内山　清貴 (ウチヤマ　キヨタカ)

Uchiyama, Kiyotaka

写真a

所属（所属キャンパス）

医学部 バクスター包括的腎代替療法展開医学寄附講座 （信濃町）

職名

特任助教（有期）
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経歴 【 表示 ／ 非表示 】

  • 2020年04月
    -
    2022年03月

    慶應義塾大学, 医学部 内科学教室（腎臓・内分泌・代謝）, 助教

  • 2022年04月
    -
    継続中

    慶應義塾大学, 医学部 内科学教室（腎臓・内分泌・代謝）, 特任助教

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学歴 【 表示 ／ 非表示 】

  • 2000年04月
    -
    2006年03月

    灘中学校・灘高等学校

  • 2006年04月
    -
    2012年03月

    慶應義塾大学, 医学部

  • 2016年04月
    -
    2020年03月

    慶應義塾大学, 医学部, 医学研究科博士課程（内科専攻）

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研究分野 【 表示 ／ 非表示 】

  • ライフサイエンス / 腎臓内科学

  • ライフサイエンス / リハビリテーション科学

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著書 【 表示 ／ 非表示 】

  • イラストでわかる腎臓・透析療法・透析患者の体

    花房, 規男, メディカ出版, 2021年12月,  ページ数： 270p

    担当範囲: 腹膜透析の種類

  • 血液透析診療指針

    岡田, 一義, 井上, 朋子, 島, 久登, 田代, 学(腎臓内科医), 水口, 潤, 東京医学社, 2021年06月,  ページ数： xvii, 364p

    担当範囲: ビタミン

  • エビデンスに基づく多発性囊胞腎(PKD)診療ガイドライン

    厚生労働科学研究費補助金難治性疾患等政策研究事業(難治性疾患政策研究事業)難治性腎障害に関する調査研究班, 成田, 一衛, 東京医学社, 2020年08月,  ページ数： xi, 92p

    担当範囲: 1 進行を抑制する治療 1）降圧療法

  • 臨床検査法提要

    奥村, 伸生, 金井, 正光, 戸塚, 実, 本田, 孝行, 矢冨, 裕, 金原出版, 2020年05月,  ページ数： 2012p

    担当範囲: 腹膜透析

  • 腹膜透析診療指針

    岡田, 一義, 橋本, 寛文, 水口, 潤, 東京医学社, 2019年07月,  ページ数： ix, 165p

    担当範囲: カテーテルトラブル診療指針

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論文 【 表示 ／ 非表示 】

  • Cystic Kidney Diseases That Require a Differential Diagnosis from Autosomal Dominant Polycystic Kidney Disease (ADPKD)

    Sekine A., Hidaka S., Moriyama T., Shikida Y., Shimazu K., Ishikawa E., Uchiyama K., Kataoka H., Kawano H., Kurashige M., Sato M., Suwabe T., Nakatani S., Otsuka T., Kai H., Katayama K., Makabe S., Manabe S., Shimabukuro W., Nakanishi K., Nishio S., Hattanda F., Hanaoka K., Miura K., Hayashi H., Hoshino J., Tsuchiya K., Mochizuki T., Horie S., Narita I., Muto S.

    Journal of Clinical Medicine （Journal of Clinical Medicine)  11 （ 21 ） 6528 - 6528 2022年11月

    　概要を見る

    Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cystic kidney disease, with patients often having a positive family history that is characterized by a similar phenotype. However, in atypical cases, particularly those in which family history is unclear, a differential diagnosis between ADPKD and other cystic kidney diseases is important. When diagnosing ADPKD, cystic kidney diseases that can easily be excluded using clinical information include: multiple simple renal cysts, acquired cystic kidney disease (ACKD), multilocular renal cyst/multilocular cystic nephroma/polycystic nephroma, multicystic kidney/multicystic dysplastic kidney (MCDK), and unilateral renal cystic disease (URCD). However, there are other cystic kidney diseases that usually require genetic testing, or another means of supplementing clinical information to enable a differential diagnosis of ADPKD. These include autosomal recessive polycystic kidney disease (ARPKD), autosomal dominant tubulointerstitial kidney disease (ADTKD), nephronophthisis (NPH), oral-facial-digital (OFD) syndrome type 1, and neoplastic cystic kidney disease, such as tuberous sclerosis (TSC) and Von Hippel-Lindau (VHL) syndrome. To help physicians evaluate cystic kidney diseases, this article provides a review of cystic kidney diseases for which a differential diagnosis is required for ADPKD.

  • Effect of Tolvaptan in Patients with Chronic Kidney Disease Stage G5, and Impact of Concomitant Use of Thiazide Diuretics: A Retrospective Cohort Study

    Uchiyama K., Kojima D., Hama E.Y., Nagasaka T., Nakayama T., Takahashi R., Tajima T., Morimoto K., Washida N., Itoh H.

