Details of a Researcher - Inoue, Hiroyoshi

Papers - Inoue, Hiroyoshi

Division display >> ／ All the affair displays 1 - 126 of about 126

Chemoenzymatic semisynthesis of caffeic acid β-phenethyl ester, an antioxidative component in propolis, from raw coffee bean extract

Hashimoto R, Iai H, Fujita R, Hanaya K, Higashibayashi S, Inoue H, Sugai T

Bioscience, biotechnology, and biochemistry (Bioscience, biotechnology, and biochemistry) 85 ( 3 ) 476 - 480 2021.02

Joint Work, ISSN 0916-8451

Caffeic acid β-phenethyl ester (CAPE), an antioxidative bioactive catechol isolated from propolis, was semisynthesized from chlorogenic acid and related compounds in an extract of raw (unroasted) Robusta coffee (Coffea canephora) beans in 5 steps and a total yield of 31%. Oxidative degradation of the intermediates and target molecule was prevented by alkaline hydrolysis of the chlorogenic acids in the presence of sodium dithionite (Na2S2O4) and deprotection of the catecholic diacetate precursor by Candida antarctica lipase B-mediated transesterification as the final step.

Access to Document (DOI)

バナナの長期摂取がヒト腸内フローラおよび血液生化学に与える効果の研究　ランダム化並行群間比較試験

伊藤明子, 石川大仁, 井上浩義

薬理と治療 (ライフサイエンス出版(株)) 49 ( 2 ) 259 - 269 2021.02

ISSN 0386-3603

健常成人男女を対象に、バナナを4週間連続摂取したときの腸内フローラ、ビタミンB6の変化、血液中の脂質、電解質、糖代謝マーカー、微量栄養素の変化を調べた。試験参加者の体組成についてバナナ摂取群と非摂取群いずれも有意な変化はみられなかったものの、バナナ摂取群のうちBMI上位(BMI≧24)者において統計学的に有意にBMIが減少した。ビタミンB6は、バナナ摂取群、非摂取群いずれにおいても有意な変化はみられなかった。収縮期血圧では、バナナ摂取群と非摂取群の群間差で4週間の摂取介入後に、バナナ摂取群が有意に減少していた。最終糖化産物は両群いずれにおいても有意な変化はみられなかった。腸内細菌叢を次世代シークエンサー法で調べた結果、バナナ摂取群でいくつかの有用な細菌叢の増加、望ましくないと考えられている細菌叢の減少がみられた。安全性評価のための血液検査の結果では、バナナ摂取群でクレアチニンが有意に上昇し、介入後の群間比較でもバナナ群のクレアチニンが上昇していた。またバナナ群において尿酸が有意に上昇していた。HbA1cがバナナ群も非摂取群も両方の群において上昇していた。塩素が介入前の時点でバナナ摂取群のほうが非摂取群よりも有意に高かったものの、4週間の試験期間後に非摂取群で有意に上昇していた。さらに、マグネシウムがバナナ摂取群で有意に上昇していた。

ヨーグルトおよびすりごまの長期摂取がアレルギー性鼻炎・アレルギー性結膜炎による目や鼻の不快感に与える効果の研究　ランダム化並行群間比較試験

伊藤明子, 渡邊恵梨子, 岡村晶子, 石川大仁, 井上浩義

薬理と治療 (ライフサイエンス出版(株)) 48 ( 11 ) 1961 - 1974 2020.11

ISSN 0386-3603

ヨーグルトとすりごまの4週間摂取がアレルギー性鼻炎・アレルギー性結膜炎症状に及ぼす変化を評価した。30歳以上60歳未満の健常者43名を、1日にヨーグルト200gとすりごま大さじ2杯(約16g)を合わせて摂取する群、ヨーグルト200g摂取群、非摂取群に割り付け、介入前後の症状、血中アレルギー項目、腸内フローラの変化を調査した。その結果、ヨーグルトとすりごまを摂取した群ではアレルギー性鼻炎・アレルギー性結膜炎の自覚的症状が有意に改善し、腸内フローラの組成が変化していくつか有益な細菌叢が増加しており、特異的IgEのカバ(樺)への反応が有意に低下していた。また、CD陽性のヘルパーT細胞1とヘルパーT細胞2の比率はすべての群で有意に低下しており、ヨーグルトやすりごま摂取に起因する有害事象は認めなかった。

