Papers - Ushiba, Junichi

Depth Sensor-Based Assessment of Reachable Work Space for Visualizing and Quantifying Paretic Upper Extremity Motor Function in People with Stroke

Kohei Okuyama, Michiyuki Kawakami, Shohei Tsuchimoto, Miho Ogura, Kohsuke Okada, Katsuhiro Mizuno, Junichi Ushiba, Meigen Liu

Physical Therapy (© 2020 American Physical Therapy Association)  pzaa025 2020.02

Research paper (scientific journal), Joint Work, Accepted

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Sensorimotor Connectivity after Motor Exercise with Neurofeedback in Post-Stroke Patients with Hemiplegia

Tsuchimoto S., Shindo K., Hotta F., Hanakawa T., Liu M., Ushiba J.

Neuroscience (Neuroscience)  416   109 - 125 2019.09

Research paper (scientific journal), Joint Work, Accepted,  ISSN  03064522

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© 2019 Elsevier Ltd Impaired finger motor function in post-stroke hemiplegia is a debilitating condition with no evidence-based or accessible treatments. Here, we evaluated the neurophysiological effectiveness of direct brain control of robotic exoskeleton that provides movement support contingent with brain activity. To elucidate the mechanisms underlying the neurofeedback intervention, we assessed resting-state functional connectivity with functional magnetic resonance imaging (rsfcMRI) between the ipsilesional sensory and motor cortices before and after a single 1-h intervention. Eighteen stroke patients were randomly assigned to crossover interventions in a double-blind and sham-controlled design. One patient dropped out midway through the study, and 17 patients were included in this analysis. Interventions involved motor imagery, robotic assistance, and neuromuscular electrical stimulation administered to a paretic finger. The neurofeedback intervention delivered stimulations contingent on desynchronized ipsilesional electroencephalographic (EEG) oscillations during imagined movement, and the control intervention delivered sensorimotor stimulations that were independent of EEG oscillations. There was a significant time × intervention interaction in rsfcMRI in the ipsilesional sensorimotor cortex. Post-hoc analysis showed a larger gain in increased functional connectivity during the neurofeedback intervention. Although the neurofeedback intervention delivered fewer total sensorimotor stimulations compared to the sham-control, rsfcMRI in the ipsilesional sensorimotor cortices was increased during the neurofeedback intervention compared to the sham-control. Higher coactivation of the sensory and motor cortices during neurofeedback intervention enhanced rsfcMRI in the ipsilesional sensorimotor cortices. This study showed neurophysiological evidence that EEG-contingent neurofeedback is a promising strategy to induce intrinsic ipsilesional sensorimotor reorganization, supporting the importance of integrating closed-loop sensorimotor processing at a neurophysiological level.

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Fast Electrophysiological Mapping of Rat Cortical Motor Representation on a Time Scale of Minutes during Skin Stimulation

Kosugi A., Castagnola E., Carli S., Ricci D., Fadiga L., Taoka M., Iriki A., Ushiba J.

Neuroscience (Neuroscience)  414   245 - 254 2019.08

Research paper (scientific journal), Joint Work, Accepted,  ISSN  03064522

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© 2019 Elsevier Ltd The topographic map of motor cortical representation, called the motor map, is not invariant, but can be altered by motor learning, neurological injury, and functional recovery from injury. Although much attention has been paid to short-term changes of the motor map, robust measures have not been established. The existing mapping methods are time-consuming, and the obtained maps are confounded by time preference. The purpose of this study was to examine the dynamics of the motor map on a timescale of minutes during transient somatosensory input by a fast motor mapping technique. We applied 32-channel micro-electrocorticographic electrode arrays to the rat sensorimotor cortex for cortical stimulation, and the topographic profile of motor thresholds in forelimb muscle was identified by fast motor mapping. Sequential motor maps were obtained every few minutes before, during, and just after skin stimulation to the dorsal forearm using a wool buff. During skin stimulation, the motor map expanded and the center of gravity of the map was shifted caudally. The expansion of the map persisted for at least a few minutes after the end of skin stimulation. Although the motor threshold of the hotspot was not changed, the area in which it was decreased appeared caudally to the hotspot, which may be in the somatosensory cortex. The present study demonstrated rapid enlargement of the forelimb motor map in the order of a few minutes induced by skin stimulation. This helps to understand the spatial dynamism of motor cortical representation that is modulated rapidly by somatosensory input.

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Two-stage regression of high-density scalp electroencephalograms visualizes force regulation signaling during muscle contraction

Hayashi M., Tsuchimoto S., Mizuguchi N., Miyatake M., Kasuga S., Ushiba J.

Journal of Neural Engineering (Journal of Neural Engineering)  16 ( 5 )  2019.08

Research paper (scientific journal), Joint Work, Accepted,  ISSN  17412560

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© 2019 IOP Publishing Ltd. Objective. A critical feature for the maintenance of precise skeletal muscle force production by the human brain is its ability to configure motor function activity dynamically and adaptively in response to visual and somatosensory information. Existing studies have concluded that not only the sensorimotor area but also distributed cortical areas act cooperatively in the generation of motor commands for voluntary force production to the desired level. However, less attention has been paid to such physiological mechanisms in conventional brain-computer interface (BCI) design and implementation. We proposed a new, physiologically inspired two-stage decoding method to see its contribution on accuracy improvement of BCI. Approach. We performed whole-head high-density scalp electroencephalographic (EEG) recording during a right finger force-matching task at three strength levels (20%, 40%, and 60% maximal voluntary contraction following a resting state). A two-stage regression approach was employed that decodes muscle contraction level from EEG signals in the multi-level force-matching task and translates them into: (1) presence/absence of muscle contraction as a first stage; and (2) muscle contraction level as a second stage. Dimensionality reduction of the EEG signals, using principal component analysis, avoided multicollinearity during multiple regression, and data-driven stepwise multiple regression identified EEG components that were involved in the multi-level force-matching task. Main results. An alternatively tuned two-stage regressor accurately decoded muscle contraction level with online processing rather than the conventional decoders, and identified EEG components that were related to voluntary force production. Relaxation/contraction state-dependent EEG components were localized dominantly in the contralateral parieto-temporal regions, whereas multi-level force regulation-dependent EEG components came from the fronto-parietal regions. Significance. Our findings identify respective cortical signalings during relaxation/contraction and multi-level force regulation using a sensor-based approach with EEG. Simulation-based assessment of the current physiologically inspired decoding technique proved improved accuracy in online BCI control.

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Development of Rehabilitation System with Brain-Computer Interface for Subacute Stroke Patients

Hashimoto Y., Kakui T., Ushiba J., Liu M., Kamada K., Ota T.

Proceedings - 2018 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2018 (Proceedings - 2018 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2018)     51 - 56 2019.01

Research paper (international conference proceedings), Joint Work,  ISSN  9781538666500

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© 2018 IEEE. There have been recent advances in brain-computer interfaces for post-stroke rehabilitation. In particular, compact and embedded brain-computer interface systems with neuromuscular electrical stimulation have been developed by industry and academia, and some of them can potentially be used at the bedside. However, limited studies have demonstrated their safety and feasibility for treatment in subacute stroke patients. The aim of this pilot study was to first develop a brain-computer interface system for subacute stroke inpatients that is usable at the bedside and to show the safety and feasibility using a small cohort of inpatients. Four hemiplegic stroke inpatients in the very early phase (7-24 days from stroke onset) participated in this study. The portable brain-computer interface system shows the amplitude of sensorimotor rhythms extracted from scalp electroencephalograms in real time. Patients attempted to extend the wrist on their affected side, and neuromuscular electrical stimulation was applied only when the brain-computer interface system detected significant movement intention-related electroencephalogram changes. Each brain-computer interface training lasted 40 minutes. On average, 120-200 training trials of the wrist extension task were successfully and safely conducted over 3.3 days (range 2-4 days) with the bedside brain-computer interface system. Furthermore, electroencephalogram results showed a new significant event-related desynchronization in the damaged hemisphere after training. These results clearly show the proposed bedside brain-computer interface system's safety and feasibility and also demonstrated electrophysiological plasticity in the damaged hemisphere in subacute patients with post-stroke hemiplegia. Larger clinical studies are needed to identify the brain-computer interface system's clinical efficacy and its effect size in the subacute post-stroke patient population.

