広瀬 寛 (ヒロセ ヒロシ)

Hirose, Hiroshi

写真a

所属(所属キャンパス)

研究所・センター等 保健管理センター (日吉)

職名

准教授

特記事項

広瀬 寛

外部リンク

その他の所属・職名 【 表示 / 非表示

  • 医学部, 内科学(腎臓・内分泌・代謝), 兼担准教授

  • 医学部, 医学部予防医療センター, 兼担准教授

経歴 【 表示 / 非表示

  • 1988年05月
    -
    1992年02月

    大学助手(医学部内科学) 無給

  • 1992年03月
    -
    1993年02月

    大学助手(医学部内科学) 有給

  • 1993年03月
    -
    1996年05月

    大学助手(医学部内科学) 無給

  • 1996年06月
    -
    1999年03月

    大学助手(保健管理センター)

  • 1996年06月
    -
    継続中

    日吉診療所医師

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学歴 【 表示 / 非表示

  • 1986年03月

    慶應義塾, 医学部, 医学科

    大学, 卒業

学位 【 表示 / 非表示

  • 医学博士, 慶應義塾, 論文, 1993年09月

 

研究分野 【 表示 / 非表示

  • 代謝学

  • 応用健康科学

研究テーマ 【 表示 / 非表示

  • アディポサイトカインやメタボリックシンドロームの縦断的検討, 

    2010年04月
    -
    継続中

  • アディポサイトカインやSNPsを指標とした、メタボリックシンドロームの縦断的検討, 

    2000年04月
    -
    2010年03月

 

著書 【 表示 / 非表示

  • 改訂・保健衛生

    広瀬 寛, 慶應義塾大学出版会, 2014年04月

    担当範囲: 肥満とやせ(成人)/糖尿病/脂質異常症(高脂血症)(成人)

  • アディポネクチンとその受容体

    広瀬 寛, フジメディカル出版, 2008年06月

  • 別冊・医学のあゆみ state of arts 2004-2006

    広瀬 寛, 2004年04月

    担当範囲: 724-727

  • 分子糖尿病学の進歩-基礎から臨床まで-2004

    広瀬 寛、山本幸宏、齊藤郁夫, 東京・金原出版, 2004年03月

    担当範囲: 102-106

論文 【 表示 / 非表示

  • Features of and preventive measures against hypertension in the young

    Kawabe H., Azegami T., Takeda A., Kanda T., Saito I., Saruta T., Hirose H.

    Hypertension Research (Hypertension Research)  2019年

    ISSN  09169636

     概要を見る

    © 2019, The Author(s). The Japanese hypertension guidelines report that essential hypertension is detected in 1–3% of upper elementary and high school students during blood pressure (BP) screenings. Hypertension in these age groups is an emerging public health concern mainly attributed to the rising rate of pediatric obesity. Considering the existence of BP tracking phenomenon, early preventive education and instruction are necessary, especially for male students with moderately elevated BP showing a tendency toward obesity, despite the low prevalence of hypertension in high school students. Students with a positive family history of hypertension and those born with low birth weight need the same measures. Lifestyle habits, such as increased alcohol intake, dramatically change once students begin university; thus, early education and instruction regarding the factors influencing BP are necessary. In particular, for male students with higher BP during high school, caution regarding increased body weight is required irrespective of their level of obesity. Young adults aged <40 years should be educated about the association between body weight and hypertension. Particular caution surrounding lifestyle habits, including drinking and smoking, is warranted in male hypertensive subjects because hypertension at a young age is strongly associated with obesity. BP monitoring and the management of obesity should be considered efficient approaches to the detection and treatment of hypertension. For the lifetime prevention of hypertension, it is essential to be aware of one’s health status and learn about healthy lifestyles beginning in childhood. BP measurement may be an appropriate means to achieve this goal.

  • Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21

    Tanikawa C., Kamatani Y., Toyoshima O., Sakamoto H., Ito H., Takahashi A., Momozawa Y., Hirata M., Fuse N., Takai-Igarashi T., Shimizu A., Sasaki M., Yamaji T., Sawada N., Iwasaki M., Tsugane S., Naito M., Hishida A., Wakai K., Furusyo N., Murakami Y., Nakamura Y., Imoto I., Inazawa J., Oze I., Sato N., Tanioka F., Sugimura H., Hirose H., Yoshida T., Matsuo K., Kubo M., Matsuda K.

    Cancer Science (Cancer Science)  109 ( 12 ) 4015 - 4024 2018年12月

    ISSN  13479032

     概要を見る

    © 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. Gastric cancer is the third leading cause of cancer mortality in Japan and worldwide. Although previous studies identify various genetic variations associated with gastric cancer, host genetic factors are largely unidentified. To identify novel gastric cancer loci in the Japanese population, herein, we carried out a large-scale genome-wide association study using 6171 cases and 27 178 controls followed by three replication analyses. Analysis using a total of 11 507 cases and 38 904 controls identified two novel loci on 12q24.11-12 (rs6490061, P = 3.20 × 10 −8 with an odds ratio [OR] of 0.905) and 20q11.21 (rs2376549, P = 8.11 × 10 −10 with an OR of 1.109). rs6490061 is located at intron 19 of the CUX2 gene, and its expression was suppressed by Helicobacter pylori infection. rs2376549 is included within the gene cluster of DEFB families that encode antibacterial peptides. We also found a significant association of rs7849280 in the ABO gene locus on 9q34.2 (P = 2.64 × 10 −13 with an OR of 1.148). CUX2 and ABO expression in gastric mucosal tissues was significantly associated with rs6490061 and rs7849280 (P = 0.0153 and 8.00 × 10 −11 ), respectively. Our findings show the crucial roles of genetic variations in the pathogenesis of gastric cancer.

  • Temporal trends in renal function and birthweight in Japanese adolescent males (1998-2015)

    Kanda T., Takeda A., Hirose H., Abe T., Urai H., Inokuchi M., Wakino S., Tokumura M., Itoh H., Kawabe H.

    Nephrology Dialysis Transplantation (Nephrology Dialysis Transplantation)  33 ( 2 ) 304 - 310 2018年02月

    ISSN  09310509

     概要を見る

    © 2017 The Author . Published by Oxford University Press on behalf of ERA-EDTA. Background Low birthweight (LBW) is a worldwide public health problem, demonstrating an increasing incidence in developed countries, including Japan. LBW is also a risk factor for later development of chronic kidney disease (CKD). To date, studies have not evaluated the population impacts of increasing LBW rates on renal function. Methods Estimated glomerular filtration rate (EGFR) was evaluated in 3737 Japanese adolescent males (15-16 years old) using annual cross-sectional data over an 18-year period (1998-2015). Results Between the initial (1998-2003) and final (2010-15) periods of the study, the mean birthweight decreased from 3213.4 ± 383.8 to 3116.2 ± 382.3 g and the LBW rate increased from 2.5 to 5.5% (both P ≤ 0.01). Additionally, the mean EGFR decreased from 105.1 ± 15.9 to 97.4 ± 13.8 mL/min/1.73 m 2 and the prevalence of mildly reduced renal function (EGFR ≤ 60-<90 mL/min/1.73 m 2) increased from 16.4 to 30.0% (both P ≤ 0.01), most evident in the LBW group (from 10.3 to 41.7%, P ≤0.01). The prevalence of proteinuria also increased significantly. Mildly reduced renal function was significantly associated with LBW [odds ratio (LBW 3000-3999 g) 1.51; 95% confidence interval 1.00-2.55; P = 0.047]. Conclusions In this population of Japanese adolescents, the frequency of mildly reduced renal function increased as the LBW frequency increased. Our findings may have implications for the broader Japanese population as well as for other populations in which the prevalence of LBW is increasing.

  • Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

    Demenais F., Margaritte-Jeannin P., Barnes K., Cookson W., Altmüller J., Ang W., Barr R., Beaty T., Becker A., Beilby J., Bisgaard H., Bjornsdottir U., Bleecker E., Bønnelykke K., Boomsma D., Bouzigon E., Brightling C., Brossard M., Brusselle G., Burchard E., Burkart K., Bush A., Chan-Yeung M., Chung K., Couto Alves A., Curtin J., Custovic A., Daley D., De Jongste J., Del-Rio-Navarro B., Donohue K., Duijts L., Eng C., Eriksson J., Farrall M., Fedorova Y., Feenstra B., Ferreira M., Freidin M., Gajdos Z., Gauderman J., Gehring U., Geller F., Genuneit J., Gharib S., Gilliland F., Granell R., Graves P., Gudbjartsson D., Haahtela T., Heckbert S., Heederik D., Heinrich J., Heliövaara M., Henderson J., Himes B., Hirose H., Hirschhorn J., Hofman A., Holt P., Hottenga J., Hudson T., Hui J., Imboden M., Ivanov V., Jaddoe V., James A., Janson C., Jarvelin M., Jarvis D., Jones G., Jonsdottir I., Jousilahti P., Kabesch M., Kähönen M., Kantor D., Karunas A., Khusnutdinova E., Koppelman G., Kozyrskyj A., Kreiner E., Kubo M., Kumar R., Kumar A., Kuokkanen M., Lahousse L., Laitinen T., Laprise C., Lathrop M., Lau S., Lee Y., Lehtimäki T., Letort S., Levin A., Li G., Liang L., Loehr L., London S., Loth D., Manichaikul A.

    Nature Genetics (Nature Genetics)  50 ( 1 ) 42 - 50 2018年01月

    ISSN  10614036

     概要を見る

    © 2017 The Author(s). We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.

  • Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese

    広瀬 寛

    JOURNAL OF DIABETES RESEARCH 2017年

    研究論文(学術雑誌),  ISSN  2314-6745

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KOARA(リポジトリ)収録論文等 【 表示 / 非表示

研究発表 【 表示 / 非表示

  • オプション健診受診者における血清高分子量アディポネクチン濃度測定の意義

    広瀬 寛

    第57回日本人間ドック学会 (長野県松本市) , 2016年07月, 口頭(一般)

  • 人間ドック健診受診者における血圧状態と内臓脂肪・皮下脂肪面積やインスリン抵抗性指数(HOMA-R)などとの関連の検討

    広瀬 寛

    第38回日本高血圧学会 (愛媛県松山市) , 2015年10月, 口頭(一般)

  • Prediction of metabolic syndrome using artificial neural network system and clinical data

    広瀬 寛

    第43回日本動脈硬化学会 (札幌) , 2015年07月, シンポジウム・ワークショップ パネル(指名)

  • Associations of blood pressure status with visceral fat area and insulin resistance index, HOMA-R in men in a health checkup program

    広瀬 寛

    第25回欧州高血圧学会 (イタリア、ミラノ) , 2015年06月, ポスター(一般)

  • 高分子量アディポネクチンは有用な血中マーカーである

    広瀬 寛

    第42回日本総合健診医学会, 2014年01月, 口頭(一般)

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担当授業科目 【 表示 / 非表示

  • 現代社会と医学Ⅰ

    2019年度

担当経験のある授業科目 【 表示 / 非表示

  • 保健衛生

    慶應義塾, 2017年度, 通年, 教養科目, 講義, 専任, 1時間, 200人

    生活習慣病

  • 保健衛生

    慶應義塾, 2016年度, 通年, 教養科目, 講義, 専任, 1時間, 200人

    生活習慣病

  • 保健衛生

    慶應義塾, 2015年度, 通年, 教養科目, 講義, 専任, 1時間, 200人

    生活習慣病