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Papers - FUJII Chieko

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Studies on drinking behavior, personality and L-dopa induced hallcination of idiopathic Parkinson's disease

藤井千枝子

筑波大学医学研究科学位論文 2001

Research paper (other academic), Single Work

換気と保温（住環境と看護）

藤井千枝子

看護学雑誌 65 ( 7 ) 602-607 2001

Research paper (scientific journal), Single Work

住居の清潔（住環境と看護）

藤井千枝子

看護学雑誌 65 ( 7 ) 607-614 2001

Research paper (scientific journal), Single Work

安全と安楽（住環境と看護）

藤井千枝子

看護学雑誌 65 ( 7 ) 614-621 2001

Research paper (scientific journal), Single Work

家庭の医療廃棄物

藤井千枝子

看護学雑誌 65 ( 7 ) 621-623 2001

Research paper (scientific journal), Single Work

福祉用具の活用と住宅改装・住宅整備

藤井千枝子

看護学雑誌 65 ( 7 ) 624-627 2001

Research paper (scientific journal), Single Work

Cross-cultural traits for personality of patients with Parkinson's disease in Japan

Fujii Chieko, Harada Shoji, Ohkoshi Norio, Hayashi Akito, Yoshizawa Kazuo

American Journal of Medical Genetics - Neuropsychiatric Genetics 96 ( 1 ) 1 - 3 2000.02

ISSN 1552-4841

Recent studies suggest that Parkinson's disease (PD) is associated with particular personality traits. Using Cloningers's Tridimensional Personality Questionnaire (TPQ), Menza and colleagues [1993: Neurology 43: 505-508] reported a possible association between PD and a reduced score in the novelty seeking (NS) dimension of the TPQ. We sought to determine whether this association, which was found in a study conducted in the United States, could also be found among Japanese PD patients. We performed personality assessments of 67 Japanese PD patients, using the TPQ test. The results suggest that Japanese PD patients have significantly lower scores in the NS dimension of the TPQ, as well as significantly higher harm avoidance (HA) scores, compared with matched control subjects. Furthermore, the PD patients undergoing treatment for depression using antidepressant drugs scored significantly higher in the HA dimension than PD patients who did not receive antidepressant drug treatment. Our results suggest that the high HA score, and the low NS score in the TPQ test observed in patients with PD, is a cross-cultural phenomenon, although the influence of depression, long-term treatment, and premorbid gene/environmental interactions may also affect these personality traits. (C) 2000 Wiley-Liss, Inc.

Access to Document (DOI)

孤発性パーキンソン病と関連する遺伝的変異の検索

藤井千枝子、原田勝二

第８回DNA多型学会 2000

Research paper (conference, symposium, etc.), Joint Work, Accepted

アルデヒド脱水酵素2の遺伝子型とアルコール飲料の嗜好性との関連

石橋徳雄、原田勝二、藤井千枝子、田口文子、石井照周

日本アルコール薬物医学会 34 ( 2 ) 117-129 2000

Research paper (scientific journal), Joint Work, Accepted

A novel polymorphism of the ALDH2 gene Linkage disequilibrium and an association with Alcoholism

Harada S, Okubo T, Nakamura T,Fujii C, Nomura F, Higuchi S, Tsutsumi M

Alcoholism:Clin & Experiment Res 23 ( 6 ) 958-962 2000

Research paper (scientific journal), Joint Work, Accepted

排泄ケア教育の授業展開-手話とロールプレイを用いて

藤井千枝子

介護福祉教育学雑誌 5 ( 1 ) 20-23 2000

Research paper (scientific journal), Single Work, Accepted

看護における遺伝医学-チームアプローチのなかの役割を考える

藤井千枝子

看護展望 24 ( 13 ) 1505-1512 2000

Research paper (scientific journal), Single Work

Investigation of Genetic Variants Correlated with idiopathic Parkinson's disease

Fujii C, Harada S

DNA多型 8 43-48 2000

Research paper (scientific journal), Joint Work

包帯法

藤井千枝子

看護実践の科学　看護技術のチェックポイント 24 ( 7 ) 96-98 2000

Research paper (scientific journal), Single Work

死後の処置

藤井千枝子

看護実践の科学　看護技術のチェックポイント 24 ( 7 ) 114-117 2000

Research paper (scientific journal), Single Work

内分泌・感染（アレルギー）疾患に関する看護技術の知識

藤井千枝子

クリニカルスタディ 20 ( 10 ) 939-942 2000

Research paper (scientific journal), Single Work

Parkinson病患者の嫌酒傾向に関与する遺伝要因の探求

藤井千枝子、原田勝二、大越教夫、林明人、吉沢和朗

遺伝子診療学会 2000

Research paper (conference, symposium, etc.), Joint Work, Accepted

A novel polymorphism (-357 G/A) of the ALDH2 gene

Harada Shoji, Okubo Takehito, Nakamura Takako, Fujii Chieko, Nomura Fumio, Higuchi Susumu, Tsutsumi Mikihiro

