Wakaizumi, Kenta

写真a

Affiliation

School of Medicine, Department of Anesthesiology （Shinanomachi）

Position

Assistant Professor/Senior Assistant Professor
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Career 【 Display / hide 】

  • 2006.04
    -
    2008.03

    National Hospital Organization, Tokyo Medical Center, 臨床研修医

  • 2008.04
    -
    2012.03

    Keio University, School of Medicine Department of Anesthesiology, 専修医

  • 2009.04
    -
    2010.03

    川崎市立川崎病院, 麻酔科

  • 2010.04
    -
    2011.03

    埼玉医科大学総合医療センター, 麻酔科, 助教

  • 2012.04
    -
    2012.09

    Keio University, School of Medicine Department of Anesthesiology, 助教

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Academic Background 【 Display / hide 】

  • 2000.04
    -
    2006.03

    Keio University, School of Medicine, 医学科

  • 2013.04
    -
    2017.03

    Keio University, Graduate School of Medicine

  • 2017.04
    -
    2018.03

    Keio University, Graduate School of Economics

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Research Areas 【 Display / hide 】

  • Humanities & Social Sciences / Business administration (Behavioral Economics)

  • Life Science / Anatomy and histopathology of nervous system (Brain Imaging)

  • Life Science / Function of nervous system (Neuroeconomics)

  • Life Science / Anesthesiology (Pain Management)

  • Life Science / Anesthesiology (Postoperative Pain)

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Research Keywords 【 Display / hide 】

  • Opioid

  • Graph Theory

  • Dopamine

  • Reward System

  • Chronic Pain

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Books 【 Display / hide 】

  • 現代経済学の潮流

    大垣, 昌夫, 春野, 雅彦, カーステン・ヘルマン=ピラート, 竹内, 幹, 若泉, 謙太, 東洋経済新報社, 2021.12,  Page： xiv, 248p

    Scope: 第7章 神経経済学（パネル討論B）

    　View Summary

    編者 宇井貴志／加納 隆／西山慶彦／林 正義

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Papers 【 Display / hide 】

  • Effect of repeated transforaminal epidural low-dose dexamethasone injections on glucose profiles of diabetic and non-diabetic patients with low back pain.

    Reiko Hoshino, Kenta Wakaizumi, Yasuhisa Otsuka, Hiroshi Morisaki, Shizuko Kosugi

    Journal of anesthesia （Journal of Anesthesia)  37 （ 2 ） 261 - 267 2023.04

    ISSN  09138668

    　View Summary

    PURPOSE: We aimed to investigate the effect of repeated transforaminal epidural low-dose dexamethasone injections on glucose profiles and pituitary-adrenal axis functions of diabetic and non-diabetic patients with low back pain. METHODS: A total of 28 patients (ten diabetic [DM group] and 18 non-diabetic patients [non-DM group]) with low back pain were followed-up. Transforaminal epidural low-dose dexamethasone (1.65 mg) injections were repeated every 7-14 days for 8 weeks. Fasting blood sugar (FBS), hemoglobin A1c (HbA1c), morning plasma adrenocorticotropin (ACTH), and cortisol levels were measured at baseline and during the 8-week follow-up period. RESULTS: There were no significant changes in FBS and HbA1c levels between baseline and 8-week follow-up period in both DM and non-DM groups (difference in FBS [95% confidence Interval, CI]: - 0.6 mg/dL [- 6.4, 5.1], p = 0.83 in the non-DM group, - 0.2 mg/dL [- 26.2, 25.8], p = 0.99 in the DM group; difference in HbA1c [95% CI] - 0.02% [- 0.1, 0.1], p = 0.69 in the non-DM group, 0.04% [- 0.3, 0.4], p = 0.79 in the DM group). There were no significant longitudinal changes in ACTH and cortisol levels (ACTH, p = 0.38 [baseline vs. 8 week], p = 0.58 [non-DM vs. DM]; cortisol, p = 0.52 [baseline vs. 8 week], p = 0.90 [non-DM vs. DM]). CONCLUSIONS: Repeated transforaminal epidural low-dose dexamethasone injections provided no significant elevations in blood glucose or suppression of the pituitary-adrenal axis for two months from the first injection in both diabetic and non-diabetic patients. Our results indicate the intermediate-term safety of repeated transforaminal epidural low-dose dexamethasone injections with regard to the effect on glucose profile and pituitary-adrenal axis functions.

  • Influence of exercise on pain is associated with resting-state functional connections: A cross-sectional functional brain imaging study

    Wakaizumi K., Reckziegel D., Jabakhanji R., Apkarian A.V., Baliki M.N.

