Terakawa, Mitsuhiro

写真a

Affiliation

Faculty of Science and Technology, Department of Electronics and Electrical Engineering (Yagami)

Position

Associate Professor

E-mail Address

E-mail address

Related Websites

Career 【 Display / hide

  • 2005
    -
    2007

    Japan Society for the Promotion of Science, Doctoral Course Students (DC)

  • 2007
    -
    2008

    Massachusetts General Hospital, Wellman Center for Photomedicine, Research Fellow

  • 2007
    -
    2008

    Japan Society for the Promotion of Science, Postdoctoral Fellow

  • 2009
    -
    2010

    Keio University, Research Associate

  • 2010.04
    -
    2013.03

    Keio University, Department of Electronics and Electrical Engineering, Assistant Professor

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Academic Background 【 Display / hide

  • 2003.03

    Keio University, Science and Technology, Department of Electronics and Electrical Engineering

    University, Graduated

  • 2005.03

    Keio University, Science and Technology, Integrated Design Engineering

    Graduate School, Completed, Master's course

  • 2007.09

    Keio University, Science and Technology, Integrated Design Engineering

    Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide

  • 博士(工学), 慶應義塾大学, 2007.09

Matters concerning Career Achievements 【 Display / hide

  • 2013.04
    -
    2014.03

    電子工学科2年生担任

  • 2014.04
    -
    2015.03

    大学院総合デザイン工学専攻 専攻幹事

  • 2014.04
    -
    2015.03

    電子工学科3年生担任

  • 2015.04
    -
    2018.03

    大学院 研究科委員

  • 2016.04
    -
    2018.03

    大学院総合デザイン工学専攻 専攻幹事

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Research Areas 【 Display / hide

  • Optical engineering, Photon science (laser processing, multi-photon manufacturing, softmaterials and biomaterials)

Research Keywords 【 Display / hide

  • Laser processing

  • Soft materials

  • Biomaterials

  • Laser-based precise processing

  • Multi-photon photoreduction and photopolymerization

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Books 【 Display / hide

  • Micro and Nano Fabrication Technology

    Mitsuhiro Terakawa, Springer, 2018

    Scope: Chapter "Femtosecond Laser Direct Writing"

  • Ultrafast Laser Processing: From Micro- to Nanoscale

    Mitsuhiro Terakawa, Minoru Obara, Pan Stanford Publishing, 2013

    Scope: Chapter 7 Nanoablation Using Nanosphere and Nanotip

  • Gold Nanoparticles: Properties, Characterization, and Fabrication

    Y. Tanaka, M. Terakawa, M. Obara, N. Nedyalkov, P. Atanasov, Nova Science Publishers, 2009

    Scope: Chapter 6 Plasmonic Nanopatterning of the Material Surface Mediated with Gold Nanoparticles Excited by a Femtosecond Laser Pulse

  • 「ウイルスを用いない遺伝子導入法の材料, 技術, 方法論の新たな展開」

    佐藤俊一, 寺川光洋, 小原實, メディカルドゥ, 2006

    Scope: 160-166

Papers 【 Display / hide

  • Laser direct writing of highly crystalline graphene on PDMS for fingertip-sized piezoelectric sensors

    Shuichiro Hayashi, Fumiya Morosawa, Mitsuhiro Terakawa

    Advanced Engineering Materials (Wiley)   2021.06

    Research paper (scientific journal), Joint Work, Accepted

  • Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization

    Hiroki Sugiyama, Kaneto Tsunemitsu, Hiroaki Onoe, Kotaro Obata, Koji Sugioka, Mitsuhiro Terakawa

    Scientific Reports (Springer Nature)  11 ( 1 ) 10892 2021.05

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    The mechanical strength of hydrogel microstructures is crucial for obtaining the desired flexibility, robustness, and biocompatibility for various applications such as cell scaffolds and soft microrobots. In this study, we demonstrate the fabrication of microstructures composed of cellulose nanofibers (CNFs) and poly(ethylene glycol) diacrylate (PEGDA) hydrogels by multiphoton polymerization. The stress of the fabricated microstructure during tensile testing increased with an increase in the CNF concentration, indicating that the mechanical strength of the microstructure was enhanced by using CNFs as fillers. Moreover, the swelling ratio of the microstructure increased with increasing CNF concentration in the PEGDA hydrogel. Our results show the potential of the technique for the microfabrication of advanced cell scaffolds and soft microrobots with the desired mechanical strength.

