Matsumoto, Midori

写真a

Affiliation

Faculty of Science and Technology, Department of Biosciences and Informatics （Yagami）

Position

Associate Professor

External Links
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Career 【 Display / hide 】

  • 1987.04
    -
    1988.10

    三菱化成生命科学研究所

  • 1988.11
    -
    2000.03

    東京工業大学生命理工学部生命理学科, 助手

  • 2000.04
    -
    2002.03

    慶應義塾大学理工学部化学科,　専任講師

  • 2002.04
    -
    2004.03

    慶應義塾大学理工学部生命情報学科,　教室幹事

  • 2002.04
    -
    Present

    慶應義塾大学理工学部生命情報学科,　助教授

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Academic Background 【 Display / hide 】

  • 1981.03

    Konan University, Faculty of Science, 生物学科

    University, Graduated

  • 1983.03

    Nara Women's University, Graduate School, Division of Natural Science, 生物学専攻

    Graduate School, Completed, Master's course

  • 1987.03

    Osaka University, Graduate School, Division of Medicine, 生理系

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 医学　, Osaka University, 1987.03

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Research Areas 【 Display / hide 】

  • Developmental biology (Developmental Biology)

  • Animal physiology/Animal behavior (Animal Physiology/Behavior)

  • Biodiversity/Systematics (Living Organisms Diversity/Classification)

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Research Keywords 【 Display / hide 】

  • planarian Reproductive strategy

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Research Themes 【 Display / hide 】

  • Reproductive strategy in Tardigrade, 

    2015.04
    -
    Present

  • Sexual reproduction of triploid planarian, 

    2005.04
    -
    Present

  • Reproductive strategy in planarian, 

    2000.04
    -
    Present

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Books 【 Display / hide 】

  • Reproductive strategy in planarian

    MATSUMOTO MIDORI, 慶應義塾出版会, 2015.09

  • 棘皮動物の受精

    MATSUMOTO MIDORI, 化学同人, 2014

  • Echinoderms in a Changing World

    MASAHIRO NARUSE, HIROSHI SAKAYA, MOTONORI HOSHI and MIDORI MATSUMOTO, 2013

    Scope: 297

    　View Summary

    棘皮動物における先体反応誘起物質の保存性について論じた。

  • Sperm Cell Research in the 21st Century: Historical Discoveries to New Horizons

    MIDORI MATSUMOTO, MASAHIRO NARUSE, KEISUKE NIIKURA and MOTONORI HOSHI, 2013

    Scope: 174-178

    　View Summary

    ヒトデ先体反応誘起分子群の協調的な作用について紹介した。

  • Echinoderms in a Changing World

    MIDORI MATSUMOTO, OSAMU KAWASE, SADIQUL M.ISLAM, MASAHIRO NARUSE and MOTONORI HOSHI, 2013

    Scope: 263

    　View Summary

    ヒトデ先体反応の細胞内cGMP,cAMP,Ca2+についての先体反応誘起分子群による協調的な調節機構について紹介した。

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Papers 【 Display / hide 】

  • A comprehensive comparison of sex-inducing activity in asexual worms of the planarian Dugesia ryukyuensis: The crucial sex-inducing substance appears to be present in yolk glands in Tricladida

    Nakagawa H., Sekii K., Maezawa T., Kitamura M., Miyashita S., Abukawa M., Matsumoto M., Kobayashi K.

