論文 - 藤井　進也

Sight vs. Sound Judgments of Music Performance Depend on Relative Performer Quality: Cross-cultural Evidence From Classical Piano and Tsugaru Shamisen Competitions

Chiba G., Ozaki Y., Fujii S., & Savage P. E.

Collabra: Psychology, 9(1), 2023. 9 （ 1 ）  2023年05月

研究論文（学術雑誌）, 査読有り

Skin Cold Stimulation Can Modulate the Perceptual Rating of Musical Chords

Ishikawa, Y., Konno, R., Fujii, S., Nakatani, M.

IEEE Transactions on Haptics 2023年05月

研究論文（学術雑誌）, 共著, 査読有り

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Impaired mismatch negativity reflects the inability to perceive beat interval in patients with schizophrenia

Takahashi Y., Fujii S., Osakabe Y., Hoshino H., Konno R., Kakamu T., Fukushima T., Matsumoto T., Yoshida K., Aoki S., Kanno K., Oi N., Ueda Y., Suzutani K., Sato A., Mori Y., Wada T., Shiga T., Itagaki S., Miura I., & Yabe H

Schizophrenia Research （Elsevier）  254   40 - 41 2023年02月

研究論文（学術雑誌）, 共著, 査読有り

Decrease in gamma-band auditory steady-state response in patients with treatment-resistant schizophrenia

Ogyu K., Matsushita K., Honda S., Wada M., Tamura S., Takenouchi K., Tobari Y., Kusudo K., Kato H., Koizumi T., Arai N., Koreki A., Matsui M., Uchida H., Fujii S., Onaya M., Hirano Y., Mimura M., Nakajima S., & Noda Y.

Schizophrenia Research （Elsevier）  252   129 - 137 2023年01月

研究論文（学術雑誌）, 共著, 査読有り

Music rhythm perception and production relate to treatment response in schizophrenia

Honda S., Matsushita K., Noda Y., Tarumi R., Nomiyama N., Tsugawa S., Nakajima S., Mimura M., & Fujii S.

Schizophrenia Research （Elsevier）  252   69 - 76 2023年01月

研究論文（学術雑誌）, 共著, 最終著者, 責任著者, 査読有り

Towards a cross-cultural framework for predictive coding of music

Savage P. E., & Fujii S.

Nature Reviews Neuroscience （Springer Nature）  2022年08月

研究論文（学術雑誌）, 共著, 最終著者, 査読有り

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Transition between individually different and common features in skilled drumming movements

Takiyama K., Hirashima M., & Fujii S

Frontiers in Sports and Active Living （Frontiers）  4 2022年07月

研究論文（学術雑誌）, 共著, 最終著者, 査読有り

　概要を見る

Why do professional athletes and musicians exhibit individually different motion patterns? For example, baseball pitchers generate various pitching forms, e.g., variable wind-up, cocking, and follow-through forms. However, they commonly rotate their wrists and fingers at increasingly high speeds via shoulder and trunk motions. Despite the universality of common and individually different motion patterns in skilled movements, the abovementioned question remains unanswered. Here, we focus on a motion required to hit a snare drum, including the indirect phase of task achievement (i.e., the early movement and mid-flight phases) and the direct phase of task achievement (i.e., the hit phase). We apply tensor decomposition to collected kinematic data for the drum-hitting motion, enabling us to decompose high-dimensional and time-varying motion data into individually different and common movement patterns. As a result, individually different motion patterns emerge during the indirect phase of task achievement, and common motion patterns are evident in the direct phase of task achievement. Athletes and musicians are thus possibly allowed to perform individually different motion patterns during the indirect phase of task achievement. Additionally, they are required to exhibit common patterns during the direct phase of task achievement.

