Details of a Researcher - MOROZUMI Satoshi

MOROZUMI Satoshi

写真a

Affiliation: Faculty of Pharmacy, Department of Pharmacy Faculty of Pharmacy, Department of Pharmacy, Division of Physiological Chemistry and Metabolism (Shiba-Kyoritsu)

Position: Research Associate/Assistant Professor/Instructor

Contact Address: 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-0011

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Career 【 Display / hide 】

2024.10

-

Present

Keio university, Faculty of pharmacy, Assistant Professor

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Academic Background 【 Display / hide 】

2015.04

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2021.03

Keio University, 薬学部, 薬学科

University, Graduated
2021.04

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2024.09

Keio University, 薬学研究科

Graduate School, Withdrawal before completion

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Research Areas 【 Display / hide 】

Life Science / Molecular biology
Life Science / Bacteriology

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Research Keywords 【 Display / hide 】

Untargeted lipidomics
Bioactive molecules
Microbiota

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Papers 【 Display / hide 】

The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation

Doré E., Joly-Beauparlant C., Morozumi S., Mathieu A., Lévesque T., Allaeys I., Duchez A.C., Cloutier N., Leclercq M., Bodein A., Payré C., Martin C., Petit-Paitel A., Gelb M.H., Rangachari M., Murakami M., Davidovic L., Flamand N., Arita M., Lambeau G., Droit A., Boilard E.

JCI Insight 7 ( 2 ) 2022.01

Research paper (scientific journal), Joint Work, Accepted

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Secreted phospholipase A2-IIA (sPLA2-IIA) hydrolyzes phospholipids to liberate lysophospholipids and fatty acids. Given its poor activity toward eukaryotic cell membranes, its role in the generation of proinflammatory lipid mediators is unclear. Conversely, sPLA2-IIA efficiently hydrolyzes bacterial membranes. Here, we show that sPLA2-IIA affects the immune system by acting on the intestinal microbial flora. Using mice overexpressing transgene-driven human sPLA2-IIA, we found that the intestinal microbiota was critical for both induction of an immune phenotype and promotion of inflammatory arthritis. The expression of sPLA2-IIA led to alterations of the intestinal microbiota composition, but housing in a more stringent pathogen-free facility revealed that its expression could affect the immune system in the absence of changes to the composition of this flora. In contrast, untargeted lipidomic analysis focusing on bacteria-derived lipid mediators revealed that sPLA2-IIA could profoundly alter the fecal lipidome. The data suggest that a singular protein, sPLA2-IIA, produces systemic effects on the immune system through its activity on the microbiota and its lipidome.
- Access to Document (DOI)

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Reviews, Commentaries, etc. 【 Display / hide 】

腸内細菌が産生する脂質代謝物の構造と機能

両角諭、岡橋伸幸、有田誠

生化学 (日本生化学会) 95 ( 4 ) 428 - 435 2023.08

Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author
Structures and functions of the gut microbial lipidome

Morozumi S., Ueda M., Okahashi N., Arita M.

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1867 ( 3 ) 2022.03

Article, review, commentary, editorial, etc. (scientific journal), Joint Work, Lead author, ISSN 13881981

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Microbial lipids provide signals that are responsible for maintaining host health and controlling disease. The differences in the structures of microbial lipids have been shown to alter receptor selectivity and agonist/antagonist activity. Advanced lipidomics is an emerging field that helps to elucidate the complex bacterial lipid diversity. The use of cutting-edge technologies is expected to lead to the discovery of new functional metabolites involved in host homeostasis. This review aims to describe recent updates on functional lipid metabolites derived from gut microbiota, their structure-activity relationships, and advanced lipidomics technologies.
- Access to Document (DOI)