    Zoological Letters （Zoological Letters)  4 （ 1 ）  2018.06

    　View Summary

    © 2018 The Author(s). Background: Turbellarian species can post-embryonically produce germ line cells from pluripotent stem cells called neoblasts, which enables some of them to switch between an asexual and a sexual state in response to environmental changes. Certain low-molecular-weight compounds contained in sexually mature animals act as sex-inducing substances that trigger post-embryonic germ cell development in asexual worms of the freshwater planarian Dugesia ryukyuensis (Tricladida). These sex-inducing substances may provide clues to the molecular mechanism of this reproductive switch. However, limited information about these sex-inducing substances is available. Results: Our assay system based on feeding sex-inducing substances to asexual worms of D. ryukyuensis is useful for evaluating sex-inducing activity. We used the freshwater planarians D. ryukyuensis and Bdellocephala brunnea (Tricladida), land planarian Bipalium nobile (Tricladida), and marine flatworm Thysanozoon brocchii (Polycladida) as sources of the sex-inducing substances. Using an assay system, we showed that the three Tricladida species had sufficient sex-inducing activity to fully induce hermaphroditic reproductive organs in asexual worms of D. ryukyuensis. However, the sex-inducing activity of T. brocchii was sufficient only to induce a pair of ovaries. We found that yolk glands, which are found in Tricladida but not Polycladida, may contain the sex-inducing substance that can fully sexualize asexual worms of D. ryukyuensis. Conclusions: Our results suggest that within Tricladida, there are one or more common compounds or functional analogs capable of fully sexualizing asexual worms of D. ryukyuensis; namely, the crucial sex-inducing substance (hydrophilic and heat-stable, but not a peptide) produced in yolk glands.

  • Inhibition of Dr-dut gene causes DNA damage in planarian

    MATSUMOTO MIDORI

    Molecular Reproduction and Development （Molecular Reproduction and Development)  85 （ 3 ） 188 - 196 2018

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  1040452X

    　View Summary

    © 2018 Wiley Periodicals, Inc. The DUT gene encodes Deoxyuridine triphosphatase (dUTPase), which is involved in nucleotide metabolism. dUTPase prevents uracil misincorporation in DNA by balancing the intracellular ratio between dUTP and dTTP. This study aimed to investigate the role of Dr-dut gene in the planarian Dugesia ryukyuensis by assessing the consequences of Dr-dut silencing on known phenomena, including regeneration following amputation and radiation damage. We functionally disrupted planarian Dr-dut mRNA by feeding RNAi-containing food to animals. Dr-dut RNAi resulted in the death of planarians in 28 days, and elevated double-stranded DNA breakage. Expression of the DNA damage response gene Dr-atm and the DNA repair genes Dr-rad51 and Dr-rad51c temporarily increased, and then decreased following the onset of feeding. When RNAi-treated planarians were amputated, both head and tail parts failed to regenerate, and the animals died in 25 and 29 days, respectively. Administration of 5-fluorouracil (5-FU) also resulted in death and DNA damage, and synergistically caused higher genotoxicity in planarian fed Dr-dut RNAi-containing food.

  • A comprehensive comparison of sex-inducing activity in asexual worms of the planarian Dugesia ryukyuensis

    MATSUMOTO MIDORI

    Zoological Science 36 （ 2 ） 120 - 127 2018

    Joint Work, Accepted

  • The identification of D-tryptophan as a bioactive substance for postembryonic ovarian development in the planarian Dugesia ryukyuensis

    Kazuya Kobayashi, Takanobu Maezawa, Hiroyuki Tanaka, Hiroyuki Onuki, Yurie Horiguchi, Hiroshi Hirota, Tetsuo #HKazuya Kobayashi#H, #HTakanobu Maezawa#H, #HHiroyuki Tanaka#H, #HHiroyuki Onuki#H, #HYurie Horiguchi#H, #HHiroshi Hirota#H, #HTetsuo Ishida#H, #HKihachiro Horiike#H, #HYasutoshi Agata#H, #HManabu Aoki#H, #HMotonori Hoshi#H, #HMidori Matsumoto#H

    Scientific Report 7   45175 2017

    Joint Work, Accepted

  • Protein kinase A activity leads to the extension of the acrosomal process in starfish sperm

    MATSUMOTO MIDORI

    Molecular Reproduction and Development 84 （ 7 ） 614 - 625 2017

    Research paper (scientific journal), Joint Work

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • Sexual Reproduction and Meiosis in the Triploid Planarian Dugesia ryukyuensis

    MATSUMOTO MIDORIAyako Chinone

    Oocyte Maturation and Fertilization Meeting IV, 2015.06

  • 生殖戦略（仮題）

    MATSUMOTO MIDORI

    東京大学理学部特別講義, 2014.10, Public discourse, seminar, tutorial, course, lecture and others

  • 性の有無を決めるものは何か？

    MATSUMOTO MIDORI

    2013年度慶應義塾大学教養研究センター極東証券寄付講座「生命の教養学」「性」, 2014.04, Public discourse, seminar, tutorial, course, lecture and others