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Evaluating the Effectiveness and Safety of the Electroencephalogram-Based Brain-Machine Interface Rehabilitation System for Patients With Severe Hemiparetic Stroke: Protocol for a Randomized Controlled Trial (BEST-BRAIN Trial)

Katsuhiro Mizuno, Takayuki Abe, Junichi Ushiba, Michiyuki Kawakami, Tomomi Ohwa, Kazuto Hagimura, Miho Ogura, Kohei Okuyama, Toshiyuki Fujiwara, Meigen Liu

JMIR Research Protocols 7 ( 12 ) e12339 2018.12

Research paper (scientific journal), Joint Work, Accepted

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Precise estimation of human corticospinal excitability associated with the levels of motor imagery-related EEG desynchronization extracted by a locked-in amplifier algorithm

Kensho Takahashi, Kenji Kato, Nobuaki Mizuguchi, Junichi Ushiba

Journal of NeuroEngineering and Rehabilitation (Journal of neuroengineering and rehabilitation)  15 ( 93 )  2018.11

Research paper (scientific journal), Joint Work, Accepted

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BACKGROUND: Physical motor exercise aided by an electroencephalogram (EEG)-based brain-computer interface (BCI) is known to improve motor recovery in patients with stroke. In such a BCI paradigm, event-related desynchronization (ERD) in the alpha and beta bands extracted from EEG recorded over the primary sensorimotor area (SM1) is often used, since ERD has been suggested to be associated with an increase of corticospinal excitability. Recently, we demonstrated a novel online lock-in amplifier (LIA) algorithm to estimate the amplitude modulation of motor-related SM1 ERD. With this algorithm, the delay time, accuracy, and stability to estimate motor-related SM1 ERD were significantly improved compared with the conventional fast Fourier transformation (FFT) algorithm. These technical improvements to extract an ERD trace imply a potential advantage for a better trace of the excitatory status of the SM1 in a BCI context. Therefore, the aim of this study was to assess the precision of LIA-based ERD tracking for estimation of corticospinal excitability using a transcranial magnetic stimulation (TMS) paradigm.METHODS: The motor evoked potentials (MEPs) induced by single-pulse TMS over the primary motor cortex depending on the magnitudes of SM1 ERD (i.e., 35% and 70%) extracted by the online LIA or FFT algorithm were monitored during a motor imagery task of wrist extension in 17 healthy participants. Then, the peak-to-peak amplitudes of MEPs and their variabilities were assessed to investigate the precision of the algorithms.RESULTS: We found greater MEP amplitude evoked by single-pulse TMS triggered by motor imagery-related alpha SM1 ERD than at rest. This enhancement was associated with the magnitude of ERD in both FFT and LIA algorithms. Moreover, we found that the variabilities of peak-to-peak MEP amplitudes at 35% and 70% ERDs calculated by the novel online LIA algorithm were smaller than those extracted using the conventional FFT algorithm.CONCLUSIONS: The present study demonstrated that the calculation of motor imagery-related SM1 ERDs using the novel online LIA algorithm led to a more precise estimation of corticospinal excitability than when the ordinary FFT-based algorithm was used.

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Prolonged Aftereffect of Visuomotor Adaptation to Gradually Distorted Reality Displayed on a See-Through Head-Mounted Device

Shoko Kasuga, Ryota Mori, Shunichi Kasahara, Junichi Rekimoto, Junichi Ushiba

International Journal of Human-Computer Interaction (International Journal of Human-Computer Interaction)  35 ( 15 ) 1345 - 1351 2018.10

Research paper (scientific journal), Joint Work, Accepted,  ISSN  10447318

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© 2018, © 2018 Taylor & Francis Group, LLC. Growing evidence suggests that the gradual transformation of visuomotor association drives a distinct learning process from abrupt transformation in humans. In the current study, we developed a novel omnidirectional visuomotor transformation paradigm to study details of such difference in more realistic environment than conventional experimental systems. Participants were asked to perform a repetitive three-dimensional (3D) arm-reaching task to a target on a front touch panel, wearing a video see-through head-mounted device that displayed a rotating view of surrounding images. In the abrupt condition, the images were rotated by 20°; in the gradual condition, the rotation was increased in a stepwise-manner from 0° to 20°. In both conditions, pointing errors were decreased after adaptation. Further, although the aftereffect of adaptation was not different between conditions, the speed of decay of the aftereffect, which was quantified by an exponential fit, was slower in the gradual condition, suggesting longer-lasting aftereffects for the gradual shift.

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Muscle-selective disinhibition of corticomotor representations using a motor imagery-based brain-computer interface.

Mitsuaki Takemi, Tsuyoshi Maeda, Yoshihisa Masakado, Hartwig Roman Siebner, Junichi Ushiba

NeuroImage (NeuroImage)  183   597 - 605 2018.08

Research paper (scientific journal), Joint Work, Accepted,  ISSN  10538119

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© 2018 Bridging between brain activity and machine control, brain-computer interface (BCI) can be employed to activate distributed neural circuits implicated in a specific aspect of motor control. Using a motor imagery-based BCI paradigm, we previously found a disinhibition within the primary motor cortex contralateral to the imagined movement, as evidenced by event-related desynchronization (ERD) of oscillatory cortical activity. Yet it is unclear whether this BCI approach does selectively facilitate corticomotor representations targeted by the imagery. To address this question, we used brain state-dependent transcranial magnetic stimulation while participants performed kinesthetic motor imagery of wrist movements with their right hand and received online visual feedback of the ERD. Single and paired-pulse magnetic stimulation were given to the left primary motor cortex at a low or high level of ERD to assess intracortical excitability. While intracortical facilitation showed no modulation by ERD, short-latency intracortical inhibition was reduced the higher the ERD. Intracortical disinhibition was only found in the agonist muscle targeted by motor imagery at high ERD level, but not in the antagonist muscle. Single pulse motor-evoked potential was also increased the higher the ERD. However, at high ERD level, this facilitatory effect on overall corticospinal excitability was not selective to the agonist muscle. Analogous results were found in two independent experiments, in which participants either performed kinesthetic motor imagery of wrist extension or flexion. Our results showed that motor imagery-based BCI can selectively disinhibit the corticomotor output to the agonist muscle, enabling effector-specific training in patients with motor paralysis.

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Calcium transient dynamics of neural ensembles in the primary motor cortex of naturally behaving monkeys

Takahiro Kondo, Risa Saito, Masaki Otaka, Kimika Yoshino-Saito, Akihiro Yamanaka, Tetsuo Yamamori, Akiya Watakabe, Hiroaki Mizukami, Mark J. Schnitzer, Kenji F. Tanaka, Junichi Ushiba(*), Hideyuki Okano(*) *: Double corresponding author.

Cell Reports (Cell Reports)  24 ( 8 ) 2191 - 2195 2018.08

Research paper (scientific journal), Joint Work, Accepted

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無麻酔・自由行動下でのコモン・マーモセット一次運動野皮質ニューロン活動を、蛍光カルシウムプローブと光ファイバー顕微鏡を用いて100個単位で観察することに成功し、運動中だけでなく運動前や運動後の神経活動パターンも上肢運動方向を符号化していることを明らかにした。

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Brain-computer interfaces for stroke rehabilitation: summary of the 2016 BCI Meeting in Asilomar

Guger C., Millán J., Mattia D., Ushiba J., Soekadar S., Prabhakaran V., Mrachacz-Kersting N., Kamada K., Allison B.

Brain-Computer Interfaces (Brain-Computer Interfaces)  5 ( 2-3 ) 41 - 57 2018.07

ISSN  2326263X

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© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Brain-computer interfaces (BCIs) based on motor imagery have been gaining attention as tools to facilitate recovery from movement disorders resulting from stroke or other causes. These BCIs can detect imagined movements that are typically required within conventional rehabilitation therapy. This information about the timing, intensity, and location of imagined movements can help assess compliance and control feedback mechanisms such as functional electrical stimulation (FES) and virtual avatars. Here, we review work from eight groups that each presented recent results with BCI-based rehabilitation at a workshop during the 6th International Brain-Computer Interface Meeting. We also present major directions and challenges for future research.

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Subjective vividness of kinesthetic motor imagery is associated with the similarity in magnitude of sensorimotor event-related desynchronization between motor execution and motor imagery

Hisato Toriyama, Junichi Ushiba, Junichi Ushiyama

Frontiers in Human Neuroscience 12 (Frontiers in Human Neuroscience)  295 (10 pages) 2018.07

Research paper (scientific journal), Joint Work, Accepted

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上肢運動想起時に体性感覚運動野近傍の頭皮脳波で観察される事象関連脱同期現象は、被験者の運動内観の鮮明さに相関することを明らかにした。

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Structural gray matter changes in the hippocampus and the primary motor cortex on an-hour-to-one-day scale can predict arm-reaching performance improvement

Midori Kodama, Takashi Ono, Fumio Yamashita, Hiroki Ebata, Meigen Liu, Shoko Kasuga, Junichi Ushiba.

