KEIO RESEARCHERS INFORMATION SYSTEM

Career 【 Display / hide 】

Career 【 Display / hide 】

• 2002.10

  -

  2015.03

  慶應義塾大学, 医学部小児科, 研究員

• 2010.04

  -

  2015.03

  東京家政学院大学, 現代生活学部健康栄養学科, 准教授

• 2015.04

  -

  Present

  Keio University, Health Center, Assistant Professor

Academic Background 【 Display / hide 】

Academic Background 【 Display / hide 】

• 1988.04

  -

  1994.03

  Keio University, 医学部

  Japan, University, Graduated

Academic Degrees 【 Display / hide 】

Academic Degrees 【 Display / hide 】

• 博士(医学), Keio University, Dissertation, 2005.12

Licenses and Qualifications 【 Display / hide 】

Licenses and Qualifications 【 Display / hide 】

• 医師免許, 1994.05

• 日本小児科学会小児科専門医, 1998.05

• 日本小児循環器学会小児循環器専門医, 2015

Research Areas 【 Display / hide 】

Research Areas 【 Display / hide 】

• Pediatrics

• Developmental biology

• Cell biology

Research Keywords 【 Display / hide 】

Research Keywords 【 Display / hide 】

• Cardiovascular development

• Calcium signaling

Research Themes 【 Display / hide 】

Research Themes 【 Display / hide 】

• Calcium signaling in physiology and pathology, 

  1998.07

  -

  Present

• Molecular mechanisms of congenital heart diseases, 

  2002.10

  -

  Present

Papers, etc., Registered in KOARA 【 Display / hide 】

Papers, etc., Registered in KOARA 【 Display / hide 】

• Roles of stem cell antigen-1 in the pulmonary endothelium

  Uchida, Keiko

  科学研究費補助金研究成果報告書 2018

• A role of T-box genes in development of cardiovascular diseases

  Uchida, Keiko

  科学研究費補助金研究成果報告書 2018

• Intracellular calcium signals inhibiting the progression of pulmonary arterial hypertension

  Uchida, Keiko

  科学研究費補助金研究成果報告書 2016

• Basic research of prevention and intervention for congenital cardiac outflow tract defects using animal models

  Uchida, Keiko

  科学研究費補助金研究成果報告書 2015

• Exploring the molecular mechanism of embryonic pulmonary vascular development

  Uchida, Keiko

  科学研究費補助金研究成果報告書 2013

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

Research Projects of Competitive Funds, etc. 【 Display / hide 】

• Exploring novel proangiogenic factors of pulmonary artery using a LacZ reporter mouse for pulmonary artery smooth muscle

  2020.04

  -

  2023.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, 内田 敬子, Grant-in-Aid for Scientific Research (C), Principal Investigator

• Roles of Tbx4 for Pulmonary Vascular Development and Pulmonary Hypertension

  2017.04

  -

  2020.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, 内田　敬子, Grant-in-Aid for Scientific Research (C), Principal Investigator

• Intracellular Calcium Signals Inhibiting the Progression of Pulmonary Arterial Hypertension

  2014.04

  -

  2017.03

  MEXT,JSPS, Grant-in-Aid for Scientific Research, 内田　敬子, Grant-in-Aid for Scientific Research (C), Principal Investigator

  　View Summary

  Inositol trisphosphate receptor (IP3R) is an intracellular Ca2+ release channel. As we found the strong expression of the type 2 IP3R (IP3R2) in the pulmonary arterial smooth muscle cells (PASMCs), we investigated the contribution of IP3R2 to pathophysiology of PAH.
  IP3R2 knockout (KO) mice treated with chronic hypoxia showed higher PA pressure and RV pressure than WT mice in echocardiography. RV hypertrophy and medial wall thickness of PASMCs were more severe in KO. There was significant decrease of TUNEL positive cells in KO, suggesting that apoptosis was reduced in KO PASMCs. Ca2+ imaging revealed that SOCE was enhanced in KO compared with WT. Taken together, chronic hypoxia-induced PAH was deteriorated in IP3R2 KO. The deletion of IP3R2 gene led to inhibition of apoptosis and enhanced SOCE in PASMCs, probably resulting in acceleration of the progression of PAH induced by chronic hypoxia.

Courses Taught 【 Display / hide 】

Courses Taught 【 Display / hide 】

• MEDICINE IN MODERN SOCIETY 2

  2020

• MEDICINE IN MODERN SOCIETY 2

  2019