A dipping method for radioactivity measurement in water using plastic scintillator

Furuta E, Akiyama K, Inoue H, Kataoka Y, Sensui M

Journal of Radioanalytical and Nuclear Chemistry (Journal of Radioanalytical and Nuclear Chemistry) 324 ( 1 ) 109 - 122 2020.04

Joint Work, ISSN 02365731

A new dipping method was studied for the measurement of radioactive solution using plastic scintillator sheets and pellets (PSs) and a liquid scintillation counter. The method consists of analyzing the PSs dipped into test solution composed of nine compounds with five different radionuclides, and measuring them by using the ‘in solution’ and ‘without solution’ method. A qualitative analysis based on the obtained spectra and a quantitative analysis by using the empirical linear relationships between radioactivity and count rate were possible. Minimum detectable activities of this method were calculated and compared with World Health Organization guidelines for drinking water.

Access to Document (DOI)

A novel HIF inhibitor halofuginone prevents neurodegeneration in a murine model of retinal ischemia-reperfusion

Kunimi H, Miwa Y, Inoue H, Tsubota K, Kurihara T

International Journal of Molecular Sciences (International Journal of Molecular Sciences) 20 ( 13 ) 2019.07

Joint Work, ISSN 16616596

Neurodegeneration caused with retinal ischemia or high intraocular pressure is irreversible in general. We have focused on the role of hypoxia-inducible factor (HIF) in retinal homeostasis and revealed that HIF inhibition may be effective against retinal neovascular and neurodegeneration. In this study, we performed in vitro screening of natural products and found halofuginone, which is a derivative of febrifugine extracted from hydrangea, as a novel HIF inhibitor. Administration of halofuginone showed a significant neuroprotective effect by inhibiting HIF-1α expression in a murine retinal ischemia-reperfusion model histologically and functionally. These results indicate that halofuginone can be a neuroprotective agent in ischemic retinal degenerative diseases.

Access to Document (DOI)

Integral role of receptor for advanced glycation end products (RAGE) in nondiabetic atherosclerosis

Uekita H, Ishibashi T, Shiomi M, Koyama H, Ohtsuka S, Yamamoto H, Yamagishi S, Inoue H, Itabe H, Sugimoto K, Kamioka M, Ohkawara H, Wada I, Yasuchika T

Fukushima journal of medical science (Fukushima journal of medical science) 65 ( 3 ) 109 - 121 2019

Joint Work, ISSN 0016-2590

An advanced glycation end products (AGE)/a receptor for AGE (RAGE) axis plays a central role in the pathogenesis of diabetic vascular remodeling. This study was conducted to clarify the role of RAGE in nondiabetic atherosclerosis. We used the aortic and coronary atherosclerotic lesions of Watanabe heritable hyperlipidemic (WHHL) rabbits prone to myocardial infarction (WHHLMI) at 1 to 14 months. Immunohistochemistry demonstrated the significant expression of RAGE as early as at 1 month with the stronger expression at 3 and 7 months, which was remarkably diminished at 14 months. RAGE expression was concordant with AGE accumulation. The major original sources of RAGE expression were macrophages and smooth muscle cells in addition to endothelial cells, and RAGE expression was distributed in the areas of phospholipid products, a component of oxidized LDL and nitrotyrosine. The concentrations of serum AGE did not alter significantly with aging. These findings suggested the expression of RAGE was induced by hyperlipidemia and oxidative stress independent of diabetes in WHHLMI rabbits. Additionally, our in vitro study showed that silencing of RAGE tended to attenuate oxidized-LDL-triggered PAI-1 expression in human cultured macrophages, as well as oxidized-LDL-induced tissue factor expression in peritoneal macrophages, suggesting a possible role of RAGE in prothrombogenic molecular regulation. In conclusion, the present study provides in vivo evidence that RAGE plays an integral role in the initiation and progression of nondiabetic atherosclerosis, suggesting that RAGE may be a novel target for treating not only diabetic but also nondiabetic vascular complications.

