Terakawa, Mitsuhiro

写真a

Affiliation

Faculty of Science and Technology, Department of Electronics and Electrical Engineering （Yagami）

Position

Associate Professor

E-mail Address

E-mail address

Related Websites
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Career 【 Display / hide 】

  • 2005
    -
    2007

    Japan Society for the Promotion of Science, Doctoral Course Students (DC)

  • 2007
    -
    2008

    Massachusetts General Hospital, Wellman Center for Photomedicine, Research Fellow

  • 2007
    -
    2008

    Japan Society for the Promotion of Science, Postdoctoral Fellow

  • 2009
    -
    2010

    Keio University, Research Associate

  • 2010.04
    -
    2013.03

    Keio University, Department of Electronics and Electrical Engineering, Assistant Professor

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Academic Background 【 Display / hide 】

  • 2003.03

    Keio University, Science and Technology, Department of Electronics and Electrical Engineering

    University, Graduated

  • 2005.03

    Keio University, Science and Technology, Integrated Design Engineering

    Graduate School, Completed, Master's course

  • 2007.09

    Keio University, Science and Technology, Integrated Design Engineering

    Graduate School, Completed, Doctoral course

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Academic Degrees 【 Display / hide 】

  • 博士（工学）, 慶應義塾大学, 2007.09

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Matters concerning Career Achievements 【 Display / hide 】

  • 2013.04
    -
    2014.03

    電子工学科２年生担任

  • 2014.04
    -
    2015.03

    大学院総合デザイン工学専攻　専攻幹事

  • 2014.04
    -
    2015.03

    電子工学科３年生担任

  • 2016.04
    -
    2018.03

    大学院総合デザイン工学専攻　専攻幹事

  • 2016.10
    -
    2017.09

    理工学メディアセンター協議会委員

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Research Areas 【 Display / hide 】

  • Optical engineering, Photon science (laser processing, multi-photon manufacturing, softmaterials and biomaterials)

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Research Keywords 【 Display / hide 】

  • Laser processing

  • Soft materials

  • Biomaterials

  • Laser-based precise processing

  • Multi-photon photoreduction and photopolymerization

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Books 【 Display / hide 】

  • Micro and Nano Fabrication Technology

    Mitsuhiro Terakawa, Springer, 2018

    Scope: Chapter "Femtosecond Laser Direct Writing"

  • Ultrafast Laser Processing: From Micro- to Nanoscale

    Mitsuhiro Terakawa, Minoru Obara, Pan Stanford Publishing, 2013

    Scope: Chapter 7 Nanoablation Using Nanosphere and Nanotip

  • Gold Nanoparticles: Properties, Characterization, and Fabrication

    Y. Tanaka, M. Terakawa, M. Obara, N. Nedyalkov, P. Atanasov, Nova Science Publishers, 2009

    Scope: Chapter 6 Plasmonic Nanopatterning of the Material Surface Mediated with Gold Nanoparticles Excited by a Femtosecond Laser Pulse

  • 「ウイルスを用いない遺伝子導入法の材料, 技術, 方法論の新たな展開」

    佐藤俊一, 寺川光洋, 小原實, メディカルドゥ, 2006

    Scope: 160-166

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Papers 【 Display / hide 】

  • Multiphoton photoreduction for dual-wavelength-light-driven shrinkage and actuation in hydrogel

    Kosuke Mizuguchi, Yo Nagano, Hiroaki Nishiyama, Hiroaki Onoe, Mitsuhiro Terakawa

    Optical Materials Express （The Optical Society (OSA))  10 （ 8 ） 1931 - 1931 2020.07

    Research paper (scientific journal), Joint Work, Accepted

    　View Summary

    © 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. The dual-wavelength-driven shrinkage of metal microstructures and hydrogel actuation are demonstrated by the fabrication of multi-metal microstructures in hydrogels by multiphoton photoreduction. Silver and gold microstructures were fabricated in a poly-Nisopropylacrylamide (PNIPAm) hydrogel. Because of the different optical resonances of the metals, wavelength-dependent shrinkage of metal microstructures was demonstrated concurrently with the volume change of the supporting hydrogel by light stimulation. Furthermore, the direction of actuation of the hydrogel was controlled by switching the wavelength of light stimulation. The results indicate the potential of multiphoton photoreduction for applications in light-driven optical components and micro-robots fabricated with soft materials.

