Papers - Mochizuki, Mayumi

Development and evaluation of an overseas clinical rotation program for undergraduate pharmacy students in Japan.

Ohtani H, Mitsui R, Akiyoshi T, Imaoka A, Abe Y, Kanke M, Nakamura T, Foster P, Mochizuki M.

Curr Pharm Teach Learn. 9 ( 3 ) 452 - 459 2017.05

Research paper (scientific journal), Joint Work, Accepted

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Ethnic and gender differences in genetic polymorphisms of tumor necrosis factor (TNF)-α in a Japanese population.

Hakamata　J, Hashiguchi M, Tsuru T, Tanaka T, Irie S, Shimizu M, Mochizuki M.

Jpn J Clin Pharmacol Ther 48 ( (2) ) 21 - 26 2017

Research paper (scientific journal), Accepted

災害時に有効活用できるOTC医薬品

鹿村恵明、田中愛佳、根岸健一、下平秀夫、若林進、塚原俊夫、野村香織、出石啓治、宮崎長一郎、望月眞弓、上村直樹

医薬品情報学 (日本医薬品情報学会)  18 ( 4 ) 242 - 250 2017

Research paper (scientific journal), Accepted

生活習慣病患者のスイッチOTC医薬品に対する意識調査

成井 浩二, 石川 あゆみ, 小原 安希子, 鈴木 悠希, 岡本 有史, 富澤 崇, 望月 眞弓, 渡辺 謹三

社会薬学 (日本社会薬学会)  35 ( 2 ) 62 - 68 2016.12

Research paper (scientific journal), Accepted

Sex Differences in mRNA Expression of Reduced Folate Carrier-1, Folypolyformyl Glutamate Synthase, and γ-Glutamyl Hydrolase in a Healthy Japanese Population

Hashiguchi Masayuki, Tanaka Takanori, Shimizu Mikiko, Tsuru Tomomi, Chiyoda Takeshi, Miyawaki Kumika, Irie Shin, Takeuchi Osamu, Hakamata Jun, Mochizuki Mayumi

Journal of Clinical Pharmacology 56 ( 12 ) 1563 - 1569 2016.12

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0091-2700

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<p>Sex differences in the prevalence of autoimmune diseases such as rheumatoid arthritis (RA) are well known, but little is known about those differences in relation to therapeutic response. Reduced folate carrier-1 (RFC-1), folypolyformyl glutamate synthase (FPGS), and γ-glutamyl hydrolase (GGH) are important transporters and enzymes that convert methotrexate (MTX) in the body. This study investigated the sex differences in mRNA expression of RFC-1, FPGS, and GGH in 190 unrelated healthy Japanese people. The genotypes and mRNA expression were determined using the real-time PCR method. Significant differences between men and women were observed in RFC-1, FPGS, and GGH mRNA expression. The mRNA expression of FPGS and GGH was greater in women than that in men, but the expression of RFC-1 was less in the former than the latter. In stratified analysis by genotype, significant differences in sex-specific mRNA expression were observed in G/G of FPGS, C/C of GGH 452, and C/C of GGH -401. All showed greater mRNA expression in women than in men. In the 5 single-nucleotide polymorphisms RFC-1 80G&gt;A, RFC-1 -43T&gt;C, FPGS 1994G&gt;A, GGH 452C&gt;T, and GGH -401C&gt;T examined, the FPGS 1994 G/G (1.46-fold), GGH 452 C/C (2.16-fold), and GGH -401 C/C (2.68-fold) genotypes showed significantly higher mRNA expression in women than in men. Healthy Japanese adults in this study showed sex-specific differences in mRNA expression that differed among RFC-1, FPGS, and GGH. Therefore, the relationship between genetic polymorphisms and mRNA expression including sex differences might contribute to the variation in the efficacy/toxicity of MTX in patients with RA.</p>

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Possible involvement of distinct phylogenetic clusters of HIV-1 variants in the discrepancies between coreceptor tropism predictions based on viral RNA and proviral DNA.

Kotani H, Sudo K, Hasegawa N, Fujiwara H, Hayakawa T, Iketani O, Yamaguchi M, Mochizuki M, Iwata S, Kato S.

J Pharm Health Care Sci (Bio Med Central)  2   31 2016.11

Research paper (scientific journal), Joint Work, Accepted

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セルフメディケーションにおける薬剤師と需要者間の双方向性コミュニケーションの実現に向けた質問紙調査

高橋 由佳, 石井 伊都子, 望月 眞弓, 山下 純

医薬品情報学 (日本医薬品情報学会)  18 ( 3 ) 160 - 171 2016.11

Research paper (scientific journal), Joint Work, Accepted

Application of indirect comparison to the drug development process: forecasting direct comparison study results

Kunitomi T, Hashiguchi M, Mochizuki M.

