Details of a Researcher

Papers - HIRATA Aya

Division display 21 - 40 of about 58 ／ All the affair displays >>

Determinants of salt taste threshold among urban residents: the KOBE study

WAKAKO Minami, SATA Mizuki, KUBOTA Yoshimi, NISHIDA Yoko, KUBO Sachimi, HIGASHIYAMA Aya, HIRATA Takumi, KADOTA Aya, HIRATA Aya, MIYAZAKI Junji, KAWAHARA Mizuki, KUWABARA Kazuyo, SUGIYAMA Daisuke, MIYAMATSU Naomi, MIYAMOTO Yoshihiro, OKAMURA Tomonori

Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH) (Japanese Society of Public Health) advpub ( 0 ) 2023

ISSN 05461766

Objectives Though having a high salt taste threshold has been associated with hypertension, its exact determinants remains unclear. This study aimed to identify the determinants of salt taste threshold in a community-based population and to determine the relationship between salt taste thresholds and the simultaneous presence of multiple determinants.Methods Of the 1,117 participants of the baseline survey of the Kobe study, a cohort study of healthy urban residents, aged 40-74 years, with no history of cancer or cardiovascular diseases, nor undergoing treatment for hypertension, diabetes, or dyslipidemia, was conducted. Among them, 1,116 underwent the salt taste threshold test, and urine samples were collected to determine their estimated salt intake. The salt taste threshold test was carried out using SALSAVE®, with a salt taste threshold of 0.6% defined as normal, and that of 0.8% or more defined as high. A binomial logistic regression model was used, with high salt taste threshold as the objective variable, and life and family status, education, smoking and alcohol drinking status, intake status of salt dried fish, stress indicators, and daily salt intake (estimated from the urine sample) as the explanatory variables. A binomial logistic regression analysis was conducted, through multivariate analysis using the forced entry method, with factors influencing salt taste threshold as explanatory variables, and salt taste threshold (normal/high) as the objective variable. This analysis was performed excluding the urinary sodium-to-potassium ratio to account for multicollinearity with the estimated daily salt intake.Results The mean age was 60.9±9.0 years for men, and 58.0±8.7 years for women. The salt taste threshold was normal in 80.9% (n=903) of the participants (73.6% [n=251] men and 84.1% [n=652] women), and high in 19.1% (n=213) of the participants (26.3% [n=90] men and 15.9% [n=123] women). Multivariate analysis revealed that smoking habits were significantly associated with a higher salt taste threshold, with an odds ratio (95% confidence interval) of 2.51 (1.33-4.74) for all participants. The odds ratio for a high salt taste threshold was 1.45 (1.03-2.03) for the top 25% estimated daily salt intake group, showing a significant association with a high salt taste threshold. In the analysis by sex, smoking habits were associated with higher salt taste thresholds, while an association with estimated daily salt intake was observed only in men.Conclusion Smoking status and estimated daily salt intake were associated with higher salt taste thresholds in healthy urban residents.

Association between visceral fat accumulation and decline in the estimated glomerular filtration rate based on cystatin C in the Japanese urban population: the KOBE study

Tanabe Ayumi, Hirata Aya, Kuwabara Kazuyo, Kubo Sachimi, Higashiyama Aya, Hirata Takumi, Sugiyama Daisuke, Nishida Yoko, Kubota Yoshimi, Kadota Aya, Nishikawa Tomofumi, Miyamatsu Naomi, Miyamoto Yoshihiro, Okamura Tomonori