    Neurobiology of Pain （Neurobiology of Pain)  13 2023.01

    　View Summary

    Exercise is associated with lower prevalence and severity of pain, and is widely recommended for pain management. However, the mechanisms the exercise effect on pain remain unclear. In this study, we examined the association of exercise with pain and aimed to identify its neurobiological mediators. We utilized a baseline data of a clinical trial for people with low back pain. Participants reported pain intensity and exercise habit, as well as pain-related psychological and emotional assessments. We also obtained brain imaging data using a resting-state functional MRI and performed mediation analyses to identify brain regions mediating the exercise effect on pain. Forty-five people with low back pain (mean pain intensity = 59.6 and mean duration = 9.9 weeks) were included in this study. Participants with an exercise habit (n = 29) showed significant less pain compared to those without an exercise habit (n = 16). Mediation analysis using resting-state functional connectivity identified the left thalamus, right amygdala, and medial prefrontal cortex as statistical mediators of the exercise effect on pain (indirect effect = −0.460, 95% confidence interval = −0.767 to −0.153). In conclusion, our findings suggest that brain function of the specific regions is probably a neuro-mechanism of exercise alleviating pain.

  • A Cross-Sectional Study of the Impact of Pain Severity on Absenteeism and Presenteeism Among Japanese Full-Time Workers

    Chisato Tanaka, Kenta Wakaizumi, Saki Takaoka, Ko Matsudaira, Masaru Mimura, Daisuke Fujisawa, Shizuko Kosugi

    Pain and Therapy （Springer Science and Business Media LLC)  11 （ 4 ） 1179 - 1193 2022.12

    ISSN  21938237

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    INTRODUCTION: Pain is known to have a high impact on work performance, but there are several confounding factors, such as stress and mental issues. Little is known about the impact of pain severity on work performance when adjusted for such confounding factors. The aim of this study was to identify the effect of pain severity on absence from work (absenteeism) and reduced performance (presenteeism). METHODS: A cross-sectional study was conducted among full-time workers at an industrial manufacturing company in Japan. Participants were assessed using a self-reported questionnaire, including work performance evaluations, pain characteristics, pain-related fear, psychological distress, stress at the workplace and home, workaholism, and self-awareness. Principal component analysis was utilized to decrease the dimensions of the measures, and orthogonal rotation was performed on identified components with an eigenvalue > 1.0. Multivariable logistic regression analyses were performed to determine the association between pain severity and absenteeism and presenteeism, and were adjusted for confounding factors. We also analyzed the association between pain intensity and presenteeism using multivariable logistic regression analyses. RESULTS: A total of 349 workers participated in the study. Six principal components were identified as confounding factors: work stress, regulation, mental instability, less support, home stress, and life dissatisfaction. Multivariable logistic regression analyses showed significant associations of moderate to severe pain with absenteeism (p = 0.02) and low and high presenteeism (p = 0.004 and 0.009, respectively), adjusted for age, sex, body mass index, short sleep, and the six principal components. Pain intensity was also significantly associated with low and high presenteeism (p = 0.002 and 0.014, respectively) in people with pain. CONCLUSIONS: Pain severity is a risk factor for absenteeism and presenteeism, even if workers have comorbid psychological stress or mental health problems.

  • Association of chronic low back and neck pain classification based on ICD-11 with interdisciplinary pain treatment outcomes

    HOSHINO Reiko, HONDA Ayaka, SHINOHARA Yuta, ISHIKAWA Aiko, TANAKA Chisato, TSUJI Osahiko, WAKAIZUMI Kenta, MORISAKI Hiroshi, KOSUGI Shizuko

    Journal of Japan Society of Pain Clinicians （Japan Society of Pain Clinicians)  29 （ 9 ） 187 - 192 2022.09

    Accepted,  ISSN  1340-4903

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    We investigated the association of chronic low back and neck pain classification based on ICD-11 with pain relief under interdisciplinary pain management. A total of 212 patients with chronic musculoskeletal pain, who visited the Interdisciplinary Pain Center of Keio University Hospital, were categorized into chronic primary musculoskeletal pain (CPMP), chronic secondary musculoskeletal pain, and chronic neuropathic pain (CNP) groups based on ICD-11 and followed-up. We assessed pain intensity using the Brief Pain Inventory (BPI) at the first visit and at 3 months. Improvement of pain was defined as ≥30％ reduction in the BPI. Multivariate logistic regression analysis revealed that CNP were significantly associated with a greater improvement of pain after adjusting for sex, age, duration of pain, level of pain self-efficacy, and treatment options. [odds ratio (CNP/CPMP) (95％ confidence interval); 2.52 (1.25–5.09, p＝0.02)]. We concluded that the ICD-11 code for chronic low back and neck pain is significantly associated with pain treatment outcomes.