Frontiers in Human Neuroscience 12 (Frontiers in Human Neuroscience)  209 (11 pages) 2018.06

Research paper (scientific journal), Joint Work, Accepted

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視野左右鏡像反転環境下での上肢到達運動を5日間にわたって継続し、磁気共鳴画像法による脳構造撮像をおこなった結果、初回訓練後に一次運動野と海馬の灰白質信号が変化した被験者では5日後の運動パフォーマンスが高かったことを明らかにした。

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Resting-state pallidal-cortical oscillatory couplings in patients with predominant phasic and tonic dystonia

Fusako Yokochi, Kenji Kato, Hirokazu Iwamuro, Tsutomu Kamiyama, Katsuo Kimura, Akihiro Yugeta, Ryoichi Okiyama, makoto Taniguchi, Satoko Kumada, Junichi Ushiba

Frontiers in Neurology 9 (Frontiers in Neurology)  375 (12 pages) ( MAY )  2018.05

Research paper (scientific journal), Joint Work, Accepted

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ジストニア患者における淡蒼球-大脳皮質間の機能結合を解析したところ、特定周波数の結合強度によってジストニアサブタイプを分類することが可能であることを認めた。

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Change in reciprocal inhibition of the forearm with motor imagery among patients with chronic stroke.

Michiyuki Kawakami, Kohei Okuyama, Yoko Takahashi, Miho Hiramoto, Atsuko Nishimura, Junichi Ushiba, Toshiyuki Fujiwara and Meigen Liu

Neural Plasticity (Neural Plasticity)  2018   394636 (9 pages) 2018.04

Research paper (scientific journal), Joint Work, Accepted,  ISSN  20905904

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慢性期脳卒中片麻痺患者の麻痺側上肢運動企図時に、拮抗筋との間に形成されている脊髄内相反抑制神経回路が増強すること、皮質損傷例よりも皮質下構造損傷例のほうがその効果が著明であること、10日間にわたる継続的なブレイン・マシン・インターフェース訓練によってその効果が更に増強することを報告した。

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Brain-computer interfaces for post-stroke motor rehabilitation: a meta-analysis

Maria A. Cervera, Surjo R. Soekadar, Junichi Ushiba, José del R. Millán, Meigen Liu, Niels Bibaumer, Gangadhar Garipelli

Annals of Clinical and Translational Neurology (Annals of Clinical and Translational Neurology)  5 ( 5 ) 651 - 663 2018.03

Research paper (scientific journal), Joint Work, Accepted

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脳卒中片麻痺上肢に対するブレイン・マシン・インターフェース訓練に関するランダム比較試験（9件）をメタアナリシスした結果、比較対象群に対して有意に治療効果が高いことを明らかにした。

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Accurate motor mapping in awake common marmosets using micro-electrocorticographical stimulation and stochastic threshold estimation.

Akito Kosugi, Mitsuaki Takemi, Banty Tia, Elisa Castagnola, Alberto Ansaldo, Kenta Sato, Friedmann Awiszus, Kazuhiko Seki, Davide Ricci, Luciano Fadiga, Atsushi Iriki, Junichi Ushiba.

Journal of Neural Engineering (Journal of Neural Engineering)  15 ( 3 ) 036019 2018.03

Research paper (scientific journal), Joint Work, Accepted,  ISSN  17412560

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運動皮質へのパルス電流刺激強度と誘発筋電図振幅の小標本分布から運動閾値を推定するアルゴリズムを利用して、非麻酔下コモン・マーモセットでの高速運動地図作成法を確立した。

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Acquisition of a mental strategy to control a virtual tail via brain-computer interface.

Ayaka Fujisawa, Shoko Kasuga, Takaharu Suzuki, Junichi Ushiba.

Cognitive Neuroscience (Cognitive Neuroscience)  26 ( 1 ) 1 - 14 2018.01

Research paper (scientific journal), Joint Work, Accepted,  ISSN  17588928

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コンピュータ・グラフィックスで生成された尻尾様オブジェクトを頭皮脳波変化で動作させるブレイン・マシン・インターフェースを構築し、適応過程におけるユーザーの内観変化を分析した。

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Feasibility of task-specific brain-machine interface training for upper extremity paralysis in patients with chronic hemiparetic stroke

Atsuko Nishimoto, Michiyuki Kawakami, Toshiyuki Fujiwara, Miho Hiramoto, Kaoru Honaga , Kaoru Abe, Katsuhiro Mizuno, Junichi Ushiba, Meigen Liu.

Journal of Rehabilitation Medicine (Journal of Rehabilitation Medicine)  50 ( 1 ) 52 - 58 2018.01

Research paper (scientific journal), Joint Work, Accepted,  ISSN  16501977

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臨床運用性を担保したブレイン・マシン・インターフェース（BMI）訓練が脳卒中重度片麻痺上肢の手指機能の改善をもたらすことと、BMIの正動率が運動機能スケールの改善に送還することを臨床研究により明らかにした。

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Online detection of amplitude modulation of motor-related EEG desynchronization using a lock-in amplifier: Comparison with a fast Fourier transform, a continuous wavelet transform, and an autoregressive algorithm.

Kenji Kato, Kensho Takahashi, Nobuaki Mizuguchi, Junichi Ushiba.

Journal of Neuroscience Methods (Journal of Neuroscience Methods)  293   289 - 298 2018.01

Research paper (scientific journal), Joint Work, Accepted,  ISSN  01650270

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ブレイン・マシン・インターフェースで利用されている頭皮脳波成分は、ロックインアンプ機構によって低遅延・高精密に実時間検出できることを示した。

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A study on skill acquisition mechanism and development of skill transfer systems

Koike H., Rekimoto J., Ushiba J., Furuya S., Ito A.

CEUR Workshop Proceedings (CEUR Workshop Proceedings)  2068 2018

ISSN  16130073

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© 2018 Copyright for the individual papers remains with the authors. This paper describes our project which studies skill acqui- sition mechanism and develops skill transfer systems. To clarify skill acquisition mechanism, we analyze top athletes, elite music performers and handicapped persons who have advanced skills which are not found in ordinary people. Then we will develop skill transfer systems by using advanced computer vision, robotics and artificial intelligence.

Cortical control of object-specific grasp relies on adjustments of both activity and effective connectivity: a common marmoset study

Banty Tia, Mitsuaki Takemi, Akito Kosugi, Elisa Castagnola, Alberto Ansaldo, Takafumi Nakamura, Davide Ricci, Junichi Ushiba, Luciano Fadiga, and Atsushi Iriki

Journal of Physiology 595 ( 23 ) 7203 - 7221 2017.12

Research paper (scientific journal), Joint Work, Accepted

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霊長類モデル動物であるコモン・マーモセットの脳表を被覆する硬膜電極を作成し、運動野内の複数領域が手指運動種選択的に機能結合特性を変化させることを明らかにした。

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Rapid identification of cortical motor areas in rodents by high-frequency automatic cortical stimulation and novel motor threshold algorithm

Mitsuaki Takemi, Elisa Castagnola, Alberto Ansaldo, Davide Ricci, Luciano Fadiga, Miki Taoka, Atsushi Iriki, Junichi Ushiba.

Frontiers in Neuroscience 11 ( 580 (14 pages) )  2017.10

Research paper (scientific journal), Joint Work, Accepted

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多点皮質電極、マルチプレクサを用いた計算機制御、最尤推定による運動閾値推定から構成される高速運動地図作成法を開発し、麻酔下ラットを対象にその有用性を実証した。

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Corticomuscular coherence reflects somatosensory feedback gains during motor adaptation.

Shoko Kasuga, Natsumi Momose, Junichi Ushiyama, Junichi Ushiba.