Access to Document (DOI)

Synthesis of enantiomerically enriched drug precursors and an insect pheromone via reduction of ketones using commercially available carbonyl reductase screening kit “Chiralscreen® OH”

Nagai T, Sakurai S, Natori N, Hataoka M, Kinoshita T, Inoue H, Hanaya K, Shoji M, Sugai T

Bioorganic and Medicinal Chemistry (Bioorganic and Medicinal Chemistry) 26 ( 7 ) 1304 - 1313 2018.04

Joint Work, ISSN 09680896

Commercially available “Chiralscreen® OH” starter kit containing five types of carbonyl reductases (E001, E007, E031, E039, and E078) was used for the reduction of several aromatic and aliphatic ketones to obtain enantiomerically enriched drug precursors and an insect pheromone. Almost stereochemically pure secondary alcohols, used in the synthesis of drugs such as (R)-rasagiline mesylate, (S)-rivastigmine, (R)-chlorphenesin carbamate, and (R)-mexiletine, and the insect pheromone (4S,5R)-sitophilure, were conveniently obtained. The enzymes worked well with ketones containing at least one non-bulky substituent at the carbonyl group. The diverse stereochemical preference of the above five carbonyl reductases was clarified.

Access to Document (DOI)

Development of a functional thyroid model based on an organoid culture system

Saito Y, Onishi N, Takami H, Seishima R, Inoue H, Hirata Y, Kameyama K, Tsuchihashi K, Sugihara E, Uchino S, Ito K, Kawakubo H, Takeuchi H, Kitagawa Y, Saya H, Nagano O

Biochemical and Biophysical Research Communications (Biochemical and Biophysical Research Communications) 497 ( 2 ) 783 - 789 2018.03

Joint Work, ISSN 0006291X

The low turnover rate of thyroid follicular cells and the lack of a long-term thyroid cell culture system have hampered studies of thyroid carcinogenesis. We have now established a thyroid organoid culture system that supports thyroid cell proliferation in vitro. The established mouse thyroid organoids performed thyroid functions including thyroglobulin synthesis, iodide uptake, and the production and release of thyroid hormone. Furthermore, transplantation of the organoids into recipient mice resulted in the formation of normal thyroid–like tissue capable of iodide uptake and thyroglobulin production in vivo. Finally, forced expression of oncogenic NRAS (NRAS ) in thyroid organoids established from p53 knockout mice and transplantation of the manipulated organoids into mouse recipients generated a model of poorly differentiated thyroid cancer. Our findings suggest that this newly developed thyroid organoid culture system is a potential research tool for the study of thyroid physiology and pathology including thyroid cancer. Q61R

Access to Document (DOI)

Ezetimibe reduces urinary albumin excretion in hypercholesterolemic type 2 diabetic patients with microalbuminuria.

INOUE Hiroyoshi

J Int Med Res 40 ( 2 ) 798-803 2012

Research paper (scientific journal), Joint Work, Accepted

Statins and hemoperfusion improve 28-day survival in septic shock patients.

INOUE Hiroyoshi

Central European Journal of Medicine 7 ( 4 ) 475-480 2012

Research paper (scientific journal), Joint Work, Accepted

Selenium Compound Protects Corneal Epithelium against Oxidative Stress.

INOUE Hiroyoshi

PLoS One 7 ( 9 ) e45612 2012

Research paper (scientific journal), Joint Work, Accepted

放射性物質の除染技術

INOUE Hiroyoshi

HEDORO 115 ( 9 ) 14-19 2012

Research paper (scientific journal), Joint Work, Accepted

放射線障害の機構

INOUE Hiroyoshi

日本抗加齢医学会雑誌 7 ( 5 ) 671-675 2011

Research paper (scientific journal), Joint Work, Accepted

低線量放射線と疫学調査

INOUE Hiroyoshi

日本抗加齢医学会雑誌 7 ( 5 ) 682-685 2011

Research paper (scientific journal), Joint Work, Accepted

Metal ion and vitamin adsorption profiles of phosphate binder ion-exchange resins

K.Takagi, K.Masuda, M.Yamazaki, C.Itoh, M.Wasaki, INOUE Hiroyoshi

Clinical Nephrology 73 ( 1 ) 30-35 2010

Research paper (other academic), Joint Work, Accepted

Serum level of pigment epithelium derived factor (PEDF) is an independent determinant of resting heart rate in Japanese subjects.

