Matsumoto, Midori

写真a

Affiliation

Faculty of Science and Technology, Department of Biosciences and Informatics （Yagami）

Position

Associate Professor

External Links
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Career 【 Display / hide 】

  • 1987.04
    -
    1988.10

    三菱化成生命科学研究所

  • 1988.11
    -
    2000.03

    東京工業大学生命理工学部生命理学科, 助手

  • 2000.04
    -
    2002.03

    慶應義塾大学理工学部化学科,　専任講師

  • 2002.04
    -
    2004.03

    慶應義塾大学理工学部生命情報学科,　教室幹事

  • 2002.04
    -
    Present

    慶應義塾大学理工学部生命情報学科,　助教授

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Academic Background 【 Display / hide 】

  • 1981.03

    Konan University, Faculty of Science, 生物学科

    University, Graduated

  • 1983.03

    Nara Women's University, Graduate School, Division of Natural Science, 生物学専攻

    Graduate School, Completed, Master's course

  • 1987.03

    Osaka University, Graduate School, Division of Medicine, 生理系

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 医学　, Osaka University, 1987.03

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Research Areas 【 Display / hide 】

  • Life Science / Developmental biology (Developmental Biology)

  • Life Science / Animal physiological chemistry, physiology and behavioral biology (Animal Physiology/Behavior)

  • Life Science / Biodiversity and systematics (Living Organisms Diversity/Classification)

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Research Keywords 【 Display / hide 】

  • Planarian, Tardigrada, Reproductive strategy

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Research Themes 【 Display / hide 】

  • Reproductive strategy in Tardigrade, 

    2015.04
    -
    Present

  • Sexual reproduction of triploid planarian, 

    2005.04
    -
    Present

  • Reproductive strategy in planarian, 

    2000.04
    -
    Present

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Books 【 Display / hide 】

  • Reproductive strategy in planarian

    MATSUMOTO MIDORI, 慶應義塾出版会, 2015.09

  • 棘皮動物の受精

    MATSUMOTO MIDORI, 化学同人, 2014

  • Echinoderms in a Changing World

    MASAHIRO NARUSE, HIROSHI SAKAYA, MOTONORI HOSHI and MIDORI MATSUMOTO, 2013

    Scope: 297

    　View Summary

    棘皮動物における先体反応誘起物質の保存性について論じた。

  • Sperm Cell Research in the 21st Century: Historical Discoveries to New Horizons

    MIDORI MATSUMOTO, MASAHIRO NARUSE, KEISUKE NIIKURA and MOTONORI HOSHI, 2013

    Scope: 174-178

    　View Summary

    ヒトデ先体反応誘起分子群の協調的な作用について紹介した。

  • Echinoderms in a Changing World

    MIDORI MATSUMOTO, OSAMU KAWASE, SADIQUL M.ISLAM, MASAHIRO NARUSE and MOTONORI HOSHI, 2013

    Scope: 263

    　View Summary

    ヒトデ先体反応の細胞内cGMP,cAMP,Ca2+についての先体反応誘起分子群による協調的な調節機構について紹介した。

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Papers 【 Display / hide 】

  • Co-localization of DrPiwi-1 and DrPiwi-2 in the oogonial cytoplasm is essential for oocyte differentiation in sexualized planarians

    Kimoto C., Nakagawa H., Hasegawa R., Nodono H., Matsumoto M.

    Cells and Development （Cells and Development)  167 2021.09

    ISSN  26672901

    　View Summary

    P-Element-induced wimpy testis (Piwi) subfamily proteins form complexes that bind to Piwi-interacting RNA. This interaction is crucial for stem cell regulation and formation, maintenance of germline stem cells, and gametogenesis in several metazoans. Planarians are effective models for studying stem cells. In the planarian Dugesia ryukyuensis, DrPiwi-1 is essential for the development of germ cells, but not somatic cells and sexual organs. DrPiwi-2 is indispensable for regeneration. In this study, we aimed to investigate the effects of Piwi on the differentiation of germ cells using monoclonal antibodies against DrPiwi-1 and DrPiwi-2. DrPiwi-1 and DrPiwi-2 co-localized more in immature germ cells than in mature germ cells in the ovary. DrPiwi-1 was found in the cytoplasm of early oogonia as undifferentiated germ cells, whereas DrPiwi-2 was found to localize not only in the nuclei but also in the cytoplasm of early oogonia. In descendant germ cells (oocytes), DrPiwi-2 was not present in the cytoplasm, but was strongly detected in the nucleolus. Moreover, we found that DrPiwi-1 forms a complex with DrPiwi-2. The cause of DrPiwi-1 depletion may be the severe reduction in the DrPiwi-2 level in the cytoplasm of oogonia. These results suggest that the formation of the DrPiwi-1 and DrPiwi-2 complex in the cytoplasm of oogonia is essential for oocyte differentiation. Our findings support the conclusion that DrPiwi-1 forms a complex with DrPiwi-2 in the cytoplasm of undifferentiated germ cells, and it signifies the start of gametogenesis. In contrast, in the testes, Drpiwi-1 was found in undifferentiated germ cells (spermatogonia), whereas DrPiwi-2 was found in descendant germ cells (spermatocytes). The process of germ cell differentiation from adult stem cells in planarians may be regulated in different ways in female and male germ lines by the Piwi family.

