Kubota, Shunsuke



Graduate School of Media and Governance (Shonan Fujisawa)


Project Associate Professor (Non-tenured)


Books 【 Display / hide

  • Anti-Aging Medicine

    KUBOTA Shunsuke, 日本抗加齢医学会, 2009.10

    Scope: 特集「カロリーリストリクション」 カロリスミミックリー、レスベラトロールのサイエンス

  • からだの科学

    KUBOTA Shunsuke, 日本評論社, 2009.09

    Scope: 気になる眼の病気のすべて 「フードファクターと目」レスベラトロール

  • Functional Food

    KUBOTA Shunsuke, フジメディカル出版, 2009

    Scope: <<トピックス>> レスベラトロールの可能性

  • あたらしい眼科

    KUBOTA Shunsuke, メディカル葵出版, 2009

    Scope: 「サプリメントサイエンスセミナー」 12.レスベラトロール

  • からだの科学

    KUBOTA Shunsuke, 日本評論社, 2009

    Scope: レスベラトロール

Papers 【 Display / hide

  • Role of Sirtuins in Retinal Function Under Basal Conditions.

    KUBOTA Shunsuke

    Adv Exp Med Biol. Retinal Degenerative Diseases (Advances in Experimental Medicine and Biology)  1074 ( 1074 ) 561 - 567 2018.03

    Accepted,  ISSN  00652598

     View Summary

    © 2018, Springer International Publishing AG, part of Springer Nature. Sirtuins are NAD + -dependent enzymes that govern cellular homeostasis by regulating the acylation status of their diverse target proteins. We recently demonstrated that both rod and cone photoreceptors rely on NAMPT-mediated NAD + biosynthesis to meet their energetic requirements. Moreover, we found that this NAD + -dependent retinal homeostasis relies, in part, on maintenance of optimal activity of the mitochondrial sirtuins and of SIRT3 in particular. Nonetheless, it is unknown whether other sirtuin family members also play important roles in retinal homeostasis. Our results suggest that SIRT1, SIRT2, SIRT4, and SIRT6 are dispensable for retinal survival at baseline, as individual deletion of each of these sirtuins does not cause retinal degeneration by fundus biomicroscopy or retinal dysfunction by ERG. These findings have significant implications and inform future studies investigating the mechanisms underlying the central role of NAD + biosynthesis in retinal survival and function.

  • Neuroprotective role of retinal SIRT3 against acute photo-stress.

    KUBOTA Shunsuke

    npj Aging and Mechanisms of Disease 3 ( 9 )  2017.12


  • Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice.

    KUBOTA Shunsuke

    Cell Metabolism 24 ( 6 ) 795 - 806 2016.12

  • NAMPT-mediated NAD+ Biosynthesis Regulates Photoreceptor Neuron Survival and Vision via Mitochondrial Isocitrate Dehydrogenase Activity.

    KUBOTA Shunsuke

    Cell Reports 17 ( 1 ) 69 - 85 2016.09


  • L10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis.

    KUBOTA Shunsuke

    Nature Communications 6 ( 7847 )  2015.08


display all >>

Papers, etc., Registered in KOARA 【 Display / hide

Presentations 【 Display / hide

  • 網膜色素変性:長寿因子による治療可能性

    KUBOTA Shunsuke

    第71回日本栄養・食糧学会大会 (沖縄) , 2017.05, Public discourse, seminar, tutorial, course, lecture and others

  • 網膜色素変性:長寿因子による治療可能性

    KUBOTA Shunsuke

    第71回日本栄養・食糧学会大会, 2017.05

  • Role of Sirtuins in AMD

    KUBOTA Shunsuke

    18TH ADVANCED VITREOUS SURGERY COURSE ALBERT EYE RESEARCH INSTITUTE 2013 Robert Machemer Foundation Vitreoretinal Scholarship (North Carolina, USA) , 2013, Public discourse, seminar, tutorial, course, lecture and others, Duke University

  • 糖尿病網膜症におけるAMPキナーゼの役割

    KUBOTA Shunsuke

    第9回日本坑加齢医学会 (東京) , 2011.05

  • 糖尿病網膜症におけるAMPキナーゼの役割について

    KUBOTA Shunsuke

    第115回日本眼科学会 (東京) , 2011.05

display all >>

Research Projects of Competitive Funds, etc. 【 Display / hide

  • The effect of anti-inflammatory agent, Gnetin in diabetic retinopathy


    MEXT,JSPS, Grant-in-Aid for Scientific Research, 久保田 俊介, Grant-in-Aid for Scientific Research (C), Principal Investigator