Endocrine Journal (The Japan Endocrine Society) 70 ( 1 ) 97 - 106 2023

ISSN 09188959

Although metabolic syndrome, including visceral fat accumulation, causes kidney and cardiovascular diseases, the impact of visceral fat accumulation on mild decreased renal function remains unclear. This study examines the association between visceral fat area (VFA) measured by bioimpedance methods and the estimated glomerular filtration rate based on serum cystatin C (eGFRcys) in the Japanese urban population. This community-based cross-sectional study enrolled 952 individuals (287 men, 665 women) who participated in the second follow-up survey of the Kobe Orthopedic and Biomedical Epidemiological (KOBE) study. We compared the multivariate-adjusted means of eGFRcys among VFA quartile groups by gender using the analysis of covariance. Models were adjusted for age, high blood pressure, hypercholesterolemia, glucose intolerance, smoking, and alcohol use, and further adjusted for body mass index (BMI). The highest VFA quartile group had lower eGFRcys than the lowest VFA quartile group after adjusted for cardiometabolic risk factors, except for BMI (93.1 [95% confidence interval (CI), 90.1–96.2] vs. 82.1 [95% CI, 79.1–85.0] in men and 95.8 [95% CI, 94.1–97.5] vs. 89.4 [95% CI, 87.8–90.9] in women). Moreover, further adjustment for BMI revealed a similar result in men (93.5 [95% CI, 89.8–97.2] vs. 81.6 [95% CI, 77.9–85.3]), while no significant association was found in women. This study suggests a significant association between increased VFA levels and lower eGFRcys levels independent of cardiometabolic risk factors, such as glucose intolerance and hypercholesterolemia in men and women, as well as independent of BMI in men.

Determinants of double product: a cross-sectional study of urban residents in Japan

Nakagoshi Natsuko, Kubo Sachimi, Nishida Yoko, Kuwabara Kazuyo, Hirata Aya, Sata Mizuki, Higashiyama Aya, Kubota Yoshimi, Hirata Takumi, Tatsumi Yukako, Kawamura Kuniko, Miyazaki Junji, Miyamatsu Naomi, Sugiyama Daisuke, Miyamoto Yoshihiro, Okamura Tomonori

Environmental Health and Preventive Medicine (The Japanese Society for Hygiene) 28 ( 0 ) 37 - 37 2023

ISSN 1342078X

Background: The current study aimed to investigate the determinants of high double product (DP) by evaluating the association between resting DP, which is calculated as systolic blood pressure (SBP) multiplied by heart rate (HR), and blood test results and lifestyle factors.Methods: This research included 973 participants in the baseline survey of the KOBE study, which included a cohort of urban residents. The possible DP determinants were identified by examining the association between lifestyle factors and laboratory findings and DP by analyzing covariance adjusted for sex and age. Logistic regression analysis was performed with high DP (SBP × HR ≥ 9145 mmHg beats/min or quintile according to sex) as outcome and DP determinants as independent variables.Results: Age, hematocrit, and gamma-glutamyl transferase (log) level were positively associated with a high DP in both men and women. In addition, a high DP was positively associated with Homeostatic Model Assessment for Insulin Resistance score in women alone. Meanwhile, the amount of exercise was negatively associated with a high DP in men alone.Conclusions: High DP values at rest were associated with insulin resistance, gamma-glutamyl transferase, and the amount of exercise in participants without underlying disease.

Predicting habitual water intake from lifestyle questions

Tanaka, H; Mizuma, K; Nakamura, Y; Hirata, A; Miyazaki, J; Suzuki, K; Seta, H; Watanabe, H; Suzuki, T; Watanabe, R; Murayama, N; Okamura, T; Nakamura, S

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 27 ( 18 ) 8829 - 8841 2023

ISSN 1128-3602

Effect of Chronic Kidney Disease or Anemia or Both on Cardiovascular Mortality in a 25-Year Follow-Up Study of Japanese General Population (From NIPPON DATA90)

Kubo Kota, Okamura Tomonori, Sugiyama Daisuke, Hisamatsu Takashi, Hirata Aya, Kadota Aya, Kondo Keiko, Hirata Takumi, Higashiyama Aya, Hayakawa Takehito, Miyamoto Yoshihiro, Okayama Akira, Miura Katsuyuki, Ueshima Hirotsugu

AMERICAN JOURNAL OF CARDIOLOGY 184 1 - 6 2022.12

ISSN 0002-9149

Access to Document (DOI)

Impact of hypertension and diabetes on the onset of chronic kidney disease in a general Japanese population

Kaneyama Akira, Hirata Aya, Hirata Takumi, Imai Yukiko, Kuwabara Kazuyo, Funamoto Mika, Sugiyama Daisuke, Okamura Tomonori

HYPERTENSION RESEARCH 2022.09

ISSN 0916-9636

Access to Document (DOI)

Association Between Clinical Backgrounds and Malignant Progression of Suspected Intraductal Papillary Mucinous Neoplasm

Fukushima Genki, Abe Kodai, Kitago Minoru, Iwasaki Eisuke, Hirata Aya, Takemura Ryo, Ishii Ryota, Yagi Hiroshi, Abe Yuta, Hasegawa Yasushi, Fukuhara Seiichiro, Hori Shutaro, Tanaka Masayuki, Nakano Yutaka, Yokose Takahiro, Shimane Gaku, Kitagawa Yuko