  • Femtosecond laser-induced graphitization of transparent cellulose nanofiber films

    Fumiya Morosawa, Shuichiro Hayashi, Mitsuhiro Terakawa

    ACS Sustainable Chemistry & Engineering (ACS Sustainable Chemistry and Engineering)  9 ( 7 ) 2955 - 2961 2021.02

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    © 2021 American Chemical Society. Laser graphitization allows for the spatially targeted modification of biomasses into electrically conductive structures and is a promising technique for the development of sustainable electronic devices. Out of the many biomasses, cellulose nanofiber (CNF) is a sustainable biomass which exhibits unique properties, such as mechanical strength and optical transparency. In this study, we demonstrated the fabrication of highly conductive graphitic carbon from CNFs using a high-repetition femtosecond laser. A conductivity as high as 6.9 S/cm was obtained by single scanning of the laser beam, which is estimated to be more than 100 times higher than the conductivity reported previously. From the Raman analysis of the structure, the formation of highly crystalline graphitic carbon was indicated, which contributes to the high conductivity. In the case of high-repetition femtosecond laser irradiation, it is considered that strong optical effects, in addition to thermal effects, contribute to the degradation of CNFs, resulting in the formation of highly crystalline graphitic carbon. Our presented technique allows for the direct writing of highly conductive graphitic carbon on CNF films, and the development of sustainable electronic devices, using mechanically robust and transparent CNF films as the substrate, should be realized.

  • Fabrication of hollow channels surrounded by gold nanoparticles in hydrogel by femtosecond laser irradiation

    Izumi Takayama, Akito Katayama, Mitsuhiro Terakawa

    Nanomaterials (Nanomaterials)  10 ( 12 ) 2529 - 10 2020.12

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    © 2020 by the authors. Licensee MDPI, Basel, Switzerland. The fabrication of hollow channels surrounded by gold nanoparticles in poly(ethylene glycol) diacrylate (PEGDA) is demonstrated. The absorption spectra show that gold nanoparticles were formed at the periphery of the focus by reduction of gold ions. The microscope observation and Raman spectroscopy analyses indicate that the center of the channels were void of PEGDA, which can be attributed to the femtosecond laser-induced degradation of the hydrogel. Since both the hydrogel and gold nanoparticles are biocompatible, this technique of fabricating hollow channels surrounded by gold nanoparticles is promising for tissue engineering, drug screening, and lab-on-a-chip devices.

  • Anionic fluorophore-assisted fabrication of gold microstructures inside a hydrogel by multi-photon photoreduction

    Manan Machida, Weilu Shen, Hiroaki Onoe, Yuki Hiruta, Alexander Heisterkamp, Eric Mazur, and Mitsuhiro Terakawa

    Optical Materials Express (The Optical Society (OSA))  11 ( 1 ) 48 - 58 2020.12

    Research paper (scientific journal), Joint Work, Accepted

     View Summary

    © 2020 Optical Society of America. All Rights Reserved. The fabrication of accentuated gold microstructures is demonstrated by multi-photon photoreduction inside an anionic fluorophore-containing hydrogel. We attempted to facilitate gold-ion photoreduction near the focal point of laser pulses, expecting the donation of electrons by the oxidation of fluorophores in the vicinity of gold ions. The presence of anionic FITCdextran also inhibited the spontaneous reduction in untargeted zones, which is attributed to the coordination of gold ions and the anionic FITC-dextran. Simultaneous facilitation and inhibition are promising for the fabrication of dense metal microstructures in the targeted zone while maintaining the hydrogel's light permeability.

