Faculty of Letters (Hiyoshi)


Associate Professor

External Links

Career 【 Display / hide

  • 2011.04

    National Center of Neurology and Psychiatry, Department of Psychophysiology, 研究員

  • 2014.04

    Keio University, Department of Psychology, Faculty of Literature, Assistant Professore

  • 2019.04

    Keio University, Department of Psychology, Associate Professor

Academic Background 【 Display / hide

  • 2001.04

    Keio University, Faculty of Literature, Department of Psychology

    University, Graduated

  • 2005.04

    Keio University, Graduate School of Human Relations, Department of Psychology

    Graduate School, Completed, Master's course

  • 2007.04

    Keio University, Graduate School of Human Relations, Department of Psychology

    Graduate School, Withdrawal after completion of doctoral course requirements, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(心理学), 慶應義塾大学, Coursework, 2013.02


Research Areas 【 Display / hide

  • Humanities & Social Sciences / Experimental psychology

  • Life Science / Basic brain sciences

Research Keywords 【 Display / hide

  • Interoception

  • Affective neuroscience

  • emotion

  • Neuropsychology

  • Cognitive neuroscience


Books 【 Display / hide

  • Neurocognitive mechanisms of social anxiety and interoception

    Terasawa Y., Umeda S., Island of Reil (Insula) in the Human Brain: Anatomical, Functional, Clinical and Surgical Aspects, 2018.07

  • Island of Reil (Insula) in the Human Brain

    TERASAWA Yuri, UMEDA Satoshi, Springer, 2018.01

    Scope: Neurocognitive Mechanisms of Social Anxiety and Interoception

  • Memory in a Social Context

    Terasawa Yuri, Umeda Satoshi, Springer, 2017.12

    Scope: The impact of interoception on memory

     View Summary

    <p>Using interoception as a keyword, this chapter has summarized how changes in the internal physical state are encoded and how the processing of interoceptive information affects the memory of episodes and events. Interoceptive information processing is discussed frequently in the context of emotion in psychology. On the other hand, research studies and literature that have examined its relation to episodic memory are rare. However, changes in the internal physical state exist at the foundation of various concepts that have examined its relationship with memory. To understand the relationship more precisely, we focused on the following issues in this chapter: emotional arousal and bodily responses; effects of bodily responses on memory encoding; judgment related to memories and bodily response; and insular cortex and memory consolidation. Throughout the chapter, we presented the possibility that change in the physical state itself plays a role in latently supporting the encoding and recollection process.</p>

Papers 【 Display / hide

  • Paradoxical somatic information processing for interoception and anxiety in alexithymia

    Yuri Terasawa, Kentaro Oba, Yuki Motomura, Ruri Katsunuma, Hiroki Murakami, Yoshiya Moriguchi

    European Journal of Neuroscience (Wiley)   2021.11

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  0953816X

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    The concept of alexithymia has garnered much attention in an attempt to understand the psychological mechanisms underlying the experience of feeling an emotion. In this study, we aimed to understand how the interoceptive processing in an emotional context relates to problems of alexithymia in recognizing self-emotions. Therefore, we prepared experimental conditions to induce emotional awareness based on interoceptive information. As such, we asked participants to be aware of interoception under an anxiety-generating situation anticipating pain, having them evaluate their subjective anxiety levels in this context. High alexithymia participants showed attenuated functional connectivity within their ‘interoception network’, particularly between the insula and the somatosensory areas when they focused on interoception. In contrast, they had enhanced functional connectivity between these regions when they focused on their anxiety about pain. Although access to somatic information is supposed to be more strongly activated while attending to interoception in the context of primary sensory processing, high alexithymia individuals were biased as this process was activated when they felt emotions, suggesting they recognize primitive and unprocessed bodily sensations as emotions. The paradoxical somatic information processing may reflect their brain function pathology for feeling emotions and their difficulty with context-dependent emotional control.

  • Effects of insular resection on interactions between cardiac interoception and emotion recognition

    Terasawa Y., Motomura K., Natsume A., Iijima K., Chalise L., Sugiura J., Yamamoto H., Koyama K., Wakabayashi T., Umeda S.

