Papers - Iwata, Hiroki

心不全患者のトリプルワーミー回避に関する歯薬連携の新規モデル構築の契機となった1例

前瀬 鞠、近藤 慎吾、林 直子、岩田 紘樹、小林 典子、岡本 侑子、榎木 裕紀、漆畑 俊哉、山浦 克典

薬局薬学  2026

Research paper (scientific journal), Joint Work, Accepted

A blended learning program sustains pharmacists’ oral health support competency for 15 months: A longitudinal study

Hayashi N, Goto T, Shiga Y, Okazaki M, Sano A, Maida N, Iwata H, Matsui H, Kondo S, Kobayashi N, Yamaura K

Drug Discoveries & Therapeutics  2026

Research paper (scientific journal), Joint Work, Accepted

Community pharmacist’s perceptions and needs regarding oral health care advice in Japan

Iwata H, Yoshida R, Hayashi N, Kobayashi N, Fujimoto K, Yamaura K

The Keio Journal of Medicine 74 ( 4 ) 205 - 213 2025.12

Research paper (scientific journal), Joint Work, Lead author, Accepted

Community pharmacists' attitudes and experiences regarding the promotion of vaccinations in Japan

Hiroki Iwata, Taiki Kirihara, Noriko Kobayashi, Yuki Nakamura, Tomoko Koike, Katsunori Yamaura

The Keio Journal of Medicine  2025.11

Research paper (scientific journal), Joint Work, Lead author, Accepted

Analysis of drug-induced xerostomia using the Japanese Adverse Drug Event Report Database

Shingo Kondo, Mari Maese, Nozomi Ito, Yuko Okamoto, Hiroki Iwata, Noriko Kobayashi, Katsunori Yamaura

BPB Reports 8 ( 5 ) 133 - 137 2025.10

Research paper (scientific journal), Joint Work, Accepted

Sex Differences in Electrolyte Disturbances Among Diuretic Users According to Renal Function and Age

Maida N, Kondo S, Hayashi N, Iwata H, Kobayashi N, Yamaura K

Drug Safety 48 ( 10 ) 1149 - 1159 2025.10

Research paper (scientific journal), Joint Work, Accepted

Analysis of Factors Affecting Oral Bacterial Counts and Oral Frailty Among Community Pharmacy Users in Japan

Shingo Kondo, Kanon Maki, Naoko Hayashi, Yuko Okamoto, Hiroki Iwata, Noriko Kobayashi, Katsunori Yamaura

International Journal of Oral Care  2025.10

Research paper (scientific journal), Joint Work, Accepted

Use of Dysphagia-Inducing Drugs and Risk of Aspiration Pneumonia: A Cross-Sectional Analysis Using a Japanese Claims Database

Hayashi N, Yoshida M, Maida N, Kondo S, Ogawa M, Iwata H, Kobayashi N, Yamaura K

Drugs Real World Outcomes  2025.09

Research paper (scientific journal), Joint Work, Accepted

Loneliness and analgesic overuse among low-dose estrogen-progestin users in Japan

Fujimoto T, Iwata H, Kobayashi N, Kondo S, Yamaura K

BMC Women's Health 25 ( 1 ) 422 2025.09

Research paper (scientific journal), Joint Work, Accepted

Identification of issues related to the enteral nutrients using a database of near-miss events from community pharmacies

Shingo Kondo, Mari Maese, Hiroki Iwata, Noriko Kobayashi, Katsunori Yamaura

The Keio Journal of Medicine 74 ( 2 ) 86 - 95 2025.06

Research paper (scientific journal), Joint Work, Accepted

• Access to Document (DOI)

口腔乾燥を誘発する薬剤の高齢患者に対する処方実態と要因

近藤 慎吾, 佐野 邦大, 林 直子, 藤島 清太郎, 岩田 紘樹, 小林 典子, 山浦 克典

医療薬学 51 ( 6 ) 355 - 365 2025.06

Research paper (scientific journal), Joint Work, Accepted

Practical training reduces aspiration-linked gaps in pressure ulcer education for pharmacy students