  • Negative effect of anger on chronic pain intensity is modified by multiple mood states other than anger: A large population-based cross-sectional study in Japan.

    Keiko Yamada, Tomoko Fujii, Yasuhiko Kubota, Kenta Wakaizumi, Hiroyuki Oka, K O Matsudaira

    Modern rheumatology （Modern Rheumatology)  32 （ 3 ） 650 - 657 2022.05

    Accepted,  ISSN  14397595

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    OBJECTIVES: To investigate whether mood states other than anger can modify the association between anger and pain intensity in individuals with chronic pain. METHODS: We analysed 22,059 participants with chronic pain, including 214 participants with rheumatoid arthritis (RA), who completed a questionnaire. The Profile of Mood States short form (POMS-SF) was used to assess six dimensions of mood states (anger-hostility, tension-anxiety, depression-dejection, confusion, fatigue, and vigour). A numerical rating scale (NRS) assessed pain intensity. We examined the association between anger-hostility and the NRS and the relationship between POMS-SF components. Moderation analyses were used to investigate whether the five mood states other than anger-hostility modified the effect of anger-hostility on the NRS. RESULTS: Anger-hostility contributed to pain intensity. Although increased mood states other than vigour were associated with increased pain intensity, these increased mood states appeared to suppress the effect of anger-hostility on pain intensity. Increased vigour was associated with decreased pain intensity and increased the effect of anger-hostility on pain intensity. CONCLUSIONS: Mood states other than anger may influence the association between anger and pain intensity in individuals with chronic pain. It is important to focus on complicated mood states and anger in individuals with chronic pain, including RA.

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Papers, etc., Registered in KOARA 【 Display / hide 】

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Reviews, Commentaries, etc. 【 Display / hide 】

  • ぶらり研究室探訪記4 慶應義塾大学医学部 麻酔学教室

    東條 健太郎, 若泉 謙太

    LiSA (株式会社医学書院)  30 ( 2 ) 210 - 213 2023.02

    ISSN  1340-8836

  • 神経経済学入門 : 痛みの脳科学とは 意思決定のしくみを理解し,最適な治療介入を目指す

    若泉 謙太

    LiSA = リサ : Life support and anesthesia : 周術期管理を核とした総合誌 (株式会社医学書院)  30 ( 1 ) 117 - 124 2023.01

    Lead author, Corresponding author,  ISSN  1340-8836

  • 言語的妥当性を担保した日本語版symptom catastrophizing scale(症状の破局的思考尺度)の作成

    山田 恵子, 若泉 謙太, 壬生 彰, 向後 響, 井関 雅子, 西上 智彦

    麻酔 (克誠堂出版(株))  71 ( 5 ) 554 - 561 2022.05

    ISSN  0021-4892

    　View Summary

    "症状の破局的思考尺度(symptom catastrophizing scale:SCS)"について、国際指針に準拠した手順で日本語翻訳とパイロット調査を行い、言語的な妥当性が担保された日本語版を作成した。今後、日本でもSCSが患者の破局的思考評価や臨床研究に活用されることが期待される。(著者抄録)

  • 「日本ペインクリニック学会第55回学術集会」から得たこと，考えたこと−ハイブリッド型学術集会の参加体験と学会の今後の方向性−

    Kenta Wakaizumi

    ペインクリニック 42 ( 10 ) 1193 - 1198 2021.10

    Lead author, Last author, Corresponding author

  • 言語的妥当性のある日本語版患者心象変化の多面的評価尺度(Multidimensional Evaluation Scale for Patient Impression Change-Japanese version:MPIC-J)の開発

    若泉 謙太, 山田 恵子, 西上 智彦, 壬生 彰, 向後 響, 小杉 志都子, 森崎 浩

    日本ペインクリニック学会誌 ((一社)日本ペインクリニック学会)  28 ( 5 ) 59 - 63 2021.05

    Lead author, Corresponding author,  ISSN  1340-4903

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Presentations 【 Display / hide 】

  • Brain functional network and pain

    Kenta Wakaizumi

    Japanese Society for Spine Surgery and Related Research, 

    2022.04
    , 

    Symposium, workshop panel (nominated)