  • Myoblast adhesion and proliferation on biodegradable polymer films with femtosecond laser-fabricated micro through-holes

    Izumi Takayama, Naonari Kondo, Stefan Kalies, Alexander Heisterkamp, Mitsuhiro Terakawa

    Journal of Biophotonics （Wiley)  13 （ 7 ）  2020.04

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  1864063X

    　View Summary

    © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Controlling cell adhesion and cell differentiation is necessary to fabricate a tissue with arbitrary properties for tissue engineering applications. A substrate with a porous structure as a cell scaffold allows the diffusion of the cell culture medium through the scaffold. In this work, we show that the femtosecond laser fabricated micro through-holes in biodegradable polymer films, enhance myoblast adhesion, and accelerates proliferation and differentiation. ChR2-C2C12 and UT-C2C12 cells were seeded on the films with micro through-holes each fabricated by a single femtosecond laser pulse. Cell adhesion was enhanced on films with holes fabricated by laser irradiation. In addition, cell proliferation was accelerated on films with micro through-holes that penetrate the film, compared to on films with micro craters that do not penetrate the film. On films with arrays consisting of micro through-holes, cells aligned along the arrays and cell fusion was enhanced, indicating the acceleration of cell differentiation.

  • Synthesis of silicon carbide nanocrystals and multilayer graphitic carbon by femtosecond laser irradiation of polydimethylsiloxane

    Shuichiro Hayashi, Fumiya Morosawa, Mitsuhiro Terakawa

    Nanoscale Advances （Royal Society of Chemistry)  2 （ 5 ） 1886 - 1893 2020.03

    Research paper (scientific journal), Joint Work, Accepted

    　View Summary

    © The Royal Society of Chemistry 2020. Laser-based modification of polymer materials has been emerging as a versatile and efficient technique to simultaneously form and pattern electrically conductive materials. Recently, it has been revealed that native polydimethylsiloxane (PDMS) can be modified into electrically conductive structures using femtosecond laser irradiation; however, the details regarding the structures formed by this method have yet to be revealed. In this work, structures were fabricated by focusing and scanning femtosecond laser pulses onto the surface of PDMS. Raman Spectroscopy and Transmission Electron Microscopy (TEM) analyses revealed the formation of silicon carbide (SiC) nanocrystals, as well as multilayer graphitic carbon, in the modified regions of PDMS. The state of the formed material differed depending on the distance from the focal spot, suggesting that photo-thermal effects contributed to the degradation of PDMS into conductive material. Electrical conductivity measurements, in addition to Raman results, indicated that the amount of disorder in the formed graphitic carbon contributes to the electrical conductivity of the fabricated structures.

  • Effect of Pd-decoration on the sensing properties of ZnO nanostructures

    Dilova T., Atanasova G., Og. Dikovska A., Avdeev G., Machida M., Terakawa M., Stefanov P., Nedyalkov N.

    Thin Solid Films （Thin Solid Films)  693   137693 2020.01

    ISSN  00406090

    　View Summary

    © 2019 Elsevier B.V. In this work, we present fabrication and studies of pure and Pd-decorated ZnO nanostructures on Ag-coated substrates in view of gas-sensing application. The sensor elements consist of a dense structure of ZnO nanobelts. The chemical composition of the surface and gas-sensing properties of pure and Pd-doped nanostructures were studied and compared. On the surface of the Pd-decorated ZnO samples, the presence was found of Pd and Pd-Ag clusters, as well as isolated Pd2+ ions were incorporated into the ZnO lattice. The Pd-ZnO sensor element showed a better response to CO, NH3, and acetone compared to the pure ZnO sample. The Pd-ZnO sample exhibited its highest response to exposure to acetone at room temperature. We associate the improvement of sensing performance of the Pd-decorated ZnO nanostructures with the increased number of adsorption centers on the surface due to the Pd nanoparticles.

  • Luminescence properties of laser-induced silver clusters in borosilicate glass

    N. Nedyalkov, A. Kikovska, M. Koleva, N. Stankova, R. Nikov, E. Borisova, Ts Genova, L. Aleksandrov, R. Iordanova, M. Terakawa

    Optical Materials （Elsevier)  100 2019.12

    Research paper (scientific journal), Joint Work, Accepted,  ISSN  09253467

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    © 2019 Elsevier B.V. This paper describes the luminescence properties of small silver clusters formed by laser treatment of silver-doped borosilicate glass. Using irradiation by a Nd:YAG nanosecond laser system operating at the fourth harmonic wavelength (266 nm), areas are formed in the glass samples that emit bright luminescence peaking at about 600 nm when excited by UV light in the spectral range 300–390 nm. The influence is presented and discussed of the glass composition and the laser processing parameters on the emission characteristics. It is further shown that the luminescent properties are affected by the fluence of the excitation source, namely, a complete quenching of the emission is achieved above a certain value. The luminescence of the irradiated areas is explained by the formation of Ag clusters due to irradiation-induced reduction of Ag ions and increased atom mobility resulting from the local heating. The limited stability of the luminescent areas upon UV radiation can be related to heat-induced cluster decomposition and re-oxidation. The results obtained provide a new insight in the optical properties of noble-metal nanostructures and could form the basis of fabrication of complex optical systems and luminescent component used in the study of, e.g., biological systems.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • 超短パルスレーザーによる多光子還元

