Iwasaki, Arihiro

写真a

Affiliation

Faculty of Science and Technology, Department of Chemistry (Yagami)

Position

Research Associate/Assistant Professor/Instructor

Related Websites

External Links

Career 【 Display / hide

  • 2009
    -
    2013.03

    リアル化学株式会社, 開発部開発課

  • 2014.04
    -
    2015.03

    慶應義塾大学大学院, 理工学研究科, 助教(有期・研究奨励)

  • 2015.04
    -
    2017.03

    慶應義塾大学, 理工学部化学科, 助教(有期)

  • 2017.04
    -
    Present

    慶應義塾大学, 理工学部化学科, 助教

Academic Background 【 Display / hide

  • 2003.04
    -
    2007.03

    Keio University, 理工学部, 化学科

    日本, University, Graduated, Other

  • 2007.04
    -
    2009.03

    Keio University, 理工学研究科, 基礎理工学専攻

    日本, Graduate School, Completed, Master's course

  • 2013.04
    -
    2016.03

    Keio University, 理工学研究科, 基礎理工学専攻

    日本, Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(理学), 慶應義塾大学, Coursework, 2016.03

    海洋シアノバクテリア由来ペプチド性化合物の構造と生物活性

 

Research Areas 【 Display / hide

  • Biomolecular chemistry

Research Keywords 【 Display / hide

  • 海洋天然物化学

 

Papers 【 Display / hide

  • 20-N-methylpurpuramine E

    Teruya Toshiaki, Iwasaki Arihiro, Suenaga Kiyotake

    Bulletin of the Chemical Society of Japan 81 ( 8 ) 1026 - 1027 2008.08

    Joint Work, Accepted,  ISSN  0009-2673

  • Isolation and structure of koshikalide, a 14-membered macrolide from the marine cyanobacterium Lyngbya sp.

    Iwasaki Arihiro, Teruya Toshiaki, Suenaga Kiyotake

    Tetrahedron Letters 51 ( 6 ) 959 - 960 2010.02

    Joint Work, Accepted,  ISSN  0040-4039

     View Summary

    <p>A 14-membered macrolide, koshikalide (1), was isolated from the marine cyanobacterium Lyngbya sp., and its planar structure was elucidated by spectroscopic analysis. The relative stereochemistry of C-11 and C-13 was elucidated by NOESY experiments and by an analysis of 1H-1H coupling constants. Koshikalide (1) exhibited weak cytotoxicity against HeLa S3 cells. © 2009 Elsevier Ltd. All rights reserved.</p>

  • Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.

    Iwasaki Arihiro, Ohno Osamu, Sumimoto Shinpei, Suda Shoichiro, Suenaga Kiyotake

    Tetrahedron Letters 55 ( 30 ) 4126 - 4128 2014.07

    Joint Work, Accepted,  ISSN  0040-4039

     View Summary

    <p>Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells. © 2014 Elsevier Ltd. All rights reserved.</p>

  • An inhibitor of the adipogenic differentiation of 3T3-L1 cells, yoshinone A, and its analogs, isolated from the marine cyanobacterium Leptolyngbya sp.

    Inuzuka Toshiyasu, Yamamoto Keita, Iwasaki Arihiro, Ohno Osamu, Suenaga Kiyotake, Kawazoe Yoshinori, Uemura Daisuke

    Tetrahedron Letters 55 ( 49 ) 6711 - 6714 2014.12

    Joint Work, Accepted,  ISSN  0040-4039

     View Summary

    <p>Three novel compounds, yoshinones A, B1, and B2, were isolated from the marine cyanobacterium Leptolyngbya sp., and their structures were elucidated by NMR spectral analysis. Yoshinone A, but not yoshinone B1 or B2, inhibited the differentiation of 3T3-L1 cells into adipocytes. In addition, yoshinone A did not exhibit cytotoxicity, suggesting that yoshinone A may be useful in studies on the treatment of obesity.</p>

  • Kurahyne, an acetylene-containing lipopeptide from a marine cyanobacterial assemblage of Lyngbya sp.