INOUE Hiroyoshi

Int J Cardiol. 136 ( 2 ) 245-7 2009.08

Research paper (scientific journal), Joint Work, Accepted

Serum levels of pigment epithelium-derived factor (PEDF) are positively associated with visceral adiposity in Japanese patients with type 2 diabetes.

INOUE Hiroyoshi

Diabetes Metab Res Rev. 25 ( 1 ) 52-56 2009

Research paper (scientific journal), Joint Work, Accepted

Pigment epithelium-derived factor (PEDF) prevents platelet activation and aggregation in diabetic rats by blocking deleterious effects of advanced glycation end-products (AGEs).

INOUE Hiroyoshi

Diabetes Metab Res Rev. 25 ( 3 ) 266-271 2009

Research paper (scientific journal), Joint Work, Accepted

PET検査施設における放射線被ばく管理．

IINO Yasuyo, INOUE Hiroyoshi

久留米大学医学部放射性同位元素施設紀要 6 1-4 2008

Research paper (bulletin of university, research institution), Joint Work

Olmesartan Blocks Inflammatory Reactions in Endothelial Cells Evoked by Advanced Glycation End Products by Suppressing Generation of Reactive Oxygen Species.

INOUE Hiroyoshi

Ophthalmic Res. 40 ( 1 ) 10-15 2008

Research paper (scientific journal), Joint Work, Accepted

Circulating advanced glycation end products (AGEs) and soluble form of receptor for AGEs (sRAGE) are independent determinants of serum monocyte chemoattractant protein-1 (MCP-1) levels in patients with type 2 diabetes.

INOUE Hiroyoshi

Diabetes Metab Res Rev. 24 ( 2 ) 109-114 2008

Research paper (scientific journal), Joint Work, Accepted

Olmesartan blocks advanced glycation end products (AGEs)-induced angiogenesis in vitro by suppressing receptor for AGEs (RAGE) expression.

INOUE Hiroyoshi

Microvasc Res. 75 ( 1 ) 130-134 2008

Research paper (scientific journal), Joint Work, Accepted

A novel secreted protease from Pseudomonas aeruginosa activates NF-kappaB through protease-activated receptors.

INOUE Hiroyoshi

Cell Microbiol. 10 ( 7 ) 1491-1504 2008

Research paper (scientific journal), Joint Work, Accepted

Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with type 2 diabetes.

INOUE Hiroyoshi

Microvasc Res. 76 ( 1 ) 52-56 2008

Research paper (scientific journal), Joint Work, Accepted

アポラクトフェリンと終末糖化産物（AGEｓ）

INOUE Hiroyoshi

食品工業 51 ( 12 ) 26-31 2008

Research paper (scientific journal), Single Work

親子で育む原子力・放射線の理解－教育コンテンツから教育機会・教育環境の整備の時代へ

INOUE Hiroyoshi

広領域教育 70 7-18 2008

Research paper (scientific journal), Single Work

Telmisartan inhibits advanced glycation end-products (AGEs)-elicited endothelial cell injury by suppressing AGE receptor (RAGE) expression via peroxisome proliferator-activated receptor-gammaactivation.

INOUE Hiroyoshi

Protein Pept Lett 15 ( 8 ) 850-853 2008

Research paper (scientific journal), Joint Work

生体分子認識－放射性物質と非放射性物質の利用－.

INOUE Hiroyoshi

久留米医学会雑誌 70 ( 6-7 ) 171-177 2007

Research paper (scientific journal), Single Work, Accepted

A novel pleiotropic effect of atorvastatin on advanced glycation end product (AGE)-related disorders.

