Takeuchi, Tsutomu



School of Medicine (Mita)


Professor Emeritus

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  • PRESENT General Director, Keio University Hospital Division of Rheumatology,Department of Internal Medicine,School of Medicine, Keio UniversityProfessor of Internal Medicine, Chief of Rheumatology, School of Medicine, Keio University 35 Shinanomachi, SHINJYUKU, TOKYO 160-8582, JAPAN Tel: 3-5363-3147, Fax: 3-5363-3149 EDUCATION Keio University, Faculty of Medicine, MD 1980 Keio University, Faculty of Medicine, PhD 1984 TRAINING INTERNSHIP & RESIDENCES 1980-1983: Resident on Internal Medicine, Keio University Hospital RESEARCH FELLOWSHIP 1980-1984: Clinical and research fellow, Division of Rheumatology and Clinical Immunology, Keio University 1985-1986: Research Fellow, Tumor Immunology (Prof. S.Schlossman), Dana-Farber Cancer Institute ACADEMIC APOINTMENTS 1984-1985: Research associate, Rheumatology/Clinical Immunology, Keio University Faculty of Medicine 1986-1988: Associate of Medicine, Saitama Medical University 1989-1992: Assistant Professor of Medicine, Saitama Medical University 1993-1998: Associate Professor of Medicine, Saitama Medical University 1998-2009: Professor of Medicine, Saitama Medical University 2004-2009: Vice dean of Saitama Medical University 2009-present: Professor of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University 2011.10-2013.9  The assistant dean, School of Medicine, Keio University 2013 October. General Director, Keio University Hospital EDITORIAL ACTIVITY 1992-: Editorial board of Japanese Journal of Infectious Diseases 1999-2007: Associate editor of Modern Rheumatology 2008-2009: Transmitting Editor of Modern Rheumatology 1999-present: Editorial board of Japanese Journal of Clinical Rheumatology 2001-present: Editorial board of Clinical Rheumatology (ILAR) 2005-2007: Editorial Board of Clinical Immunology (USA) 2008-present: Editorial Board of Rheumatology (British Society for Rheumatology:BSR) 2012 Editorial Board of Annals of the Rheumatic Diseases 2013-Associated Editor of Rheumatology

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  • School of Medicine, 内科学(リウマチ), General Director, Keio University Hospital


Research Areas 【 Display / hide

  • Life Science / Connective tissue disease and allergy

Research Keywords 【 Display / hide

  • 生物学的製剤

  • 自己免疫疾患

  • Rheumatoid Arthritis


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  • Significant association between joint ultrasonographic parameters and synovial inflammatory factors in rheumatoid arthritis

    Kondo Y., Suzuki K., Inoue Y., Sakata K., Takahashi C., Takeshita M., Kassai Y., Miyazaki T., Morita R., Niki Y., Kaneko Y., Yasuoka H., Yamaoka K., Yoshimura A., Takeuchi T.

    Arthritis Research and Therapy (Arthritis Research and Therapy)  21 ( 1 ) 14 2019.10

    Research paper (scientific journal), Accepted,  ISSN  14786354

     View Summary

    © 2019 The Author(s). Background: Ultrasonography (US) can directly demonstrate joint inflammation, including grayscale (GS) signs of synovial hypertrophy and power Doppler (PD) techniques to demonstrate increased blood flow and vascularization. Recently, echogenicity, especially hypoechoic synovium, has also been associated with local inflammatory activity. However, only a few studies have demonstrated correlation between histopathologic and immunopathologic evaluation and US findings. The aim of this study was to clarify whether joint US findings including synovial hypertrophy, vascularity, and echogenicity can accurately characterize synovial pathophysiology in patients with active rheumatoid arthritis (RA). Methods: A total of 44 patients with RA were included, both treated (n = 25) and untreated (n = 19) and scheduled for US examination of the knee joint with synovial fluid (SF) aspiration and two treated patients also underwent synovial biopsy. US images were quantitatively analyzed using grayscale assessment of synovial hypertrophy and PD for vascularity and echogenicity. Levels of nine SF cytokines and growth factors were also measured. Results: Both US synovial hypertrophy and PD vascularity significantly correlated with SF inflammatory cytokine levels such as IL-6, IL-8, IL-1β and IL-10 in untreated patients. Angiogenic factors, including vascular endothelial growth factor (VEGF), only correlated with PD vascularity. In the treated patients, the associations between synovial hypertrophy and any cytokines were diminished, although synovial vascularity and echogenicity correlated with IL-6 and VEGF (p < 0.05). Histopathologic analysis revealed that hypoechogenicity of the synovium correlated with marked infiltration of lymphocytes and hypervascularity. Conclusions: We demonstrated the pathophysiological origins of US findings in the joint. The degree of US vascularity of the synovium correlated with local inflammatory cytokine levels and angiogenetic factors in patients with active RA. Synovial echogenicity, and not hypertrophy, correlated with inflammation, especially in treated patients with RA.

  • Effects of the anti-RANKL antibody denosumab on joint structural damage in patients with rheumatoid arthritis treated with conventional synthetic disease-modifying antirheumatic drugs (DESIRABLE study): a randomised, double-blind, placebo-controlled phase 3 trial.

    Takeuchi T, Tanaka Y, Soen S, Yamanaka H, Yoneda T, Tanaka S, Nitta T, Okubo N, Genant HK, van der Heijde D

    Annals of the rheumatic diseases  2019.04

    Research paper (scientific journal), Accepted,  ISSN  0003-4967

  • Efficacy and safety of namilumab, a human monoclonal antibody against granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand in patients with rheumatoid arthritis (RA) with either an inadequate response to background methotrexate therapy or an inadequate response or intolerance to an anti-TNF (tumour necrosis factor) biologic therapy: a randomized, controlled trial

    Taylor Peter C., Saurigny Didier, Vencovsky Jiri, Takeuchi Tsutomu, Nakamura Tadashi, Matsievskaia Galina, Hunt Barbara, Wagner Thomas, Souberbielle Bernard

    ARTHRITIS RESEARCH & THERAPY 21 ( 1 ) 101 2019.04

    Research paper (scientific journal), Accepted,  ISSN  1478-6354

  • Clinicopathological features of clinical methotrexate-related lymphoproliferative disorders.

    Tokuhira M, Saito S, Suzuki K, Higashi M, Momose S, Shimizu T, Mori T, Kimura Y, Amano K, Okamoto S, Takeuchi T, Tamaru JI, Kizaki M

    Leukemia & lymphoma    1 - 8 2019.04

    Research paper (scientific journal), Accepted,  ISSN  1042-8194

  • Demographics and clinical characteristics associated with sustained remission and continuation of sustained remission in patients with rheumatoid arthritis treated with adalimumab

    Kimura Noriko, Suzuki Katsuya, Takeuchi Tsutomu


    Research paper (scientific journal), Accepted,  ISSN  1880-8190

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  • Molecular signatures in pre-RA patients by multi-omics analysis


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • 自己免疫疾患における病変局所の自己反応性免疫細胞の網羅的解析


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

  • Investigation of regulatory mechanism of secretary protein kinase and its application for treatment of rheumatoid arthritis


    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Principal investigator

     View Summary

    We have identified FAM20A which regulates post-transcriptional protein modification as a molecule associated with pathophysiology of rheumatoid arthritis in the previous research using peripheral blood. In this research, we generated anti-FAM20A antibody and deeply analyzed association between FAM20A and affected sites. Our investigation successfully revealed the expression affected site and its induction by inflammatory cytokines. These findings suggested that post-transcriptional protein modification involved in pathophysiology of rheumatoid arthritis.


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