論文 - 花岡　健二郎

M cell-dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer's patches.

Komiyama S, Kodaira Y, Maeda R, Sugiura Y, Suzuki K, Saeki A, Kinashi Y, Oguchi H, Takano K, Onawa S, Matsui A, Sasaki E, Hattori-Muroi K, Kimura S, Fujimura Y, Ka Y, Ogura T, Hanaoka K, Ito M, Watarai H, Kaisho T, Udagawa N, Takahashi D, Hase K

Proceedings of the National Academy of Sciences of the United States of America 123 （ 2 ） e2506550123 2026年01月

研究論文（学術雑誌）, 査読有り,  ISSN  0027-8424

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Thermo-responsive targeting of polymeric micelles by controlling the cellular uptake based on the change of their surface arginine density

Yamada, S; Sasaki, E; Ohno, H; Nagase, K; Hanaoka, K

COMMUNICATIONS CHEMISTRY 8 （ 1 ） 325 2025年11月

研究論文（学術雑誌）, 査読有り,  ISSN  2399-3669

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Development of a silicon phthalocyanine analogue for near-infrared photoimmunotherapy and its application to HTLV-1-infected leukemic cells

Fuse, Y; Sasaki, E; Tamaki, M; Kawamura, S; Ohno, H; Yamada, S; Yasunaga, M; Takakura, H; Hanaoka, H; Kobayashi, H; Nakasone, H; Hanaoka, K

RSC CHEMICAL BIOLOGY 6 （ 10 ） 1576 - 1584 2025年10月

研究論文（学術雑誌）, 査読有り,  ISSN  2633-0679

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Formation of actin mesh structures and alpha-smooth muscle actin dynamics in fibroblasts contribute to dermal regeneration in mouse fetus

Takaya, K; Wang, Q; Imbe, Y; Nobusue, H; Okabe, K; Sakai, S; Aramaki-Hattori, N; Hanaoka, K; Saya, H; Kishi, K

PLOS ONE 20 （ 9 ） e0331006 2025年09月

研究論文（学術雑誌）, 査読有り

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Recent advances in fluorogenic probes based on twisted intramolecular charge transfer (TICT) for live-cell imaging

Ohno, H; Sumitani, S; Sasaki, E; Yamada, S; Hanaoka, K

CHEMICAL COMMUNICATIONS 61 （ 69 ） 12871 - 12884 2025年08月

研究論文（学術雑誌）, 査読有り,  ISSN  1359-7345

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Development of a near-infrared fluorescence probe for hypochlorous acid based on the phenyl-induced twisted intramolecular charge transfer (p-TICT) mechanism

Ohno, H; Sumitani, S; Chuluun-Erdene, A; Kuchimaru, T; Yamada, S; Sasaki, E; Hanaoka, K

CHEMICAL COMMUNICATIONS 61 （ 57 ） 10522 - 10525 2025年07月

研究論文（学術雑誌）, 査読有り,  ISSN  1359-7345

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SPATIAL TRANSCRIPTOMICS REVEAL THE ROLE OF MMP12 IN THE PATHOGENESIS OF GIANT CELL ARTERITIS

Onishi, S; Yoshida, H; Magi, M; Kato, C; Matsumoto, K; Suzuki, K; Takeshita, M; Kuramoto, J; Yazawa, M; Kato, T; Yamada, S; Sasaki, E; Hanaoka, K; Akiyama, M; Kondo, Y; Kikuchi, J; Kaneko, Y

ANNALS OF THE RHEUMATIC DISEASES 84   383 - 384 2025年06月

研究論文（学術雑誌）, 査読有り,  ISSN  0003-4967

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Trans-omics landscape of systemic vasculitis identified matrix metalloproteinase 12 as a novel signature molecule.

Matsumoto K, Suzuki K, Magi M, Onishi S, Yoshida H, Takeshita M, Kuramoto J, Yazawa M, Kato T, Shimizu H, Ito T, Yamada S, Sasaki E, Hanaoka K, Noguchi-Sasaki M, Matsumoto Y, Takeuchi T, Kaneko Y

Rheumatology (Oxford, England) 64 （ 8 ） 4766 - 4775 2025年03月

研究論文（学術雑誌）, 査読有り,  ISSN  1462-0324

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Development of a near-infrared fluorescent probe for the selective detection of severe hypoxia

Kasai, T; Fujita, K; Komatsu, T; Ueno, T; Kojima, R; Hanaoka, K; Urano, Y

RSC CHEMICAL BIOLOGY 6 （ 3 ） 449 - 456 2025年03月

研究論文（学術雑誌）, 査読有り,  ISSN  2633-0679

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Identification of Fungal Metabolite Gliotoxin as a Potent Inhibitor Against Bacterial <i>O</i>-Acetylserine Sulfhydrylase CysK and CysM

Rahman, A; Ono, K; Toyomoto, T; Hanaoka, K; Sawa, T

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 26 （ 3 ）  2025年02月

研究論文（学術雑誌）, 査読有り,  ISSN  1661-6596

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Heat-guided drug delivery via thermally induced crosslinking of polymeric micelles

Yamada, S; Sasaki, E; Ohno, H; Hanaoka, K

COMMUNICATIONS CHEMISTRY 7 （ 1 ） 287 2024年12月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  2399-3669

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In vitro selection of dye-fluorescence-enhancing peptide aptamer by cDNA display.

