論文 - 渡辺　光博

Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen

Kubota M., Kawashima M., Inoue S., Imada T., Nakamura S., Kubota S., Watanabe M., Takemura R., Tsubota K.

Scientific Reports 11 （ 1 ）  2021年12月

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　概要を見る

The incidence of dry eye disease is increasing worldwide because of the aging population and increasing use of information technology. Dry eye disease manifests as tear-layer instability and inflammation caused by osmotic hypersensitization in tear fluids; however, to our knowledge, no agent that treats both pathologies simultaneously is available. Molecular hydrogen (H2) is known to be effective against various diseases; therefore, we aimed to elucidate the effects of H2 on tear dynamics and the treatment of dry eye disease. We revealed that administering a persistent H2-generating supplement increased the human exhaled H2 concentration (p < 0.01) and improved tear stability (p < 0.01) and dry eye symptoms (p < 0.05) significantly. Furthermore, H2 significantly increased tear secretion in healthy mice (p < 0.05) and significantly suppressed tear reduction in a murine dry eye model (p = 0.007). H2 significantly and safely improved tear stability and dry eye symptoms in a small exploratory group of 10 human subjects, a subset of whom reported dry eye symptoms prior to treatment. Furthermore, it increased tear secretion rapidly in normal mice. Therefore, H2 may be a safe and effective new treatment for dry eye disease and thus larger trials are warranted.

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Neuroprotective role of retinal SIRT3 against acute photo-stress.

Ban N, Ozawa Y, Osada H, Lin JB, Toda E, Watanabe M, Yuki K, Kubota S, Apte RS, Tsubota K.

NPJ Aging Mech Dis .  ３   19 2017年12月

研究論文（学術雑誌）, 共著

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Aerobic exercise increases tear secretion in type 2 diabetic mice.

Sano K, Kawashima M, Ito A, Inaba T, Morimoto K, Watanabe M, Tsubota K.

Invest Ophthalmol Vis Sci. 55 （ (7) ） 4287 - 4294 2014年05月

研究論文（学術雑誌）, 共著, 査読有り

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Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders

Kawashima M, Ozawa Y, Shinmura K, Inaba T, Nakamura S, Kawakita T, Tsubota K.

Experimental Gerontology 48 （ 10 ） 1096 - 1100 2013年10月

共著, 査読有り

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Light-dark condition regulates sirtuin mRNA levels in the retina

Ban N, Ozawa Y, Inaba T, Miyake S, Shinmura K, Tsubota K.

Experimental Gerontology 48 （ 11 ） 1212 - 1217 2013年04月

研究論文（学術雑誌）, 共著, 査読有り

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Dietary Lactoferrin Alleviates Age-Related Lacrimal Gland Dysfunction in Mice.

Kawashima M, Kawakita T, Inaba T, Okada N, Ito M, Shimmura S, Watanabe M, Shinmura K, Tsubota K.

PLoS ONE 7 （ 3 ） 1 - 8 2012年03月

研究論文（学術雑誌）, 共著, 査読有り

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In vitro algaecide effect of disinfectants on Prototheca zopfii genotypes 1 and 2.

Sobukawa H, Watanabe M, Kano R, Ito T, Onozaki M, Hasegawa A, Kamata H.

J Vet Med Sci .  73 （ 11 ） 1527 - 1529 2011年11月

研究論文（学術雑誌）, 共著

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Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter.

Schoonjans K, Watanabe M, Suzuki H, Mahfoudi M, Krey G, Wahli W, Grimaldi P, Staels B, Yamamoto T, Auwerx J.

J Biol Chem. 270 （ 33 ） 19269 - 19276 1995年08月

研究論文（学術雑誌）, 共著, 査読有り

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Multiple promoters in rat acyl-CoA synthetase gene mediate differential expression of multiple transcripts with 5'-end heterogeneity.

Suzuki H, Watanabe M, Fujino T, Yamamoto T.

J Biol Chem. 270 （ 16 ） 9676 - 9682 1995年04月

研究論文（学術雑誌）, 共著, 査読有り

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肝トリグリセリド合成の制御機構の解析 コレステロール摂取によるlipin発現の抑制.

小浜孝士, 赤木和貴, 長岡彩香, 堀内尚美, 加藤里奈, 山口智広, 渡辺光博, 板部洋之.

脂質生化学研究 52   115 - 118 2010年05月

研究論文（学術雑誌）, 共著,  ISSN  02851520

胆汁酸代謝網羅的解析による老化機構解明

渡辺光博

上原記念生命科学財団研究報告集 23   1 - 7 2009年12月

研究論文（大学，研究機関等紀要）, 単著

シグナル伝達分子としての胆汁酸の生態制御機能網羅的解析と老化制御研究への応用

渡辺光博, 谷川原祐介, 伊藤裕.

大和証券ヘルス財団研究業績集 32   58 - 63 2009年03月

研究論文（大学，研究機関等紀要）, 共著

Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide

Yokoyama Y.,Takashina Y., Morel J-D.,Taworntawat T.,Kitamura N., Nagano U., Tanigaki T., Nakamura A., Miyazaki T., Taoka H., Mottis A., Perino A., Shinjo A., Suzuki N., Takekawa S., Fukuda S., Honda A., Ishihara K., Arita M., Tsubota K., Auwerx J., Watanabe M.

iScience （Science Direct）  28 （ 6 ） 112603 2025年06月

研究論文（学術雑誌）, 共著, 最終著者, 責任著者

　概要を見る

Nori is a component of the traditional Japanese diet. The Japanese have a low prevalence of obesity and cardiovascular disease worldwide, and components of nori may have disease-preventive effects. Here, we focused on porphyran, which is abundant in nori that is discarded due to discoloration, and investigated the effects of nori-derived porphyran on gut microbiota, bile acid composition, and ceramide synthesis. Administration of porphyran to mice prevented obesity, diabetes, metabolic dysfunction-associated steatohepatitis (MASH), and hepatocellular carcinoma (HCC). This improvement correlates with a decrease in secondary bile acids, a decrease in intestinal farnesoid X receptor (FXR) signaling, and a marked decrease in blood ceramide. Porphyran, abundant in discolored nori, should be the subject of future translational research to prevent diseases with significant unmet medical needs and improve global environmental sustainability.

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