Aomori, Tohru

写真a

Affiliation

Faculty of Pharmacy, Department of Pharmacy 病院薬学講座 (Shiba-Kyoritsu)

Position

Associate Professor

 

Books 【 Display / hide

  • 「アンサングシンデレラ」・「治療薬マニュアル」コラボ小冊子

    青森達, 医学書院, 2020

  • 老年医学(上)-基礎・臨床研究の最新動向-

    青森達, 望月眞弓, 日本臨牀社, 2018

    Contact page: 347-353

  • 早期臨床体験テキスト

    AOMORI Tohru, ネオメディカル, 2017

  • 精神科領域におけるEBP. Progressive Pharmacist

    AOMORI Tohru, 2010

  • 薬剤師による処方支援 ワルファリン投与における処方支援

    AOMORI Tohru, 医薬ジャーナル, 2008

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Papers 【 Display / hide

  • Effect of a lever aid on hand strength required for using a handheld inhaler correctly

    Nakada Hideo, Aomori Tohru, Mochizuki Mayumi

    International Journal of Pharmaceutics (International Journal of Pharmaceutics)  596 2021.03

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  03785173

     View Summary

    © 2021 The Author(s) In the treatment of asthma and chronic obstructive pulmonary disease, using a lever aid to improve drug delivery from an inhaler is recommended for patients with poor muscle strength. However, no studies have investigated the effect on hand strength of using a lever aid. Here, we measured hand strength before and after operating a lever aid and tried to predict the required strength. We compared the pinch force required to activate a pressurized metered dose inhaler (pMDI) and a dry powder inhaler as well as the rotational torque required to activate a soft mist inhaler (SMI) before and after attaching a lever aid. We then assessed the correlation between the theoretical and measured pinch force after fitting the lever aid. Use of the lever aid significantly reduced the pinch force required for pMDI operation from 26.13–48.74 N to 4.90–16.87 N. In contrast, using a lever aid significantly reduced the force needed to rotate SMI, although the rotational torque required to operate did not change. There was a significant positive correlation between the theoretical and measured pinch forces required to activate a pMDI fitted with a lever aid. Using a lever aid will increase the number of patients who can use this device.

  • Lorlatinib-induced visual and auditory hallucinations: a case report

    Hakamata Jun, Nakata Hideo, Muramatsu Hiroshi, Masuzawa Keita, Terai Hideki, Ikemura Shinnosuke, Fukunaga Koichi, Aomori Tohru

    Clinical Case Reports 00   1 - 4 2021

    Research paper (scientific journal), Joint Work, Accepted

  • Peripheral blood biomarkers predict immune-related adverse events in non-small cell lung cancer patients treated with pembrolizumab: a multicenter retrospective study

    Egami Saeka, Kawazoe Hitoshi, Hashimoto Hironobu, Uozumi Ryuji, Arami Toko, Sakaiyama Naomi, Ohe Yuichiro, Nakada Hideo, Aomori Tohru, Ikemra Shinnosuke, Fukunaga Koichi, Yamaguchi Masakazu, Nakamura Tomonori

    Journal of Cancer (Journal of Cancer)  12 ( 7 ) 2105 - 2112 2021

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    © 2021 Ivyspring International Publisher. All rights reserved. Background: Pembrolizumab is currently the standard treatment for patients with advanced non-small cell lung cancer (NSCLC). However, the association between immune-related adverse events (irAEs) and peripheral blood cell counts remains unclear. We aimed at identifying peripheral blood cell counts that may predict the development of pembrolizumab-induced irAEs. Methods: We retrospectively analyzed data on consecutive patients with advanced NSCLC who received pembrolizumab monotherapy as first-line or later-line therapy at the National Cancer Center Hospital and Keio University Hospital. We used data between December 2015 and November 2018. The primary endpoint was the relationship between peripheral blood cell count data and early-onset irAEs during the 6-weeks study period. Receiver operating characteristic (ROC) curve and multivariable logistic regression analyses were performed. Results: In total, 92 patients were evaluated, of whom 45 (48.9%) had at least one irAE during the first 6-weeks after treatment initiation. The ROC curves revealed that the optimal cutoff of pretreatment absolute lymphocyte count (ALC), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) for onset of irAEs were 1459, 2.320, 1.538, and 165, respectively. Multivariable logistic regression analyses revealed that pretreatment ALC>1450 and LMR>1.6 were significantly associated with a reduced risk for onset of any irAEs, whereas pretreatment NLR>2.3 and PLR>165 were significantly associated with an increased risk. Conclusions: The findings suggest that considering the routine availability of blood cell count data before the initiation of treatment with pembrolizumab, it may be useful in identifying early-onset irAEs during the 6-weeks study period in clinical practice.