Kubo T, Koike T, Ouchi T, Khaliq N, Sasaki E, Kuroda K, Ueda M, Hanaoka K, Nemoto N

Analytical biochemistry 698   115722 2024年11月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0003-2697

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Development of a Fluorescence Probe for Detecting Nitroreductase Activity Based on Steric Repulsion-Induced Twisted Intramolecular Charge Transfer (sr-TICT)

Sugimoto, M; Sasaki, E; Ohno, H; Ikeno, T; Yamada, S; Hanaoka, K

CHEMICAL & PHARMACEUTICAL BULLETIN 72 （ 9 ） 810 - 816 2024年09月

研究論文（学術雑誌）, 共著, 最終著者, 責任著者, 査読有り,  ISSN  0009-2363

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Recent advances in Si-rhodamine-based fluorescent probes for live-cell imaging

Ohno, H; Sasaki, E; Yamada, S; Hanaoka, K

ORGANIC & BIOMOLECULAR CHEMISTRY 22 （ 16 ） 3099 - 3108 2024年04月

研究論文（学術雑誌）, 共著, 最終著者, 責任著者, 査読有り,  ISSN  1477-0520

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Thioester-Based Coupled Fluorogenic Assays in Microdevice for the Detection of Single-Molecule Enzyme Activities of Esterases with Specified Substrate Recognition

Ukegawa, T; Komatsu, T; Minoda, M; Matsumoto, T; Iwasaka, T; Mizuno, T; Tachibana, R; Sakamoto, S; Hanaoka, K; Kusuhara, H; Honda, K; Watanabe, R; Urano, Y

ADVANCED SCIENCE 11 （ 10 ） e2306559 2024年03月

研究論文（学術雑誌）, 共著, 査読有り

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A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT)

Hanaoka, K; Ikeno, T; Iwaki, S; Deguchi, S; Takayama, K; Mizuguchi, H; Tao, F; Kojima, N; Ohno, H; Sasaki, E; Komatsu, T; Ueno, T; Maeda, K; Kusuhara, H; Urano, Y

SCIENCE ADVANCES 10 （ 7 ） eadi8847 2024年02月

研究論文（学術雑誌）, 共著, 筆頭著者, 責任著者, 査読有り,  ISSN  2375-2548

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Whole-Body and Whole-Organ 3D Imaging of Hypoxia Using an Activatable Covalent Fluorescent Probe Compatible with Tissue Clearing

Sakamoto, DM; Tamura, I; Yi, B; Hasegawa, S; Saito, Y; Yamada, N; Takakusagi, Y; Kubota, SI; Kobayashi, M; Harada, H; Hanaoka, K; Taki, M; Nangaku, M; Tainaka, K; Sando, S

ACS NANO 18 （ 6 ） 5167 - 5179 2024年02月

研究論文（学術雑誌）, 査読有り,  ISSN  1936-0851

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Discovery of a cystathionine <i>γ</i>-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation

Echizen, H; Hanaoka, K; Shimamoto, K; Hibi, R; Toma-Fukai, S; Ohno, H; Sasaki, E; Komatsu, T; Ueno, T; Tsuchiya, Y; Watanabe, Y; Otsuka, T; Saito, H; Nagatoishi, S; Tsumoto, K; Kojima, H; Okabe, T; Shimizu, T; Urano, Y

SCIENTIFIC REPORTS 13 （ 1 ） 16456 2023年09月

研究論文（学術雑誌）, 共著, 責任著者, 査読有り,  ISSN  2045-2322

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Development of pathway-oriented screening to identify compounds to control 2-methylglyoxal metabolism in tumor cells.

Yanagi K, Komatsu T, Fujikawa Y, Kojima H, Okabe T, Nagano T, Ueno T, Hanaoka K, Urano Y

Communications chemistry 6 （ 1 ） 68 2023年04月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  2399-3669

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Real-time in situ X-ray micro-computed tomography study of the effect of impurities on the crystallization of amorphous nifedipine.

Amano Y, Misawa T, Miyazaki T, Ando D, Koide T, Izutsu KI, Kanazawa H, Hanaoka K, Yamamoto E

Journal of pharmaceutical and biomedical analysis 226   115248 2023年01月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0731-7085

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