Kim, Yungi

写真a

Affiliation

Faculty of Pharmacy 創薬研究センター (Shiba-Kyoritsu)

Position

Professor (Non-tenured)

Career 【 Display / hide

  • 2006.01
    -
    2011.07

    University of Michigan, Department of Pathology, Post-doctral fellow

  • 2011.07
    -
    2013.06

    筑波大学, 医学医療系, 助教

  • 2013.06
    -
    2015.06

    University of Michigan, Department of Pathology, Research Investigator

  • 2015.06
    -
    2016.07

    Vedanta Biosciences, Inc., Senior Scientist

  • 2016.08
    -
    2018.09

    慶應義塾大学, 薬学部生化学講座, 准教授

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Academic Degrees 【 Display / hide

  • 博士(薬学), 北里大学, 2005.03

Licenses and Qualifications 【 Display / hide

  • 薬剤師, 2000

 

Research Keywords 【 Display / hide

  • アレルギー

  • 感染免疫

  • 腸内細菌

  • 自然免疫

Research Themes 【 Display / hide

  • 腸内環境調節と炎症性疾患の制御に関する研究, 

    2016
    -
    Present

 

Books 【 Display / hide

  • ヒトマイクロバイオーム Vol.2 ~解析技術の進展とデータ駆動型・ターゲット機能型研究最前線~

    金 倫基,  (株)エヌティーエス, 2020.06

    Scope: 第2節 乳幼児の腸内細菌叢の特性

  • 腸内細菌叢を標的とした医薬品と保健機能食品の開発

    金 倫基, 技術情報協会, 2018.09

    Scope: 腸内細菌叢の創薬応用の研究開発の現状と可能性について

  • ヒトマイクロバイオーム研究最前線

    金 倫基渋谷 彰, (株)エヌ・ティー・エス, 2016.03

    Scope: 腸内細菌叢と喘息

Papers 【 Display / hide

  • Specific adsorption of a β-lactam antibiotic in vivo by an anionexchange resin for protection of the intestinal microbiota

    Li S., Yakabe K., Zai K., Liu Y., Kishimura A., Hase K., Kim Y.G., Mori T., Katayama Y.

    Biomaterials Science Accepted 2021.10

    Research paper (scientific journal), Joint Work, Accepted

  • Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice

    Aoki R., Onuki M., Hattori K., Ito M., Yamada T., Kamikado K., Kim Y.G., Nakamoto N., Kimura I., Clarke J.M., Kanai T, Hase K.

    Microbiome 9 ( 1 ) 188 2021.09

    Research paper (scientific journal), Joint Work, Accepted

  • Seaweed Dietary Fiber Sodium Alginate Suppresses the Migration of Colonic Inflammatory Monocytes and Diet-Induced Metabolic Syndrome via the Gut Microbiota

    Ejima R., Akiyama M., Sato H., Tomioka S., Yakabe K., Kimizuka T., Seki N., Fujimura Y.. Hirayama A., Fukuda S., Hase K., Kim Y.G.

    Nutrients (Nutrients)  13 ( 8 ) 2812 2021.08

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    Metabolic syndrome (MetS) is a multifactorial chronic metabolic disorder that affects ap-proximately one billion people worldwide. Recent studies have evaluated whether targeting the gut microbiota can prevent MetS. This study aimed to assess the ability of dietary fiber to control MetS by modulating gut microbiota composition. Sodium alginate (SA) is a seaweed-derived dietary fiber that suppresses high-fat diet (HFD)-induced MetS via an effect on the gut microbiota. We observed that SA supplementation significantly decreased body weight gain, cholesterol levels, and fat weight, while improving glucose tolerance in HFD-fed mice. SA changed the gut microbiota composition and significantly increased the abundance of Bacteroides. Antibiotic treatment completely abolished the suppressive effects of SA on MetS. Mechanistically, SA decreased the number of co-lonic inflammatory monocytes, which promote MetS development, in a gut microbiota-dependent manner. The abundance of Bacteroides was negatively correlated with that of inflammatory mono-cytes and positively correlated with the levels of several gut metabolites. The present study revealed a novel food function of SA in preventing HFD-induced MetS through its action on gut microbiota.

  • Macropinocytosis and SARS-CoV-2 cell entry

    Sun X., Zheng W., Hua R., Liu Y., Wang L., Kim Y.G. , Liu X., Mimuro H., Shen Z., Li L., Yoshida S.