Tapping Performance of Professional and Amateur Darbuka Players

Honda K. and Fujii S

Frontiers in Psychology （Frontiers）  13 （ 861821 ）  2022年06月

研究論文（学術雑誌）, 共著, 最終著者, 査読有り

　概要を見る

Motor learning is a process whereby the acquisition of new skills occurs with practice, and can be influenced by the provision of feedback. An important question is what frequency of feedback facilitates motor learning. The guidance hypothesis assumes that the provision of less augmented feedback is better than more because a learner can use his/her own inherent feedback. However, it is unclear whether this hypothesis holds true for all types of augmented feedback, including for example sonified information about performance. Thus, we aimed to test what frequency of augmented sonified feedback facilitates the motor learning of a novel joint coordination pattern. Twenty healthy volunteers first reached to a target with their arm (baseline phase). We manipulated this baseline kinematic data for each individual to create a novel target joint coordination pattern. Participants then practiced to learn the novel target joint coordination pattern, receiving either feedback on every trial i.e., 100% feedback (n = 10), or every other trial, i.e., 50% feedback (n = 10; acquisition phase). We created a sonification system to provide the feedback. This feedback was a pure tone that varied in intensity in proportion to the error of the performed joint coordination relative to the target pattern. Thus, the auditory feedback contained information about performance in real-time (i.e., “concurrent, knowledge of performance feedback”). Participants performed the novel joint coordination pattern with no-feedback immediately after the acquisition phase (immediate retention phase), and on the next day (delayed retention phase). The root-mean squared error (RMSE) and variable error (VE) of joint coordination were significantly reduced during the acquisition phase in both 100 and 50% feedback groups. There was no significant difference in VE between the groups at immediate and delayed retention phases. However, at both these retention phases, the 100% feedback group showed significantly smaller RMSE than the 50% group. Thus, contrary to the guidance hypothesis, our findings suggest that the provision of more, concurrent knowledge of performance auditory feedback during the acquisition of a novel joint coordination pattern, may result in better skill retention.

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Anticipatory regulation of cardiovascular system on emergence of auditory-motor interaction in young infants

Shinya Y., Oku K., Watanabe H., Taga G., Fujii S

Experimental Brain Research （Springer）  240   1661 - 1671 2022年05月

研究論文（学術雑誌）, 最終著者, 査読有り

　概要を見る

Humans develop auditory-motor interaction to produce a variety of rhythmic sounds using body movements, which are often produced and amplified with tools, such as drumming. The extended production of sounds allows us to express a wide range of emotions, accompanied by physiological changes. According to previous studies, even young infants enhance movements in response to auditory feedback. However, their exhibition of physiological adaptation on the emergence of auditory-motor interaction is unclear. We investigated the movement and cardiac changes associated with auditory feedback to spontaneous limb movements in 3-month-old infants. The results showed that infants increased the frequency of limb movements inducing auditory feedback, while they exhibited a more regular rhythm of the limb movements. Furthermore, heart rate increase associated with the limb movement was first inhibited immediately after the timing of the auditory feedback, which may reflect sustained attention to the auditory stimuli. Then, through auditory-motor experience, the heart rate increase was inhibited even prior to the auditory feedback, leading to suppression of the peak intensity of the heart rate increase. These findings suggest that young infants regulate the cardiovascular system as well as limb movements in anticipation of the auditory feedback. The anticipatory regulation associated with movement and attentional changes may contribute to reduced cardiovascular stress in auditory-motor interaction, and provide a developmental basis for more sophisticated goal-directed behavior of producing rhythmic sounds.

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Anticipatory regulation of cardiovascular system on emergence of auditory-motor interaction in young infants

Shinya Y., Oku K., Watanabe H., Taga G., Fujii S

bioRxiv 2022年03月

研究論文（学術雑誌）, 最終著者

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Sight vs. sound in the judgment of music performance: Cross-cultural evidence from classical piano and Tsugaru shamisen competitions [Stage 1 Registered Report]

Chiba G., Ozaki Y., Fujii S., & Savage P. E.

Peer Community In Registered Reports 2022年

Agreement among human and automated transcriptions of global songs

Ozaki Y., McBride J., Benetos E., Pfordresher P., Six J., Tierney A. T., Proutskova P., Sakai E., Kondo H., Fukatsu H., Fujii, S., & Savage P. E.

Proceedings of the 22nd International Conference on Music Information Retrieval (ISMIR 2021) （ISMIR）     500 - 508 2021年

研究論文（国際会議プロシーディングス）, 共著, 査読有り

Frontostriatal Structural Connectivity and Striatal Glutamatergic Levels in Treatment-Resistant Schizophrenia: An Integrative Analysis of DTI and 1H-MRS

Ochi R., Tarumi R., Noda Y., Tsugawa S., Plitman E., Wada M., Honda S., Matsushita K., Chakravarty M.M., Graff-Guerrero A., Fujii S., Matsui M., Uchida H., Mimura M, Nakajima S.