    Iwasaki Arihiro, Ohno Osamu, Sumimoto Shinpei, Suda Shoichiro, Suenaga Kiyotake

    RSC Advances 4 ( 25 ) 12840 - 12843 2014

    Joint Work, Accepted

     View Summary

    <p>Kurahyne, a new acetylene-containing lipopeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Kurahyne inhibited the growth of human cancer cells and induced apoptosis in HeLa cells, and it seemed to localize in mitochondria. This journal is © the Partner Organisations 2014.</p>

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Papers, etc., Registered in KOARA 【 Display / hide

Presentations 【 Display / hide

  • 海洋リポペプチドJahanyne類の構造活性相関とビオチンプローブの合成

    日本化学会第98春季年会, 2018.03, Oral Presentation(general)

  • 海洋シアノバクテリア由来の新規ポリケチド caldorin の単離と構造

    日本化学会第98春季年会, 2018.03, Oral Presentation(general)

  • 海洋産リポペプチドMinnamide Aの合成研究と立体化学の決定

    日本化学会第98春季年会, 2018.03, Oral Presentation(general)

  • 新規チアゾール含有ポリケチドtomurulineの合成研究

    IWASAKI Arihiro

    日本化学会第98春季年会, 2018.03, Oral Presentation(general)

  • Total Synthesis and Biological Evaluations of Biselyngbyasides

    日本化学会第98春季年会, 2018.03, Oral Presentation(general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 海洋生物がもつ末端アルキン天然物のケミカルスペースの開拓

    2021.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 岩崎 有紘, Grant-in-Aid for Early-Career Scientists , Principal Investigator

  • 海洋天然物由来の抗寄生虫薬リードの創出

    2018.04
    -
    2021.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 岩崎 有紘, Grant-in-Aid for Early-Career Scientists , Principal Investigator

  • Elucidation of the mode of action of kurahyne, an ER-stress inducer

    2015.08
    -
    2017.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 岩崎 有紘, Grant-in-Aid for Research Activity Start-up , Principal Investigator

     View Summary

    Kurahyne is a marine natural product that exhibits osteoclast differentiation-inhibitory activity and sarco/endoplasmic reticulum Ca2+-ATPase (SERCA)-inhibitory activity. In this study, I have investigated the detailed mechanisms of these activities.
    As a result, we have found the following things;
    (1) Prohibitin-1 and -2 can play an important role in the osteoclast differentiation-inhibitory activity of kurahyne; (2) Specific fourteen amino-acid residues in SERCA are identified as a possible kurahyne-binding site; (3) Two kurahyne-related marine natural products were isolated, and the structure determination and the total synthesis of them were achieved. Furthermore, some knowledge regarding a structure-activity relationship was obtained.

Awards 【 Display / hide

  • 化学療法基盤支援活動第3回シンポジウム 優秀ポスター賞

    岩崎有紘, 2014.05, 文部科学省 科研費・がん支援 化学療法基盤支援活動班, 海洋シアノバクテリア由来新規小胞体ストレス誘導剤kurahyneの単離と機能解析

  • 新規素材探索研究会 第13回セミナー 最優秀ポスター賞

    岩崎有紘, 2014.06, 新規素材探索研究会, 海洋シアノバクテリア由来新規小胞体ストレス誘導剤kurahyneの単離と機能解析

  • 日本化学会第95春季年会 学生講演賞

    岩崎有紘, 2015.03, 日本化学会, 海洋微細藻類由来新規リポペプチドの構造および生物活性

  • 新学術領域研究「天然物ケミカルバイオロジー」第7回若手研究者ワークショップ 優秀講演賞

    2015.06, 新学術領域研究「天然物ケミカルバイオロジー」, 藍藻由来新規アポトーシス誘導剤、クラハインの構造と作用機序解明

  • 日本ケミカルバイオロジー学会 第10回年会 ポスター賞

    2015.06, 日本ケミカルバイオロジー学会, 海洋生物由来新規生物活性物質の構造と生物活性

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Courses Taught 【 Display / hide

  • LABORATORY IN SCIENCE

    2021

  • LABORATORIES IN CHEMISTRY 2

    2021

  • LABORATORY IN SCIENCE

    2020

  • LABORATORIES IN CHEMISTRY 2

    2020

  • LABORATORY IN SCIENCE

    2019

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Courses Previously Taught 【 Display / hide

  • 自然科学実験

    Keio University, 2017

  • 化学実験第2

    Keio University, 2015

  • 自然科学実験

    Keio University, 2015

 

Memberships in Academic Societies 【 Display / hide

  • 日本化学会

     
  • 日本ケミカルバイオロジー学会

     
  • 毒素シンポジウム

     
  • 有機合成化学協会

     

Committee Experiences 【 Display / hide

  • 2015.01
    -
    2015.09

    第57回天然有機化合物討論会実行委員, 第57回天然有機化合物討論会実行委員会

  • 2015.12
    -
    2016.05

    第4回慶應有機化学若手シンポジウム実行委員, 慶應有機化学若手シンポジウム実行委員会

  • 2016.05
    -
    2017.03

    会場・総務小委員会委員, 日本化学会・第97春季年会

  • 2016.12
    -
    2017.05

    第5回慶應有機化学若手シンポジウム実行委員, 慶應有機化学若手シンポジウム実行委員会

  • 2016.08
    -
    2017.07

    第52回天然物談話会実行委員, 第52回天然物談話会実行委員会

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