  • Effect of renin-angiotensin system inhibitors on pemetrexed plus platinum-induced hematological toxicities: A multicenter retrospective study using a propensity score analysis.

    Arami Toko, Kawazoe Hitoshi, Uozumi Ryuji, Hashimoto Hironobu, Egami Saeka, Sakiyama Naomi, Ohe Yuichiro, Nakada Hideo, Aomori Tohru, Ikemura Shinnosuke, Yasuda Hiroyuki, Kawada Ichiro, Fukunaga Koichi Soejima Kenzo, Yamaguchi Masakazu, Nakamura Tomonori

    Die Pharmazie  2021

    Research paper (scientific journal), Joint Work, Accepted

  • Formulation development of mucoadhesive microparticle-laden gels for oral mucositis: An in vitro and in vivo study

    Sakurai H., Ikeuchi-Takahashi Y., Kobayashi A., Yoshimura N., Ishihara C., Aomori T., Onishi H.

    Pharmaceutics (Pharmaceutics)  12 ( 7 ) 1 - 16 2020.07

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    © 2020 by the authors. Licensee MDPI, Basel, Switzerland. In order to relieve pain due to oral mucositis, we attempted to develop mucoadhesive microparticles containing indomethacin (IM) and gel preparations with IM microparticles that can be applied to the oral cavity. The mucoadhesive microparticles were prepared with a simple composition consisting of IM and polyvinyl alcohol (PVA). Two kinds of PVA with different block properties were used, and microparticles were prepared by heating-filtration and mixing-drying. From the X-ray powder diffraction patterns, differential scanning calorimetry thermograms, and morphological features of the IM microparticles, IM should exist as polymorphic forms in the microparticles. Rapid drug release properties were observed in the IM microparticles. Increased drug retention was observed in IM microparticles containing PVA, and the IM-NK(50) gel, using a common block character PVA and heating-filtration, showed good long-term drug retention properties. In vivo experiments showing significantly higher drug concentrations in the oral mucosa were observed with IM microparticles prepared by heating-filtration, and the IM-NK(50) gel maintained significantly higher drug concentrations in the oral mucosa. From these results, the IM-NK(50) gel may be useful as a preparation for relieving oral mucositis pain.

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Papers, etc., Registered in KOARA 【 Display / hide

Presentations 【 Display / hide

  • 吸入手技エラー判別用慣性計測装置搭載アタッチメントの開発

    西江美幸, 正木克宜, 中田英夫, 袴田潤, 江崎大航, 冨保紗希, 笹原広太郎, 浅岡雅人, 砂田啓英也, 秋山勇人, 入江美聡, 奥隅真一, 田野﨑貴絵, 加畑宏樹, 富樫信之, 髙野俊也, 下野誠通, 津田壮一郎, 青森達, 福永興壱

    第61回日本呼吸器学会学術講演会, 2021.04, Poster (general)

  • 眠気への影響から検討したH1受容体拮抗薬のノセボ効果

    石本奈緒, 井澤美苗, 中田英夫, 青森達, 望月眞弓

    日本薬学会141年会, 2021.03, Oral Presentation(general)

  • 高速液体クロマトグラフ「LM1010」を用いたHPLC法と免疫学的測定法による臨床測定方法の比較検討

    石川駿, 中田英夫, 木村元範, 袴田潤, 木村枝里香, 津田壮一郎, 早川智久,金澤秀子, 青森達

    日本薬学会141年会, 2021.03, Poster (general)