Schizophrenia Bulletin Open （Oxford Academic）  1 （ 1 ）  2020年10月

研究論文（学術雑誌）, 共著, 査読有り

　概要を見る

Given that approximately one-third of patients with schizophrenia do not respond to antipsychotics, different neurobiological bases may underlie treatment resistance in schizophrenia. Previous studies showed that treatment response is associated with both frontostriatal connectivity and glutamatergic neurometabolite levels in the caudate in patients with schizophrenia, which leads to the hypothesis that the relationship between them may be altered, specifically in patients with treatment-resistant schizophrenia (TRS). Employing analyses of covariance and subsequent partial correlation analyses, we compared the relationship between glutamate+glutamine (Glx) levels in the caudate and fractional anisotropy (FA) values in the tract between the dorsolateral prefrontal cortex and caudate in 19 patients with TRS, 20 patients responsive to first-line antipsychotics (FL-Resp), and 19 healthy controls (HCs). TRS was defined by severe positive symptomatology despite first-line antipsychotic treatment. Patients with TRS had lower FA values in the bilateral frontostriatal tracts than patients with FL-Resp and HCs (P < .001), while no group differences were found in caudate Glx levels. There was a significant frontostriatal FA value-by-group interaction on caudate Glx levels (F = 7.37, P = .009). Frontostriatal FA values positively correlated with caudate Glx levels in HCs (r = −.55, P = .028), while they were negatively associated with caudate Glx levels in the TRS group (r = .53, P = .043). Furthermore, in the FL-Resp group, frontostriatal FA values did not significantly correlated with caudate Glx levels. The altered relationship between white matter integrity and the glutamate system in the frontostriatal circuit in the TRS group may reflect the pathophysiology underlying treatment response/resistance in schizophrenia.

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Perceptual vs. automated judgments of music copyright infringement

Yuan Y., Oishi S., Cronin C., Müllensiefen D., Atkinson Q. D., Fujii S., Savage P. E.

Proceedings of the 21st International Society for Music Information Retrieval Conference (ISMIR 2020) （ISMIR）     23 - 29 2020年10月

研究論文（国際会議プロシーディングス）, 共著, 査読有り

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Resting-state isolated effective connectivity of the cingulate cortex as a neurophysiological biomarker in patients with severe treatment-resistant schizophrenia

Wada M., Nakajima S., Tarumi R., Masuda F., Miyazaki T., Tsugawa S., Ogyu K., Honda S., Matsushita K., Kikuchi Y., Fujii S., Blumberger D.M., Daskalakis Z.J., Mimura M., Noda Y.

Journal of Personalized Medicine （Journal of Personalized Medicine）  10 （ 3 ） 1 - 12 2020年08月

研究論文（学術雑誌）, 査読有り

　概要を見る

Background: The neural basis of treatment-resistant schizophrenia (TRS) remains unclear. Previous neuroimaging studies suggest that aberrant connectivity between the anterior cingulate cortex (ACC) and default mode network (DMN) may play a key role in the pathophysiology of TRS. Thus, we aimed to examine the connectivity between the ACC and posterior cingulate cortex (PCC), a hub of the DMN, computing isolated effective coherence (iCoh), which represents causal effective connectivity. Methods: Resting-state electroencephalogram with 19 channels was acquired from seventeen patients with TRS and thirty patients with non-TRS (nTRS). The iCoh values between the PCC and ACC were calculated using sLORETA software. We conducted four-way analyses of variance (ANOVAs) for iCoh values with group as a between-subject factor and frequency, directionality, and laterality as within-subject factors and post-hoc independent t-tests. Results: The ANOVA and post-hoc t-tests for the iCoh ratio of directionality from PCC to ACC showed significant findings in delta (t = 7.659, p = 0.008) and theta (t = 8.066, p = 0.007) bands in the left side (TRS < nTRS). Conclusion: Left delta and theta PCC and ACC iCoh ratio may represent a neurophysiological basis of TRS. Given the preliminary nature of this study, these results warrant further study to confirm the importance of iCoh as a clinical indicator for treatment-resistance. 45 45

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Thalamic and striato-pallidal volumes in schizophrenia patients and individuals at risk for psychosis: A multi-atlas segmentation study

Takahashi T., Tsugawa S., Nakajima S., Plitman E., Chakravarty M.M., Masuda F., Wada M., Kurose S., Ochi R., Matsushita K., Sasabayashi D., Nakamura M., Nishikawa Y., Takayanagi Y., Nishiyama S., Higuchi Y., Mizukami Y., Furuichi A., Kido M., Hashimoto R., Noguchi K., Fujii S., Mimura M., Noda Y., Suzuki M.

Schizophrenia Research （Elsevier）  243   268 - 275 2020年05月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  09209964

　概要を見る

Despite previous neuroimaging studies demonstrating morphological abnormalities of the thalamus and other subcortical structures in patients with schizophrenia, the potential role of the thalamus and its subdivisions in the pathophysiology of this illness remains elusive. It is also unclear whether similar changes of these structures occur in individuals at high risk for psychosis. In this study, magnetic resonance imaging was employed with the Multiple Automatically Generated Templates (MAGeT) brain segmentation algorithm to determine volumes of the thalamic subdivisions, the striatum (caudate, putamen, and nucleus accumbens), and the globus pallidus in 62 patients with schizophrenia, 38 individuals with an at-risk mental state (ARMS) [4 of whom (10.5%) subsequently developed schizophrenia], and 61 healthy subjects. Cognitive function of the patients was assessed by using the Brief Assessment of Cognition in Schizophrenia (BACS) and the Schizophrenia Cognition Rating Scale (SCoRS). Thalamic volume (particularly the medial dorsal and ventral lateral nuclei) was smaller in the schizophrenia group than the ARMS and control groups, while there were no differences for the striatum and globus pallidus. In the schizophrenia group, the reduction of thalamic ventral lateral nucleus volume was significantly associated with lower BACS score. The pallidal volume was positively correlated with the dose of antipsychotic treatment in the schizophrenia group. These results suggest that patients with schizophrenia, but not those with ARMS, exhibit volume reduction in specific thalamic subdivisions, which may underlie core clinical features of this illness.