  • マイクロポンプ搭載、新時代PCAによる3つのやさしさと未来

    若泉 謙太

    日本臨床麻酔学会誌, 

    2021.10
    , 

    Public lecture, seminar, tutorial, course, or other speech, 日本臨床麻酔学会

  • 若手研究者から痛み治療への提言 ペイン・クリニシャンが神経ブロックの有効性を実証するためのデータ・サイエンス

    若泉 謙太

    日本ペインクリニック学会誌, 

    2021.06
    , 

    Symposium, workshop panel (nominated), (一社)日本ペインクリニック学会

  • 痛みの重症度は職場でのアブセンティズムとプレゼンティズムの独立したリスク因子である

    高岡 早紀, 若泉 謙太, 星野 麗子, 本田 あやか, 篠原 佑太, 森崎 浩, 小杉 志都子

    日本ペインクリニック学会誌, 

    2021.06
    , 

    (一社)日本ペインクリニック学会

  • 喫煙と痛みの中枢性感作症候群との関連 疫学的検討

    千葉 聡子, 山田 恵子, 河合 愛子, 濱岡 早枝子, 鈴木 博子, 原 厚子, 若泉 謙太, 山口 敬介, 井関 雅子

    日本ペインクリニック学会誌, 

    2021.06
    , 

    (一社)日本ペインクリニック学会

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Research Projects of Competitive Funds, etc. 【 Display / hide 】

  • 就労制限を来たした慢性疼痛患者の就労支援に寄与する多角的包括的研究

    2022.04
    -
    2025.03

    厚生労働科学研究費, 慢性の痛み政策研究事業, Coinvestigator(s)

  • 在宅勤務下の健康的な生活行動に関する脳神経基盤の検討

    2021.09
    -
    2022.08

    花王健康科学研究会, Principal investigator

  • 非がん性疼痛に対するインターネット支援型認知行動療法の開発と脳科学的機序の検討

    2021.04
    -
    2024.03

    日本学術振興会, 科学研究費助成事業 基盤研究(B), 基盤研究(B), No Setting

  • Development of Japanese version of the multidimensional evaluation scale for patient impression change for non-cancer pain

    2021.04
    -
    2024.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists , Principal investigator

  • AMPA受容体密度を指標とした慢性疼痛患者の痛み定量化バイオマーカー開発研究

    2021.04
    -
    2024.03

    日本医療研究開発機構（AMED）, 慢性の痛み解明研究事業, Coinvestigator(s)

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Awards 【 Display / hide 】

  • 2021年度ペインクリニック学会優秀論文賞（原著臨床部門）

    星野麗子, 本田あやか, 篠原佑太, 石川愛子, 田中智里, 辻収彦, 若泉謙太, 森崎浩, 小杉志都子, 2023.07, Japanese Society for Pain Clinicians, 集学的痛みセンターにおける慢性腰痛・頚部痛の治療反応性ーICD-11に基づく慢性痛分類による比較ー

  • 2021年度ペインクリニック学会優秀論文賞（原著臨床部門）

    本田 あやか, 星野 麗子, 篠原 佑太, 石川 愛子, 田中 智里, 高岡 早紀, 辻 収彦, 西村 大輔, 若泉 謙太, 森崎 浩, 小杉 志都子, 2022.07, Japanese Society for Pain Clinicians, 脊椎由来疼痛の保存的治療における疼痛関連アウトカムに影響する因子の検討

    Type of Award： Honored in official journal of a scientific society, scientific journal

  • Special Paper Award

    Kenta Wakaizumi, 2021.05, The United Japanese researchers Around the world, Psychosocial, functional and emotional correlates of long-term opioid use in chronic back pain patients: a cross-sectional case-control study

    Type of Award： Award from publisher, newspaper, foundation, etc.

  • Best Presenter Award

    Kenta Wakaizumi, 2020.07, The United Japanese researchers Around the world and The Cheiron Initiative, 家族留学のすゝめ

    Type of Award： Award from international society, conference, symposium, etc.,  Country： United States

  • Financial Aid Award

    Kenta Wakaizumi, 2014, International Association for the Study of Pain, Aerobic exercise relieves chronic pain and increases the micro RNA 200b/429 expressions in nucleus accumbens neurons

    Type of Award： Award from international society, conference, symposium, etc.,  Country： Argentina

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Memberships in Academic Societies 【 Display / hide 】

  • Organization for Human Brain Mapping, 

    2018
    -
    2019

  • Society for Neuroscience, 

    2018
    -
    2019

  • International Association for the Study of Pain, 

    2016
    -
    Present

  • 日本疼痛学会, 

    2014
    -
    Present

  • 日本慢性疼痛学会, 

    2014
    -
    Present

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