論文 - 松元　一明

大学病院でのICT病棟ラウンドにおける指摘事項の解析.

川村英樹, 折田美千代, 中川彩, 松元一明, 茂見茜里, 郡山豊泰, 西順一郎.

日本環境感染学会誌 28   25 - 28 2013年01月

研究論文（学術雑誌）, 共著, 査読有り

Pharmacokinetics of ampicillin-sulbactam and the renal function-based optimization of dosing regimens for prophylaxis in patients undergoing cardiovascular surgery.

Yokoyama Yuta, Matsumoto Kazuaki, Yamamoto Hiroyuki, Iguro Yoshifumi, Imoto Yutaka, Ikawa Kazuro, Morikawa Norifumi, Ishida Shiro, Okano Yoshiro, Watanabe Erika, Shimodozono Yoshihiro, Yamada Katsushi, Takeda Yasuo.

JOURNAL OF INFECTION AND CHEMOTHERAPY 18 （ 6 ） 878 - 882 2012年12月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1341-321X

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The Development of Appropriate Dosage of Anti-bacterial and Anti-fungal Agents Based on Pharmacokinetics and Pharmacodynamics.

Matsumoto Kazuaki.

YAKUGAKU ZASSHI 132 （ 10 ） 1171 - 1177 2012年10月

研究論文（学術雑誌）, 単著, 査読有り,  ISSN  0031-6903

Characterization of the hepatic cellular uptake of alpha(1)-acid glycoprotein (AGP), part 1: A peptide moiety of human AGP is recognized by the hemoglobin beta-chain on mouse liver parenchymal cells.

Nishi Koji, Komori Hisakazu, Kikuchi Mari, Uehara Nao, Fukunaga Naoko, Matsumoto Kazuaki, Watanabe Hiroshi, Nakajou Keisuke, Misumi Shogo, Suenaga Ayaka, Maruyama Toru, Otagiri Masaki.

JOURNAL OF PHARMACEUTICAL SCIENCES （WILEY-BLACKWELL）  101 （ 4 ） 1599 - 1606 2012年04月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0022-3549

　概要を見る

Human a1-acid glycoprotein (AGP), a serum glycoprotein, is known to have anti-inflammatory activity. We recently reported that AGP was mainly incorporated into the liver in mice via a receptor-mediated pathway, although the mechanism for this was largely unknown. The objective of this study was to identify the specific cellular surface protein that recognizes the peptide moiety of AGP. Pharmacokinetic studies of 111InAGP and 111In recombinant glycan-deficient AGP (rAGP) in mice demonstrated that both AGPs are mainly distributed to the liver and kidney, but hepatic and renal uptake clearance of rAGP was higher than that for AGP. Hepatic uptake of rAGP was inhibited in the presence of 100-fold excess of unlabeled AGP, indicating that the hepatic uptake of rAGP shared a common route with that of AGP and that it recognized the peptide moiety of AGPs. In ligand blotting analyses using crude cellular membrane fraction of mice liver, a band corresponding to a 16 kDa protein was observed to bind to both AGPs. Interestingly, matrix-assisted laser desorption ionizationtime-of-flight mass spectrometry MALDITOF-MS and western blotting analyses indicated that this 16 kDa protein is the hemoglobin beta-chain (HBB). It, therefore, appears that HBB is associated with the hepatic uptake of AGP via a direct interaction with its peptide moiety. (c) 2011 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:15991606, 2012

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Reduction in the incidence of MRSA with use of alcohol-based hand rub solutions and gloves.

Matsumoto Kazuaki, Shigemi Akari, Yaji Keiko, Shimodozono Yoshihiro, Takeda Yasuo, Ikawa Kazuro, Morikawa Norifumi, Miyanohara Hiroaki, Kawamura Hideki, Orita Michiyo, Tokuda Koichi, Nishi Junichiro, Yamada Katsushi.

JOURNAL OF INFECTION AND CHEMOTHERAPY 18 （ 2 ） 269 - 271 2012年04月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1341-321X

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抗菌薬TDMガイドライン.

竹末芳生, 大曲貴夫, 笠原敬, 関雅文, 髙倉俊二, 高橋佳子, 時松一成, 松元一明, 三鴨廣繁, 木村利美, 谷川原祐介, 五十嵐正博, 岡田賢二, 木村匡男, 小林昌宏, 西圭史, 浜田幸宏, 望月敬浩.