PANCREAS 51 ( 6 ) 617 - 623 2022.07

ISSN 0885-3177

Access to Document (DOI)

Serum modified high-density lipoprotein and risk of atherosclerotic cardiovascular disease in a Japanese community-based nested case-control study

Sata Mizuki, Kakino Akemi, Hirata Aya, Iida Miho, Usami Yoko, Harada Sei, Fujita Yoshiko, Kohsaka Shun, Izawa Yoshikane, Sawano Mitsuaki, Oki Koichi, Sugiyama Daisuke, Takahashi Shinichi, Takebayashi Toru, Sawamura Tatsuya, Okamura Tomonori

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY 29 ( 5 ) E193 - E195 2022.05

ISSN 2047-4873

Access to Document (DOI)

Accumulated unhealthy behaviours and insomnia in Japanese dwellers with and without cardiovascular risk factors: a cross-sectional study

Kato Suzuka, Harada Sei, Iida Miho, Kuwabara Kazuyo, Sugiyama Daisuke, Takeuchi Ayano, Sata Mizuki, Matsumoto Minako, Kurihara Ayako, Hirata Aya, Okamura Tomonori, Takebayashi Toru

BMJ OPEN 12 ( 4 ) 2022.04

ISSN 2044-6055

Access to Document (DOI)

Prediction of Lifetime Risk of Cardiovascular Disease Deaths Stratified by Sex in the Japanese Population

Imai Yukiko, Tanaka Sachiko Mizuno, Satoh Michihiro, Hirata Takumi, Murakami Yoshitaka, Miura Katsuyuki, Waki Takashi, Hirata Aya, Sairenchi Toshimi, Irie Fujiko, Sata Mizuki, Ninomiya Toshiharu, Ohkubo Takayoshi, Ishikawa Shizukiyo, Miyamoto Yoshihiro, Ohnishi Hirofumi, Saitoh Shigeyuki, Tamakoshi Akiko, Yamada Michiko, Kiyama Masahiko, Iso Hiroyasu, Sakata Kiyomi, Nakagawa Hideaki, Okayama Akira, Ueshima Hirotsugu, Okamura Tomonori

JOURNAL OF THE AMERICAN HEART ASSOCIATION 10 ( 23 ) 2021.12

Access to Document (DOI)

Erratum to “Validity Assessment of Self-reported Medication Use for Hypertension, Diabetes, and Dyslipidemia in a Pharmacoepidemiologic Study by Comparison With Health Insurance Claims” [J Epidemiol 31 (9) (2021) 495–502]

Matsumoto Minako, Harada Sei, Iida Miho, Kato Suzuka, Sata Mizuki, Hirata Aya, Kuwabara Kazuyo, Takeuchi Ayano, Sugiyama Daisuke, Okamura Tomonori, Takebayashi Toru

Journal of Epidemiology (Japan Epidemiological Association) 31 ( 9 ) 520 - 521 2021.09

ISSN 09175040

Association between environmental cadmium exposure and plasma and urinary metabolite profiles in Japanese cohort study

Ishibashi Yoshiki, Harada Sei, Eitaki Yoko, Iida Miho, Kurihara Ayako, Hirata Aya, Shibuki Takuma, Okamura Tomonori, Hirayama Akiyoshi, Sugimoto Masahiro, Soga Tomoyoshi, Tomita Masaru, Takebayashi Toru

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 50 2021.09

ISSN 0300-5771

Change of smoking habits by introducing and spreading heated tobacco products in Japan

Harada Sei, Sata Mizuki, Matsumoto Minako, Takeuchi Ayano, Iida Miho, Kato Suzuka, Hirata Aya, Kuwabara Kazuyo, Sugiyama Daisuke, Okamura Tomonori, Takebayashi Toru

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 50 93 - 93 2021.09

ISSN 0300-5771

Access to Document (DOI)

SARS-CoV-2 Infection among Medical Institution Faculty and Healthcare Workers in Tokyo, Japan