Kondo S, Mima R, Okui R, Iwata H, Kawamoto Y, Kobayashi N, Furuta K, Yamaura K

Drug Discov Ther 19 ( 2 ) 90 - 95 2025.05

Research paper (scientific journal), Joint Work, Accepted

腎機能の低下者に対して注意が必要なOTC医薬品の解析

近藤慎吾、前瀬鞠、古堅彩子、岩田紘樹、小林典子、山浦克典

薬局薬学 17 ( 1 ) 126 - 135 2025.04

Research paper (scientific journal), Joint Work, Accepted

Sex-related differences regarding headache triggered by low barometric pressure in Japan

Fujimoto T, Iwata H, Kobayashi N, Kondo S, Yamaura K

BMC Research Notes (Springer Nature)  17 ( 1 ) 203 2024.07

Research paper (scientific journal), Joint Work, Accepted

• Access to Document (DOI)

Lack of information on gender differences in the package inserts of prescription drugs in Japan

Narumi Maida, Shingo Kondo, Masanori Ogawa, Naoko Hayashi, Hiroki Iwata, Noriko Kobayashi, Katsunori Yamaura

Drug Discoveries & Therapeutics 17 ( 6 ) 396 - 403 2024.01

Research paper (scientific journal), Joint Work, Accepted

実務実習を修了した上級生が関わるセルフメディケーション実習の学修効果

筒井和斗、小林典子、中村友紀、岩田紘樹、山浦克典

薬学教育 7   231 - 237 2024.01

Research paper (scientific journal), Joint Work, Accepted

• Access to Document (DOI)

実務実習終了時における到達度評価を向上させる要因は何か？

石川春樹，河添　仁，岩田紘樹，中村友紀，地引綾，横山雄太， 小林典子，鈴木小夜，山浦克典，中村智徳

医療薬学 49 ( 4 ) 173 - 182 2023.04

Research paper (scientific journal), Joint Work, Accepted

Most dentists approve of oral health check-ups for local residents at community pharmacies and desire collaboration with community pharmacists

Hiroki Iwata, Keisuke Nakamura, Noriko Kobayashi, Kazuko Fujimoto, Naoko Hayashi, Katsunori Yamaura

Drug Discoveries & Therapeutics 16 ( 6 ) 309 - 312 2022.12

Research paper (scientific journal), Joint Work, Lead author, Accepted

診療所が保有する患者情報の共有による薬局における効果的な服薬フォローアップ法確立のための探索研究

吉村悠平、林直子、今津嘉宏、森田清子、鶴田奈津子、岩田紘樹、小林典子、藤本和子、川本嘉子、山浦克典

医療薬学 48 ( 10 ) 443 - 453 2022.10

Research paper (scientific journal), Joint Work, Accepted

薬剤師によるアンチ・ドーピング活動推進のためのスポーツサプリメントに関する学習の課題と対策

大場法隆、香取諒太、藤本和子、小林典子、岩田紘樹、山浦克典

医療薬学 48 ( 9 ) 405 - 418 2022.09

Research paper (scientific journal), Joint Work, Accepted

薬学教育モデル・コアカリキュラムに基づく実務実習におけるルーブリック形式の概略評価は実習生のパフォーマンスレベルを測定できるか？

河添 仁,鈴木小夜,平賀ゆい,横山雄太,地引 綾,岩田紘樹,小林典子,藤本和子,中田英夫,青森 達,山浦克典,中村智徳

医療薬学 47 ( 9 ) 513 - 524 2021.09

Research paper (scientific journal), Joint Work, Accepted

Patient satisfaction with oral health check-ups at a community pharmacy and their effect on oral self-care habits and dental consultation behavior

Hiroki Iwata, Koichi Shibano, Mitsuhiro Okazaki, Kotaro Fujimaki, Noriko Kobayashi, Kazuko Fujimoto, Naoko Hayashi, Tomoyuki Goto, Katsunori Yamaura