  • Reproduction of Mesobiotus: Comparison of Morphology and Behavior in the Family Macrobiotidae (Tardigrada: Eutardigrada)

    Sugiura, Kenta, and Matsumoto, Midori

    Zoological Science （Zoological Society of Japan)  38 （ 5 ）  2021.07

    Research paper (scientific journal), Joint Work, Accepted

  • Milnesium (Tardigrada: Apochela) in Japan: The First Confirmed Record of Milnesium tardigradum s.s: The Description of Milnesium pacificum sp. nov.

    Sugiura K., Minato H., Matsumoto M., Suzuki A.C.

    Zoological Science （Zoological Science)  37 （ 5 ） 476 - 495 2020.10

    ISSN  02890003

    　View Summary

    Presently, more than 40 species of the genus MilnesiumDoyère, 1840 (Tardigrada: Eutardigrada: Apochela: Milnesiidae) have been described. In Japan, however, almost all records of milnesiid tardigrades should be re-examined with the current criteria on the taxonomy of this genus, except for one species, the recently described Milnesium inceptum Morek, Suzuki, Schill, Georgiev, Yankova, Marley, and Michalczyk, 2019. In this study, we found two species, Milnesium pacificum sp. nov. and Milnesium tardigradumDoyère, 1840, from three southern islands and two cold regions in Japan, respectively. Milnesium pacificum sp. nov., having dorsal sculpturing, exhibits an early positive change in claw configuration. On the other hand, M. tardigradum s.s. from Japan has an early negative claw configuration change, as has been reported in a recent study on the neotype population of this species. We performed DNA barcoding for both species, which indicated that M. pacificum sp. nov. has a close affinity with an undescribed Milnesium species collected from Brazil, and that M. tardigradum from Japan represents the recently described subclade that contains specimens from Poland, Hungary, and Russia. The chromosome numbers were 2n = 14 in M. pacificum sp. nov. and 2n = 10 in M. tardigradum. We detected at least three species of the genus Milnesium present in Japan. Our results advance the investigation of the relationship between phylogenetic position and characteristic morphology as well as expand the known geographic range of M. tardigradum.

  • Distribution of Macrobiotus shonaicus Stec, Arakawa & Michalczyk, 2018 (Tardigrada: Eutardigrada: Macrobiotidae) in Japan

    Sugiura K., Arakawa K., Matsumoto M.

    Zootaxa （Zootaxa)  4767 （ 1 ） 56 - 70 2020.04

    ISSN  11755326

    　View Summary

    To date, only seven species of Macrobiotidae (Parachela; Eutardigrada; Tardigrada) have been reported from Japan, including the recently described Macrobiotus shonaicus Stec et al., 2018 from the Shonai region of Japan. This species has flexible filaments on the egg processes and is known to proliferate only through sexual reproduction. Here, we report a multifaceted analysis of nine populations of M. shonaicus found on four Japanese islands. DNA sequencing of the cytochrome oxidase subunit I (COI) and internal transcribed spacer 2 (ITS-2) of the nine populations revealed 8 and 11 haplotypes, respectively. The extensive morphometric analysis showed considerably greater variability in the morphology of eggs than of animals. In addition to the morphological and molecular data, we confirmed the karyotype and found that all populations had a chromosome number of n = 6. Moreover, we observed and filmed mating behaviour between all studied populations of M. shonaicus. Our results clearly indicated that M. shonaicus is widely distributed throughout Japan.

  • Spermatozoa morphology changes during reproduction and first observation of acrosomal contact in two dioecious species of Macrobiotidae (Tardigrada: Eutardigrada)

    Sugiura K., Matsumoto M.

    Zygote （Zygote)   2020

    ISSN  09671994

    　View Summary

    Mating behaviours for two species of dioecious eutardigrades: a strain of Paramacrobiotus sp. and Macrobiotus shonaicus (Stec et al.2018) have been recorded previously, and observations have indicated that spermatozoa of both species are first released into the environment, then swim through the cloaca of the females and into the spermatheca. The fusion of gamete nuclei has not yet occurred in a laid egg. Therefore, it has been suggested that fertilization is completed externally as the egg is released into the environment before the nuclei of the gametes fuse. In the present study, the spermatozoa of both Paramacrobiotus sp. and M. shonaicus spermatozoa underwent morphological changes during reproduction. In morphometrical analyses of testicular spermatozoa, the tail, mid-piece, nucleus, and acrosome were significantly longer in Paramacrobiotus sp. compared with M. shonaicus. The nuclei of both the testicular and spermathecal spermatozoa were equally coiled, but the latter had shorter tails in both species. These spermatozoa were present on the surface of the egg chorion after oviposition. The tip of the acrosomes lay buried in the chorion, suggesting that penetration had occurred. We also proposed that the reduced tail is a conserved trait, at least in Macrobiotidae.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