Neuroscience Research (Neuroscience Research)  131   10 - 18 2017.10

Research paper (scientific journal), Joint Work, Accepted,  ISSN  01680102

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指先の位置制御課題中にみられる脳波筋電図コヒーレンス現象は、主動筋からの感覚情報に対して割り当てられた中枢神経系のゲインを反映していることを明らかにした。

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Ipsilateral EEG mu rhythm reflects the excitability of uncrossed pathways projecting to shoulder muscles

Keita Hasegawa, Shoko Kasuga, Kenichi Takasaki, Katsuhiro Mizuno, Meigen Liu, Junichi Ushiba

Journal of NeuroEngineering and Rehabilitation 14 ( 1 ) 85 (11 pages) 2017.08

Research paper (scientific journal), Joint Work, Accepted

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肩屈曲イメージ中に同側半球の頭皮脳波から得られるミュー律動成分は、同側を走行する非交差性の皮質脊髄路の興奮性を反映していることを、経頭蓋磁気刺激法を用いた電気生理学的検討により明らかにした。

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Resting-state fluctuations of EEG sensorimotor rhythm reflect BOLD activities in the pericentral areas: A simultaneous EEG-fMRI study

Shohei Tsuchimoto, Shuka Shibusawa, Nobuaki Mizuguchi, Kenji Kato, Hiroki Ebata, Meigen Liu, Takashi Hanakawa, Junichi Ushiba

Fronties in Human Neuroscience 11   Article Id: 356 (10pages) 2017.07

Research paper (scientific journal), Joint Work, Accepted

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頭皮脳波と機能的磁気共鳴脳イメージングの同時計測系を新規構築し、脳波上に認められる安静時ミュー律動の振幅が体性感覚運動野の活動に送還することを明らかにした。

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Muscle architectural properties in the common marmoset(Callithrix jacchus)

Naomichi Ogihara, Motoharu Oishi, Ryogo Kanai, Hikaru Shimada, Takahiro Kondo, Kimika Yoshino-Saito, Junichi Ushiba, Hideyuki Okano

Primates 58 ( 3 ) 461 - 472 2017.07

Research paper (scientific journal), Joint Work, Accepted

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霊長類モデル動物であるコモン・マーモセットの筋骨格モデルを構築し、体幹筋群が小さく、肘伸展筋や肩周筋が大きいなどの生物学的特徴があることを明らかにした。

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Three-dimensional kinematic and kinetic analysis of quadrupedal walking in the common marmoset (Callithrix jacchus)

Hikaru Shimada, Ryogo Kanai, Takahiro Kondo, Kimika Yoshino, Akito Uchida, Junichi Ushiba, Hideyuki Okano, Naomichi Ogihara

Neuroscience Research 125   11 - 20 2017.06

Research paper (scientific journal), Joint Work, Accepted

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霊長類モデル動物であるコモン・マーモセットの歩行動作を三次元解析して、前肢と後肢のリズムパターンが他の霊長類とは異なる対角パターンを示し、床反力を活用した跳躍的歩容を呈することを明らかにした。

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Help, hope, and hype: Ethical dimensions of neuroprosthetics.

Jens Clausen, Eberhard Fetz, John Donoghue, Junichi Ushiba, Ulrike Sporhase, Jennifer Chandler, Niels Birbaumar, Surjo R. Soekadar

Science 356 ( 6345 ) 1338 - 1339 2017.06

Research paper (scientific journal), Joint Work, Accepted

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ブレイン・マシン・インターフェース技術の社会実装に向けた倫理的、法的な整備の必要性に関して、バイオハッキングやプライバシー管理等の項目ごとに現状を分析した。

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Inhibitory interneuron circuits at cortical and spinal levels are associated with individual differenecs in corticomuscular coherence during isometric voluntary contraction

Ryosuke Matsuya, Junichi Ushiyama, Junichi Ushiba

Scientific Reports 7   Article ID: 44417 (11pages) 2017.03

Research paper (scientific journal), Joint Work, Accepted

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脊髄内レンショウ抑制回路が脳波筋電図コヒーレンスに関与することを明らかにした。

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Individual difference in β-band corticomuscular coherence and its relation to force steadiness during isometric voluntary ankle dorsiflexion in healthy humans

Junichi Ushiyama, Junya Yamada, Meigen Liu, Junichi Ushiba

Clinical Neurophysiology 128 ( 2 ) 303 - 311 2017.02

Research paper (scientific journal), Joint Work, Accepted

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皮質脊髄路の律動的活動性を表す脳波筋電図コヒーレンスが高値になるほど、筋収縮時の発揮張力安定性が低下することを明らかにした。

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A new therapeutic application of brain-machine interface (BMI) training followed by hybrid assistive neuromuscular dynamic stimulation (HANDS) therapy for patients with severe hemiparetic stroke: A proof of concept study

Michiyuki Kawakami, Toshiyuki Fujiwara, Junichi Ushiba, Atsuko Nishimoto, Kaoru Abe, Kaoru Honaga, Atsuko Nishimura, Katsuhiro Mizuno, Mitsuhiko Kodama, Yoshihisa Masakado, Meigen Liu

Restrative Neurology and Neuroscience 34 ( 5 ) 789 - 797 2016.09

Research paper (scientific journal), Joint Work, Accepted

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慢性期脳卒中重度片麻痺症例に対してBMIを施行し、機能回復を認めた症例に対して筋電制御型電気刺激治療であるHANDSへ移行することで、最小臨床効果量を大幅に超えた治療効果が発言することを報告した。これにより、臨床運用上のクリニカルパスの構築に成功した。

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Robotic assessment of upper limb function after proximal humeral fracture: personal experience as a patient and occupational therapist.

Atsuko Nishimoto, Yohei Otaka, Shoko Kasuga, Eri Otaka, Kotaro Yamazaki, Junichi Ushiba, Meigen Liu

The Keio Journal of Medicine 65 ( 3 ) 57 - 63 2016.09

Research paper (scientific journal), Joint Work, Accepted

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上腕骨頭骨折症例について、損傷後急性期からの機能回復プロセスを外骨格ロボットにより縦断的に評価し、代償的動作の一過的な獲得とその後の運動再学習プロセスが時期特異的に生じることを示した。

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Frequency-specific synchronization in the bilateral subthalamic nuclei depending on voluntary muscle contraction and relaxation in patients with Parkinson's disease.

Kenji Kato, Fusako Yokochi, Hirokazu Iwamuro, Takashi Kawasaki , Koichi Hamada, Ayako Isoo, Katsuo Kimura, Ryoichi Okiyama, Makoto Taniguchi, Junichi Ushiba.

Frontiers in Human Neuroscience 10   Article ID: 131 (13pages) 2016.03

Research paper (scientific journal), Joint Work, Accepted

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パーキンソン病症例につき、脳深部電極を用いて両側視床下核の神経活動を計測し、頭皮脳波から推定した両側体性感覚運動野の神経活動との機能結合を解析したところ、複数の周波数領域で過剰な同期性が生じることを認めた。

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Bilateral coherence between motor cortices and subthalamic nuclei in patients with Parkinson's disease.

Kenji Kato, Fusako Yokochi, Makoto Taniguchi, Ryoichi Okiyama, Takashi Kawasaki, Katsuo Kimura, Junichi Ushiba

Clinical neurophysiology 126 ( 10 ) 1941 - 1950 2015.10

Research paper (scientific journal), Joint Work, Accepted

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パーキンソン病による振戦の発生に関わる皮質-基底核の神経活動を両側性に記録し、それらの機能結合解析をおこなった。また、その機能結合強度が運動障害の程度と相関することを見出した。

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Histological and electrophysiological analysis of the corticospinal pathway to forelimb motoneurons in common marmosets.

Takahiro Kondo, Yamato Yoshihara, Kimika Yoshino-Saitoa, Tomofumi Sekiguchi, Akito Kosugi, Yuta Miyazaki, Yukio Nishimura, Hirotaka J. Okano, Masaya Nakamura, Hideyuki Okano, Tadashi Isa, Junichi Ushiba

Neuroscience Research 98   35 - 44 2015.09

Research paper (scientific journal), Joint Work, Accepted

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小型霊長類モデル動物であるコモン・マーモセットの皮質脊髄路について、電気生理学的特徴と解剖学的特徴を同定した。

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Clinical usefulness and validity of robotic measures of reaching movement in hemiparetic stroke patients.

Eri Otaka, Yohei Otaka, Shoko Kasuga, Atsuko Nishimoto, Kotaro Yamazaki, Michiyuki Kawakami, Junichi Ushiba, Meigen Liu

Journal of NeuroEngineering and Rehabilitation 12   Article ID: 66 (10pages) 2015.08

Research paper (scientific journal), Joint Work, Accepted

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脳卒中片麻痺患者を対象として、上肢運動用外骨格ロボットKINARMによる運動機能評価スコアと従来の臨床評価指標との関連性を検討し、ロボットによる機能評価の妥当性と特徴を明らかにした。

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Learning feedback and feedforward control in a mirror-reversed visual environment.

