論文 - 花岡　健二郎

Trans-omics landscape of systemic vasculitis identified matrix metalloproteinase 12 as a novel signature molecule.

Matsumoto K, Suzuki K, Magi M, Onishi S, Yoshida H, Takeshita M, Kuramoto J, Yazawa M, Kato T, Shimizu H, Ito T, Yamada S, Sasaki E, Hanaoka K, Noguchi-Sasaki M, Matsumoto Y, Takeuchi T, Kaneko Y

Rheumatology (Oxford, England) 2025年03月

ISSN  1462-0324

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Development of a near-infrared fluorescent probe for the selective detection of severe hypoxia

Kasai, T; Fujita, K; Komatsu, T; Ueno, T; Kojima, R; Hanaoka, K; Urano, Y

RSC CHEMICAL BIOLOGY 6 （ 3 ） 449 - 456 2025年03月

ISSN  2633-0679

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Identification of Fungal Metabolite Gliotoxin as a Potent Inhibitor Against Bacterial <i>O</i>-Acetylserine Sulfhydrylase CysK and CysM

Rahman, A; Ono, K; Toyomoto, T; Hanaoka, K; Sawa, T

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 26 （ 3 ）  2025年02月

ISSN  1661-6596

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Heat-guided drug delivery via thermally induced crosslinking of polymeric micelles

Yamada, S; Sasaki, E; Ohno, H; Hanaoka, K

COMMUNICATIONS CHEMISTRY 7 （ 1 ） 287 2024年12月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  2399-3669

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In vitro selection of dye-fluorescence-enhancing peptide aptamer by cDNA display.

Kubo T, Koike T, Ouchi T, Khaliq N, Sasaki E, Kuroda K, Ueda M, Hanaoka K, Nemoto N

Analytical biochemistry 698   115722 2024年11月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0003-2697

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Development of a Fluorescence Probe for Detecting Nitroreductase Activity Based on Steric Repulsion-Induced Twisted Intramolecular Charge Transfer (sr-TICT)

Sugimoto, M; Sasaki, E; Ohno, H; Ikeno, T; Yamada, S; Hanaoka, K

CHEMICAL & PHARMACEUTICAL BULLETIN 72 （ 9 ） 810 - 816 2024年09月

研究論文（学術雑誌）, 共著, 最終著者, 責任著者, 査読有り,  ISSN  0009-2363

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Recent advances in Si-rhodamine-based fluorescent probes for live-cell imaging

Ohno, H; Sasaki, E; Yamada, S; Hanaoka, K

ORGANIC & BIOMOLECULAR CHEMISTRY 22 （ 16 ） 3099 - 3108 2024年04月

研究論文（学術雑誌）, 共著, 最終著者, 責任著者, 査読有り,  ISSN  1477-0520

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Thioester-Based Coupled Fluorogenic Assays in Microdevice for the Detection of Single-Molecule Enzyme Activities of Esterases with Specified Substrate Recognition

Ukegawa, T; Komatsu, T; Minoda, M; Matsumoto, T; Iwasaka, T; Mizuno, T; Tachibana, R; Sakamoto, S; Hanaoka, K; Kusuhara, H; Honda, K; Watanabe, R; Urano, Y

ADVANCED SCIENCE 11 （ 10 ） e2306559 2024年03月

研究論文（学術雑誌）, 共著, 査読有り

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A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT)

Hanaoka, K; Ikeno, T; Iwaki, S; Deguchi, S; Takayama, K; Mizuguchi, H; Tao, F; Kojima, N; Ohno, H; Sasaki, E; Komatsu, T; Ueno, T; Maeda, K; Kusuhara, H; Urano, Y

SCIENCE ADVANCES 10 （ 7 ） eadi8847 2024年02月

研究論文（学術雑誌）, 共著, 筆頭著者, 責任著者, 査読有り,  ISSN  2375-2548

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Whole-Body and Whole-Organ 3D Imaging of Hypoxia Using an Activatable Covalent Fluorescent Probe Compatible with Tissue Clearing

Sakamoto, DM; Tamura, I; Yi, B; Hasegawa, S; Saito, Y; Yamada, N; Takakusagi, Y; Kubota, SI; Kobayashi, M; Harada, H; Hanaoka, K; Taki, M; Nangaku, M; Tainaka, K; Sando, S

ACS NANO 18 （ 6 ） 5167 - 5179 2024年02月

研究論文（学術雑誌）, 査読有り,  ISSN  1936-0851

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Discovery of a cystathionine <i>γ</i>-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation

Echizen, H; Hanaoka, K; Shimamoto, K; Hibi, R; Toma-Fukai, S; Ohno, H; Sasaki, E; Komatsu, T; Ueno, T; Tsuchiya, Y; Watanabe, Y; Otsuka, T; Saito, H; Nagatoishi, S; Tsumoto, K; Kojima, H; Okabe, T; Shimizu, T; Urano, Y

SCIENTIFIC REPORTS 13 （ 1 ） 16456 2023年09月

研究論文（学術雑誌）, 共著, 責任著者, 査読有り,  ISSN  2045-2322

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Development of pathway-oriented screening to identify compounds to control 2-methylglyoxal metabolism in tumor cells.

