Details of a Researcher - Mitsukura, Yasue

Papers - Mitsukura, Yasue

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河本紗弥，伊香賀俊治，満倉靖恵，吉田吏志，池田知之

日本建築学会環境系論文集 (日本建築学会) 87 ( 798 ) 492 - 502 2022.08

It is important to prevent hypertension, which is a risk factor for cardiovascular disease and severe COVID-19. In addition, as more people work from home, it is desirable to improve intellectual productivity at home. Therefore, in this study, we clarify the effects of the thermal insulation performance of houses on physiological responses and productivity in remote workers. We obtained the following findings. (1) When insulation performance was higher, systolic blood pressure was lower, and the skin temperature and the blood flow rate of the feet were higher; (2) As insulation performance increased, productivity increased.

Oscillatory population-level activity of dorsal raphe serotonergic neurons sculpts sleep structure

Tomonobu Kato, Yasue Mitsukura, Keitaro Yoshida, Masaru Mimura, Norio Takata, and Kenji F. Tanaka

Journal of Neuroscience (Journal of Neuroscience) pp. JN-RM-2288-21 2022.08

Dorsal raphe (DR) 5-HT neurons regulate sleep–wake transitions. Previous studies demonstrated that single-unit activity of DR 5-HT neurons is high during wakefulness, decreases during non-rapid eye movement (NREM) sleep, and ceases during rapid eye movement (REM) sleep. However, characteristics of the population-level activity of DR 5-HT neurons, which influence the entire brain, are largely unknown. Here, we measured population activities of 5-HT neurons in the male and female mouse DR across the sleep–wake cycle by ratiometric fiber photometry. We found a slow oscillatory activity of compound intracellular Ca2+ signals during NREM sleep. The trough of the concave 5-HT activity increased across sleep progression, but 5-HT activity always returned to that seen during the wake period. When the trough reached a minimum and remained there, REM sleep was initiated. We also found a unique coupling of the oscillatory 5-HT activity and wideband EEG power fluctuation. Furthermore, optogenetic activation of 5-HT neurons during NREM sleep triggered a high EMG power and induced wakefulness, demonstrating a causal role of 5-HT neuron activation. Optogenetic inhibition induced REM sleep or sustained NREM, with an EEG power increase and EEG fluctuation, and pharmacological silencing of 5-HT activity using a selective serotonin reuptake inhibitor led to sustained NREM, with an EEG power decrease and EEG fluctuation. These inhibitory manipulations supported the association between oscillatory 5-HT activity and EEG fluctuation. We propose that NREM sleep is not a monotonous state, but rather it contains dynamic changes that coincide with the oscillatory population-level activity of DR 5-HT neurons.

住宅断熱性能の違いが生理学的反応及び在宅作業成績に及ぼす影響に関する被験者実験

河本紗弥, 伊香賀俊治, 満倉靖恵, 吉田吏志, 池田知之

日本建築学会環境系論文集 87 ( 798 ) 492 - 502 2022.08

Investigation of stress reduction during remote work and impact on sleep status caused by drinking carbonated water

KOSUGI WATARU, MIZUNO SEIICHI, OTA EISAKU, MITSUKURA YASUE

電気学会電子・情報・システム部門大会(Web) 2022.08

Contactless Continuous Heart Rate Monitoring System using Ballistocardiography

Brian Sumali, Yasue Mitsukura*, Toshihiko Nishimura

PLOS ONE (PLOS ONE) Vol. 17 ( No. 7 ) pp. e0272072 2022.07

Cardiovascular disease is the number one cause of death in the world and is a serious problem. In the case of cardiopulmonary arrest due to myocardial infarction, the survival rate is as low as 13.3% one month after resuscitation, which birthed the need for continuous heart monitoring. In this study, we develop a Ballistocardiogram (BCG) measurement system using a load cell installed on a chair and a heart rate estimation algorithm that is robust to waveform changes, with the aim of constructing a non-contact heart rate acquisition system. The proposed system was evaluated by utilizing data obtained from 13 healthy subjects and 1 subject with abnormal ECG who were simultaneously measured with ECG. The output of the BCG system was confirmed to change with the same period as the ECG data obtained as the correct answer, and the synchronization of the R-peak positions was confirmed for all cases. As a result of comparing the heart rate intervals estimated from BCG and those obtained from ECG, it was confirmed that the same heart rate variability (HRV) features could be obtained even for abnormal ECG subject.