Nishimura Tomoyasu, Uwamino Yoshifumi, Uno Shunsuke, Kashimura Shoko, Shiraki Toshikimi, Kurafuji Toshinobu, Morita Maasa, Noguchi Masayo, Azegami Tatsuhiko, Yamada-Goto Nobuko, Murai-Takeda Ayano, Yokoyama Hirokazu, Kuwabara Kazuyo, Kato Suzuka, Matsumoto Minako, Hirata Aya, Iida Miho, Harada Sei, Ishizaka Tamami, Misawa Kana, Murata Mitsuru, Saya Hideyuki, Amagai Masayuki, Kitagawa Yuko, Takeuchi Tsutomu, Mori Masaaki, Takebayashi Toru, Hasegawa Naoki, the Keio Donner Project Team

Internal Medicine (The Japanese Society of Internal Medicine) 60 ( 16 ) 2569 - 2575 2021.08

ISSN 09182918

Objective To consider effective measures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in medical institutions, this study estimated the SARS-CoV-2 infection rate among healthcare workers (HCWs) in Tokyo, Japan, and determined the specific findings for mild coronavirus disease 2019 (COVID-19) cases. Methods This study analyzed the results of serologic tests to detect immunoglobulin G antibodies against SARS-CoV-2 and evaluated the demographic and clinical characteristics of the faculty and HCWs at a Tokyo medical institution in August 2020. The demographic and clinical characteristics of participants with antibody-positive results were compared to those of participants with antibody-negative results. Materials This study recruited 2,341 faculty and HCWs at a Tokyo medical institution, 21 of whom had a COVID-19 history. Results Of the 2,320 participants without a COVID-19 history, 20 (0.862%) had positive serologic test results. A fever and dysgeusia or dysosmia occurred with greater frequency among the participants with positive test results than in those with negative results [odds ratio (OR), 5.475; 95% confidence interval (CI), 1.960-15.293 and OR, 24.158; 95% CI, 2.693-216.720, respectively]. No significant difference was observed in the positivity rate between HCWs providing medical care for COVID-19 patients using adequate protection and other HCWs (OR, 2.514; 95% CI, 0.959-6.588). Conclusion To reduce the risk of COVID-19 spread in medical institutions, faculty and HCWs should follow standard and necessary transmission-based precautions, and those with a fever and dysgeusia or dysosmia should excuse themselves from work as soon as possible.

Reliability of urinary charged metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry

Ishibashi Yoshiki, Harada Sei, Takeuchi Ayano, Iida Miho, Kurihara Ayako, Kato Suzuka, Kuwabara Kazuyo, Hirata Aya, Shibuki Takuma, Okamura Tomonori, Sugiyama Daisuke, Sato Asako, Amano Kaori, Hirayama Akiyoshi, Sugimoto Masahiro, Soga Tomoyoshi, Tomita Masaru, Takebayashi Toru

SCIENTIFIC REPORTS 11 ( 1 ) 2021.04

ISSN 2045-2322

Access to Document (DOI)

Electrocardiographic Left Atrial Abnormality and B-Type Natriuretic Peptide in a General Japanese Population: NIPPON DATA2010

Shoji Satoshi, Kadota Aya, Ueshima Hirotsugu, Okayama Akira, Miura Katsuyuki, for the NIPPON DATA2010 Research Group, Kohsaka Shun, Sawano Mitsuaki, Okamura Tomonori, Hirata Aya, Sugiyama Daisuke, Ohkubo Takayoshi, Nakamura Yasuyuki, Watanabe Makoto

Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ (一般社団法人日本動脈硬化学会) 28 ( 1 ) 34 - 43 2021

ISSN 1340-3478

Aims: P-wave terminal force in lead V1 (PTFV1) is an electrocardiogram marker of increased left atrial pressure and may be a noninvasive and early detectable marker for future cardiovascular events in the general population compared to serum B-type natriuretic peptide (BNP) concentration. The clinical significance of PTFV1 in the contemporary general population is an area of unmet need. We aimed to demonstrate the correlation between PTFV1 and BNP concentrations in a contemporary representative Japanese population. Methods: Among 2,898 adult men and women from 300 randomly selected districts throughout Japan (NIPPON DATA2010), we analyzed 2,556 participants without cardiovascular disease (stroke, myocardial infarction, and atrial fibrillation). Elevated BNP was defined as a value of ≥ 20 pg/mL based on the definition from the Japanese Circulation Society guidelines. Results: In total, 125 (4.9%) participants had PTFV1. Participants with PTFV1 were older with a higher prevalence of hypertension, major electrocardiographic findings, and elevated BNP concentrations (13.5 [6.9, 22.8] versus 7.8 [4.4, 14.5] pg/mL; P＜0.001). After adjustment for confounders, PTFV1 was correlated with elevated BNP (odds ratio, 1.66; 95% confidence interval, 1.05–2.62; P=0.030). This correlation was consistent among various subgroups and was particularly evident in those aged ＜65 years or those without a history of hypertension. Conclusions: In the contemporary general population cohort, PTFV1 was independently related to high BNP concentration. PTFV1 may be an alternative marker to BNP in identifying individuals at a higher risk of future cardiovascular events in the East Asian population.