    寺川光洋

    光アライアンス 30 ( 8 ) 55 - 58 2019.08

    Introduction and explanation (commerce magazine), Single Work

  • Femtosecond Laser Processing of Biodegradable Polymers

    Mitsuhiro Terakawa

    Applied Sciences 8 ( 7 ) 1123 2018.07

    Introduction and explanation (scientific journal), Single Work

    　View Summary

    © 2018 by the authors. Biodegradable polymers have attracted increasing attention in tissue engineering and drug delivery systems owing to their high biocompatibility and biodegradability. Among the various methods for shape forming and modification of biodegradable polymers, laser processing has advantages in a dry processing approach that can process complex-shaped surfaces without using toxic chemical components. This review provides an overview of femtosecond laser processing of biodegradable polymers, especially in the last decade. The interaction mechanism of femtosecond laser pulse and biodegradable polymers, e.g., bond dissociation after laser irradiation, affects the degradable property of biodegradable polymers, which has the potential to control the degradation and sustainability of a structure. Applied studies on controlling cell behavior, tissue scaffolding, and drug release are also described.

  • フェムト秒レーザーによるソフトマテリアル・金属複合微細構造の作製

    寺川光洋、町田茉南、中島康貴

    レーザー研究 (レーザー学会)  46 ( 5 ) 272 - 276 2018.05

    Introduction and explanation (scientific journal), Joint Work

  • 短パルス光の音響的および機械的作用に基づいた薬剤輸送セラノスティックス

    角井泰之、川内聡子、寺川光洋、佐藤俊一

    レーザー研究 45 ( 11 ) 709 - 713 2017.11

    Introduction and explanation (scientific journal), Joint Work

  • パルスレーザーでコントロールする銀ナノプレートの抗菌活性

    市丸裕晃、Kaung KYAW、川越嵩之、寺川光洋、宮澤雄太、溝口大剛、津志田雅之、新留琢郎

    レーザー研究 45 ( 11 ) 705 - 708 2017.11

    Introduction and explanation (scientific journal), Joint Work

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Presentations 【 Display / hide 】

  • (Invited) Femtosecond laser-induced modification of elastomers to conductive materials

    M. Terakawa, S. Hayashi, F. Morosawa, N. Nedyalkov

    The International School on Quantum Electronics "Laser Physics and Applications (ISCQE) (2020), 2020.09, Oral Presentation(guest/special)

  • (Invited) Multiphoton photoreduction in hydrogel

    M. Terakawa

    14th Pacific Rim Conference on Lasers and Electro-Optics (CLEO Pacific Rim 2020), 2020.08, Oral Presentation(guest/special)

  • Femtosecond-laser-induced graphitic carbon from transparent cellulose nanofiber films

    F. Morosawa, S. Hayashi, and M. Terakawa

    14th Pacific Rim Conference on Lasers and Electro-Optics (CLEO Pacific Rim 2020), 2020.08, Poster (general)

  • Fabrication of the light-responsive microchannel inside hydrogel

    Yo Nagano, Kosuke Mizuguchi, Hiroaki Onoe, Mitsuhiro Terakawa

    21st International Symposium on Laser Precision Microfabrication 2020 (LPM2020), 2020.06, Oral Presentation(general)

  • (Invited) Spatially-targeted laser fabrication of multimaterial microstructures in hydrogel

    M. Terakawa, M. Machida, K. Mizuguchi, R. Sano, H. Onoe, T. Niidome, A. Heisterkamp

    Photonics West 2020, 2020.02, Oral Presentation(guest/special)

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 回折限界を超える極微細金属構造のレーザーファブリケーション