Shoko Kasuga, Sebastian Telgen, Junichi Ushiba, Daichi Nozaki, Jorn Diedrichsen

Journal of Neurophysiology 114 ( 4 ) 2187 - 2193 2015.08

Research paper (scientific journal), Joint Work, Accepted

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新奇な視覚環境における上肢到達運動の脳内内部モデルを学習により獲得する際、フィードバック制御システムとフィードフォワード制御システムは独立的に獲得され、それらの間にはトレードオフの関係があることを示した。

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Transcranial direct current stimulation enhances mu rhythm desynchronization during motor imagery that depends on handedness

Shoko Kasuga, Yayoi Matsushika, Yuko Kasashima-Shindo, Daiki Kamatani, Toshiki Fujiwara, Meigen Liu, Junichi Ushiba

Laterality 20 ( 4 ) 453 - 468 2015.07

Research paper (scientific journal), Joint Work, Accepted

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一次運動野に対する経頭蓋直流電気刺激により、運動企図にともなう脳波の事象関連脱同期が促進され、その効果には利き手により差があることを示した。

• Access to Document (DOI)

Alteration of a motor learning rule under mirror-reversal transformation does not depend on the amplitude of visual error

Shoko Kasuga, Makiko Kurata, Meigen Liu,Junichi Ushiba

Neuroscience Research 94   62 - 69 2015.05

Research paper (scientific journal), Joint Work, Accepted

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新奇な視覚環境における運動スキルの獲得においては、運動計画と視覚フィードバックとの間の誤差の絶対量ではなく誤差が持続した試行回数が重要な役割を担うことを示した。

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Brain-computer interface training combined with transcranial direct current stimulation in patients with chronic severe hemiparesis: Proof of concept study.

Yuko Kasashima-Shindo, Toshiyuki Fujiwara, Junichi Ushiba, Yayoi Matsushika, Daisuke Kamatani, Misa Oto, Takashi Ono, Atsuko Nishimoto, Keiichiro Shindo, Michiyuki Kawakami, Tetsuya Tsuji, Meigen Liu

Journal of rehabilitation medicine 47 ( 4 ) 318 - 324 2015.04

Research paper (scientific journal), Joint Work, Accepted

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脳卒中重度片麻痺患者に対してブレイン・マシン・インターフェース治療を実施する際に、皮質興奮性を高める作用がある経頭蓋直流電流刺激法を併用することで、治療効果の保持効果が高くなることを明らかにした。

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Sensorimotor event-related desynchronization represents the excitability of human spinal motoneurons.

Mitsuaki Takemi, Yoshihisa Masakado, Meigen Liu, Junichi Ushiba

Neuroscience 297   58 - 67 2015.03

Research paper (scientific journal), Joint Work, Accepted

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対側体性感覚運動野近傍から導出される頭皮脳波反応をともなう手指運動イメージは、脊髄にある運動ニューロン群の興奮を高めることを示した。

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Multimodal sensory feedback associated with motor attempts alters BOLD responses to paralyzed hand movement in chronic stroke patients.

Takashi Ono, Yutaka Tomita, Manabu Inose, Tetsuo Ota, Akio Kimura, Meigen Liu, Junichi Ushiba

Brain Topography 28 ( 2 ) 340 - 351 2015.03

Research paper (scientific journal), Joint Work, Accepted

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慢性期脳卒中重度片麻痺に対してブレイン・マシン・インターフェース治療を施した結果、障害側体性感覚運動野ならびに補足運動野の活動が上昇することを機能的磁気共鳴画像法による解析から明らかにした。

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Three-dimensional motion analysis of arm-reaching movements in healthy and hemispinalized common marmosets.

Mitsuaki Takemi, Takahiro Kondo, Kimika Yoshino-Saito, Tomofumi Sekiguchi, Akito Kosugi, Shoko Kasuga, James Hirotaka Okano, Hideyuki Okano, Junichi Ushiba

Behavioural brain research 275   259 - 268 2014.12

Research paper (scientific journal), Joint Work, Accepted

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小型霊長類モデル動物であるコモンマーモセットの健常個体ならびに脊髄損傷個体の上肢到達運動について、バイオメカニクス的観点からその特性を明らかにし、運動障害の定量評価法を提案した。

• Access to Document (DOI)

Developing a new experimental system for an undergraduate laboratory exercise to teach theories of visuomotor learning

Shoko Kasuga, Junichi Ushiba

The Journal of Undergraduate Neuroscience Education 13 ( 1 ) A1 - 7 2014.10

Research paper (scientific journal), Joint Work, Accepted

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計算論的神経科学で標準的に用いられている上肢到達運動と視覚回転課題を、ノートPCとタッチパッドによって模擬できる教材を開発し、教材としての有用性と運動学習課題としての科学的妥当性を検証した。作成したプログラムはインターネット上で無償公開した。

Functional recovery from chronic writer's cramp by brain-computer interface rehabilitation: a case report

Yasunari Hashimoto, Tstsuo Ota, Masahiko Mukaino, Meigen Liu, Junichi Ushiba

BMC Neuroscience 15   Article ID: 103 (7pages) 2014.09

Research paper (scientific journal), Joint Work, Accepted

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慢性期書痙患者の運動関連脳波を実時間計測し、病態スコアを視覚フィードバックすることで、運動機能回復がもたらされることを報告した。

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Brain-computer interface with somatosensory feedback improves functional recovery from severe hemiplegia due to chronic stroke

Takashi Ono, Keiichiro Shindo, Kimiko Kawashima, Naoki Ota, Mari Ito, Tetsuo Ota, Masahiko Mukaino, Toshiyuki Fujiwara, Akio Kimura, Meigen Liu, Junichi Ushiba

Frontiers in Neuroengineering 7   Article ID: 19 (8pages) 2014.07

Research paper (scientific journal), Joint Work, Accepted

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慢性期脳卒中重度片麻痺に対するブレイン・マシン・インターフェース治療では、脳活動の視覚フィードバックではなく、麻痺筋からの体性感覚フィードバックが機能回復につながることを明らかにした。

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Efficacy of brain-computer interface-driven neuromuscular electrical stimulation for chronic hemiplegia

Masahiko Mukaino, Takashi Ono, Keiichiro Shindo, Toshiyuki Fujiwara, Tetsuo Ota, Akio Kimura, Meigen Liu, JUNICHI USHIBA

Journal of Rehabilitation Medicine 46 ( 4 ) 378 - 382 2014.04

Research paper (scientific journal), Joint Work, Accepted

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慢性期脳卒中重度片麻痺に対するブレイン・マシン・インターフェース治療（BMI）を試行し、コントロール介入との比較検討をおこなった結果、機能的脳画像、頭皮脳波、皮質筋間の機能結合性、随意筋電図、臨床スコアの全てにおいてBMI介入の有効性を認めた。

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Different strategy of hand choice after learning of constant and incremental dynamical perturbation in arm reaching

Chie Habagishi, Shoko Kasuga, Yohei Otaka, Meigen Liu, JUNICHI USHIBA

Frontiers in Human Neuroscience 8   Article ID: 92 (12pages) 2014.02

Research paper (scientific journal), Joint Work, Accepted

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到達運動課題における使用手選択の意思決定には、一側上肢にかかる負荷の絶対量ではなく、試行間の変動性が関わっていることを明らかにした。

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Relationship between event-related desynchronization and cortical excitability in healthy subjects and stroke patients

Koji Aono, Shotaro Miyashita, Yosuke Fujiwara, Mitsuhiko Kodama, Kozo Hanayama, Yoshihisa Masakado, JUNICHI USHIBA

The Tokai Journal of Experimental and Clinical Medicine 38 ( 4 ) 123 - 128 2013.12

Research paper (scientific journal), Accepted

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健常成人と脳卒中片麻痺患者を対象として、一側（麻痺側）上肢の手指運動企図にともなう頭皮脳波反応の特性を解析し、皮質脊髄路興奮性との間に相関が認められることを明らかにした。

Event-related desynchronization reflects downregulation of intracortical inhibition in human primary motor cortex.

Mitsuaki Takemi, Yoshihisa Masakado, Meigen Liu, JUNICHI USHIBA

Journal of Neurophysiology 110 ( 5 ) 1158 - 1166 2013.09

Research paper (scientific journal), Joint Work, Accepted

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上肢運動イメージ時に生じる頭皮脳波変化の強度に応じて、皮質脊髄路の興奮性および一次運動野内GABA性抑制性介在ニューロンの脱抑制が進むことを明らかにした。

Daily training with realistic visual feedback improves reproducibility of event-related desynchronisation following hand motor imagery

Takashi Ono, Akio Kimura, Junichi Ushiba

Clinical Neurophysiology 124 ( 9 ) 1779 - 1786 2013.09

Research paper (scientific journal), Joint Work, Accepted

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ブレイン・マシン・インターフェースを用いた運動訓練時において、視覚フィードバックオブジェクトの種類が学習効率を規定することを明らかにした。

A pilot study of sensory feedback by transcutaneous electrical nerve stimulation to improve manipulation deficit caused by severe sensory loss after stroke.

