慶應義塾研究者情報データベース

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• 2020年04月

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  2022年03月

  慶應義塾大学, 医学部 内科学教室（腎臓・内分泌・代謝）, 助教

• 2022年04月

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  継続中

  慶應義塾大学, 医学部 内科学教室（腎臓・内分泌・代謝）, 特任助教

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• 2000年04月

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  2006年03月

  灘中学校・灘高等学校

• 2006年04月

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  2012年03月

  慶應義塾大学, 医学部

• 2016年04月

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  2020年03月

  慶應義塾大学, 医学部, 医学研究科博士課程（内科専攻）

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• ライフサイエンス / 腎臓内科学

• ライフサイエンス / リハビリテーション科学

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• イラストでわかる腎臓・透析療法・透析患者の体

  花房, 規男, メディカ出版, 2021年12月,  ページ数： 270p

  担当範囲: 腹膜透析の種類

• 血液透析診療指針

  岡田, 一義, 井上, 朋子, 島, 久登, 田代, 学(腎臓内科医), 水口, 潤, 東京医学社, 2021年06月,  ページ数： xvii, 364p

  担当範囲: ビタミン

• エビデンスに基づく多発性囊胞腎(PKD)診療ガイドライン

  厚生労働科学研究費補助金難治性疾患等政策研究事業(難治性疾患政策研究事業)難治性腎障害に関する調査研究班, 成田, 一衛, 東京医学社, 2020年08月,  ページ数： xi, 92p

  担当範囲: 1 進行を抑制する治療 1）降圧療法

• 臨床検査法提要

  奥村, 伸生, 金井, 正光, 戸塚, 実, 本田, 孝行, 矢冨, 裕, 金原出版, 2020年05月,  ページ数： 2012p

  担当範囲: 腹膜透析

• 腹膜透析診療指針

  岡田, 一義, 橋本, 寛文, 水口, 潤, 東京医学社, 2019年07月,  ページ数： ix, 165p

  担当範囲: カテーテルトラブル診療指針

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• Effect of Tolvaptan in Patients with Chronic Kidney Disease Stage G5, and Impact of Concomitant Use of Thiazide Diuretics: A Retrospective Cohort Study

  Uchiyama K., Kojima D., Hama E.Y., Nagasaka T., Nakayama T., Takahashi R., Tajima T., Morimoto K., Washida N., Itoh H.

  Drugs - Real World Outcomes （Drugs - Real World Outcomes)  2022年08月

  筆頭著者, 責任著者, 査読有り,  ISSN  2199-1154

  　概要を見る

  Background: The diuretic effect of tolvaptan, a vasopressin V2 receptor antagonist, in patients with severe renal dysfunction remains poorly characterized. Thiazide diuretics reduce urinary volume (UV) in patients with nephrogenic diabetes insipidus, which lacks V2 receptor function. Objective: This retrospective study investigated the acute urinary effects of tolvaptan in patients with stage G5 chronic kidney disease and congestive heart failure (CHF), and the impact of thiazide diuretics on the urinary effects of tolvaptan. Methods: UVs 24 h before and after tolvaptan administration and 30-day dialysis initiation rate were compared between patients with and without thiazide diuretic administration. Results: Thiazide diuretics were used in 26 of the 106 recruited patients (age 73.4 ± 13.0 years; estimated glomerular filtration rate 8.07 ± 3.13 mL/min/1.73 m2). The pre- and post-tolvaptan 24-h UVs were significantly higher in patients not administered thiazide diuretics (1043.4 ± 645.6 vs. 1422.2 ± 774.0 mL/day; p < 0.001) than in those administered thiazide diuretics (1177.3 ± 686.5 vs. 1173.1 ± 629.1 mL/day; p = 0.93). In a multivariate regression model, thiazide diuretic use was significantly associated with decreased 24-h UV (β coefficient − 486.7, 95% confidence interval [CI] − 674.5 to − 298.8); increased urine osmolality (β coefficient 37.7, 95% CI 17.1–58.4); increased body weight (β coefficient 0.62, 95% CI 0.31–0.92); and increased 30-day dialysis initiation rate (odds ratio 3.40, 95% CI 1.18–9.82) after tolvaptan administration. Conclusions: Tolvaptan exhibited significant diuretic effects in patients with CHF, including those with severe renal dysfunction, which were diminished with concomitant thiazide diuretic use.

  • Access to Document (DOI)

• Late Dialysis Modality Education Could Negatively Predict Peritoneal Dialysis Selection

  Nakayama T., Nishioka K., Uchiyama K., Morimoto K., Kusahana E., Washida N., Yamaguchi S., Azegami T., Yoshida T., Itoh H.