Drug Discoveries & Therapeutics 14 ( 6 ) 319 - 324 2021.01

Research paper (scientific journal), Joint Work, Lead author, Accepted

代表的８疾患と薬局実習が病院実習の到達度に与える影響

清宮啓介，津田壮一郎，池淵由香，鈴木小夜，地引綾，岩田紘樹，横山雄太，河添仁，小林典子，藤本和子，山浦克典，中村智徳，村松博，青森達，望月眞弓

医療薬学 46 ( 12 ) 715 - 721 2020.12

Research paper (scientific journal), Joint Work, Accepted

患者の処方薬に関する情報源の実態と入手情報の満足度およびニーズ調査

荒川健人，渡邊伸一，林直子，岩田紘樹，小林典子，藤本和子，山浦克典

医療薬学 46 ( 11 ) 615 - 627 2020.11

Research paper (scientific journal), Joint Work, Accepted

抗がん剤副作用情報の入手に関する経験と患者の服薬調節行動の関連性

熊谷智樹，渡邊伸一，林直子，岩田紘樹，小林典子，藤本和子，山浦克典

医療薬学 46 ( 11 ) 628 - 639 2020.11

Research paper (scientific journal), Joint Work, Accepted

A survey on awareness of the "finger-tip unit" and medication guidance for the use of topical steroids among community pharmacists

Oishi N, Iwata H, Kobayashi N, Fujimoto K, Yamaura K

Drug discoveries & therapeutics 13 ( 3 ) 128 - 132 2019.07

Research paper (scientific journal), Joint Work, Accepted

• Access to Document (DOI)

Expression of precipitating factors of pruritus found in humans in an imiquimod-induced psoriasis mouse model.

Oishi N, Iwata H, Kambe N, Kobayashi N, Fujimoto K, Sato H, Hisaka A, Ueno K, Yamaura K

Heliyon (Heliyon)  5 ( 6 ) e01981 2019.06

Research paper (scientific journal), Joint Work, Accepted,  ISSN  24058440

　View Summary

© 2019 The Authors Aims: To use a mouse model of imiquimod-induced psoriasis to investigate the relationship between pruritus and mast cells, nerve growth factor (NGF) and endogenous pruritogenic peptides, which are highly expressed in the skin of psoriasis patients. Main methods: We developed a mouse model of imiquimod-induced psoriasis and measured the frequency and duration of the model animals’ self-scratching behavior using the SCLABA®-Real real-time scratch counting system. We then harvested the ears and subjected them to toluidine blue staining and real-time PCR. Key findings: Topical application of imiquimod increased the Psoriasis Area and Severity Index score as well as the frequency and duration of self-scratching. Regarding internal factors, increases in mast cells number and mRNA expression of NGF and endogenous pruritogenic peptide precursor were confirmed. Significance: Self-scratching behavior is accompanied by increased number of mast cells and expression of NGF and endogenous pruritogenic peptides in our imiquimod-induced psoriasis model. The expression of these factors was consistent with the features in patients with pruritic psoriasis, suggesting that our model reflects at least some of the precipitating factors of pruritus found in humans.

• Access to Document (DOI)

Nationwide Survey Aimed at the Spread and Continuation of Self-Blood Tests at Community Pharmacies—Second Report: Disincentives among Pharmacies Not Designated as Bioanalytical Labs

Genki Miyazaki, Hiroki Iwata, Noriko Kobayashi, Kazuko Fujimoto, Kana Yoshida, Mitsuhiro Okazaki, Katsunori Yamaura

医療薬学 43 ( 1 ) 34 - 40 2017.01

Research paper (scientific journal), Joint Work, Accepted

A study on the usefulness of a simple lipid measurement for the early detection of dyslipidemia and recognition of dyslipidemia among local residents

Hiroki Iwata, Ryo Masuo, Mitsuhiro Okazaki, Masakatsu Fukumoto, Kazuko Fujimoto, Noriko Kobayashi, Katsunori Yamaura

Jpn.J.Soc.Pharm. 35 ( 2 ) 80 - 86 2016.12

Research paper (scientific journal), Joint Work, Accepted

Disincentives to the Continuation of Self-blood Tests at Community Pharmacies Designated as Bioanalytical Labs

吉田加奈，岩田紘樹，小林典子，藤本和子，岡﨑光洋，山浦克典

医療薬学 42 ( 7 ) 543 - 549 2016.07

Research paper (scientific journal), Joint Work, Accepted

Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells.