Psychological Impressions and Real-Time KANSEI Trajectory of Music Listeners Resulting from Differences in Piano Performance Methods

Yumi Shima, Tsutomu Sato, Yasue Mitsukura, Tetsuya Toma

Emotional Engineering Vol. 9 2022.07

This study aimed to analyze how differences in piano techniques affect the KANSEI of music listeners. A prior timbre analysis of piano techniques was conducted using frequency analysis to investigate the effects of differences in performance techniques on music listeners; however, it was not possible to clearly capture the nuanced differences in performance techniques. It was found that even though the differences in the expressions and textures of sound could not be analyzed by frequency analyses, they did provide different psychological impressions to music listeners. To evaluate the impressions formed based on performance methods, we conducted KANSEI measurements using a simple electroencephalograph and an impression evaluation experiment using the semantic differential (SD) method. Our findings suggest that music listeners’ KANSEI, resulting from differences in performance methods, is related to changes in the tune of music.

A Study on Legume-Based Noodles as Staple Food for Office Workers

Sumali B., Yoshimoto J., Kobayashi H., Yamada M., Maeda T., Mitsukura Y.

Frontiers in Nutrition (Frontiers in Nutrition) 9 807350 2022.06

ISSN 2296-861X

This study aims to verify the effects of “legume-based noodles” as a staple food for lunch, specifically: blood glucose, cognitive function tests, Kansei value, work questionnaires, typing, and body weight. The experiment is divided into two groups: the intervention group (legumes-based noodle) and the control group (regular lunch). Both groups have similar menu except the staple food. The intervention group resulted in a statistically significant lower blood glucose area under the curve (AUC) and lower maximum blood glucose levels during the afternoon work hours on weekdays. In addition, the Kansei value “concentration” decreased at the end of the workday in the control group compared to before and after lunch but did not decrease in the intervention group. Furthermore, the number of typing accuracy was higher in the intervention group than in the control group, and the questionnaire responses for “work efficiency” and “motivation” were more positive. These results suggest that eating legume-based noodles may lead to improved performance of office workers.

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非接触センシングによる睡眠の医療的 5 段階判定

満倉靖恵

O plus E (アドコム・メディア) ( 485 ) 2022.05

Characteristics of single-channel electroencephalogram in depression during conversation with noise reduction technology

Mitsukura Y., Tazawa Y., Nakamura R., Sumali B., Nakagawa T., Hori S., Mimura M., Kishimoto T.

PLoS ONE (PLoS ONE) 17 ( 4 April ) e0266518 2022.04

ISSN 1932-6203

Background Previous studies have attempted to characterize depression using electroencephalography (EEG), but results have been inconsistent. New noise reduction technology allows EEG acquisition during conversation. Methods We recorded EEG from 40 patients with depression as they engaged in conversation using a single-channel EEG device while conducting real-time noise reduction and compared them to those of 40 healthy subjects. Differences in EEG between patients and controls, as well as differences in patients’ depression severity, were examined using the ratio of the power spectrum at each frequency. In addition, the effects of medications were examined in a similar way. Results In comparing healthy controls and depression patients, significant power spectrum differences were observed at 3 Hz, 4 Hz, and 10 Hz and higher frequencies. In the patient group, differences in the power spectrum were observed between asymptomatic patients and healthy individuals, and between patients of each respective severity level and healthy individuals. In addition, significant differences were observed at multiple frequencies when comparing patients who did and did not take antidepressants, antipsychotics, and/or benzodiazepines. However, the power spectra still remained significantly different between non-medicated patients and healthy individuals. Limitations The small sample size may have caused Type II error. Patients’ demographic characteristics varied. Moreover, most patients were taking various medications, and cannot be compared to the non-medicated control group. Conclusion A study with a larger sample size should be conducted to gauge reproducibility, but the methods used in this study could be useful in clinical practice as a biomarker of depression.

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Frontotemporal EEG as potential biomarker for early MCI: a case–control study

Mitsukura Y., Sumali B., Watanabe H., Ikaga T., Nishimura T.