Access to Document (DOI)

Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90

Hirata Aya, Kondo Keiko, Miura Katsuyuki, Okayama Akira, Ueshima Hirotsugu, Okamura Tomonori, Hirata Takumi, Sugiyama Daisuke, Ohkubo Takayoshi, Okuda Nagako, Kita Yoshikuni, Hayakawa Takehito, Kadota Aya

Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ (日本疫学会) 2021

ISSN 0917-5040

Background: Non-fasting triglycerides (TG) are considered a better predictor of cardiovascular disease (CVD) than fasting TG. However, the effect of non-fasting TG on fatal CVD events remains unclear. In the present study, we aimed to explore the relationship between non-fasting TG and CVD mortality in a Japanese general population.Methods: A total of 6,831 participants without a history of CVD, in which those who had a blood sampling over 8 hours or more after a meal were excluded, were followed for 18.0 years. We divided participants into seven groups according to non-fasting TG levels: ≤59 mg/dL, 60–89 mg/dL, 90–119 mg/dL, 120–149 mg/dL, 150–179 mg/dL, 180–209 mg/dL, and ≥210 mg/dL, and estimated the multivariable-adjusted hazard ratios (HRs) of each TG group for CVD mortality after adjusting for potential confounders, including high density lipoprotein cholesterol. Additionally, we performed analysis stratified by age <65 and ≥65 years.Results: During the follow-up period, 433 deaths due to CVD were detected. Compared with a non-fasting TG of 150–179 mg/dL, non-fasting TG ≥210 mg/dL was significantly associated with increased risk for CVD mortality (HR 1.56: 95% CI, 1.01–2.41). Additionally, lower levels of non-fasting TG were also significantly associated with increased risk for fatal CVD. In participants aged ≥65 years, lower levels of non-fasting TG had a stronger impact on increased risk for CVD mortality, while higher levels of non-fasting TG had a stronger impact in those aged <65 years.Conclusion: In a general Japanese population, we observed a U-shaped association between non-fasting TG and fatal CVD events.

Access to Document (DOI)

Impact of resting heart rate on cardiovascular mortality according to serum albumin levels in a 24-year follow-up study on a general Japanese population: NIPPON DATA80

Liu Yiwei, Okayama Akira, Ueshima Hirotsugu, Hirata Aya, Okamura Tomonori, Sugiyama Daisuke, Hirata Takumi, Kadota Aya, Kondo Keiko, Ohkubo Takayoshi, Miura Katsuyuki

Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ (日本疫学会) 2021

ISSN 0917-5040

BackgroundElevated resting heart rate (RHR) is associated with an increased risk for cardiovascular disease (CVD) and all-cause mortality. However, the findings of cohort studies differed. Thus, the impact of RHR on CVD mortality might be different according to the background of the population. Therefore, we examined the relationship of RHR and CVD mortality according to serum ALB levels in a Japanese general population.MethodsIn total, 8363 individuals without a history of CVD were followed-up for 24.0 years. The participants were divided into four groups according to the quartiles of RHR (Q1–Q4), and they were further classified into the high and low ALB groups based on a median value of 44 g/L. We estimated the multivariable-adjusted hazard ratios (HRs) of CVD mortality in each RHR group based on ALB levels, and the interaction between RHR and ALB groups on CVD mortality was evaluated.ResultsWe found no significant association between RHR and CVD mortality. However, the Q4 of RHR was significantly associated with an increased risk for CVD mortality (HR: 1.27 [95% confidence interval, CI: 1.02–1.57]) in participants with a low ALB level. Meanwhile, the Q4 of RHR was significantly correlated with a decreased risk for CVD morality in those with a high ALB level (HR: 0.61 [95% CI: 0.47–0.79]) after adjusting for covariates. A significant interaction between RHR and ALB for CVD mortality was shown (p<0.001).ConclusionsThe impact of RHR on CVD mortality differed according to ALB levels in a general Japanese population.

