Papers - Toshima, Kazunobu

Photodegradation of Target Oligosaccharides by Light-Activated Small Molecules.

Daisuke　Takahashi, Shingo Hirono, Chigusa Hayashi, Masayuki Igarashi, Yoshio Nishimura, Kazunobu Toshima

Angew. Chem. Int. Ed. 49 ( 52 ) 10096-10100 2010.11

Research paper (scientific journal), Joint Work, Accepted

Total Synthesis of Incednam, the Aglycon of Incednine

Takashi Ohtani, Shinya Tsukamoto, Hiroshi Kanda, Kensuke Misawa, Yoshifumi Urakawa, Takahiro Fujimaki, Masaya Imoto, Yoshikazu Takahashi, Daisuke Takahashi, Kazunobu Toshima*

Org. Lett. 12 ( 21 ) 5068-5071 2010.11

Research paper (scientific journal), Joint Work, Accepted

A Novel Glycosylation of Inactive Glycosyl Donors Using an Ionic Liquid Containing a Protic Acid under Reduced Pressure Conditions

Yasutaka Kuroiwa, Maiko Sekine, Satoshi Tomono, Daisuke Takahashi, Kazunobu Toshima*

Tetrahedron Lett. 51 ( 48 ) 6294-6297 2010.09

Research paper (scientific journal), Joint Work, Accepted

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従来の糖供与体よりも安定かつ調整容易なメチルグリコシドや1-OH糖が、再利用可能なプロトン酸含有イオン液体中、速やかに活性化されること、さらに、減圧条件下に付すことで、グリコシル化反応が効率的に進行することを示した論文。

第三の生命鎖は制御できるか？-糖鎖の機能を人為的に操る新技術-

Daisuke Takahashi, Kazunobu Toshima

化学 (化学同人)  65 ( 8 ) 74-75 2010.08

Research paper (scientific journal), Joint Work

Photo-degradation of Amyloid beta by a Designed Fullerene-sugar Hybrid

Yasunori Ishida, Shuho Tanimoto, Daisuke Takahashi, Kazunobu Toshima*

Med. Chem. Commun. 1 ( 3 ) 212-215 2010.08

Research paper (scientific journal), Joint Work, Accepted

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新規にデザイン・合成したフラーレンと糖とのハイブリッド分子が、アミロイドβの凝集を阻害するだけでなく、人体に害のない長波長紫外光の照射下、アミドロイドβのモノマーおよびオリゴマーを効果的に光分解することを示した論文。

光感受性分子標的薬の創製研究

TOSHIMA KAZUNOBU

日本発ブロックバスターを目指して-創薬研究の最前線- (シーエムシー出版)     118-125 2010.05

Research paper (scientific journal), Single Work, Accepted

Effective and Chemoselective Glycosylations Using 2,3-Unsaturated Sugars

Shunichi Kusumi, Kaname Sasaki, Sainan Wang, Tatsuya Watanabe, Daisuke Takahashi, Kazunobu Toshima*

Org. Biomol. Chem. 8 ( 14 ) 3164-3178 2010.05

Research paper (scientific journal), Joint Work, Accepted

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生体内におけるリゾチームの糖鎖加水分解反応に着眼し、デザイン・合成した2,3-不飽和糖が2,3-飽和糖および2,3-不飽和-4-ケト糖よりも有意に高い反応性を有することを示し、この反応性の差を利用した化学選択的グリコシル化反応が2,3-ジデオキシ糖鎖の効率的な合成法として有効であることを示した論文。

Chemoselective glycosylations using 2,3-unsaturated-4-keto glycosyl donors

S. Kusumi, S. Wang, T. Watanabe, K. Sasaki, D. Takahashi, K. Toshima

Organic & Biomolecular Chemistry 8 ( 5 ) 988-990 2010.03

Research paper (scientific journal), Single Work, Accepted

糖鎖を認識する超分子

Daisuke Takahashi, Kazunobu Toshima

BIO INDUSTRY (シーエムシー出版)  27 ( 2 ) 12-17 2010.02

Research paper (scientific journal), Single Work,  ISSN  0910-6545

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糖鎖を認識する超分子化合物の分子デザイン、機能および将来の有用性を展望した総説。

標的糖鎖を光分解する生体機能分子の創製

TOSHIMA KAZUNOBU

バイオインダストリー 27 ( 2 ) 43-48 2010.02

Research paper (scientific journal), Single Work

新しい分子標的薬とその設計：光感受性分子標的薬

TOSHIMA KAZUNOBU

腎と透析 67 ( 5 ) 577-582 2009.11

Research paper (scientific journal), Single Work

High-Molecular-Weight Polycarbonate synthesized by Enzymatic Ring-Opening Polymerization of Cyclic Carbonate as a Green Process

YAMAMOTO YOSHIO, KAIHARA SACHIKO, TOSHIMA KAZUNOBU, MATSUMURA SHUICHI

Macromolecular Bioscience (Wiley-VCH)  9 ( 10 ) 968-978 2009.10

Research paper (scientific journal), Joint Work, Accepted

Synthesis and Properties of Polycarboxylate-type Green Surfactants with S- or N-Linkages

OKADA YUU, BANNO TAISUKE,TOSHIMA KAZUNOBU,MATSUMURA SHUICHI

Journal of Oleo Science (日本油化学会)  58 ( 10 ) 519-528 2009.10

Research paper (scientific journal), Joint Work, Accepted

Target-selective degradation of cancer-related proteins by novel photo-sensitizers for molecular-targeted photodynamic therapy

TOSHIMA KAZUNOBU

Cancer Science 100 ( 9 ) 1581-1584 2009.09

Research paper (scientific journal), Joint Work, Accepted

Target-selective degradation of proteins and oligosaccharides by light-activated hybrid molecules for molecular-targeted photodynamic therapy

TOSHIMA KAZUNOBU

Future Medicinal Chemistry 1 ( 6 ) 1113-1124 2009.09

Research paper (scientific journal), Single Work, Accepted

Synthesis and Properties of Gemini-type Cationic Surfactants Containing Carbonate Linkages in the Linker Moiety Directed Toward Green and Sustainable Chemistry

Taisuke Banno, Kazunobu Toshima, Kazuo Kawada, MATSUMURA SHUICHI

Journal of Surfactants and Detergents (Springer)  12 ( 3 ) 249-259 2009.08

Research paper (scientific journal), Joint Work, Accepted

Hydrolysis of disaccharides by metal species in neutral homogeneous conditions

D. Takahashi, S. Kobayashi, K. Tsumura, K. Toshima

Chemistry Letteers 38 ( 7 ) 728-729 2009.07

Research paper (scientific journal), Joint Work, Accepted

Synthetic studies on incednine: synthesis of the C1-C13 pentaenoic acid segment

T. Ohtani, H. Kanda, K. Misawa, Y. Urakawa, K. Toshima

Tetrahedron Letters 50 ( 19 ) 2270-2273 2009.05

Research paper (scientific journal), Joint Work, Accepted

Direct Enzymatic Synthesis of a Polyester with Free Pendant Mercapto Groups

Makoto Kato, Kazunobu Toshima,MATSUMURA SHUICHI

Biomacromolceules (American Chemical Society)  10 ( 2 ) 366-373 2009.02

Research paper (scientific journal), Joint Work, Accepted

Target-selective photo-degradation of HIV-1 protease by a fullerene-sugar hybrid

S. Tanimoto, S. Sakai, S. Matsumura, D. Takahashi MATSUMURA SHUICHI K. Toshima

Chemical Communications (RSC Publishing)   ( 44 ) 5767-5769 2008.11

Research paper (scientific journal), Joint Work