  • 受精と免疫からみた自己非自己認識

    MATSUMOTO MIDORI

    広島大学理学部生物科学特別講義, 2014.01, Public discourse, seminar, tutorial, course, lecture and others

    　View Summary

    自己と非自己の認識について無脊椎動物を通して受精と免疫の両側面から紹介する。

  • 身体のつくり

    MATSUMOTO MIDORI

    2013年慶應義塾大学日吉キャンパス公開講座, 2013.11, Public discourse, seminar, tutorial, course, lecture and others

    　View Summary

    動物学的なヒトの身体の構造について、それらを創る元とのある幹細胞の性質について論じた。

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Mechanism of meiosis in triploid planarian- Different chromosome elimination between sex.

    2018.04
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 松本　緑, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • Environmental parameter on the circannual rhythm of reproductive strategy in planarian

    2014.04
    -
    2017.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 松本　緑, Grant-in-Aid for Scientific Research (C), Principal Investigator

    　View Summary

    There are races in planarian with switching of reproduction modes of between asexual and sexual, depending on the change of season. To identify the environmental parameter to induce the switching of reproduction modes, we collected Dugeisa ryukyuensis regularly in Okinawa through one year and established some strains, which switch between sexual mode and asexual mode under the constant environment in the laboratory (called as switching mode). The worms of the switching mode were asexual mode in summer. When their living condition had been changed from summer condition to winter condition (15 C in temperature and 10L14D in photoperiod), their reproduction modes were switched from asexual to sexual.
    Unfortunately, worms of switching modes could not maintained their characters during three years or more. Therefore, it is necessary to constantly established some new strains, which switch between sexual mode and asexual mode under the constant environment for this experiment.

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Works 【 Display / hide 】

  • ハムスターの体温を遠隔測定.....小型テレメトリ装置の制作

    松本　緑

    1983
    , 

    Other, Single

    　View Details

    小動物体温測定装置の製作（設計）

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Courses Taught 【 Display / hide 】

  • TOPICS IN DEVELOPMENTAL BIOLOGY

    2020

  • TOPICS IN BIOSCIENCES AND INFORMATICS 1

    2020

  • SEMINAR IN BIOSCIENCES AND INFORMATICS

    2020

  • INTRODUCTION TO BIOLOGY TODAY

    2020

  • INTRODUCTION TO BIOLOGY

    2020

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Courses Previously Taught 【 Display / hide 】

  • Basic Biology

    Keio University, 2016, Spring Semester, Other, Lecture, Within own ｆaculty, 1h, 20people

  • Developmental Biology

    Keio University, 2016, Autumn Semester, Major subject, Lecture, Within own ｆaculty, 1h, 20people

  • Topics in Developmental Biology

    Keio University, 2016, Spring Semester, Major subject, Lecture, Within own ｆaculty, 1h, 35people

  • Synthetic Biology

    Keio University, 2016, Spring Semester, Major subject, Lecture, Within own ｆaculty, 1h, 20people

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Social Activities 【 Display / hide 】

  • 独立行政法人日本学術振興会

    2007.12
    -
    2010.11
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Memberships in Academic Societies 【 Display / hide 】

  • 社団法人日本動物学会関東支部会準備委員会, 

    2010.01
    -
    2011.03

  • 社団法人日本動物学会関東支部公開講演会運営委員会, 

    2009.07
    -
    2010.06

  • 社団法人日本動物学会関東支部, 

    2008.10
    -
    2010.06

  • Trends in Glycoscience and Glycotechnology (TIGG), 

    2008.01
    -
    2010.12

  • International Society of Invertebrate Reproduction and Development, 

    2005.08
    -
    Present

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Committee Experiences 【 Display / hide 】

  • 2017
    -
    Present

    商議員, 公益財団法人日本科学協会

  • 2016.12
    -
    2017.11

    科学研究費委員会専門委員, 独立行政法人日本学術振興会

  • 2016
    -
    2020

    第3期NISTEP定点調査対象候補者, 科学技術・学術政策研究所

  • 2015.04
    -
    2016.06

    関東支部　支部委員, 公益社団法人日本動物学会

  • 2014.08
    -
    2015.07

    特別研究員等審査会専門委員及び国際事業委員会書面審査員, 独立行政法人日本学術振興会

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