Yanagi K, Komatsu T, Fujikawa Y, Kojima H, Okabe T, Nagano T, Ueno T, Hanaoka K, Urano Y

Communications chemistry 6 （ 1 ） 68 2023年04月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  2399-3669

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Real-time in situ X-ray micro-computed tomography study of the effect of impurities on the crystallization of amorphous nifedipine.

Amano Y, Misawa T, Miyazaki T, Ando D, Koide T, Izutsu KI, Kanazawa H, Hanaoka K, Yamamoto E

Journal of pharmaceutical and biomedical analysis 226   115248 2023年01月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0731-7085

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Alkyl gallates inhibit serine O-acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics.

Toyomoto T, Ono K, Shiba T, Momitani K, Zhang T, Tsutsuki H, Ishikawa T, Hoso K, Hamada K, Rahman A, Wen L, Maeda Y, Yamamoto K, Matsuoka M, Hanaoka K, Niidome T, Akaike T, Sawa T

Frontiers in microbiology 14   1276447 2023年

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1664-302X

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Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors.

Aung W, Tsuji AB, Hanaoka K, Higashi T

World journal of clinical oncology 13 （ 11 ） 880 - 895 2022年11月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  2218-4333

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General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process

Hanaoka Kenjiro, Iwaki Shimpei, Yagi Kiyoshi, Myochin Takuya, Ikeno Takayuki, Ohno Hisashi, Sasaki Eita, Komatsu Toru, Ueno Tasuku, Uchigashima Motokazu, Mikuni Takayasu, Tainaka Kazuki, Tahara Shinya, Takeuchi Satoshi, Tahara Tahei, Uchiyama Masanobu, Nagano Tetsuo, Urano Yasuteru

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 144 （ 43 ） 19778 - 19790 2022年10月

研究論文（学術雑誌）, 共著, 筆頭著者, 責任著者, 査読有り,  ISSN  0002-7863

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RELATIONSHIP BETWEEN MOUSE WOUND HEALING AND KERATIN 17

Ito M., Imbe Y., Wang Q., Aramaki N., Okabe K., Sakai S., Takaya K., Kanazawa H., Hanaoka K., Kishi K.

WOUND REPAIR AND REGENERATION 30 （ 4 ） A9 - A9 2022年07月

ISSN  1067-1927

SEARCH FOR THE FORMATION MECHANISM OF ACTIN CABLE FOR COMPLETE SKIN REGENERATION

Imbe Y., Ito M., Wang Q., Aramaki N., Okabe K., Sakai S., Takaya K., Kanazawa H., Hanaoka K., Kishi K.

WOUND REPAIR AND REGENERATION 30 （ 4 ） A9 - A9 2022年07月

ISSN  1067-1927

Development of a fluorescent probe library enabling efficient screening of tumour-imaging probes based on discovery of biomarker enzymatic activities.

Kuriki Y, Yoshioka T, Kamiya M, Komatsu T, Takamaru H, Fujita K, Iwaki H, Nanjo A, Akagi Y, Takeshita K, Hino H, Hino R, Kojima R, Ueno T, Hanaoka K, Abe S, Saito Y, Nakajima J, Urano Y

Chemical science 13 （ 16 ） 4474 - 4481 2022年04月

研究論文（学術雑誌）, 査読有り,  ISSN  2041-6520

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Molecular design of near-infrared (NIR) fluorescent probes targeting exopeptidase and application for detection of dipeptidyl peptidase 4 (DPP-4) activity

Hoshino Yuki, Hanaoka Kenjiro, Sakamoto Kei, Yasunaga Masahiro, Kojima Takashi, Kotani Daisuke, Nomoto Ayumu, Sasaki Eita, Komatsu Toru, Ueno Tasuku, Takamaru Hiroyuki, Saito Yutaka, Seto Yasuyuki, Urano Yasuteru

RSC CHEMICAL BIOLOGY 3 （ 7 ） 859 - 867 2022年03月

研究論文（学術雑誌）, 筆頭著者, 責任著者, 査読有り,  ISSN  2633-0679

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