Kahori Kita, Yohei Otaka, Kotaro Takeda, Sachiko Sakata, JUNICHI USHIBA, Kunitsugu Kondo, Meigen Liu, Rieko Osu

Journal of NeuroEngineering and Rehabilitation 10 ( 1 ) 55 2013.06

Research paper (scientific journal), Joint Work, Accepted

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脳卒中による感覚障害症例に対して、触覚センサの出力に応じた電気刺激パルスを表在感覚残存部位に与えることで、手指運動機能が改善することを報告した。

EEG-based classification of imaginary left and right foot movements using beta rebound.

Yasunari Hashimoto, JUNICHI USHIBA

Clinical Neurophysiology 124 ( 11 ) 2153 - 2160 2013.06

Research paper (scientific journal), Joint Work, Accepted

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大脳皮質の三次元構造を考慮して頭皮脳波の誘導手法を最適化することにより、左足と右足の運動想起の有無を弁別できることを明らかにした。

Prolonged reaction time during episodes of elevated β-band corticomuscular coupling and associated oscillatory muscle activity

Ryosuke Matsuya, Junichi Ushiyama, Junichi Ushiba

Journal of Applied Physiology 114 ( 7 ) 896 - 904 2013.04

Research paper (scientific journal), Joint Work, Accepted

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脳波筋電図コヒーレンスが発現した時間帯では、外部キューに応答する反応時間課題の処理に時間遅れが生じることを明らかにした。

Age-related differences in cognitive function for interlimb coordination during split-belt walking: A pilot study

Mayumi Saito, Masaki Hyodo, Yoshihisa Masakado, Yutaka Tomita, Junichi Ushiba

Somatosensory and Motor Research 30 ( 1 ) 56-63 2013.01

Research paper (scientific journal), Joint Work, Accepted

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歩行時の肢間協調作用が年齢によって異なることを明らかにした。

Use of a cane for recovery from backward balance loss during treadmill walking.

Masaki Hyodo, Mayumi Saito, Junichi Ushiba, Yutaka Tomita, Yoshihisa Masakado

Somatosensory and Motor Research 30 ( 2 ) 65 - 71 2013

Research paper (scientific journal), Joint Work, Accepted

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杖使用歩行では、環境から与えられた急速な外乱に対して脆弱になり、転倒リスクが高まることを明らかにした。

Newer challenges to restore hemiparetic upper extremity after stroke: HANDS therapy and BMI neurorehabilitation.

Meigen Liu, Toshiyuki Fujiwara, Keiichiro Shindo, Yuko Kasashima, Yohei Otaka, Tetsuya Tsuji, Junichi UshibaJunichi Ushiba

Hong Kong Physiotherapy Journal 30 ( (2) ) 83 - 92 2012.12

Research paper (scientific journal), Joint Work

On-Demand Control System for Deep Brain Stimulation for Treatment of Intention Tremor

Takamitsu Yamamoto, Yoichi Katayama, Junichi Ushiba, Hiroko Yoshino, Toshiki Obuchi, Kazutaka Kobayashi, Hideki Oshima, Chikashi Fukaya

Neuromodulation 16 ( 3 ) 230 - 235 2012.10

Research paper (scientific journal), Joint Work, Accepted

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パーキンソン病患者の基底核に埋植した電気刺激装置を、振戦を呈する筋から誘導された表面筋電図の状態に応じて自動的に駆動するシステムを構築し、その有用性を検討した。

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Modulation of event-related desynchronization during motor imagery with transcranial direct current stimulation (tDCS) in patients with chronic hemiparetic stroke

Yuko Kasashima, Toshiyuki Fujiwara, Yayoi Matsushika, Tetsuya Tsuji, Kimitaka Hase, Junichi Ushiyama, Junichi Ushiba, Meigen Liu

Experimental Brain Research 221 ( 3 ) 263-268 2012.09

Research paper (scientific journal), Joint Work, Accepted

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慢性期脳卒中片麻痺上肢の運動想起にともなって生じる事象関連脱同期が、経頭蓋電流刺激法によって増大することを明らかにした。

State of intracortical inhibitory interneuron activity in patients with chronic stroke

Kaoru Honaga, Toshiyuki Fujiwara, Tetsuya Tuji, Kimitaka Hase, Junichi Ushiba, Meigen Liu

Clinical Neurophysiology 124 ( 2 ) 264-370 2012.08

Research paper (scientific journal), Joint Work, Accepted

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慢性期脳卒中患者における皮質内抑制が健常成人よりも高値であることを示した。

Anticipatory postural adjustments contribute to age-related changes in compensatory steps associated with unilateral perturbations.

Masaki Hyodo, Mayumi Saito, Junichi Ushiba, Yutaka Tomita, Mihoko Minami, Yoshihisa Masakado

Gait and Posture 36 ( 3 ) 625-630 2012.07

Research paper (scientific journal), Joint Work, Accepted

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歩行中の一側下肢にインパルス状の機械的外乱を与えた際にみられる転倒予防応答が、年齢層によって大きく異なることを見いだした。

The comparison of motor learning performance with and without feedback

Abbas Orand, Junichi Ushiba, Yutaka Tomita, Satoshi Honda

Somatosensory and Motor Research 29 ( 3 ) 103-110 2012.07

Research paper (scientific journal), Joint Work, Accepted

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頭皮脳波の視覚フィードバックの有無によって運動学習効率が異なることを、健常成人を対象とした実験から明らかにした

The correlation between motor impairments and event-related desynchronization during motor imagery in ALS patients

Takashi Kasahara, Kentaro Terasaki, Yuki Ogawa, Junichi Ushiba, Harumichi Aramaki, Yoshihisa Masakado

BMC Neuroscience 13 ( 1 ) Article No.66 2012.06

Research paper (scientific journal), Joint Work, Accepted

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筋萎縮性側索硬化症では、球麻痺の程度に相関して上肢運動想起による事象関連脱同期現象が低値となることを明らかにした。

A pilot study of contralateral homonymous muscle activity simulated electrical stimulation in chronic hemiplegia

Rieko Osu, Yohei Otaka, Junichi Ushiba, Sachiko Sakata, Tomofumi Yamaguchi, Toshiyuki Fujiwara, Kunitsugu Kondo, Meigen Liu

Brain Injury 26 ( 9 ) 1105-1112 2012.05

Research paper (scientific journal), Joint Work, Accepted

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健常側上肢筋から誘導された表面筋電図で電気刺激をトリガし、麻痺側上肢筋を訓練する手法を開発し、その安全性と有効性を検討した。

Contraction level-related modulation of corticomuscular coherence differs between the tibialis anterior and soleus muscles in humans.

Junichi Ushiyama, Yoshihisa Masakado, Toshiyuki Fujiwara, Tetsuya Tsuji, Kimitaka Hase, Akio Kimura, Meigen Liu, Junichi Ushiba

Journal of Applied Physiology 112 ( 8 ) 1258-1267 2012.02

Research paper (scientific journal), Joint Work, Accepted

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足関節筋における脳波コヒーレンス筋電図が筋収縮強度に依存して変調される様子について解析した。

Electroencephalographic Denoising and Classification by Using Power Spectrum Density Based Independent Component Analysis and Common Spatial Pattern

Abbas Orand, Junichi Ushiba, Yutaka Tomita, Satoshi Honda

Journal of Control, Measurement, and System Integration 4 ( 6 ) 445-451 2012.01

Research paper (scientific journal), Joint Work, Accepted

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頭皮脳波に混入する種々のノイズを弁別する上で独立成分分析とCommon Spatial Pattern法の組み合わせが有効であることを実験的に示した。

Modulation of event-related desynchronization during motor imagery with transcranial direct current stimulation in a patient with severe hemiparetic stroke: a case report.

Takamichi Tohyama, Toshiyuki Fujiwara, Jun Matsumoto, Kaoru Honaga, Junichi Ushiba, Tetsuya Tsuji, Kimitaka Hase, Meigen Liu

Keio Journal of Medicine 60 ( 4 ) 114-118 2011.12

Research paper (scientific journal), Joint Work

　View Summary

脳卒中片麻痺患者に対して経頭蓋直流電流刺激を体性感覚運動皮質に与えると、運動イメージ中に観察される事象関連脱同期脳波が増大することを明らかにした。これにより、ブレイン・マシン・インターフェースによる運動器リハビリテーションの適用を拡大することに寄与した。

Effects of neurofeedback training with an electroencephalogram-based brain-computer interface for hand paralysis in patients with chronic stroke: a preliminary case series study.