Access to Document (DOI)

Association of the Estimated Coronary Artery Incidence Risk According to the Japan Atherosclerosis Society Guidelines 2017 with Cardio-Ankle Vascular Index

Sata Mizuki, Matsumoto Minako, Kurihara Ayako, Takebayashi Toru, Okamura Tomonori, Harada Sei, Sugiyama Daisuke, Kuwabara Kazuyo, Hirata Aya, Takeuchi Ayano, Iida Miho, Kato Suzuka

Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ (一般社団法人日本動脈硬化学会) 2021

ISSN 1340-3478

Aims: The categories in the comprehensive lipid and risk management guidelines were proposed by the Japan Atherosclerosis Society (JAS Guidelines 2017), which adopted the estimated 10 year absolute risk of coronary artery disease (CAD) incidence in the Suita score. We examined whether those categories were concordant with the degree of arterial stiffness. Methods: In 2014, the cardio-ankle vascular index (CAVI), an arterial stiffness parameter, was measured in 1,972 Japanese participants aged 35–74 years in Tsuruoka City, Yamagata Prefecture, Japan. We examined the mean CAVI and the proportion and odds ratios (ORs) of CAVI ≥ 9.0 on the basis of the following three management classifications using the analysis of variance and logistic regression: "Category I (Low risk)," "Category II (Middle risk)," and "Category III (High risk)." Results: The mean CAVI and proportion of CAVI ≥ 9.0 were 8.6 and 34.8% among males and 8.1 and 18.3% among females, respectively. The mean CAVI and proportion of CAVI ≥ 9.0 were associated with an estimated 10 year absolute risk for CAD among males and females, excluding High risk for females. These results were similar to the management classification by the guideline: the multivariable-adjusted ORs (95% confidence intervals) of CAVI ≥ 9.0 among Category II and Category III compared with those among Category I were 2.96 (1.61–5.43) and 7.33 (4.03–13.3) for males and 3.99 (2.55–6.24) and 3.34 (2.16–5.16) for females, respectively. Conclusions: The risk stratification, which was proposed in the JAS Guidelines 2017, is concordant with the arterial stiffness parameter.

Access to Document (DOI)

Changes in smoking habits and behaviors following the introduction and spread of heated tobacco products in Japan and its effect on FEV1 decline: a longitudinal cohort study

Harada Sei, Ishibashi Yoshiki, Sugiyama Daisuke, Okamura Tomonori, Takebayashi Toru, Sata Mizuki, Matsumoto Minako, Iida Miho, Takeuchi Ayano, Kato Suzuka, Hirata Aya, Kuwabara Kazuyo, Shibuki Takuma

Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ (日本疫学会) 2021

ISSN 0917-5040

Background: Heated tobacco product (HTP) use in Japan has rapidly increased. Despite this rapid spread, little is known about the health effects of HTP use. We conducted a longitudinal cohort study to investigate the change in smoking habits following the spread of HTP use and its effect on forced expiratory volume in one second (FEV1) decline.Methods: Participants consisted of a resident population (n=2,612, aged 67.7) with FEV1 measurement in 2012-2014 and 2018-2019, and a worksite population (n=722, aged 49.3) without FEV1 data. Participants were categorized as never, past and combustible cigarette-only smokers, and HTP-only and dual users. The association between smoking group and the change in smoking consumption for 5.6 years was examined. Differences in annual FEV1 change between smoking groups were examined in the resident population.Results: Prevalence of HTP-only and dual users in 2018-2019 was 0.8% and 0.6% in the resident population, and 5.0% and 1.9% in the worksite population, respectively. The overall number of tobacco products smoked/used increased in dual users compared to baseline, but not in others. Annual FEV1 decline in dual users tended to be greater than that in cigarette-only smokers (16 mL/yr [95% CI: -34, 2] after full adjustment). Participants switching to HTP-only use 1.7 years before had a similar FEV1 decline as cigarette-only smokers.Conclusions: HTP use, including dual use, is prevalent even in a rural region of Japan. Dual users appear to smoke/use tobacco products more and have a greater FEV1 decline. Tobacco policy should consider dual use as high-risk.

Access to Document (DOI)

　 Previous page - Next page 　