  Journal of Clinical Medicine （Journal of Clinical Medicine)  11 （ 14 ）  2022年07月

  責任著者

  　概要を見る

  Patients with end-stage renal disease are less likely to choose peritoneal dialysis (PD) as renal replacement therapy (RRT). The reasons for this biased selection are still poorly understood. In this study, we evaluated the effect of the timing of RRT education on PD selection. This single-center retrospective observational study included patients who initiated maintenance dialysis at our hospital between April 2014 and July 2021. A logistic regression analysis was performed to investigate the association of RRT education timing with PD selection. Among the 355 participants (median age [IQR] 70 (59–79) years; 28.7% female), 53 patients (14.9%) and 302 patients (85.1%) selected PD and hemodialysis, respectively. Multivariate analysis demonstrated that high estimated glomerular filtration (eGFR) at RRT education positively predicted PD selection (p < 0.05), whereas old age (p < 0.01) and high Charlson comorbidity index (p < 0.05) were negative predictors of PD selection. Female sex (p = 0.44), welfare public assistance (p = 0.78), living alone (p = 0.25), high geriatric nutritional risk index (p = 0.10) and high eGFR at first visit to the nephrology department (p = 0.83) were not significantly associated with PD selection. Late RRT education could increase the biased selection of dialysis modality.

  • Access to Document (DOI)

• High body mass index is a risk factor for transition to hemodialysis or hybrid therapy and peritoneal dialysis-related infection in Japanese patients undergoing peritoneal dialysis

  Hama E.Y., Uchiyama K., Nagasaka T., Kusahana E., Nakayama T., Yasuda I., Morimoto K., Washida N., Itoh H.

  International Urology and Nephrology （International Urology and Nephrology)  2022年06月

  責任著者, 査読有り,  ISSN  03011623

  　概要を見る

  Purpose: Obesity may negatively impact the clinical outcomes of patients undergoing peritoneal dialysis (PD). However, the impact of obesity on PD-related outcomes remains unclear. We herein examined the association of high body mass index (BMI) with complete hemodialysis (HD) transfer, transition to HD and PD/HD hybrid therapy, peritonitis, catheter exit-site and tunnel infection (ESI/TI), and heart failure-related hospitalization. Methods: This retrospective cohort study included 120 patients who underwent PD-catheter insertion between January 2008 and June 2018. BMI ≥ 25 kg/m2 at the time of PD-catheter insertion was defined as high BMI, and its association with outcomes was analyzed using the log-rank test and Cox proportional hazards models. Results: The follow-up duration was 46.2 (23.3–75.3) months. The time until transfer to HD and hybrid therapy was significantly shorter in the high BMI group than that in the low BMI group, whereas the time until HD transfer was not significantly different between the two groups (P < 0.001 and 0.18, respectively). Peritonitis-free and ESI/TI-free survivals were significantly shorter in the high BMI group than those in the low BMI group (P = 0.006 and 0.03, respectively). After adjusting for age, sex, diabetes mellitus, and estimated glomerular filtration rate, high BMI remained a significant risk factor for transferring to HD and hybrid therapy, peritonitis, and ESI/TI (hazard ratio [HR] 2.60, P < 0.001; HR 2.08, P = 0.01; HR 2.64, P = 0.02, respectively). Conclusion: BMI ≥ 25 kg/m2 is a risk factor for transition to HD and hybrid therapy, peritonitis, and ESI/TI, but not for complete HD transfer in Japanese patients with PD.

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• Health-Related Quality of Life Sleep Score Predicts Transfer to Hemodialysis among Patients on Peritoneal Dialysis

  Nagasaka T., Washida N., Uchiyama K., Hama E.Y., Kusahana E., Nakayama T., Yasuda I., Morimoto K., Itoh H.

  Healthcare (Switzerland) （Healthcare (Switzerland))  10 （ 6 ） 1030 - 1030 2022年06月

  責任著者

  　概要を見る

  Despite the superiority of peritoneal dialysis (PD) over hemodialysis (HD) regarding health-related quality of life (HRQOL), the specific HRQOL domain(s) that predict unplanned HD transfer remains uncertain. In this cohort study, we assessed the HRQOL of 50 outpatients undergoing PD using the Japanese version 1.3 Kidney Disease Quality of Life-Short Form from March 2017 to March 2018 and prospectively analyzed the association of each HRQOL component with HD transfer until June 2021. During the follow-up (41.5 (13.0–50.1) months), 21 patients were transferred to HD. In a multivariate Cox proportional hazards model adjusted for age, sex, PD vintage, urine output, Charlson comorbidity index, and incremental shuttle walking test, a higher sleep score was significantly associated with lower HD transfer rates (HR 0.70 per 10, p = 0.01). An adjusted subdistribution hazard model where elected transition to HD, death, and transplantation were considered competing events of unintended HD transfer that showed sleep score as an exclusive predictor of HD transfer (HR 0.70 per 10, p = 0.002). Our results suggest that sleep score among the HRQOL subscales is instrumental in predicting HD transfer in patients undergoing PD.