Keiichiro Shindo, Kimiko Kawashima, Junichi Ushiba, Naoki Ota, Mari Ito, Tetsuo Ota, Akio Kimura, Meigen Liu

Journal of Rehabilitation Medicine 43 ( 10 ) 951-957 2011.10

Research paper (scientific journal), Joint Work, Accepted

　View Summary

ブレイン・マシン・インターフェースを継続利用した重度脳卒中片麻痺患者８症例の上肢機能が改善したことを報告した。

Between-subject variance in the magnitude of corticomuscular coherence during tonic isometric contraction of the tibialis anterior muscle in healthy young adults.

Junichi Ushiyama, Tatsuya Suzuki, Yoshihisa Masakado, Kimitaka Hase, Akio Kimura, Meigen Liu, Junichi Ushiba

Journal of Neurophysiology 106 ( 6 ) 1379-1388 2011.09

Research paper (scientific journal), Joint Work, Accepted

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100名に及ぶ健常成人において、体性感覚運動野と骨格筋の間に見られる律動的機能相関の強度分布を明らかにした。

Transcranial direct current stimulation modulates the spinal plasticity induced with patterned electrical stimulation.

Toshiyuki Fujiwara, Tetsuya Tsuji, Kaoru Honaga, Kimitaka Hase, Junichi Ushiba, Meigen Liu

Clinical Neurophysiology 112 ( 9 ) 1834-1837 2011.09

Research paper (scientific journal), Joint Work, Accepted

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運動皮質に対する経頭蓋磁気刺激と末梢感覚電気刺激を組み合わせて刺激することで脊髄興奮性の可塑的変化を誘導できるが、大脳皮質への経頭蓋直流電流刺激によってこれを増強できることを明らかにした。

Positive afferent feedback to the human soleus muscle during quiet standing

Johan van Doornik, Christine Aevedo Coste, Junichi Ushiba, Tomas Sinkjaer

Muscle and Nerve 43 ( 5 ) 726-732 2011.04

Research paper (scientific journal), Joint Work, Accepted

Muscle fatigue-induced enhancement of corticomusclar coherence following sustained submaximal isometric contraction of the tibialis anterior muscle

Junichi Ushiyama, Masanori Katsu, Yoshinisa Masakado, Akio Kimura, Meigen Liu, Junichi Ushiba

Journal of Applied Physiology 110 ( 5 ) 1233 - 1240 2011.03

Research paper (scientific journal), Joint Work, Accepted

Design and Development of a Myo-Electric Controlled Artificial Hand: Practical Course of Junior High School Students

Yasunari Hashimoto, Junichi Ushiba, Yutaka Tomita

人とシステム 13 ( 1 ) 9-14 2011.02

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1340-637x

Transcranial direct current stimulation modulated the spinal plasticity induced with patterned electrical stimulation

Toshiyuki Fujiwara, Tetsuya Tsuji, Kaoru Honaga, Kimitaka Hase, Junichi Ushiba and Meigen Liu

Clinical Neurophysiology (Clinical Neurophysiology)  2 ( 2 )  2011.02

Research paper (scientific journal), Joint Work, Accepted

Estimating membrane potential in human motoneurons using peri-stimulus time histograms

Yasunari Hashimoto, Junichi Ushiba, Yutaka Tomita

人とシステム 13 ( 1 ) 1-8 2011.02

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1340-637x

Muscle dependency of corticomuscular coherence in upper and lower limb muscles and training-related alterations in ballet dancers and weightlifters

Junichi Ushiyama, Yuji Takahashi, Junichi Ushiba

Journal of Applied Physiology 109 ( 4 ) 1086-1095 2010.10

Research paper (scientific journal), Joint Work, Accepted

Change in brain activity through virtual reality-based brain-machine communication in a chronic tetraplegic subject with muscular dystrophy

Yasunari Hashimoto, Junichi Ushiba, Akio Kimura, Meigen Liu and Yutaka Tomita

BMC Neuroscience 11 ( 117 )  2010.09

Research paper (scientific journal), Joint Work, Accepted

Modulation of mu rhythm desynchronization during motor imagery by transcranial direct current stimulation

Jun Matsumoto, Toshiyuki Fujiwara, Osamu Takahashi, Meigen Liu, Akio Kimura, Junichi Ushiba

Journal of Neuroengineering and Rehabilitation 7 ( 27 )  2010.06

Research paper (scientific journal), Joint Work, Accepted

Correlation between EEG-EMG coherence during isometric contraction and its imaginary execution

Yasunari Hashimoto, Junichi Ushiba, Akio Kimura, Meigen Liu, Yutaka Tomita

Acta Neurobiologiae Experimentalis 70 ( 1 ) 76-85 2010.01

Research paper (scientific journal), Joint Work, Accepted

心拍呼吸強調が肺ガス交換効率に及ぼす影響

狩生咲、富田豊、牛場潤一

人とシステム 12 ( 1 ) 13-19 2009.12

Research paper (scientific journal), Joint Work, Accepted

クロススペクトル解析を用いた視覚誘発電位型ブレイン・マシン・インタフェースの開発

小川雄喜、富田豊、牛場潤一、正門由久、木村彰男、里宇明元

総合リハビリテーション (医学書院)  37 ( 11 ) 1063-1066 2009.11

Research paper (scientific journal), Joint Work, Accepted

セミリカンベントエルゴメータ駆動における体幹・下肢筋の筋電図学的分析－両脚駆動と片脚駆動の違いによる筋活動の変化－

呂隆徳、神谷晃央、新野浩隆、林伸浩、横山明正、寺林大史、牛場潤一、正門由久、木村彰男

理学療法 (メディカルプレス)  26 ( 7 ) 897-902 2009.07

Research paper (scientific journal), Joint Work, Accepted,  ISSN  910-0059

片側下腿感覚入力遮断後の立位姿勢制御 : Stabilogram-diffusion解析による検討

今井覚志、長谷公隆、牛場潤一、東海林淳一、堤則允、里宇明元

理学療法学 (社団法人日本理学療法士協会)  36 ( 3 ) 101-108 2009.06

Research paper (scientific journal), Joint Work

エルゴメーター駆動中の体幹・下肢筋活動における基礎的研究－駆動様式の違いによる筋活動の変化

林伸浩、新野浩隆、慮隆徳、寺林大史、牛場潤一、正門由久、木村彰男

総合リハビリテーション (医学書院)  36 ( 4 ) 385-390 2008.04

Research paper (scientific journal), Joint Work

EEG–EMG coherence changes in postural tasks

Yoshihisa Masakado, Junichi Ushiba, Norimitsu Tsutsumi, Yuji Takahashi, Yutaka Tomita, Aiko Kimura and Meigen Liu

Electromyogr Clin Neurophysiol 48 ( 1 ) 27-33 2008

Research paper (scientific journal), Joint Work, Accepted

Influence of mirror therapy on human motor cortex

Kenji Fukumura K, Kenichi Sugawara, Shigeo Tanabe, Junichi Ushiba and Yutaka Tomita

International Journal of Neuroscience 117 ( 7 ) 1039 - 1048 2007

Research paper (scientific journal), Joint Work

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片麻痺患者に対するミラーセラピー療法が運動皮質の可塑性を誘導する可能性について経頭蓋磁気刺激法を用いて解析した。

タッチパネルを用いた半側空間無視の評価

松岡洋平、伍石紋子、森光代、田中尚文、 牛場潤一、富田豊

人とシステム 9 ( 1 ) 6-9 2007

Research paper (scientific journal), Joint Work

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販促空間無視患者の診断装置を開発し、既存法では検出できなかったサブクリニカルレベルの患者の高感度検出を実現した

Decoding high frequency components of input signal from slowly spiking simulated neurons

Junichi Ushiba, Yutaka Tomita and Yoshihisa Masakado

Biomechanism 30 ( 4 ) 225-233 2006.11

Research paper (scientific journal), Joint Work

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単一神経細胞がシナプス前情報をスパイク列に符号化する仕組みについて、数学的およびシミュレーション技術により解析した。

Development of a short version of the motor FIM for use in long-term care settings

Shin Yamada, Meigen Liu, Kimitaka Hase, Naofumi Tanaka, Toshiyuki Fujiwara, Tetsuya Tsuji and Junichi Ushiba