    Drugs - Real World Outcomes （Drugs - Real World Outcomes)  2022年08月

    筆頭著者, 責任著者, 査読有り,  ISSN  2199-1154

    　概要を見る

    Background: The diuretic effect of tolvaptan, a vasopressin V2 receptor antagonist, in patients with severe renal dysfunction remains poorly characterized. Thiazide diuretics reduce urinary volume (UV) in patients with nephrogenic diabetes insipidus, which lacks V2 receptor function. Objective: This retrospective study investigated the acute urinary effects of tolvaptan in patients with stage G5 chronic kidney disease and congestive heart failure (CHF), and the impact of thiazide diuretics on the urinary effects of tolvaptan. Methods: UVs 24 h before and after tolvaptan administration and 30-day dialysis initiation rate were compared between patients with and without thiazide diuretic administration. Results: Thiazide diuretics were used in 26 of the 106 recruited patients (age 73.4 ± 13.0 years; estimated glomerular filtration rate 8.07 ± 3.13 mL/min/1.73 m2). The pre- and post-tolvaptan 24-h UVs were significantly higher in patients not administered thiazide diuretics (1043.4 ± 645.6 vs. 1422.2 ± 774.0 mL/day; p < 0.001) than in those administered thiazide diuretics (1177.3 ± 686.5 vs. 1173.1 ± 629.1 mL/day; p = 0.93). In a multivariate regression model, thiazide diuretic use was significantly associated with decreased 24-h UV (β coefficient − 486.7, 95% confidence interval [CI] − 674.5 to − 298.8); increased urine osmolality (β coefficient 37.7, 95% CI 17.1–58.4); increased body weight (β coefficient 0.62, 95% CI 0.31–0.92); and increased 30-day dialysis initiation rate (odds ratio 3.40, 95% CI 1.18–9.82) after tolvaptan administration. Conclusions: Tolvaptan exhibited significant diuretic effects in patients with CHF, including those with severe renal dysfunction, which were diminished with concomitant thiazide diuretic use.

  • Late Dialysis Modality Education Could Negatively Predict Peritoneal Dialysis Selection

    Nakayama T., Nishioka K., Uchiyama K., Morimoto K., Kusahana E., Washida N., Yamaguchi S., Azegami T., Yoshida T., Itoh H.

    Journal of Clinical Medicine （Journal of Clinical Medicine)  11 （ 14 ）  2022年07月

    責任著者

    　概要を見る

    Patients with end-stage renal disease are less likely to choose peritoneal dialysis (PD) as renal replacement therapy (RRT). The reasons for this biased selection are still poorly understood. In this study, we evaluated the effect of the timing of RRT education on PD selection. This single-center retrospective observational study included patients who initiated maintenance dialysis at our hospital between April 2014 and July 2021. A logistic regression analysis was performed to investigate the association of RRT education timing with PD selection. Among the 355 participants (median age [IQR] 70 (59–79) years; 28.7% female), 53 patients (14.9%) and 302 patients (85.1%) selected PD and hemodialysis, respectively. Multivariate analysis demonstrated that high estimated glomerular filtration (eGFR) at RRT education positively predicted PD selection (p < 0.05), whereas old age (p < 0.01) and high Charlson comorbidity index (p < 0.05) were negative predictors of PD selection. Female sex (p = 0.44), welfare public assistance (p = 0.78), living alone (p = 0.25), high geriatric nutritional risk index (p = 0.10) and high eGFR at first visit to the nephrology department (p = 0.83) were not significantly associated with PD selection. Late RRT education could increase the biased selection of dialysis modality.

  • High body mass index is a risk factor for transition to hemodialysis or hybrid therapy and peritoneal dialysis-related infection in Japanese patients undergoing peritoneal dialysis

    Hama E.Y., Uchiyama K., Nagasaka T., Kusahana E., Nakayama T., Yasuda I., Morimoto K., Washida N., Itoh H.

    International Urology and Nephrology （International Urology and Nephrology)  54 （ 12 ） 3193 - 3202 2022年06月

    責任著者, 査読有り,  ISSN  03011623

    　概要を見る

    Purpose: Obesity may negatively impact the clinical outcomes of patients undergoing peritoneal dialysis (PD). However, the impact of obesity on PD-related outcomes remains unclear. We herein examined the association of high body mass index (BMI) with complete hemodialysis (HD) transfer, transition to HD and PD/HD hybrid therapy, peritonitis, catheter exit-site and tunnel infection (ESI/TI), and heart failure-related hospitalization. Methods: This retrospective cohort study included 120 patients who underwent PD-catheter insertion between January 2008 and June 2018. BMI ≥ 25 kg/m2 at the time of PD-catheter insertion was defined as high BMI, and its association with outcomes was analyzed using the log-rank test and Cox proportional hazards models. Results: The follow-up duration was 46.2 (23.3–75.3) months. The time until transfer to HD and hybrid therapy was significantly shorter in the high BMI group than that in the low BMI group, whereas the time until HD transfer was not significantly different between the two groups (P < 0.001 and 0.18, respectively). Peritonitis-free and ESI/TI-free survivals were significantly shorter in the high BMI group than those in the low BMI group (P = 0.006 and 0.03, respectively). After adjusting for age, sex, diabetes mellitus, and estimated glomerular filtration rate, high BMI remained a significant risk factor for transferring to HD and hybrid therapy, peritonitis, and ESI/TI (hazard ratio [HR] 2.60, P < 0.001; HR 2.08, P = 0.01; HR 2.64, P = 0.02, respectively). Conclusion: BMI ≥ 25 kg/m2 is a risk factor for transition to HD and hybrid therapy, peritonitis, and ESI/TI, but not for complete HD transfer in Japanese patients with PD.

