大谷木 正貴 (オオヤギ マサキ)

Ohyagi, Masaki

写真a

所属(所属キャンパス)

医学部 微生物学・免疫学教室 (信濃町)

職名

特任助教(有期)

学歴 【 表示 / 非表示

  • 2002年04月
    -
    2008年03月

    東京医科歯科大学, 医学部, 医学科

    大学, 卒業

  • 2015年04月
    -
    2020年03月

    東京医科歯科大学

    大学, 修了, 博士

学位 【 表示 / 非表示

  • 博士(医学), 東京医科歯科大学, 課程, 2020年03月

 

論文 【 表示 / 非表示

  • Intrathecal IgG Synthesis and Persistent Inflammation Are Associated with White Matter Lesions in HIV-negative Patients with Cryptococcal Meningoencephalitis

    Ohyagi, M., Irioka, T., Ohkubo, T., Ishibashi, S., Takahashi, Y. K., Amano, E., Machida, A., Kuwahara, H. and Yokota, T.

    Intern Med 58 ( 21 ) 3077 - 3082 2019年11月

    ISSN  0918-2918

     概要を見る

    Objective Cryptococcal meningoencephalitis (CM) causes significant morbidity and mortality in human immunodeficiency virus (HIV)-negative and HIV-positive populations. White matter lesions (WMLs) have been reported in both populations of CM patients; however, the mechanisms underlying WML formation remain unknown. We herein report the relationship between the intrathecal immune response and the development of WMLs in HIV-negative patients with CM. Methods Eleven consecutive HIV-negative patients with CM who presented at one of three emergency hospitals in Japan from April 2001 to March 2018 were enrolled. For all patients, we retrospectively assessed the relationships between clinical and laboratory information and the presence of WMLs. Results At presentation, 6 patients had WMLs on magnetic resonance imaging (MRI). The cerebrospinal fluid immunoglobulin G (CSF IgG) index was significantly higher in the patients with WMLs than in those without WMLs (mean, 1.34 vs. 0.70, p=0.017). The time from the symptom onset to initial neuroimaging was also significantly longer in the patients with WMLs than in those without WMLs (median, 31.5 vs. 7.0 days; p=0.008). The clinical outcome was comparable among the patients with and without WMLs. Conclusion In HIV-negative patients with CM, a persistent, aberrant immune response to Cryptococcus, such as intrathecal IgG synthesis, may induce WML formation.

  • Subacute Supranuclear Palsy in anti-Hu Paraneoplastic Encephalitis

    Ohyagi, M., Ishibashi, S., Ohkubo, T., Kobayashi, Z., Mizusawa, H., Yokota, T., Emoto, H. and Kiyosawa, M.

    Can J Neurol Sci 44 ( 4 ) 444 - 446 2017年07月

    ISSN  0317-1671

  • Embolic stroke during apixaban therapy for left atrial appendage thrombus

    Ohyagi, M., Nakamura, K., Watanabe, M. and Fujigasaki, H.

    J Stroke Cerebrovasc Dis 24 ( 4 ) e101 - 2 2015年04月

    ISSN  1052-3057

     概要を見る

    Left atrial appendage (LAA) thrombus is associated with atrial fibrillation (AF) and is a powerful predictor of cardiogenic thromboembolism. Warfarin is an established anticoagulant therapy for patients with LAA thrombus to prevent thromboembolic complications. Apixaban is superior to warfarin in the prevention of thromboembolic complications in patients with AF, and there are case reports showing apixaban-associated resolution of LAA thrombus; however, the efficacy and safety of apixaban for the treatment of LAA thrombus remains unproven. Here we report a patient who experienced embolic stroke while taking apixaban for the treatment of LAA thrombus. Thrombolysis therapy was initiated at the onset of stroke and the patient recovered remarkably. Apixaban is known to make thrombi mobile and/or fragile by shifting the coagulation/fibrinolysis balance to a relative predominance of fibrinolytic activity; therefore, it is necessary to monitor for thromboembolic complications after the initiation of apixaban for the treatment of pre-existing LAA thrombus.

  • Porencephaly in a fetus and HANAC in her father: variable expression of COL4A1 mutation

    Takenouchi, T., Ohyagi, M., Torii, C., Kosaki, R., Takahashi, T. and Kosaki, K.

    Am J Med Genet A 167a ( 1 ) 156 - 8 2015年01月

    ISSN  1552-4825

     概要を見る

    COL4A1-associated disorders encompass a wide range of hereditary vasculopathy, including porencephaly and HANAC (adult-onset hemorrhagic stroke with cerebral aneurysm and retinal arterial tortuosity, renal cysts, and thenar muscle cramp). It remains elusive whether or not porencephaly and HANAC are molecularly distinctive disorders due to different classes of mutations. We report on a girl with porencephaly and an episode of microangiopathic hemolysis in infancy and her father with HANAC, both of whom had a heterozygous missense mutation of COL4A1 (c.3715G>A, p.G1239R). The current observation implies phenotypic diversities of COL4A1 mutations.

  • Progression of bilateral internal carotid artery dissection during antiplatelet therapy

    Ohyagi, M., Tao, O., Mizutani, T., Takahashi, M. and Mizusawa, H.

    Intern Med 52 ( 24 ) 2821 - 3 2013年

    ISSN  0918-2918

     概要を見る

    Bilateral internal carotid artery dissection (ICAD) is a rare but important cause of stroke in young adults. Anticoagulant and/or antiplatelet agents are usually recommended for stroke prevention;however, such treatments remain highly controversial, and there are inadequate data to compare the efficacy of anticoagulation and antiplatelet therapy. We herein report the case of 30-year-old man presenting with progressive bilateral ICAD during antiplatelet treatment. This report suggests the possibility that intramural hematomas are enlarged by antiplatelet and anticoagulant agents and draws attention to the medications associated with ICAD.

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競争的資金等の研究課題 【 表示 / 非表示

  • アルツハイマー病の早期アミロイド病理において脳内浸潤T細胞の果たす役割の解明

    2021年04月
    -
    2024年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 大谷木 正貴, 若手研究, 補助金,  代表

  • アルツハイマー病の脳内炎症における制御性T細胞の意義の解明

    2020年09月
    -
    2022年03月

    文部科学省・日本学術振興会, 科学研究費助成事業, 大谷木 正貴, 研究活動スタート支援, 補助金,  代表