日本化学療法学会雑誌 60   501 - 505 2012年

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1340-7007

抗MRSA薬投与時のTDMの実際.

松元一明, 深水知英, 金澤直子, 日髙伸之介, 棈松和子, 茂見茜里, 下堂薗権洋, 武田泰生.

日本外科感染症学会雑誌 9   113 - 123 2012年

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1349-5755

テイコプラニンにおける血中トラフ濃度20μg/mL以上の臨床的効果、安全性.

髙倉俊二, 竹末芳生, 大曲貴夫, 笠原敬, 関雅文, 高橋佳子, 時松一成, 松元一明, 三鴨廣繁.

日本化学療法学会雑誌 60   501 - 505 2012年

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1340-7007

Safety analysis of liposomal amphotericin B in adult patients: anaemia, thrombocytopenia, nephrotoxicity, hepatotoxicity and hypokalaemia.

Shigemi Akari, Matsumoto Kazuaki, Ikawa Kazuro, Yaji Keiko, Shimodozono Yoshihiro, Morikawa Norifumi, Takeda Yasuo, Yamada Katsushi.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 38 （ 5 ） 417 - 420 2011年11月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0924-8579

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An initial dosing method for teicoplanin based on the area under the serum concentration time curve required for MRSA eradication.

Kanazawa Naoko, Matsumoto Kazuaki, Ikawa Kazuro, Fukamizu Tomohide, Shigemi Akari, Yaji Keiko, Shimodozono Yoshihiro, Morikawa Norifumi, Takeda Yasuo, Yamada Katsushi.

JOURNAL OF INFECTION AND CHEMOTHERAPY （SPRINGER TOKYO）  17 （ 2 ） 297 - 300 2011年04月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1341-321X

　概要を見る

Teicoplanin is a glycopeptide antibacterial agent that has a long serum half-life and therefore takes time to achieve steady-state conditions. An appropriate initial dosing is needed for teicoplanin to promptly reach an effective serum trough concentration. However, little information is available on tailoring the initial dosing for patients with various characteristics. The objective of this study was to develop a nomogram for determining teicoplanin initial dose to promptly reach an effective trough concentration (a parts per thousand yen13 mu g/mL). A logistic regression analysis was performed to test whether the area under the concentration time curve (AUC) is a significant predictor of microbiological response (persistence 0; eradication 1). The study included 24 adult patients with methicillin-resistant Staphylococcus aureus infections [minimal inhibitory concentration (MIC) for the isolates was < 2 mu g/mL). Each AUC was estimated using individual dose, creatinine clearance (CL(cr)), and body weight data. The target value, which gives about a 0.9 microbiological eradication probability, was 750 mu g h/mL for AUC from zero to 24 h (AUC(0-24 h)). Using published population pharmacokinetic parameters, the dose required to achieve the AUC(0-24 h) target was calculated as dose (mg) = 750 x (0.00498 x CL(cr) (mL/min) + 0.00426 x body weight (kg). For various combinations of CL(cr) and body weight, we checked the calculated doses using a therapeutic drug monitoring (TDM)-supporting software and developed a nomogram. The nomogram would be useful for initial dose adjustment to promptly reach an effective serum trough concentration and avoid adverse events of teicoplanin.

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Higher linezolid exposure and higher frequency of thrombocytopenia in patients with renal dysfunction.

Matsumoto Kazuaki, Takeshita Ayumi, Ikawa Kazuro, Shigemi Akari, Yaji Keiko, Shimodozono Yoshihiro, Morikawa Norifumi, Takeda Yasuo, Yamada Katsushi.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS （ELSEVIER SCIENCE BV）  36 （ 2 ） 179 - 181 2010年08月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0924-8579

　概要を見る

The major adverse event associated with linezolid treatment is reversible myelosuppression, mostly thrombocytopenia. Recent studies have reported that the incidence of linezolid-induced thrombocytopenia was higher in patients with renal failure than in patients with normal renal function, although the underlying mechanisms of this toxicity are still unknown. The present study thus aimed to investigate the relationship between renal function and linezolid exposure as well as the effects of drug exposure on thrombocytopenia. A statistically significant (P < 0.01) strong correlation (r = 0.933) was observed between linezolid clearance and creatinine clearance. A negative correlation (r = -0.567) was also shown between linezolid clearance and blood urea nitrogen, although the correlation was not statistically significant. In thrombocytopenic patients, the trough concentration was 14.4-35.6 mg/L and the area under the plasma linezolid concentration-time curve for 24 h (AUC(24 h)) was 513.1-994.6 mg h/L; in non-thrombocytopenic patients, drug exposure was relatively low (6.9 mg/L and 7.2 mg/L for trough concentration and 294.3 mg h/L and 323.6 mg h/L for AUC(24 h)). These results provide a pharmacokinetic explanation for the mechanism of the adverse event that renal dysfunction increased linezolid trough concentration and AUC and that higher drug exposure induced thrombocytopenia. (C) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

