Kajimura, Mayumi

写真a

Affiliation

School of Medicine (Hiyoshi)

Position

Professor

External Links

Profile 【 Display / hide

  • My research focuses on how various gaseous molecules such as molecular hydrogen (H2), molecular oxygen (O2), NO, H2S, CO2 and CO are sensed in our body. We are particularly interested in the interaction between gaseous molecules and their receptor proteins, gas-sensing proteins and how these gaseous molecules modulate vascular tone in various organs. While the NO signaling has been well-defined, the CO signaling requires further investigation with respect to identifying receptor molecules and their downstream effectors. Like NO, CO has an ability to bind to the ferrous heme of a variety of proteins with high affinity; thus, it is capable of either stimulating or inhibiting catalytic activities of heme proteins. Thus in current studies we are investigating the possibility that CO targets for proteins containing prosthetic heme and by altering their activity it controls the CNS function. We use both in vivo and in vitro systems in parallel to compensate inherent weakness of each model. This requires developing techniques which range from molecular biology, cell biology, protein biochemistry, and single vessel studies to whole animals.

Career 【 Display / hide

  • 1995.11
    -
    1999.09

    Imperial College School of Medicine, London, UK, Section of Cellular & Integrative Biology, Division of Biomedical Sciences, Postdoctoral Researcher (Wellcome trust fellow)

  • 1999.10
    -
    1999.11

    Keio University School of Medicine, Department of Biochemistry, Research Associate

  • 1999.12
    -
    2006.09

    Keio University School of Medicine, Department of Biochemistry, Instructor

  • 2006.10
    -
    2008.12

    Keio University School of Medicine, Department of Biochemistry, Instructor

  • 2009.01
    -
    2012.09

    Keio University School of Medicine, Department of Biochemistry, Assistant Professor

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Academic Background 【 Display / hide

  • 1990.10
    -
    1995.12

    University of California Davis, Graduate School, School of Medicine, Physiology Graduate Group

    United State of America, Graduate School, Completed, Doctoral course

Academic Degrees 【 Display / hide

  • Doctor of Philosophy in Physiology, University of California, Davis (Davis, CA, USA), 1995.12

    The Role of Endothelial Cell-to-Extracellular Matrix Interactions to Modulate Microvessel Permeability after Hypertonic Stress in Single Perfused Microvessels

 

Research Areas 【 Display / hide

  • General medical chemistry (General Medical Chemistry)

  • Pathological medical chemistry

Research Keywords 【 Display / hide

  • Vascular Biology

  • Gaseous mediator

  • Stroke

  • Cerebral metabolism

  • Neuro-vascular coupling

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Research Themes 【 Display / hide

  • The role of gaseous mediators in the regulation of vascular functions and neural function in the central nervous system, 

    1999.10
    -
    Present

     View Summary

    My research focuses on how various gaseous molecules such as molecular oxygen (O2), NO, H2S, CO2 and CO are sensed in our body. We are particularly interested in the interaction between gaseous molecules and their receptor proteins, gas-sensing proteins and how these gaseous molecules modulate vascular tone in various organs. While the NO signaling has been well-defined, the CO signaling requires further investigation with respect to identifying receptor molecules and their downstream effectors. Like NO, CO has an ability to bind to the ferrous heme of a variety of proteins with high affinity; thus, it is capable of either stimulating or inhibiting catalytic activities of heme proteins. Thus in current studies we are investigating the possibility that CO targets for proteins containing prosthetic heme and by altering their activity it controls the CNS function. We use both in vivo and in vitro systems in parallel to compensate inherent weakness of each model. This requires developing techniques which range from molecular biology, cell biology, protein biochemistry, and single vessel studies to whole animals.

 

Papers 【 Display / hide

  • Interactions of multiple gas-transducing systems: hallmarks and uncertainties of CO, NO, and H2S gas biology

    M. Kajimura, R. Fukuda, R. M. Bateman, T. Yamamoto and M. Suematsu

    Antioxid Redox Signal 13 ( 2 ) 157 - 192 2010.07

    Research paper (scientific journal), Joint Work

  • Paradoxical ATP elevation in ischemic penumbra revealed by quantitative imaging mass spectrometry

    K. Hattori, M. Kajimura, T. Hishiki, T. Nakanishi, A. Kubo, Y. Nagahata, M. Ohmura, A. Yachie-Kinoshita, T. Matsuura, T. Morikawa, T. Nakamura, M. Setou and M. Suematsu

    Antioxid Redox Signal 13 ( 8 ) 1157 - 1167 2010.10

    Research paper (scientific journal), Joint Work

  • Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway

    T. Morikawa, M. Kajimura, T. Nakamura, T. Hishiki, T. Nakanishi, Y. Yukutake, Y. Nagahata, M. Ishikawa, K. Hattori, T. Takenouchi, T. Takahashi, I. Ishii, K. Matsubara, Y. Kabe, S. Uchiyama, E. Nagata, M. M. Gadalla, S. H. Snyder and M. Suematsu

    Proc Natl Acad Sci U S A 109 ( 4 ) 1293 - 1298 2012.01

    Research paper (scientific journal), Joint Work

  • Large-area surface-enhanced Raman spectroscopy imaging of brain ischemia by gold nanoparticles grown on random nanoarrays of transparent boehmite