J Rehabil Med 38 ( 1 ) 50-56 2006.01

Research paper (scientific journal), Single Work

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麻痺患者の運動機能評価スケールFIMについて因子分析をおこない、類似度の高いスコアを統合することで利便性を高めた．

エルゴメーター運動中の筋活動 －駆動速度による変化－

神谷晃央、横山明正、新野浩隆、慮隆徳、内田成男、島岡秀奉、牛場潤一、正門由久、大田哲生、木村彰男

運動・物理療法 16 ( 3 ) 224-229 2005.11

Research paper (scientific journal), Joint Work

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歩行運動に類似したリハビリテーション法として注目されているエルゴメータにおいて，下肢筋群の活動様式を解析した。

運動単位間コヒーレンスとFrequencygramの理論背景について

牛場 潤一

臨床脳波Vol.47(8)    pp.471-478 2005.08

Research paper (other academic), Single Work

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神経生理学分野で近年注目されている二手法についての理論基盤を整理し、数学上は同一の情報量を評価していることを明らかにした。

エルゴメーター運動の基礎的研究 －駆動速度・ピッチ音・肢位による筋活動の変化－

神谷晃央、横山明正、新野浩隆、慮隆徳、内田成男、島岡秀奉、牛場潤一、正門由久、大田哲生、木村彰男

総合リハ 33 ( 8 ) 753-758 2005.08

Research paper (scientific journal), Joint Work

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歩行運動に類似したリハビリテーション法として注目されているエルゴメータにおいて、下肢筋群の活動様式を解析した。

Inhibition from the plantar nerve to soleus muscle during the stance phase of walking

Junichi Shoji, Ken Kobayashi, Junichi Ushiba, Yasuhiro Kagamihara and Yoshihisa Masakado

Brain Res 1048 ( 1-2 ) 48-58 2005.06

Research paper (scientific journal), Joint Work

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歩行立脚期には足部支配神経からヒラメ筋への抑制性神経投射が亢進し，歩行機能を補助していることを明らかにした。

システム同定における次数決定の一方法の提案

富田豊、牛場潤一

人とシステムVol.8(1),    pp.13-15 2005.03

Research paper (other academic), Joint Work

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システム同定の次数決定方法について、周波数領域上で応答強度が著しく低下する特徴を利用した判断基準を提案した。

Post-activation depression of the soleus H-reflex in stroke patients

Yoshihisa Masakado, Yasuhiro Kagamihara, Osamu Takahashi, Kazuto Akaboshi, Yasuhiro Muraoka and Junichi Ushiba

Electromyogr Clin Neurophysiol, 45 ( 2 ) 115-122 2005.03

Research paper (scientific journal), Joint Work

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脳卒中患者での脊髄機能の変性を電気刺激法により解析し、健常者と比較してシナプス伝達効率に悪化していることを明らかにした。

Motor strategies for initiating downward-oriented movements during standing in adults

Kimitaka Hase, Megumi Sako, Junichi Ushiba and Naoichi Chino

Experimental Brain Research 158 ( 1 ) 18-27 2004.09

Research paper (scientific journal), Joint Work

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立位から座位へ移行する初期過程における重心同様と筋活動の関係について解析した。

Cortical neuromagnetic activity associated with cutaneomuscular reflex

Yoshihisa Masakado, Junichi Ushiba, Yutaka Tomita and Naoichi Chino

Electromyogr Clin Neurophysiol 44 ( 2 ) 83-87 2004.05

Research paper (scientific journal), Joint Work

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皮膚筋反射の長潜時成分は対側皮質感覚運動野を経由した反射であることを見出した。

Changes of reflex size in upper limbs using wrist splint in hemiplegic patients

Junichi Ushiba, Yoshihisa Masakado, Yoko Komune, Yoshihiro Muraoka, Naoichi Chino and Yutaka Tomita.

Electromyogr Clin Neurophysiol 44 ( 3 ) 175-182 2004.04

Research paper (scientific journal), Joint Work

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片麻痺患者の主関節を持続進展することで神経作用により痙性が低下することを見出した。

Integration-plot test for peri-stimulus time histograms in human motor units

Junichi Ushiba, Satoshi Honda, Yoichi Onishi, Yutaka Tomita and Yoshihisa Masakado.

Medical & Biological Engineering & Computing 42 ( 2 ) 264-271 2004.03

Research paper (scientific journal), Joint Work

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脊髄神経回路の探索技術であるPSTH法について、取得データの有意性を判定する統計学的分析技術を確立した。

種々の駆動姿勢におけるエルゴメータ運動中の筋活動の変化と歩行時筋活動との比較（第1報）

USHIBA JIYUN'ICHI

総合リハビリテーション 31 ( 12 ) 1167-1174 2003.12

Research paper (scientific journal), Joint Work

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歩行運動に類似したリハビリテーション法として注目されているエルゴメータにおいて、下肢筋群の活動様式を解析した。

Formula-based approach of statistical tests for peri-stimulus time histograms

Junichi Ushiba, Yoichi Onishi, Yutaka Tomita and Yoshihisa Masakado

IEEE Transaction on Biomedical Engineering, 50 ( 11 ) 1262-1267 2003.11

Research paper (scientific journal), Joint Work

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脊髄神経回路の探索技術であるPSTH法について、取得データの有意性を判定する統計学的分析技術の開発を進めた。

Reassessment of parameters for applying motor-unit triggered stimuli in peri-stimulus time histograms

Junichi Ushiba, Yasuhiro Kagamihara and Yoshihisa Masakado>

Brain Research 990 ( 1-2 ) 8-19 2003.11

Research paper (scientific journal), Joint Work

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脊髄神経回路の探索技術であるPSTH法について方法論上の限界を明らかにし、適切に運用できる実験条件を整理した。

Compound projections from extensor carpi radialis longus to biceps brachii motoneurons in human

Junichi Ushiba, Yoshihisa Masakado, Yoko Komune and Yutaka Tomita

Japanese Journal of Rehabilitation Medicine 40 ( 9 ) 600-609 2003.09

Research paper (scientific journal), Joint Work

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長橈側手根伸筋から上腕二頭筋への脊髄性単シナプス反射が存在することを電気生理学的手法により明らかにした。

エルゴメータ運動と歩行におけるH反射の変化（第2報）

USHIBA JIYUN'ICHI

臨床脳波 45 ( 7 ) 433-440 2003.07

Research paper (scientific journal), Joint Work

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歩行運動に類似したリハビリテーション法として注目されているエルゴメータにおいて、下肢筋群の神経反射様式を解析した。

PSTHの方法論：delay timeと刺激効果との関係

鏡原康裕、正門由久、牛場潤一

日本臨床神経生理学会誌 31 ( 3 ) 300-308 2003.06

Research paper (scientific journal), Joint Work

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脊髄神経回路の探索技術であるPSTH法について方法論上の限界を明らかにした。

Calculation of a 3-dimensional sensitivity distribution of single difference, double difference, concentric-ring, and concentric-ellipsoid electrodes

Hiroharu Endoh H, Junichi Ushiba and Yoshihiro Muraoka

Ergonomics of Human-System Interaction 6 ( 1 ) 7-10 2003.02

Research paper (scientific journal), Joint Work

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表面筋電図の発生機序とその波形についてシミュレーション技術により数値解析的に分析を可能とした。既存の様々な形状をした電極の特性についても合わせて解析をおこなった。

Synchronization analysis using joint peri-stimulus time histograms for human motor units

USHIBA JIYUN'ICHIYutaka Tomita and Yoshihisa Masakado

Journal of Neuroscience Methods 120 ( 2 ) 163-171 2002.10

Research paper (scientific journal), Joint Work

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同時に計測した二つの運動単位について、その同期活動量を定量評価する手法を開発した。

A cumulative sum test for peri-stimulus time histogram using the Monte Carlo method

USHIBA JIYUN'ICHI

Journal of Neuroscience Methods 118 ( 2 ) 207-214 2002.08

Research paper (scientific journal), Joint Work

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Junichi Ushiba, Yutaka Tomita, Yoshihisa Masakado and Yoko Komuneの探索技術で脊髄神経回路あるPSTH法について、CUSUM処理による高感度判定をおこない、その統計学的性質をまとめた。

Statistical test for a peri-stimulus time histogram in assessing motor neuron activity

USHIBA JIYUN'ICHI

Medical & Biological Engineering & Computing Vol.40 ( 4 ) 462-468 2002.07

Research paper (scientific journal), Joint Work

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Junichi Ushiba, Yutaka Tomita, Yoshihisa Masakado, Yoko Komune and Yoshihiro Muraoka
脊髄神経回路の探索技術であるPSTH法について、統計学的性質を整理した。