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Determination of teicoplanin trough concentration target and appropriate total dose during the first 3 days: a retrospective study in patients with MRSA infections.

Matsumoto Kazuaki, Kanazawa Naoko, Ikawa Kazuro, Fukamizu Tomohide, Shigemi Akari, Yaji Keiko, Shimodozono Yoshihiro, Morikawa Norifumi, Takeda Yasuo, Yamada Katsushi.

JOURNAL OF INFECTION AND CHEMOTHERAPY （SPRINGER TOKYO）  16 （ 3 ） 193 - 199 2010年06月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1341-321X

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An initial loading procedure has been recommended to enable teicoplanin to promptly reach an effective serum concentration for the treatment of methicillin-resistant Staphylococcus aureus (MRSA). This study aimed to retrospectively evaluate the pharmacokinetics and pharmacodynamics of teicoplanin to determine the therapeutic target for the teicoplanin trough concentration and an appropriate dosing method during the first 3 days. The mean trough concentrations were 13.2 mg/L for patients with eradication of MRSA. Moreover, logistic regression analysis showed that the teicoplanin trough concentration was 13 mg/L to achieve MRSA eradication with a probability of 89.0%. The rates of achieving a parts per thousand yen13 mg/L in a parts per thousand currency sign24, 24-36 and a parts per thousand yen36 mg/kg (total dose during the first 3 days) groups were 9.1, 48.4 and 87.5%, respectively. These results suggest that the administration of a parts per thousand yen36 mg/kg during the first 3 days is appropriate to promptly obtain a trough concentration target of a parts per thousand yen13 mg/L for the initial treatment of MRSA infections.

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腎機能障害を有する術後MRSA感染症患者2例におけるリネゾリドの体内動態.

竹下鮎美, 松元一明, 茂見茜里, 猪川和朗, 森川則文, 武田泰生, 山田勝士.

日本外科感染症学会雑誌 7   373 - 376 2010年

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1349-5755

Receptor-Mediated Uptake of Human alpha 1-Acid Glycoprotein into Liver Parenchymal Cells in Mice.

Matsumoto Kazuaki, Nishi Koji, Kikuchi Mari, Watanabe Hiroshi, Nakajou Keisuke, Komori Hisakazu, Kadowaki Daisuke, Suenaga Ayaka, Maruyama Toru, Otagiri Masaki.

DRUG METABOLISM AND PHARMACOKINETICS 25 （ 1 ） 101 - 107 2010年

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  1347-4367

Correlation between meropenem and doripenem use density and the incidence of carbapenem-resistant Pseudomonas aeruginosa.

Shigemi Akari, Matsumoto Kazuaki, Yaji Keiko, Shimodozono Yoshihiro, Takeda Yasuo, Miyanohara Hiroaki, Kawamura Hideki Orita Michiyo, Tokuda Koichi. Nishi Junichiro, Yamada Katsushi.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS （ELSEVIER SCIENCE BV）  34 （ 6 ） 589 - 591 2009年12月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0924-8579

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Optimal use of carbapenems is an important issue in the prevention of resistance in Pseudomonas aeruginosa. In this study, we investigated the correlation between antimicrobial use density (AUD) of carbapenems and imipenem/cilastatin (IPM/CS) or meropenem (MEPM) susceptibility of P. aeruginosa strains. The AUD of five carbapenems [IPM/CS, panipenem/betamipron, biapenem, MEPM and doripenem (DRPM)] was examined every 6 months between 2006 and 2008. The AUD was calculated using the defined daily doses methodology developed by the World Health Organisation. A minimum inhibitory concentration of IPM/CS or MEPM of <= 4 mg/L was considered to be sensitive. There was a significant negative correlation between MEPM susceptibility and the total AUD of MEPM and DRPM [r = -0.823, 95% confidence interval (CI) -0.035 to -0.980; P = 0.044]. Furthermore, there was a significant correlation between MEPM susceptibility and IPM/CS susceptibility (r = 0.839, 95% CI 0.084 to 0.981; P = 0.037). Cross-resistance was therefore investigated and only 5.6% of MEPM-insensitive strains were susceptible to IPM/CS, although 43.3% of IPM/CS-insensitive strains were susceptible to MEPM. These results suggest that curtailing the use of MEPM and DRPM may curb the emergence not only of MEPM-resistant strains but also IPM/CS-resistant strains. (C) 2009 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