    Blood and Genomics 5 ( 1 ) 1 - 12 2021.07

    Research paper (scientific journal), Joint Work, Accepted

  • Gut microbiota prevents sugar alcohol-induced diarrhea

    Hattori K., Akiyama M., Seki N., Yakabe K., Hase K., Kim YG

    Nutrients (Nutrients)  13 ( 6 ) 2029 2021.06

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    While poorly-absorbed sugar alcohols such as sorbitol are widely used as sweeteners, they may induce diarrhea in some individuals. However, the factors which determine an individual’s susceptibility to sugar alcohol-induced diarrhea remain unknown. Here, we show that specific gut bacteria are involved in the suppression of sorbitol-induced diarrhea. Based on 16S rDNA analysis, the abundance of Enterobacteriaceae bacteria increased in response to sorbitol consumption. We found that Escherichia coli of the family Enterobacteriaceae degraded sorbitol and suppressed sorbitol-induced diarrhea. Finally, we showed that the metabolism of sorbitol by the E. coli sugar phosphotransferase system helped suppress sorbitol-induced diarrhea. Therefore, gut microbiota prevented sugar alcohol-induced diarrhea by degrading sorbitol in the gut. The identification of the gut bacteria which respond to and degrade sugar alcohols in the intestine has implications for microbiome science, processed food science, and public health.

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Papers, etc., Registered in KOARA 【 Display / hide

Reviews, Commentaries, etc. 【 Display / hide

  • 腸内環境を変動させる因子

    金 倫基

    腸内細菌叢生態学 (実験医学)  38 ( 18 ) 3047 - 3052 2020.10

    Introduction and explanation (commerce magazine), Single Work

  • 腸内細菌叢を標的とした医薬品開発

    金 倫基

    実験医学別冊もっとよくわかる!腸内細菌叢 健康と疾患を司る“もう1つの臓器” (羊土社)     118 - 128 2020.09

    Introduction and explanation (commerce magazine), Single Work

  • 腸内細菌叢をターゲットにした創薬開発と課題

    金 倫基

    CARDIAC PRACTICE (メディカルレビュー社)  29 ( 4 ) 299 - 302 2019.02

    Introduction and explanation (commerce magazine), Single Work

  • 腸内細菌による病原微生物に対する感染抵抗性

    金 倫基

    最新医学 73 ( 4 ) 538 - 544 2018.04

    Introduction and explanation (commerce magazine)

  • 食事による腸内細菌叢および宿主生理機能の変化

    冨岡 佐和子関 夏実金 倫基

    化学工業 (化学工業社)  69 ( 3 ) 48 - 54 2018.03

    Introduction and explanation (commerce magazine), Joint Work

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Presentations 【 Display / hide

  • 腸内細菌の創薬応用

    金 倫基

    腸内デザイン学会 腸内環境をデザインする~新たな「腸内細菌叢学」を目指して~, 2020.11, Symposium, Workshop, Panelist (nomination)

  • 抗肥満作用を発揮する腸内細菌関連代謝物の探索

    金 倫基

    第20回日本抗加齢医学会総会 腸内細菌の臨床応用 ―便移植からポストバイオティクスまで, 2020.09, Oral Presentation(guest/special)

  • 抗肥満作用を発揮する腸内細菌由来代謝物の探索

    金 倫基

    第32回微生物シンポジウム, 2020.09, Symposium, Workshop, Panelist (nomination)

  • 腸内細菌と肥満

    金 倫基

    第64回日本薬学会関東支部大会 シンポジウムS5 宿主防御機構の新しい視点, 2020.09, Symposium, Workshop, Panelist (nomination)

  • 腸内微生物を対象とした Live Biotherapeutic Productsの開発の現状

    金 倫基

    第23回日本臨床腸内微生物学会総会, 2020.09, Oral Presentation(guest/special)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 炎症性腸疾患における腸内細菌病因説の検証

    2020.07
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 金 倫基, Grant-in-Aid for Challenging Research (Exploratory), Principal Investigator

  • Identification of microbiota-associated metabolite which protects against

    2020.04
    -
    2023.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 金 倫基, Grant-in-Aid for Scientific Research (B), Principal Investigator

  • 腸内細菌叢の成熟に伴う腸管病原菌に対する感染抵抗性獲得機構

    2017.04
    -
    2020.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 金 倫基, Grant-in-Aid for Young Scientists (A), Principal Investigator

 

Courses Taught 【 Display / hide

  • PATHOBIOCHEMISTRY

    2021

  • INTRODUCTION TO THE PHARMACEUTICAL SCIENCES

    2021

  • PATHOBIOCHEMISTRY

    2020

  • INTRODUCTION TO THE PHARMACEUTICAL SCIENCES

    2020

  • PATHOBIOCHEMISTRY

    2019

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