  • 吸入指導における薬剤師教育の効果

    杉谷綾佳, 末廣直哉, 袴田潤, 中田英夫, 西川はる, 飯塚直人, 佐々木駿一, 金森翔平, 金沢和幸, 傳田容子, 山吉康子, 津田壮一郎, 早川智久, 村松博, 青森達

    日本薬学会141年会, 2021.03, Poster (general)

  • 生活者にとって理解しやすい要指導・一般用医薬品添付文書のレイアウト比較調査

    宮田早緒理, 中田英夫, 小田武秀, 青森達, 望月眞弓

    日本薬学会141年会, 2021.03, Poster (general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • AI を用いた医薬品の未承認・禁忌・適応外使用データベースの構築と医療安全への応用

    2019

    2019年度慶應義塾学事振興資金(個人研究), 青森達, 青森達, Research grant, Principal Investigator

  • 慢性呼吸器疾患治療の高度化と標準化に向けた吸入動作評価技術の開発研究

    2019

    日本医療研究開発機構研究費, 橋渡し研究戦略的推進プログラム, 下野誠通, Research grant, Co-investigator

  • 生活者にとって分かりやすい要指導・一般用医薬品添付文書の構成に関する研究

    2018
    -
    2020

    日本医療研究開発機構研究費, 望月眞弓, Commissioned research, Co-investigator

  • プラセボ効果の個体間変動要因:プラセボームとパーソナリティ解析による個別薬物療法

    2018
    -
    2020

    日本学術振興会科学研究費補助金, 基盤研究 (C), 井澤美苗, Research grant, Co-investigator

  • ゲノム医療従事者の育成プログラム開発

    2018
    -
    2020

    日本医療研究開発機構研究費, 豊岡伸一, Commissioned research, Co-investigator

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Awards 【 Display / hide

  • 優秀演題賞

    富永佳子, 青森達, 早川智久, 井澤美苗, 望月眞弓, 2018.10, 第7回日本くすりと糖尿病学会学術集会, 糖尿病患者の服薬アドヒアランス不良リスク推定モデルの作成と介入支援ツールの構築 -患者への個別化対応実践のために-.

    Type of Award: Awards of National Conference, Council and Symposium

  • 学生優秀発表賞

    富永佳子, 青森達, 早川智久, 望月眞弓, 2018.03, 日本薬学会第138年会,, 糖尿病患者におけるアドヒアランス影響因子に関する研究-内的要因としての病識に着目した探索的検討-

    Type of Award: Awards of National Conference, Council and Symposium

  • 優秀発表賞

    菊山史博, 鈴木小夜, 高木彰紀, 地引綾, 横山雄太, 青森達, 中村智徳, 2017.09, 第2回日本薬学教育学会大会, 薬学実務実習が実習生の専門知識(C1~C18)の定着及び新規構築に与える影響

    Type of Award: Awards of National Conference, Council and Symposium

  • 優秀ポスター発表賞

    羽田有里, 青森達, 坡下真大, 荒木拓也, 山本康次郎, 鈴木小夜, 地引綾, 中村智徳, 2015.09, 第59回日本薬学会関東支部大会, アプレピタントによる補助療法ががん化学療法の治療経過に与える影響

    Type of Award: Awards of National Conference, Council and Symposium

  • 第66回日本食道学会学術集会優秀ポスター演題賞(メディカルスタッフ)

    荒木聖美、長嶺 歩、青森 達、荒木拓也、飯塚恵子、田中成岳、浅尾高行、桑野博行、中村智徳、山本康次郎., 2012.06, 日本食道学会, 食道癌化学放射線療法における免疫栄養剤併用の有用性.

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Courses Taught 【 Display / hide

  • STUDY OF MAJOR FIELD: (HOSPITAL PHARMACY SCIENCE)

    2021

  • SEMINAR: (HOSPITAL PHARMACY SCIENCE)

    2021

  • RESEARCH FOR BACHELOR'S THESIS 1

    2021

  • PRIOR LEARNING FOR CLINICAL PRACTICE 4

    2021

  • PRIOR LEARNING FOR CLINICAL PRACTICE 3

    2021

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