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Correlation between voriconazole trough plasma concentration and hepatotoxicity in patients with different CYP2C19 genotypes.

Matsumoto Kazuaki, Ikawa Kazuro, Abematsu Kazuko, Fukunaga Naoko, Nishida Kentaro, Fukamizu Tomohide, Shimodozono Yoshihiro, Morikawa Norifumi, Takeda Yasuo, Yamada Katsushi.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS （ELSEVIER SCIENCE BV）  34 （ 1 ） 91 - 94 2009年07月

研究論文（学術雑誌）, 共著,  ISSN  0924-8579

　概要を見る

Voriconazole metabolism is mostly mediated via the cytochrome P450 (CYP) 2C19 isozyme. The non-wild (mutant) type of CYP2C19 is generally found in 60-70% of Asian populations. Because the voriconazole trough plasma concentration has been reported to correlate with hepatotoxicity, this study investigated the effect of CYP2C19 polymorphism on the relationship between voriconazole trough concentrations and liver function abnormalities in 29 Japanese patients with fungal infections (CYP2C19 wild-type, n = 10; non-wild-type, n = 19). Hepatotoxicity, defined as liver enzyme abnormality according to the National Cancer Institute criteria, was observed in 10 (34.5%) of 29 patients with a trough concentration >= 3.9 mg/L. Logistic regression analysis suggested that the therapeutic range for the voriconazole trough concentration should be 2-4 mg/L. Non-linear pharmacokinetic analysis suggested that voriconazole therapy should be initiated with a dose of 7.2-8.9 mg/kg/day for CYP2C19 wild-type and 4.4-6.5 mg/kg/day for the non-wild-type in Japanese patients. These recommended initial dosages and subsequent dose adjustment for the target concentration range by therapeutic drug monitoring should avoid adverse events and thus enable continued effective voriconazole therapy for Japanese patients with mycoses. (C) 2009 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

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Renal function as a predictor of linezolid-induced thrombocytopenia.

Matsumoto Kazuaki, Takeda Yasuo, Takeshita Ayumi, Fukunaga Naoko, Shigemi Akari, Yaji Keiko, Shimodozono Yoshihiro, Yamada Katsushi, Ikawa Kazuro, Morikawa Norifumi.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 33 （ 1 ） 98 - 99 2009年01月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  0924-8579

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シクロスポリンおよびタクロリムスのTDM支援ソフトウェアの開発.

金子生, 猪川和朗, 福原慶, 森川則文, 福永直子, 深水知英, 松元一明, 下堂薗権洋, 武田泰生, 山田勝士.

TDM研究 26   52 - 58 2009年

研究論文（学術雑誌）, 共著, 査読有り

A retrospective study of the relationship between high-dose methotrexate chemotherapy-related toxicity and concomitant drugs: non-steroidal anti-inflammatory drugs and sulfametoxazole.

Shibayama Yoshihiko, Sata Takuya, Furuno Yumiko, Motoya Toshiro, Matsumoto Kazuaki, Fukamizu Tomohide, Fukunaga Naoko, Shimodozono Yoshihiro, Takeda Yasuo, Yamada Katsushi

JOURNAL OF APPLIED THERAPEUTIC RESEARCH 7   11 - 14 2009年

研究論文（学術雑誌）, 共著, 査読有り

Relationship between methotrexate concentration in serum and half-life of methotrexate in high-dose methotrexate therapy: a retorospective study.

Shibayama Yoshihiko, Motoya Toshiro, Yoshikawa Yoshimi, Matsumoto Kazuaki, Fukamizu Tomohide, Fukunaga Naoko, Shimodozono Yoshihiro, Takeda Yasuo, Yamada, Katsushi.

JOURNAL OF APPLIED THERAPEUTIC RESEARCH 6   25 - 28 2008年

研究論文（学術雑誌）, 共著, 査読有り