    2018.07
    -
    2021.03

    文部科学省・日本学術振興会, 科学研究費補助金　挑戦的研究（萌芽）, Research grant, Principal Investigator

  • 三次元多光子レーザープロセシングによる機能因子放出スキャフォールドの実現

    2018.04
    -
    2022.03

    文部科学省・日本学術振興会, 科学研究費補助金　基盤研究(B), 寺川光洋, Research grant, Principal Investigator

  • レーザ直接描画法による３次元フレキシブル金属構造の作製

    2016.12
    -
    2019.03

    公益財団法人　天田財団, 重点研究開発助成Ｂ課題研究, No Setting, Principal Investigator

  • 多機能光学インプラントの開発

    2016.04
    -
    2018.03

    文部科学省・日本学術振興会, 二国間交流事業共同研究/セミナー, Commissioned ｒesearch, Principal Investigator

  • 超高速ミー散乱増強光の多光子過程による再生医療用薬剤放出技術の研究

    2014.04
    -
    2018.03

    Grant-in-Aid for Scientific Research, Research grant, Principal Investigator

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Intellectual Property Rights, etc. 【 Display / hide 】

  • レーザーにより透明材料表面もしくは内部に炭化ケイ素(SiC)を一括作製する方法

    Application No.： 特願2018-92489  2018.05 

  • レーザーを用いた薬剤放出方法

    Application No.： 2013-046732  2013.03 

    Patent, National application

  • 移植組織または臓器への薬剤導入方法ならびに薬剤導入装置

    Application No.： 特願2007-196580  2007.07 

    Announcement No.： 特開2008-49150   

    Patent, National application

  • Method and apparatus for drug delivery to tissue or organ for transplant

    Application No.：   2007 

    Announcement No.： US 2009/0233987 A1  2009 

    Patent, PCT international application

  • 細胞への薬剤導入方法および細胞への薬剤導入装置

    Application No.： 特願2006-113384  2006.04 

    Announcement No.： 特開2007-284379   

    Patent, National application

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Awards 【 Display / hide 】

  • 電子・情報・システム部門研究会 優秀論文発表賞

    2014.09, 電気学会

  • 応用物理学会　講演奨励賞

    TERAKAWA Mitsuhiro, 2012.03, 応用物理学会, フェムト秒レーザの多微粒子レンズ集光場による細胞膜の単一パルスプロセッシング

    Type of Award： Awards of National Conference, Council and Symposium

  • 慶應義塾大学 総合デザイン工学専攻 優秀研究活動賞 (博士)

    TERAKAWA Mitsuhiro, 2008.03

    Type of Award： Keio commendation etc.

  • 慶應義塾大学 藤原賞

    TERAKAWA Mitsuhiro, 2007.03

    Type of Award： Keio commendation etc.

  • 日本光学会年次学術講演会 第2回Optics and Photonics Japanベストプレゼンテーション賞

    TERAKAWA Mitsuhiro, 2006.11

    Type of Award： Awards of National Conference, Council and Symposium

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Other 【 Display / hide 】

  • 2017年11月

    　View Details

    The Optical Society (OSA) News Release: Metal-Silicone Microstructures Could Enable New Types of Flexible Optical and Electrical Devices

  • 2014年03月

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    SPIE Newsroom: Femtosecond laser pulses for smart drug delivery

  • 2012年04月

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    SPIE Newsroom: Ultrafast near- and far-field nanoablation patterning

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Courses Taught 【 Display / hide 】

  • GRADUATE RESEARCH ON INTEGRATED DESIGN ENGINEERING 1

    2020

  • BACHELOR'S THESIS

    2020

  • GRADUATE RESEARCH ON INTEGRATED DESIGN ENGINEERING 2

    2020

  • RECITATION IN ELECTRONICS AND INFORMATION ENGINEERING

    2020

  • PHYSICS D

    2020

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Memberships in Academic Societies 【 Display / hide 】

  • SPIE, Senior Member, 

    2019.06
    -
    Present

  • OSA, Senior Member, 

    2019.06
    -
    Present

  • Japan Laser Processing Society, 

    2013.04
    -
    Present

  • Japan Society for Laser Surgery and Medicine, 

    2012.11
    -
    2020.09

  • The Japan Society of Applied Physics, 

    2011.06
    -
    Present

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Committee Experiences 【 Display / hide 】

  • 2020.04
    -
    Present

    委員（光加工・計測分科会）, 光産業技術振興協会　光技術動向調査委員会

  • 2020.04
    -
    Present

    光学編集委員, 日本光学会

  • 2020.04
    -
    Present

    Program Committee, Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XXI , SPIE Photonics West 2021

  • 2020.04
    -
    Present

    Program Committee, Laser Applications in Microelectronic and Optoelectronic Manufacturing (LAMOM) XXVI, SPIE Photonics West 2021

  • 2020.04
    -
    Present

    Program Committee, Nano Track, ICALEO 2020 (39th International Congress on Applications of Lasers & Electro-Optics), LIA (The Laser Institute)

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