Okuda, Takashi

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmaceutical Sciences 薬理学講座 （Shiba-Kyoritsu）

Position

Associate Professor
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Academic Degrees 【 Display / hide 】

  • 博士（理学）, The University of Tokyo, Coursework

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Research Areas 【 Display / hide 】

  • Neurochemistry/Neuropharmacology

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Papers 【 Display / hide 】

  • Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis.

    Watanabe-Matsumoto S, Moriwaki Y, Okuda T, Ohara S, Yamanaka K, Abe Y, Yasui M, Misawa H

    Neurosci. Res. （Neuroscience Research)  133   48-57 - 57 2018.08

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  01680102

    　View Summary

    © 2017 Elsevier Ireland Ltd and Japan Neuroscience Society Aquaporin-4 (AQP4) is abundantly expressed in the central nervous system and is involved in the water balance in the cellular environment. Previous studies have reported that AQP4 expression is upregulated in rat models of amyotrophic lateral sclerosis (ALS), a fatal disease that affects motor neurons in the brain and spinal cord. In this study, we report that astrocytic AQP4 overexpression is evident during the course of disease in the spinal cord of an ALS mouse model, as well as in tissue from patients with ALS. AQP4 overexpression appears to be specifically associated with ALS because it was not induced by other experimental manipulations that produced acute or chronic gliosis. In order to examine the contribution of AQP4 to ALS disease development, we crossed AQP4 knockout mice with a mouse model of ALS. Significant improvement in blood-brain barrier (BBB) permeability was observed in the AQP4-deficient ALS mouse model. However, the time to disease onset and total lifespan were reduced in the AQP4-deficient ALS mouse model. The contradictory results suggest that changes in AQP4 may be context-dependent and further studies are required to understand the precise contribution of brain water balance in ALS.

  • CHT1 (High-affinity Choline Transporter)

    Okuda, T.

    Encyclopedia of Signaling Molecules （Springer New York)   2018.06

    Research paper (scientific journal), Single Work, Accepted

  • コリン：ニューロンにおける機能

    奥田 隆志、三澤　日出巳

    Clinical Neuroscience 36 （ 6 ） 656 - 659 2018.06

    Research paper (scientific journal), Joint Work, Accepted

  • Reappraisal of VAChT-Cre: Preference in slow motor neurons innervating type I or IIa muscle fibers.

    Misawa, Hidemi, Inomata, Daijiro, Kikuchi, Miseri, Maruyama, Sae, Moriwaki, Yasuhiro, Okuda, Takashi, Nukina, Nobuyuki, Yamanaka, Tomoyuki

    GENESIS 54 （ 11 ） 568 - 572 2016.12

    Research paper (scientific journal),  ISSN  1526-954X

  • Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase. Neurodegeneration Mediated by Matrix Metalloproteinase-9

    Morisaki, Yuta, Niikura, Mamiko, Watanabe, Mizuho, Onishi, Kosuke, Tanabe, Shogo, Moriwaki, Yasuhiro, Okuda, Takashi, Ohara, Shinji, Murayama, Shigeo, Takao, Masaki, Uchida, Sae, Yamanaka, Koji, Misawa, Hidemi

    SCIENTIFIC REPORTS 6 2016.06

    Research paper (scientific journal),  ISSN  2045-2322

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Presentations 【 Display / hide 】

  • 小胞神経伝達物質トランスポーターのエンドサイトーシス・局在の分子機構

    OKUDA Takashi

    第88回日本薬理学会年会, 2015.03, Oral Presentation(general)

  • オステオポンチンはマウス脊髄におけるアルファー運動ニューロンサブタイプの新規マーカーである

    OKUDA Takashi

    第37回日本神経科学大会, 2014.09, Oral Presentation(general)

  • シナプス小胞トランスポーターのエンドサイトーシス・シグナル配列の同定

    OKUDA Takashi

    第9回トランスポーター研究会年会, 2014.06, Poster (general)

  • 筋萎縮性側索硬化症モデルマウスにおけるアクアポリン４の発現変動

    OKUDA Takashi

    日本薬学会　第134年会, 2014.03, Poster (general)

  • シナプス前性機能素子の機能と制御

    OKUDA Takashi

    東京大学農学部セミナー, 2014.03, Public discourse, seminar, tutorial, course, lecture and others

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Courses Taught 【 Display / hide 】

  • STUDY OF MAJOR FIELD: (PHARMACOLOGY)

    2020

  • SEMINAR: (PHARMACOLOGY)

    2020

  • RESEARCH FOR BACHELOR'S THESIS 1

    2020

  • PHARMACOLOGY LABORATORY COURSE

    2020

  • PHARMACOLOGY 3

    2020

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