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Using Non-Negative Matrix Factorization to Examine Treatment Resistance and Response in Patients With Schizophrenia: A Multimodal Imaging Study

Plitman Eric, Ochi Ryo, Patel Raihaan, Tsugawa Sakiko, Tarumi Ryosuke, Honda Shiori, Matsushita Karin, Fujii Shinya, Uchida Hiroyuki, Mimura Masaru, Noda Yoshihiro, Devenyi Gabriel A., Nakajima Shinichiro, Chakravarty Mallar

BIOLOGICAL PSYCHIATRY 87 （ 9 ） S350 - S350 2020年05月

査読有り,  ISSN  0006-3223

Proximal Binaural Sound Can Induce Subjective Frisson

Honda S, Ishikawa Y, Konno R, Imai E, Nomiyama N, Sakurada K, Koumura T, Kondo HM, Furukawa S, Fujii S, Nakatani M

Frontiers in Psychology （Frontiers）  11 （ 316 ） 1 - 11 2020年03月

研究論文（学術雑誌）, 共著, 査読有り

　概要を見る

バイノーラル録音した物音や音楽が、ヒトの主観的鳥肌感を増大させることを実験的に示した。

Levels of Glutamatergic Neurometabolites in Patients with Severe Treatment-resistant Schizophrenia: A Proton Magnetic Resonance Spectroscopy Study

Tarumi R, Tsugawa S, Noda Y, Plitman E, Honda S, Matsushita K, Chavez S, Sawada K, Wada M, Matsui M, Fujii S, Miyazaki T, Chakravarty MM, Uchida H, Remington G, Graff-Guerrero A, Mimura M, Nakajima S

Neuropsychopharmacology （Springer Nature）  45   632 - 640 2020年03月

研究論文（学術雑誌）, 共著, 査読有り

　概要を見る

Approximately 30% of patients with schizophrenia do not respond to antipsychotics and are thus considered to have treatment-resistant schizophrenia (TRS). To date, only four studies have examined glutamatergic neurometabolite levels using proton magnetic resonance spectroscopy (1H-MRS) in patients with TRS, collectively suggesting that glutamatergic dysfunction may be implicated in the pathophysiology of TRS. Notably, the TRS patient population in these studies had mild-to-moderate illness severity, which is not entirely reflective of what is observed in clinical practice. In this present work, we compared glutamate + glutamine (Glx) levels in the dorsal anterior cingulate cortex (dACC) and caudate among patients with TRS, patients with non-TRS, and healthy controls (HCs), using 3T 1H-MRS (PRESS, TE = 35 ms). TRS criteria were defined by severe positive symptoms (i.e., ≥5 on 2 Positive and Negative Syndrome Scale (PANSS)-positive symptom items or ≥4 on 3 PANSS-positive symptom items), despite standard antipsychotic treatment. A total of 95 participants were included (29 TRS patients [PANSS = 111.2 ± 20.4], 33 non-TRS patients [PANSS = 49.8 ± 13.7], and 33 HCs). dACC Glx levels were higher in the TRS group vs. HCs (group effect: F[2,75] = 4.74, p = 0.011; TRS vs. HCs: p = 0.012). No group differences were identified in the caudate. There were no associations between Glx levels and clinical severity in either patient group. Our results are suggestive of greater heterogeneity in TRS relative to non-TRS with respect to dACC Glx levels, necessitating further research to determine biological subtypes of TRS.

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Wearable Strain Sensor Suit for Infants to Measure Limb Movements under Interaction with Caregiver

Fujii S, Watanabe H, Taga G

Infant Behavior and Development （Elsevier Inc.）  58 （ 101418 ） 1 - 10 2020年02月

研究論文（学術雑誌）, 共著, 査読有り,  ISSN  01636383

　概要を見る

歪みセンサを配した乳児用モーションキャプチャースーツを用いた自発運動の計測技術が、加速度計を用いた計測技術と比してどのような特性があるかを明らかにした。本研究は、株式会社Xenomaとのディスカッションにより製品「e-skin Coo」を用いて実施された。

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