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Papers, etc., Registered in KOARA 【 Display / hide

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Reviews, Commentaries, etc. 【 Display / hide

  • フェムト秒レーザー改質による高分子材料への導電性付与

    林秀一郎, 寺川光洋

    表面技術 71 ( 11 ) 684 - 688 2020.11

  • 超短パルスレーザーによる多光子還元

    寺川光洋

    光アライアンス 30 ( 8 ) 55 - 58 2019.08

    Introduction and explanation (commerce magazine), Single Work

  • Femtosecond Laser Processing of Biodegradable Polymers

    Mitsuhiro Terakawa

    Applied Sciences 8 ( 7 ) 1123 2018.07

    Introduction and explanation (scientific journal), Single Work

     View Summary

    © 2018 by the authors. Biodegradable polymers have attracted increasing attention in tissue engineering and drug delivery systems owing to their high biocompatibility and biodegradability. Among the various methods for shape forming and modification of biodegradable polymers, laser processing has advantages in a dry processing approach that can process complex-shaped surfaces without using toxic chemical components. This review provides an overview of femtosecond laser processing of biodegradable polymers, especially in the last decade. The interaction mechanism of femtosecond laser pulse and biodegradable polymers, e.g., bond dissociation after laser irradiation, affects the degradable property of biodegradable polymers, which has the potential to control the degradation and sustainability of a structure. Applied studies on controlling cell behavior, tissue scaffolding, and drug release are also described.

  • フェムト秒レーザーによるソフトマテリアル・金属複合微細構造の作製

    寺川光洋、町田茉南、中島康貴

    レーザー研究 (レーザー学会)  46 ( 5 ) 272 - 276 2018.05

    Introduction and explanation (scientific journal), Joint Work

  • 短パルス光の音響的および機械的作用に基づいた薬剤輸送セラノスティックス

    角井泰之、川内聡子、寺川光洋、佐藤俊一

    レーザー研究 45 ( 11 ) 709 - 713 2017.11

    Introduction and explanation (scientific journal), Joint Work

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Presentations 【 Display / hide

  • Laser direct writing of electrically conductive graphitic carbon on cellulose nanofiber using 522-nm femtosecond laser

    F. Morosawa, S. Hayashi, M. Terakawa

    The 22nd International Symposium on Laser Precision Microfabrication (LPM 2021), 2021.06, Oral Presentation(general)

  • Multiphoton polymerization of cellulose nanofiber-reinforced hydrogel

    H. Sugiyama, K. Tsunemitsu, H. Onoe, K. Obata, K. Sugioka, M. Terakawa

    The 22nd International Symposium on Laser Precision Microfabrication (LPM 2021), 2021.06, Oral Presentation(general)

  • Laser-direct writing of a small and sensitive pressure sensor by laser-induced graphitization of PDMS

    S. Hayashi, F. Morosawa, M. Terakawa

    The 22nd International Symposium on Laser Precision Microfabrication (LPM 2021), 2021.06, Oral Presentation(general)

  • Microfabrication of double-network hydrogel with enhanced mechanical properties by multi-photon polymerization

    Kaneto Tsunemitsu, Ryo Sano, Akira Watanabe, Hiroaki Onoe, Mitsuhiro Terakawa

    SPIE Photonics West 2021, 2021.03, Oral Presentation(general)

  • Charged fluorophores-assisted fabrication of metallic structures inside hydrogel by multi-photon photoreduction

    Manan Machida, Weilu Shen, Hiroaki Onoe, Alexander Heisterkamp, Eric Mazur, Mitsuhiro Terakawa

    SPIE Photonics West 2021, 2021.03, Oral Presentation(general)

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • 回折限界を超える極微細金属構造のレーザーファブリケーション

    2018.07
    -
    2021.03

    文部科学省・日本学術振興会, 科学研究費補助金 挑戦的研究(萌芽), Research grant, Principal Investigator

  • 三次元多光子レーザープロセシングによる機能因子放出スキャフォールドの実現

    2018.04
    -
    2022.03

    文部科学省・日本学術振興会, 科学研究費補助金 基盤研究(B), 寺川光洋, Research grant, Principal Investigator

  • レーザ直接描画法による3次元フレキシブル金属構造の作製

    2016.12
    -
    2019.03

    公益財団法人 天田財団, 重点研究開発助成B課題研究, No Setting, Principal Investigator

  • 多機能光学インプラントの開発

    2016.04
    -
    2018.03

    文部科学省・日本学術振興会, 二国間交流事業共同研究/セミナー, Commissioned research, Principal Investigator

  • 超高速ミー散乱増強光の多光子過程による再生医療用薬剤放出技術の研究

    2014.04
    -
    2018.03

    Grant-in-Aid for Scientific Research, Research grant, Principal Investigator

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Intellectual Property Rights, etc. 【 Display / hide