Alcoholism: Clinical and Experimental Research 23 ( 6 ) 958 - 962 1999.06

ISSN 0145-6008

Background: Human mitochondrial aldehyde dehydrogenase (ALDH2) is a major enzyme responsible for the oxidation of acetaldehyde derived from ethanol metabolism. The human ALDH2 gene shows genetic polymorphism at position 1510 with a G to A transition in exon 12. This mutation leads to ALDH2 enzyme deficiency and protection against alcoholism. As yet, no polymorphism for the promoter region of the ALDH2 gene has been reported. Methods: We analyzed 600 nucleotides of the promoter region in addition to exon 12 from 571 Japanese, 68 Chinese, 80 Myanmar, 60 Mongolians, and 82 North-American Caucasians using single-strand conformational change polymorphism (SSCP) analysis and the polymerase chain reaction (PCR). PCR products that showed an aberrant banding pattern detected by the SSCP analysis were subjected to PCR direct sequencing. Results: A novel polymorphism at -357 with a G to A substitution was found in all the population groups, including North-American Caucasians. In addition, the polymorphic status in the promoter and exon 12 suggested linkage disequilibrium between the two loci, which indicated that among Japanese, the ALDH2*2 allele is linked to the G promoter allele, and the ALDH2*1 allele is linked to the A allele. A total of 206 healthy male controls and 185 alcoholic male patients with the homozygous ALDH2*1 genotype were analyzed for the polymorphism in the promoter. Genotypic frequencies of GG, GA, and AA for alcoholics were 54.1%, 44.3%, and 1.6%, and those for controls were 52.9%, 40.3%, and 6.8%, respectively. The A allele frequencies for alcoholics and controls were 0.24 and 0.27, respectively. A χ² test for the entire 3 x 2 table indicated significant variations in the three genotypes (χ² = 6.40, p < 0.05). However, no significant difference in allelic frequencies between the two groups was observed. Conclusion: This new polymorphism in the ALDH2 promoter is present in all populations studied. Further analysis in other ethnic groups is necessary to establish this as an additional risk factor for alcoholism.

Association between polymorphism of the cholecystokinin gene and idiopathic Parkinson's disease

Fujii Chieko, Harada S., Ohkoshi N., Hayashi A., Yoshizawa K., Ishizuka C., Nakamura T.

Clinical Genetics 56 ( 5 ) 394 - 399 1999

ISSN 0009-9163

Parkinson's disease (PD) is characterized by major alterations of neurotransmitter activity due to damage of the substantia nigra. Changes in neuropeptide concentration within the basal ganglia may play an important role in the putative dopaminergic-peptidergic interactions associated with the disease. Cholecystokinin (CCK) modulates the release of dopamine in the mesolimbic pathway and affects dopamine-related behavior. We analyzed genetic variations in the CCK gene, in both the coding and promoter region, in order to investigate the role of polymorphism in idiopathic PD. Four polymorphic sites of the CCK gene (-196G/A, -45C/T, 1270C/G, 6662C/T) were found in PD patients and controls. Complete linkage disequilibrium was observed between the -45 locus and the 1270 locus, and also a possible linkage disequilibrium was found between the -45 and -196 loci. A significant difference was found in the distributions of three identified genotypes at the -45 locus between 116 PD patients and 95 age-matched control subjects (χ² = 7.95, p = 0.018, Bonferroni correction p = 0.054). In addition, a significant difference was obtained amongst the three genotypic groups at the -45 locus when compared between PD patients who experienced hallucinations (n = 23) and those (n = 93) who did not (χ² = 8.08, p = 0.018, Bonferroni correction; p = 0.126). Our data suggested that mutations at the -45 locus in the promoter region of the CCK gene may influence vulnerability to hallucinations in PD patients treated with L-dopa.

Study on Parkinson's disease and alcohol drinking

Fujii C, Harada S, Ohkoshi N, Hayashi A, Yoshizawa K

Japan Journal of Alcohol & Drug depence 33 ( 6 ) 683-691 1999

Research paper (scientific journal), Joint Work, Accepted

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