Guligena Tuerdi, Saki Ichinomiya, Hiromi Sato, Sana Siddig, Eriko Suwa, Hiroki Iwata, Tomohiro Yano, Koichi Ueno

Cancer Letters 339   116 - 127 2013.10

Research paper (scientific journal), Joint Work, Accepted

New 2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ether Compound Induces Microtubule Depolymerization and Subsequent Apoptosis.

Hiromi Sato, Ryota Yamada, Midori Yanagihara, Hiroko Okuzawa, Hiroki Iwata, Ayako Kurosawa, Saki Ichinomiya, Rina Suzuki, Hiroyuki Okabe, Tomohiro Yano, Takuya Kumamoto, Noriyuki Suzuki, Tsutomu Ishikawa, Koichi Ueno

J. Pharmacol. Sci. 118   467 - 478 2012.03

Research paper (scientific journal), Joint Work, Accepted

モルヒネのヒトがん細胞株の増殖に対する影響

岩田紘樹，佐藤洋美，岡部裕之，矢野友啓，関根祐子，上野光一

日本緩和医療薬学雑誌 4   85 - 91 2011.10

Research paper (scientific journal), Joint Work, Accepted

A demethylating agent enhances chemosensitivity to vinblastine in a xenograft model of renal cell carcinoma

Hiroki Iwata, Hiromi Sato, Rina Suzuki, Ryota Yamada, Saki Ichinomiya, Midori Yanagihara, Hiroyuki Okabe, Yuko Sekine, Tomohiro Yano, Koichi Ueno

Int. J. Oncol. 38   1653 - 1661 2011.06

Research paper (scientific journal), Joint Work, Accepted

Up-regulation of connexin 32 gene by 5-aza-2’-deoxycytidine enhances vinblastine-induced cytotoxicity in human renal carcinoma cells via the activation of JNK signaling.

Yasuyuki Takano, Hiroki Iwata, Yasuhisa Yano, Mio Miyazawa, Nantiga Virgona, Hiromi Sato, Koichi Ueno, Tomohiro Yano

Biochem. Pharmacol. 80   463 - 470 2010.08

Research paper (scientific journal), Joint Work, Accepted

Synthesis, Physical Properties, and Cytotoxity of Nitroxyl-Aziridine Hybrid

Takuya Kumamoto, Kazuya Suzuki, Sang-kook Kim, Katsuyoshi Hoshino, Masahiro Takahashi, Hiromi Sato, Hiroki Iwata, Koichi Ueno, Masahiro Fukuzumi, Tsutomu Ishikawa

Helv. Chim. Acta 93   2109 - 2114 2010

Research paper (scientific journal), Joint Work, Accepted

Enhanced effect of connexin 43 on cisplatin-induced cytotoxicity in mesothelioma cells.

Hiromi Sato, Hiroki Iwata, Yasuyuki Takano, Ryota Yamada, Hiroko Okuzawa, Yoji Nagashima, Katsunori Yamaura, Koichi Ueno, Tomohiro Yano

J. Pharmacol. Sci. 110   466 - 475 2009.08

Research paper (scientific journal), Joint Work, Accepted

Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in mice.

Hiroki Iwata, Shizuko Tsuchiya, Koichi Ueno, Tomonori Nakamura, Shingo Yano

Eur. J. Pharmacol. 600   130 - 132 2008.12

Research paper (scientific journal), Joint Work, Accepted

Morphine leads to contraction of the ileal circular muscle via inhibition of the nitrergic pathway in mice.

Hiroki Iwata, Shizuko Tsuchiya, Tomonori Nakamura, Shingo Yano

Eur. J. Pharmacol. 574   66 - 70 2007.11

Research paper (scientific journal), Joint Work, Accepted