  • レーザーにより透明材料表面もしくは内部に炭化ケイ素(SiC)を一括作製する方法

    Application No.: 特願2018-92489  2018.05 

  • レーザーを用いた薬剤放出方法

    Application No.: 2013-046732  2013.03 

    Patent, National application

  • 移植組織または臓器への薬剤導入方法ならびに薬剤導入装置

    Application No.: 特願2007-196580  2007.07 

    Announcement No.: 特開2008-49150   

    Patent, National application

  • Method and apparatus for drug delivery to tissue or organ for transplant

    Application No.:   2007 

    Announcement No.: US 2009/0233987 A1  2009 

    Patent, PCT international application

  • 細胞への薬剤導入方法および細胞への薬剤導入装置

    Application No.: 特願2006-113384  2006.04 

    Announcement No.: 特開2007-284379   

    Patent, National application

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Awards 【 Display / hide

  • 電子・情報・システム部門研究会 優秀論文発表賞

    2014.09, 電気学会

  • 応用物理学会 講演奨励賞

    TERAKAWA Mitsuhiro, 2012.03, 応用物理学会, フェムト秒レーザの多微粒子レンズ集光場による細胞膜の単一パルスプロセッシング

    Type of Award: Awards of National Conference, Council and Symposium

  • 慶應義塾大学 総合デザイン工学専攻 優秀研究活動賞 (博士)

    TERAKAWA Mitsuhiro, 2008.03

    Type of Award: Keio commendation etc.

  • 慶應義塾大学 藤原賞

    TERAKAWA Mitsuhiro, 2007.03

    Type of Award: Keio commendation etc.

  • 日本光学会年次学術講演会 第2回Optics and Photonics Japanベストプレゼンテーション賞

    TERAKAWA Mitsuhiro, 2006.11

    Type of Award: Awards of National Conference, Council and Symposium

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Other 【 Display / hide

  • 2017年11月

     View Details

    The Optical Society (OSA) News Release: Metal-Silicone Microstructures Could Enable New Types of Flexible Optical and Electrical Devices

  • 2014年03月

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    SPIE Newsroom: Femtosecond laser pulses for smart drug delivery

  • 2012年04月

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    SPIE Newsroom: Ultrafast near- and far-field nanoablation patterning

 

Courses Taught 【 Display / hide

  • LABORATORY IN SCIENCE

    2021

  • LABORATORIES IN ELECTRONICS AND INFORMATION ENGINEERING(1)

    2021

  • INTRODUCTION TO INTERDISCIPLINARY SCIENCE AND TECHNOLOGY

    2021

  • INDEPENDENT STUDY ON INTEGRATED DESIGN ENGINEERING

    2021

  • GRADUATE RESEARCH ON INTEGRATED DESIGN ENGINEERING 2

    2021

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Memberships in Academic Societies 【 Display / hide

  • SPIE, Senior Member, 

    2019.06
    -
    Present
  • OSA, Senior Member, 

    2019.06
    -
    Present
  • Japan Laser Processing Society, 

    2013.04
    -
    Present
  • Japan Society for Laser Surgery and Medicine, 

    2012.11
    -
    2020.09
  • The Japan Society of Applied Physics, 

    2011.06
    -
    Present

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Committee Experiences 【 Display / hide

  • 2021.04
    -
    2022.01

    Program Committee, Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XXII , SPIE Photonics West 2022

  • 2021.04
    -
    2022.01

    Program Committee, Laser Applications in Microelectronic and Optoelectronic Manufacturing (LAMOM) XXVII, SPIE Photonics West 2022

  • 2020.04
    -
    Present

    光学編集委員, 日本光学会

  • 2020.04
    -
    Present

    委員(光加工・計測分科会), 光産業技術振興協会 光技術動向調査委員会

  • 2020.04
    -
    2021.03

    Program Committee, Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XXI , SPIE Photonics West 2021

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