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Presentations 【 Display / hide 】

  • Sexual Reproduction and Meiosis in the Triploid Planarian Dugesia ryukyuensis

    MATSUMOTO MIDORIAyako Chinone

    Oocyte Maturation and Fertilization Meeting IV, 

    2015.06

  • 生殖戦略（仮題）

    MATSUMOTO MIDORI

    東京大学理学部特別講義, 

    2014.10
    , 

    Public lecture, seminar, tutorial, course, or other speech

  • 性の有無を決めるものは何か？

    MATSUMOTO MIDORI

    2013年度慶應義塾大学教養研究センター極東証券寄付講座「生命の教養学」「性」, 

    2014.04
    , 

    Public lecture, seminar, tutorial, course, or other speech

  • 受精と免疫からみた自己非自己認識

    MATSUMOTO MIDORI

    広島大学理学部生物科学特別講義, 

    2014.01
    , 

    Public lecture, seminar, tutorial, course, or other speech

    　View Summary

    自己と非自己の認識について無脊椎動物を通して受精と免疫の両側面から紹介する。

  • 身体のつくり

    MATSUMOTO MIDORI

    2013年慶應義塾大学日吉キャンパス公開講座, 

    2013.11
    , 

    Public lecture, seminar, tutorial, course, or other speech

    　View Summary

    動物学的なヒトの身体の構造について、それらを創る元とのある幹細胞の性質について論じた。

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • Mechanism of meiosis in triploid planarian- Different chromosome elimination between sex.

    2018.04
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

  • Environmental parameter on the circannual rhythm of reproductive strategy in planarian

    2014.04
    -
    2017.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Principal investigator

    　View Summary

    There are races in planarian with switching of reproduction modes of between asexual and sexual, depending on the change of season. To identify the environmental parameter to induce the switching of reproduction modes, we collected Dugeisa ryukyuensis regularly in Okinawa through one year and established some strains, which switch between sexual mode and asexual mode under the constant environment in the laboratory (called as switching mode). The worms of the switching mode were asexual mode in summer. When their living condition had been changed from summer condition to winter condition (15 C in temperature and 10L14D in photoperiod), their reproduction modes were switched from asexual to sexual.
    Unfortunately, worms of switching modes could not maintained their characters during three years or more. Therefore, it is necessary to constantly established some new strains, which switch between sexual mode and asexual mode under the constant environment for this experiment.

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Works 【 Display / hide 】

  • ハムスターの体温を遠隔測定.....小型テレメトリ装置の制作

    松本　緑

    1983
    , 

    Other, Single

    　View Details

    小動物体温測定装置の製作（設計）

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Courses Taught 【 Display / hide 】

  • TOPICS IN DEVELOPMENTAL BIOLOGY

    2022

  • TOPICS IN BIOSCIENCES AND INFORMATICS 1

    2022

  • SEMINAR IN BIOSCIENCES AND INFORMATICS

    2022

  • INTRODUCTION TO BIOLOGY TODAY

    2022

  • INTRODUCTION TO BIOLOGY

    2022

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Courses Previously Taught 【 Display / hide 】

  • Basic Biology

    Keio University

    2016.04
    -
    2017.03
    , 

    Spring Semester, Other, Lecture, Within own ｆaculty, 1h, 20people

  • Developmental Biology

    Keio University

    2016.04
    -
    2017.03
    , 

    Autumn Semester, Lecture, Within own ｆaculty, 1h, 20people

  • Topics in Developmental Biology

    Keio University

    2016.04
    -
    2017.03
    , 

    Spring Semester, Lecture, Within own ｆaculty, 1h, 35people

  • Synthetic Biology

    Keio University

    2016.04
    -
    2017.03
    , 

    Spring Semester, Lecture, Within own ｆaculty, 1h, 20people

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Social Activities 【 Display / hide 】

  • 独立行政法人日本学術振興会

    2007.12
    -
    2010.11
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Memberships in Academic Societies 【 Display / hide 】

  • 社団法人日本動物学会関東支部会準備委員会, 

    2010.01
    -
    2011.03

  • 社団法人日本動物学会関東支部公開講演会運営委員会, 

    2009.07
    -
    2010.06

  • 社団法人日本動物学会関東支部, 

    2008.10
    -
    2010.06

  • Trends in Glycoscience and Glycotechnology (TIGG), 

    2008.01
    -
    2010.12

  • International Society of Invertebrate Reproduction and Development, 

    2005.08
    -
    Present

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Committee Experiences 【 Display / hide 】

  • 2017
    -
    Present

    商議員, 公益財団法人日本科学協会

  • 2016.12
    -
    2017.11

    科学研究費委員会専門委員, 独立行政法人日本学術振興会

  • 2016
    -
    2020

    第3期NISTEP定点調査対象候補者, 科学技術・学術政策研究所

  • 2015.04
    -
    2016.06

    関東支部　支部委員, 公益社団法人日本動物学会

  • 2014.08
    -
    2015.07

    特別研究員等審査会専門委員及び国際事業委員会書面審査員, 独立行政法人日本学術振興会

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