    Cortex (Cortex)  137   271 - 281 2021.04

    Accepted,  ISSN  00109452

     View Summary

    The insular cortex is considered an important region for feeling emotions through interoception. Most studies that report the role of the insula in integrating interoception and emotion have used neuroimaging techniques such as functional magnetic resonance imaging (fMRI); however, there are limited neuropsychological studies. The effects of insular lesions on emotion and interoception have not been suitably investigated. In this study, we examined the role of the insular cortex in cardiac interoception and recognizing emotions from facial expressions by comparing them pre- and post-operatively in patients with glial tumors or brain metastases associated with the insular lobe. Although no significant difference in interoceptive accuracy was observed between the two phases, there were significant associations between the changes in interoceptive accuracy and sensitivity to expressions of anger and happiness. An increased error rate in the heartbeat counting task in the post-operation phase was associated with a decreased accuracy in recognizing anger and happiness. Since most patients had left insula lesions, generalizability of the findings to patients with right lesions is a future subject. To the best of our knowledge, this is the first study to examine the change in interoception and emotion after insular resection in humans. The study results indicate that removal of the insula affects the recognition of emotions such as anger and happiness through interoceptive processing.

  • Cognitive behavioral therapy effects on frontopolar cortex function during future thinking in major depressive disorder: A randomized clinical trial

    Katayama N., Nakagawa A., Umeda S., Terasawa Y., Abe T., Kurata C., Sasaki Y., Mitsuda D., Kikuchi T., Tabuchi H., Mimura M.

    Journal of Affective Disorders (Journal of Affective Disorders)  298   644 - 655 2022.02

    ISSN  01650327

     View Summary

    Background: Despite the importance of Beck's theoretical cognitive model of psychopathology, the neural mechanisms underlying future thinking in cognitive behavioral therapy (CBT) remain elusive. Recent neuroimaging studies have shown that the function of the frontopolar cortex (Brodmann area 10 [BA10]) is associated with future thinking. We hypothesized that, compared with unstructured psychotherapy (talking control: TC), CBT may involve different neural responses in BA10 associated with future thinking. Methods: This randomized clinical trial included 38 adult patients with moderate-to-severe major depressive disorder who underwent up to 16 weeks of CBT or TC with a 6-month follow-up period. We evaluated changes in BA10 activation during distant future thinking using functional magnetic resonance imaging with a future-thinking task. We assessed frontal neurocognitive function and clinical symptoms at baseline and post-treatment. Depression severity and automatic thoughts were assessed at the 6-month follow-up. Results: We found decreased activation in the frontopolar cortex during distant future thinking after CBT (t = 3.00, df=15, p = 0.009) and no changes after TC. Further, the reduction in BA10 activity significantly correlated with changes in frontal cognitive function after the treatment (r = 0.48, p = 0.007), and in positive automatic thought after 6 months of treatments (r = 0.39; p = 0.03). Limitations: Relatively small sample size and homogenous clinical profile could limit the generalizability. Patients received pharmacotherapy including antidepressant. Conclusions: CBT appears to improve frontopolar cortex function during future thinking in a manner distinct from TC. Larger clinical trials are necessary to provide firm evidence whether BA10 activity may serve as a neuro-marker for monitoring successful depression treatment with CBT.

  • Decreased activity in the reward network of chronic insomnia patients

    Motomura Y, Katsunuma R, Ayabe N, Oba K, Terasawa Y, Kitamura S, Moriguchi Y, Hida A, Kamei Y, Mishima K

    Scientific Reports (Scientific Reports)  11 ( 1 )  2021.12

    Joint Work, Accepted

     View Summary

    © 2021, The Author(s). In modern society, many people have insomnia. Chronic insomnia has been noted as a risk factor for depression. However, there are few functional imaging studies of the brain on affective functions in chronic insomnia. This study aimed to investigate brain activities induced by emotional stimuli in chronic insomnia patients. Fifteen patients with primary insomnia and 30 age and gender matched healthy controls participated in this study. Both groups were presented images of fearful, happy, and neutral expressions consciously and non-consciously while undergoing MRI to compare the activity in regions of the brain responsible for emotions. Conscious presentation of the Happy-Neutral contrast showed significantly lower activation in the right orbitofrontal cortex of patients compared to healthy controls. The Happy-Neutral contrast presented in a non-conscious manner resulted in significantly lower activation of the ventral striatum, right insula, putamen, orbitofrontal cortex and ventral tegmental area in patients compared to healthy controls. Our findings revealed that responsiveness to positive emotional stimuli were decreased in insomniac patients. Specifically, brain networks associated with rewards and processing positive emotions showed decreased responsiveness to happy emotions especially for non-conscious image. The magnitude of activity in these areas also correlated with severity of insomnia, even after controlling for depression scale scores. These findings suggest that insomnia induces an affective functional disorder through an underlying mechanism of decreased sensitivity in the regions of the brain responsible for emotions and rewards to positive emotional stimuli.

