types of psychotherapy are found to be effective. However, the mechanisms underlying their symptoms are not fully understood. In the present study, we focused on three factors highly involved in the occurrence of symptoms: predictive autonomic nervous functions at the body level, interoceptive accuracy, and distortion of thought, and examined them in detail. The results showed that similar changes in autonomic nervous activities were observed not only in the situation of actual atmospheric pressure fluctuations, but also in the situation of merely predicting them, and that the degrees of those changes were partially associated with interoception, somatic symptom characteristics and the degree of distortion of thought.

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Courses Taught 【 Display / hide 】

  • SEMINAR IN COGNITIVE PSYCHOLOGY 2

    2025

  • SEMINAR IN COGNITIVE PSYCHOLOGY 1

    2025

  • PSYCHOLOGY OF EMOTION

    2025

  • PSYCHOLOGY 2

    2025

  • PSYCHOLOGY 1

    2025

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