    S. Yamazoe, M. Naya, M. Shiota, T. Morikawa, A. Kubo, T. Tani, T. Hishiki, T. Horiuchi, M. Suematsu and M. Kajimura

    ACS Nano 8 ( 6 ) 5622 - 5632 2014.06

    Research paper (scientific journal), Joint Work

  • Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia

    T. Takenouchi, Y. Sugiura, T. Morikawa, T. Nakanishi, Y. Nagahata, T. Sugioka, K. Honda, A. Kubo, T. Hishiki, T. Matsuura, T. Hoshino, T. Takahashi, M. Suematsu and M. Kajimura

    J Cereb Blood Flow Metab 35 ( 5 ) 794 - 805 2015.05

    Research paper (scientific journal), Joint Work,  ISSN  1559-7016

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Papers, etc., Registered in KOARA 【 Display / hide

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Presentations 【 Display / hide

  • Oxidative stress in no-mediated signaling in experimental diabetic retinopathy

    Schaefer Silke, Kajimura Mayumi, Hanawa Toshihiko, Suematsu Makoto, Watanabe Kenji

    World Congress of Internal Medicine, 2002.05, Poster (general)

  • Oxidative stress in experimental diabetic retinopathy

    Schaefer Silke, Kajimura Mayumi, Kashiba Misato, Watanabe Kenji, Uchida Kouji, Suematsu Makoto

    第72回日本生化学学会大会 (2001), 2001.11

  • 脳微小循環調節機構における一酸化炭素の役割

    Ishikawa Mami,Sekiduka Eiichi,Kajimura Mayumi,Yamaguchi Noriyuki,Terao Satoshi,Kawase Takeshi,Suematsu Makoto

    第26回日本微小循環学会, 2001.02

  • Roles of endogenous carbon monoxide in regulation of soluble guanylate cyclase-mediated nitric oxide sensing for neural transmission in rat retina

    Kajimura Mayumi, Tsuyama Shingo, Ishimura Yuzuru, Suematsu Makoto

    日本微小循環学会, 2001.02

  • NO,COによる可溶性グアニル酸シクラーゼ活性化の可視化

    Suematsu Makoto,Kajimura Mayumi,Tsuyama Shingo,Ishimura Yuzuru

    日本組織細胞化学会シンポジウム「活性酸素の視覚化」, 2000.12

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Research Projects of Competitive Funds, etc. 【 Display / hide

  • Effects of molecular hydrogen on ischemic brain injury

    2019.04
    -
    2022.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 梶村 眞弓, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • ガス分子依存性脳血流代謝カップリング機構の解明:代謝解剖学的アプローチを用いて

    2016.04
    -
    2019.03

    MEXT,JSPS, Grant-in-Aid for Scientific Research, 梶村 眞弓, Grant-in-Aid for Scientific Research (C), Principal Investigator

  • JST戦略的創造研究推進事業 ERATO国際化活動支援

    2015.07
    -
    Present

    Japan Science and Technology Agency,, The Exploratory Research for Advanced Technology (ERATO), Other, Principal Investigator

  • 公益財団法人鈴木謙三記念医科学応用研究財団 二国間学術交流集会開催助成

    2015.06
    -
    Present

    Principal Investigator

  • 定量的質量イメージング技術とオミクス解析技術を用いたがんおよび感染症の包括的解明と医学応用

    2015.04
    -
    2017.03

    島津製作所, 委託研究費, Joint research, Principal Investigator

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Awards 【 Display / hide

  • August Krogh Young Investigator Award

    2004.04, Microcirculatory Society (USA)

  • Selected for the 50th Anniversary Historical Poster

    2004.04, American Physiology Society/The Microcirculatory Society

  • International Fellowship

    1993.10, American Association of University Women

  • Regents Fellowship

    1992.10, University of California

  • August Krogh Young Investigator Award

    1998.04, The Microcirculatory Society (USA)

    Type of Award: International Academic Awards

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Courses Taught 【 Display / hide

  • LABORATORY OF BIOLOGY

    2019

  • BIOLOGY1

    2019

  • BIOLOGY

    2019

  • BIOCHEMISTRY

    2019

  • ADVANCED COURSE OF BIOLOGY

    2019

Courses Previously Taught 【 Display / hide

  • 生理学実習インストラクター

    カリフォルニア大学デイビス校, 2018

  • 神経生理学実習インストラクター 理学部4年

    カリフォルニア大学デイビス校 大学院修士課程, 2018

  • 理学部4年

    看護短期大学1年, 2018

  • 生化学セミナー

    慶應義塾大学医学部2年, 2018

  • 医化学実習コーディネーター

    慶應義塾大学医学部, 2018

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Memberships in Academic Societies 【 Display / hide

  • 日本生化学会, 

    2000.01
    -
    Present
  • The American Physiological Society, 

    1999.01
    -
    Present
  • 日本微小循環学会, 

    1998.02
    -
    Present

Committee Experiences 【 Display / hide

  • 2012.10
    -
    2016.03

    学務委員会委員, 慶應義塾大学医学部

  • 2011.10
    -
    2015.09

    自主学習委員会委員, 慶應義塾大学医学部

  • 2011.04
    -
    2015.09

    国際センター学生交換・在外研修委員会委員, 慶應義塾大学

  • 2010.02
    -
    Present

    国際交流委員長, 日本微小循環学会

     View Remarks

    Secretary General, The 10th World Congress for Microcirculation (2015, kyoto)

  • 2009.04
    -
    2015.03

    動物実験運営委員会委員, 慶應義塾大学医学部

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