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Papers, etc., Registered in KOARA 【 Display / hide

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Reviews, Commentaries, etc. 【 Display / hide

  • Effects of insular resection on interactions between cardiac interoception and emotion recognition

    Yuri Terasawa and Kazuya Motomura and Atsushi Natsume and Kentaro Iijima and Lushun Chalise and Junko Sugiura and Hiroyasu Yamamoto and Kyohei Koyama and Toshihiko Wakabayashi and Satoshi Umeda

    Cortex (Elsevier {BV})  137   271 - 281 2021.02

    Article, review, commentary, editorial, etc. (scientific journal)

  • Interoception and Mental Health: A Roadmap

    Khalsa, S.S. and Adolphs, R. and Cameron, O.G. and Critchley, H.D. and Davenport, P.W. and Feinstein, J.S. and Feusner, J.D. and Garfinkel, S.N. and Lane, R.D. and Mehling, W.E. and Meuret, A.E. and Nemeroff, C.B. and Oppenheimer, S. and Petzschner, F.H. and Pollatos, O. and Rhudy, J.L. and Schramm, L.P. and Simmons, W.K. and Stein, M.B. and Stephan, K.E. and Van den Bergh, O. and Van Diest, I. and von Leupoldt, A. and Paulus, M.P. and Ainley, V. and Al Zoubi, O. and Aupperle, R. and Avery, J. and Baxter, L. and Benke, C. and Berner, L. and Bodurka, J. and Breese, E. and Brown, T. and Burrows, K. and Cha, Y.-H. and Clausen, A. and Cosgrove, K. and Deville, D. and Duncan, L. and Duquette, P. and Ekhtiari, H. and Fine, T. and Ford, B. and Garcia Cordero, I. and Gleghorn, D. and Guereca, Y. and Harrison, N.A. and Hassanpour, M. and Hechler, T. and Heller, A. and Hellman, N. and Herbert, B. and Jarrahi, B. and Kerr, K. and Kirlic, N. and Klabunde, M. and Kraynak, T. and Kriegsman, M. and Kroll, J. and Kuplicki, R. and Lapidus, R. and Le, T. and Hagen, K.L. and Mayeli, A. and Morris, A. and Naqvi, N. and Oldroyd, K. and Pan{\'e}-Farr{\'e}, C. and Phillips, R. and Poppa, T. and Potter, W. and Puhl, M. and Safron, A. and Sala, M. and Savitz, J. and Saxon, H. and Schoenhals, W. and Stanwell-Smith, C. and Teed, A. and Terasawa, Y. and Thompson, K. and Toups, M. and Umeda, S. and Upshaw, V. and Victor, T. and Wierenga, C. and Wohlrab, C. and Yeh, H.-W. and Yoris, A. and Zeidan, F. and Zotev, V. and Zucker, N.

    Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 3 ( 6 ) 501 - 513 2018

    ISSN  24519030 24519022

  • 感情認識における島皮質の機能


    神経心理学 30 ( 1 ) 61 - 68 2014.03

    Article, review, commentary, editorial, etc. (scientific journal)

  • 島皮質と記憶障害

    寺澤悠理・梅田 聡・加藤元一郎

    Clinical Neuroscience 28 ( 4 ) 441 - 443 2010.01

    Article, review, commentary, editorial, etc. (scientific journal)

  • 虚記憶の認知神経メカニズム

    寺澤悠理・梅田 聡

    臨床精神医学 38 ( 11 ) 1589 - 1594 2009.01

    Article, review, commentary, editorial, etc. (scientific journal)

Presentations 【 Display / hide


    Ito, Yuichi, Shibata, Midori, Tanaka, Yuto, Terasawa, Yuri, Umeda, Satoshi



    Poster presentation


    Tanaka, Yuto, Ito, Yuichi, Shibata, Midori, Terasawa, Yuri, Umeda, Satoshi



    Poster presentation

Research Projects of Competitive Funds, etc. 【 Display / hide

  • Investigating the autonomic nervous system function associated with the insular cortex using awake brain mapping


    Nagoya University, Grant-in-Aid for Scientific Research (C), No Setting

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  • Somatic symptoms and distortions of emotion and thought: Cognitive neuroscientific approach


    Keio University, Grant-in-Aid for Scientific Research (A), No Setting

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  • 自律神経システムの予測処理機能と精神疾患症状との関係性の探索的解明


    Keio University, Grant-in-Aid for Challenging Research (Exploratory), No Setting

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  • 性周期および内受容感覚が感情認識・制御に及ぼす影響:認知神経科学による検討


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

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  • 感情認識における心理・神経基盤解明:脳神経外科学・認知神経科学の融合


    Nagoya University, Grant-in-Aid for Scientific Research (B), No Setting

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Courses Taught 【 Display / hide











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