J Clin Pharmacol 56 ( 9 ) 1165 - 1170 2016.09

Research paper (scientific journal), Accepted

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Pregnancy outcomes after exposure to tocilizumab: A retrospective analysis of 61 patients in Japan

Nakajima K, Watanabe O, Mochizuki M, Nakasone A, Ishizuka N, Murashima A

Mod Rheumatol 26 ( 5 ) 667 - 671 2016.09

Research paper (scientific journal), Accepted

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Socioeconomic Impacts of Policy on Rx-to-OTC Switch to Prescription of Ethical Drugs in Japan

Shimazaki, Keisuke, Takano, Yuma, Matsushima, Yukiko, Mochizuki, Mayumi, Takahashi, Kunihiko, Urushihara, Hisashi

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY 25   349 - 349 2016.08

Research paper (scientific journal),  ISSN  1053-8569

Preliminary study for predicting better methotrexate efficacy in Japanese patients with rheumatoid arthritis.

Hashiguchi M, Tsuru T, Miyawaki K, Suzaki M, Hakamata J, Shimizu M, Irie S, Mochizuki M.

J Pharm Health Care Sci. (Bio Med Central)  2   13 2016.06

Research paper (scientific journal), Joint Work, Accepted

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Genetic polymorphisms of enzyme proteins and transporters related to methotrexate response and pharmacokinetics in a Japanese population.

Hashiguchi M, Shimizu M, Hakamata J, Tsuru T, Tanaka T, Suzaki M, Miyawaki K, Chiyoda T, Takeuchi O, Hiratsuka J, Irie S, Maruyama J, Mochizuki M.

J Pharm Health Care Sci 9 ( 2 ) 35 2016

Research paper (scientific journal), Accepted

Preliminary study for predicting better methotrexate efficacy in Japanese patients with rheumatoid arthritis.

Hashiguchi M, Tsuru T, Miyawaki K, Suzaki M, Hakamata J, Shimizu M, Irie S, Mochizuki M.

J Pharm Health Care Sci 7 ( 2 ) 13 2016

Research paper (scientific journal), Accepted

Factors Affecting the Timing of Signal Detection of Adverse Drug Reactions

Masayuki Hashiguchi, Shungo Imai, Keiko Uehara, Junya Maruyama, Mikiko Shimizu, Mayumi Mochizuki

PLoS ONE 10 ( 2 ) e0144263 2015.12

Research paper (scientific journal), Joint Work, Accepted

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Student exchange program between Keio University and US universities for international clinical practice

Ohtani, Hisakazu, Foster, Patrick, Kanke, Motoko, Nakamura, Tomonori, Abe, Yoshihiro, Mochizuki, Mayumi

PHARMACOTHERAPY 35 ( 11 ) E245 - E245 2015.11

Research paper (scientific journal),  ISSN  0277-0008

Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals

Mikiko Shimizu, Masayuki Hashiguchi, Tsuyoshi Shiga, Hiro-omi Tamura, Mayumi Mochizuki

PLoS ONE 10 ( 10 ) e0139795 2015.10

Research paper (scientific journal), Joint Work, Accepted

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常用量以下の曝露量における全身性副作用の用量依存性の推定

三井 梨恵子, 秋好 健志, 今岡 鮎子, 望月 眞弓, 大谷 壽一

医薬品情報学 17 ( 2 ) 77 - 86 2015.08

Research paper (scientific journal), Accepted

Effect of database profile variation on drug safety assessment: an analysis of spontaneous adverse event reports of Japanese cases

Kaori Nomura, Kunihiko Takahashi, Yasushi Hinomura, Genta Kawaguchi, Yasuyuki Matsushita, Hiroko Marui, Tatsuhiko Anzai, Masayuki Hashiguchi, Mayumi Mochizuki

Drug Design, Development and Therapy (Dovepress)  9   3031 - 3041 2015.06

Research paper (scientific journal), Joint Work, Accepted

Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia

Masayuki Hashiguchi, Yuriko Ohta, Mikiko Shimizu, Junya Maruyama1 and Mayumi Mochizuki

Journal of Pharmaceutical Health Care and Sciences (BioMed Central)  1   14 2015.05

Research paper (scientific journal), Joint Work, Accepted

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薬学臨床系教員の現状に関するアンケート調査(第2報)

野田 幸裕, 矢野 育子, 青山 隆夫, 渡邊 美智留, 今田 愛也, 中村 均, 松下 良, 森田 邦彦, 三宅 勝志, 瀬尾 量, 上村 直樹, 富岡 佳久, 木津 純子, 望月 眞弓

医療薬学 41 ( 4 ) 223 - 235 2015.04

Research paper (scientific journal), Accepted