  • Access to Document (DOI)

• Development of Alveolar Hemorrhage After Pfizer-BioNTech COVID-19 mRNA Vaccination in a Patient With Renal-Limited Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Case Report

  Nishioka K., Yamaguchi S., Yasuda I., Yoshimoto N., Kojima D., Kaneko K., Aso M., Nagasaka T., Yoshida E., Uchiyama K., Tajima T., Yoshino J., Yoshida T., Kanda T., Itoh H.

  Frontiers in Medicine （Frontiers in Medicine)  9 2022年04月

  　概要を見る

  Since the coronavirus disease 2019 (COVID-19) pandemic continues and a new variant of the virus has emerged, the COVID-19 vaccination campaign has progressed. Rare but severe adverse outcomes of COVID-19 vaccination such as anaphylaxis and myocarditis have begun to be noticed. Of note, several cases of new-onset antineutrophil cytoplasmic antibody-associated vasculitis (AAV) after COVID-19 mRNA vaccination have been reported. However, relapse of AAV in remission has not been recognized enough as an adverse outcome of COVID-19 vaccination. We report, to our knowledge, a first case of renal-limited AAV in remission using every 6-month rituximab administration that relapsed with pulmonary hemorrhage, but not glomerulonephritis, following the first dose of the Pfizer-BioNTech COVID-19 vaccine. The patient received the COVID-19 vaccine more than 6 months after the last dose of rituximab according to the recommendations. However, his CD19+ B cell counts were found to be increased after admission, indicating that our case might have been prone to relapse after COVID-19 vaccination. Although our case cannot establish causality between AAV relapse and COVID-19 mRNA vaccination, a high level of clinical vigilance for relapse of AAV especially in patients undergoing rituximab maintenance therapy following COVID-19 vaccination should be maintained. Furthermore, elapsed time between rituximab administration and COVID-19 mRNA vaccination should be carefully adjusted based on AAV disease-activity.

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• アシストPD

  内山 清貴, 鷲田 直輝

  腎代替療法のすべて 92巻 ( 増刊号 ) 373 - 379 2022年06月

  筆頭著者

• ADPKDの治療：②非薬物治療（生活指導を中心に）

  内山 清貴

  腎臓内科 14 ( 5 ) 545 - 551 2021年11月

  筆頭著者

• 腎不全と腎代替療法 腹膜透析 14 腹膜透析の種類

  内山清貴, 鷲田直輝

  透析ケア  2021年

  ISSN  1341-1489

• 長期腹膜透析患者における、継続した腎代替療法選択の結果としての生体腎移植

  内山 清貴, 楊井 朱音, 北山 千草, 坂口 隆志, 高上 紀之, 小野 慶介, 前田 啓造, 上條 由佳, 栁 麻衣, 石橋 由孝

  腎と透析 腹膜透析2019 87巻別冊   176 - 177 2019年11月

  筆頭著者

• 長期腹膜透析後、生体腎移植を施行した高安動脈炎の一例

  楊井 朱音, 内山 清貴, 北山 千草, 坂口 隆志, 高上 紀之, 小野 慶介, 前田 啓造, 上條 由佳, 栁 麻衣, 石橋 由孝

  腎と透析 腹膜透析2019 87巻別冊   204 - 205 2019年11月

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• 若手研究者賞

  2022年06月, 日本抗加齢医学会, 慢性腎臓病における運動耐用能低下の意義および運動療法の有用性についての検討

• 三四会奨励賞

  2022年06月, 慶應義塾大学医学部 三四会, Home-based aerobic exercise and resistance training for severe chronic kidney disease: a randomized controlled trial

• 優秀演題賞

  2019年06月, 日本抗加齢医学会

• YIA 会長賞（最優秀賞）

  2019年03月, 日本腎臓リハビリテーション学会

• 優秀演題（医師部門臨床研究）

  2018年10月, 日本腹膜透析医学会

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• 多発性嚢胞腎協会, 

  2022年06月

  -

  継続中

• 日本人類遺伝学会, 

  2022年05月

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  継続中

• International Society for Peritoneal Dialysis, 

  2022年01月

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  継続中

• 日本腎臓リハビリテーション学会, 

  2018年11月

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  継続中

• 日本抗加齢医学会, 

  2018年

  -

  継続中

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• 2019年

  -

  継続中

  疾患登録・調査研究分科会 多発性嚢胞腎ワーキンググループ, 厚生労働科学研究費補助金難治性疾患等政策研究事業（難治性疾患政策研究事業） 難治性腎障害に関する調査研究班

• 2017年

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  継続中

  腹膜透析ガイドライン改訂ワーキンググループ（Systematic Review (SR)）, 一般社団法人日本透析医学会