  • Health-Related Quality of Life Sleep Score Predicts Transfer to Hemodialysis among Patients on Peritoneal Dialysis

    Nagasaka T., Washida N., Uchiyama K., Hama E.Y., Kusahana E., Nakayama T., Yasuda I., Morimoto K., Itoh H.

    Healthcare (Switzerland) （Healthcare (Switzerland))  10 （ 6 ） 1030 - 1030 2022年06月

    責任著者

    　概要を見る

    Despite the superiority of peritoneal dialysis (PD) over hemodialysis (HD) regarding health-related quality of life (HRQOL), the specific HRQOL domain(s) that predict unplanned HD transfer remains uncertain. In this cohort study, we assessed the HRQOL of 50 outpatients undergoing PD using the Japanese version 1.3 Kidney Disease Quality of Life-Short Form from March 2017 to March 2018 and prospectively analyzed the association of each HRQOL component with HD transfer until June 2021. During the follow-up (41.5 (13.0–50.1) months), 21 patients were transferred to HD. In a multivariate Cox proportional hazards model adjusted for age, sex, PD vintage, urine output, Charlson comorbidity index, and incremental shuttle walking test, a higher sleep score was significantly associated with lower HD transfer rates (HR 0.70 per 10, p = 0.01). An adjusted subdistribution hazard model where elected transition to HD, death, and transplantation were considered competing events of unintended HD transfer that showed sleep score as an exclusive predictor of HD transfer (HR 0.70 per 10, p = 0.002). Our results suggest that sleep score among the HRQOL subscales is instrumental in predicting HD transfer in patients undergoing PD.

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総説・解説等 【 表示 ／ 非表示 】

  • 腫瘍性疾患―腎細胞癌とADPKD

    内山 清貴

    腎と透析 10月増大号 特集 嚢胞腎 93 ( 4 ) 587 - 592 2022年10月

    筆頭著者, 責任著者

  • 囊胞腎，腹部手術後，大量腹水貯留の末期腎不全患者では腹膜透析は避けるべきでしょうか？

    内山 清貴, 鷲田 直輝

    臨床雑誌内科 特集 エキスパートがお答えします！ 日常臨床のあるあるの疑問 (Vol.130 No.3)  ( 2022年9月増大号 ) 600 - 603 2022年09月

    筆頭著者

  • アシストPD

    内山 清貴, 鷲田 直輝

    腎代替療法のすべて 92巻 ( 増刊号 ) 373 - 379 2022年06月

    筆頭著者

  • ADPKDの治療：②非薬物治療（生活指導を中心に）

    内山 清貴

    腎臓内科 14 ( 5 ) 545 - 551 2021年11月

    筆頭著者

  • 腎不全と腎代替療法 腹膜透析 14 腹膜透析の種類

    内山清貴, 鷲田直輝

    透析ケア  2021年

    ISSN  1341-1489

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受賞 【 表示 ／ 非表示 】

  • 若手研究者賞

    2022年06月, 日本抗加齢医学会, 慢性腎臓病における運動耐用能低下の意義および運動療法の有用性についての検討

  • 三四会奨励賞

    2022年06月, 慶應義塾大学医学部 三四会, Home-based aerobic exercise and resistance training for severe chronic kidney disease: a randomized controlled trial

  • 優秀演題賞

    2019年06月, 日本抗加齢医学会

  • YIA 会長賞（最優秀賞）

    2019年03月, 日本腎臓リハビリテーション学会

  • 優秀演題（医師部門臨床研究）

    2018年10月, 日本腹膜透析医学会

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所属学協会 【 表示 ／ 非表示 】

  • 多発性嚢胞腎協会, 

    2022年06月
    -
    継続中

  • 日本人類遺伝学会, 

    2022年05月
    -
    継続中

  • International Society for Peritoneal Dialysis, 

    2022年01月
    -
    継続中

  • 日本腎臓リハビリテーション学会, 

    2018年11月
    -
    継続中

  • 日本抗加齢医学会, 

    2018年
    -
    継続中

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委員歴 【 表示 ／ 非表示 】

  • 2019年
    -
    継続中

    疾患登録・調査研究分科会 多発性嚢胞腎ワーキンググループ, 厚生労働科学研究費補助金難治性疾患等政策研究事業（難治性疾患政策研究事業） 難治性腎障害に関する調査研究班

  • 2017年
    -
    継続中

    腹膜透析ガイドライン改訂ワーキンググループ（Systematic Review (SR)）, 一般社団法人日本透析医学会

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