BMC Psychiatry (BMC Psychiatry) 22 ( 1 ) 289 2022.04

Background: Previous studies using EEG (electroencephalography) as biomarker for dementia have attempted to research, but results have been inconsistent. Most of the studies have extremely small number of samples (average N = 15) and studies with large number of data do not have control group. We identified EEG features that may be biomarkers for dementia with 120 subjects (dementia 10, MCI 33, against control 77). Methods: We recorded EEG from 120 patients with dementia as they stayed in relaxed state using a single-channel EEG device while conducting real-time noise reduction and compared them to healthy subjects. Differences in EEG between patients and controls, as well as differences in patients’ severity, were examined using the ratio of power spectrum at each frequency. Results: In comparing healthy controls and dementia patients, significant power spectrum differences were observed at 3 Hz, 4 Hz, and 10 Hz and higher frequencies. In patient group, differences in the power spectrum were observed between asymptomatic patients and healthy individuals, and between patients of each respective severity level and healthy individuals. Conclusions: A study with a larger sample size should be conducted to gauge reproducibility, but the results implied the effectiveness of EEG in clinical practice as a biomarker of MCI (mild cognitive impairment) and/or dementia.

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新型コロナウイルス感染症(COVID-19)の重症化を早期に予測する重症化予測システムの確立

石井誠, 福永興壱, 満倉靖恵

大和証券ヘルス財団研究業績集 ((公財)大和証券ヘルス財団) ( 45 ) 185 - 188 2022.03

Feature Extraction of Brain Activity in Prefrontal Region of Depressed Patients Using Bipolar Electroencephalography

Keita Kawashima, Yasue Mitsukura

2022.03

Analysis of Pain Onset using Sustained Body Temperature

Kyoko Oka, Yasue Mitsukura

2022.03

Analysis of Steroid-Induced Sleep Structure Changes in Mice

Gento Okawa, Yasue Mitsukura

2022.03

新型コロナウイルス感染症 (COVID-19) の重症化を早期に予測する重症化予測システムの確立

石井誠, 福永興壱, 満倉靖恵

大和証券ヘルス財団研究業績集 45 185 - 188 2022.03

Online improvisation training, hybrid improvisation training and on-site improvisation training; are they the same?

Tsubota M., Sumali B., Kai M., Mitsukura Y.

Science Progress (Science Progress) 105 ( 1 ) 368504221080673 2022.02

ISSN 00368504

Background: Since the outbreak of COVID-19 in Wuhan in December 2019, lifestyle has been changing to an online-based learning and working environment rather than on-site, and improvisation training is no exception. However, no research compares the efficacy of online versus on-site training. Although we believed that the most effective way to learn improvisation is an on-site format, it is important to explore how format differences can affect learners. Method: We offer three types of training such as on-site training (n = 6) (Consisting of 1 female with age ≥40 and <50, and 5 males with ages ≥20 and <50), hybrid training (Instructor participates from online and learners participate on-site) (n = 120) (Consisting of 55 female with age ≥15 and <20, and 65 males with ages ≥15 and <50), and online training (n = 20) (Consisting of 4 female with age ≥20 and <30, and 16 males with ages ≥20 and <50) We collected pretest, test, and posttest data by using the Kansei Analyzer, a simplified electroencephalograph (EEG) and Profile of Mood States (POMS) questionnaire. Results: All formats of training displayed an increase in vigor and a decrease in depression, confusion, tension, anger, and fatigue. The online training displayed better results than the on-site training. Regardless of the format, all training displayed an increase in stress during the activities and a decrease in stress after the activity without changes in other indexes. Additionally, on-site training displayed an increase in sleepiness and stress during the activities. Some participants were tested twice but no significant differences were found between the initial results and the secondary results. Conclusion: In this study, we found evidence that online improvisation can lead to the prevention of depressive symptoms and can function as a method for the reduction of stress in conjunction with the increase of individual vigor. However, a future study is required due to the low number of participants and the absence of POMS data for the on-site training. Any future studies should account for these factors while examining other data such as blood pressure, blood sugar, and pulse.

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Prefrontal power asymmetry feature extraction for depression severity in a clinical study

Gengtao Lin, Yasue Mitsukura

2022.02

Identification of sexually dimorphic effects of oxytocin administration on electroencephalography of B6J mice

Clarissa G. Gregory, Yasue Mitsukura

2022.02

Automatic Deceleration Detection System from Fetal Heart Rate obtained by CTG

Yamamoto Hiroko, Mitsukura Yasue

2022 IEEE 17TH INTERNATIONAL CONFERENCE ON ADVANCED MOTION CONTROL (AMC) 346 - 351 2022

ISSN 1943-6572

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Analysis of the Relationship Between Calcium Ion Concentration Ratio and Behavior in Neural Activity of the Brain

Sunami Ryota, Mitsukura Yasue

2022 IEEE 17TH INTERNATIONAL CONFERENCE ON ADVANCED MOTION CONTROL (AMC) 341 - 345 2022

ISSN 1943-6572

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