INOUE Hiroyoshi

Med Hypoyheses 69 ( 2 ) 338-340 2007

Research paper (scientific journal), Joint Work, Accepted

In vitro selection of DNA aptamers that block toxic effects of AGE on cultured retinal pericytes.

INOUE Hiroyoshi

Microvasc Res. 74 65-69 2007

Research paper (scientific journal), Joint Work, Accepted

Nifedipine, a calcium-channel blocker, inhibits advanced glycation end-product-induced expression of monocyte chemoattractant protein-1 in human cultured mesangial cells.

INOUE Hiroyoshi

J Int Med Res. 35 ( 1 ) 107-112 2007

Research paper (scientific journal), Joint Work, Accepted

Oral administration of AST-120 (Kremezin) is a promising therapeutic strategy for advanced glycation end product (AGE)-related disorders.

INOUE Hiroyoshi

Med Hypotheses 69 ( 3 ) 666-668 2007

Research paper (scientific journal), Joint Work, Accepted

Pigment-epithelium-derived factor suppresses expression of receptor for advanced glycation end products in the eye of diabetic rats.

INOUE Hiroyoshi

Opthalmic Res. 39 ( 2 ) 92-97 2007

Research paper (scientific journal), Joint Work, Accepted

Extracellular Ca2+ uptake by T cells might help to make a diagnosis of acute rejection.

INOUE Hiroyoshi

Pediatr Sug Int. 23 ( 2 ) 149-153 2007

Research paper (scientific journal), Joint Work, Accepted

Serratia marcescens serralysin induces inflammatory responses through protease-activated receptor 2.

INOUE Hiroyoshi

Infect Immun. 75 ( 1 ) 164-174 2007

Research paper (scientific journal), Joint Work, Accepted

Hydrogen peroxide stimulates pigment epithelium-derived factor gene and protein expression in the human hepatocyte cell line OUMS-29.

INOUE Hiroyoshi

J Int Med Res. 35 ( 3 ) 427-432 2007

Research paper (scientific journal), Joint Work, Accepted

液体イオン交換膜を用いた放射性物質の濃縮処理－評価理論－．

INOUE Hiroyoshi

久留米大学医学部放射性同位元素施設紀要 5 1-4 2007

Research paper (bulletin of university, research institution), Single Work

糖尿病診断後の網膜症治療状況の実態調査.

INOUE Hiroyoshi

日本糖尿病教育・看護学会誌 11 ( 2 ) 150-156 2007

Research paper (scientific journal), Joint Work, Accepted

Pigment epithelium-derived factor inhibits vascular endothelial growth factor-induced vascular hyperpermeability both in vitro and in vivo.

INOUE Hiroyoshi

J Int Med Res. 35 ( 6 ) 896-899 2007

Research paper (scientific journal), Joint Work, Accepted

Bay w 9798, a dihydropyridine structurally related to nifedipine with no calcium channel-blocking properties, inhibits tumour necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in endothelial cells by suppressing reactive oxygen species generation.

INOUE Hiroyoshi

J Int Med Res. 35 ( 6 ) 886-891 2007

Research paper (scientific journal), Joint Work, Accepted

Telmisartan, an angiotensin II type 1 receptor blocker, inhibits advanced glycation end-product (AGE)-induced monocyte chemoattractant protein-1 expression in mesangial cells through downregulation of receptor for AGEs via peroxisome proliferator-activated receptor-gamma activation.

INOUE Hiroyoshi

J Int Med Res. 35 ( 4 ) 482-489 2007

Research paper (scientific journal), Joint Work, Accepted

放射線取扱主任者受験講座の試み.

INOUE Hiroyoshi

Isotope News. 6 29-31 2006

Research paper (scientific journal), Single Work, Accepted

Pleiotropic effects of nifedipine on atherosclerosis.

INOUE Hiroyoshi

Curr Pharma Design 12 ( 12 ) 1543-1547 2006

Research paper (scientific journal), Joint Work, Accepted

Pigment epithelium-derived factor (PEDF) inhibits angiotensin-II0induced vascular endothelial growth factor (VEGF) expression in MOLT-3 T cells through anti-oxidative properties.

INOUE Hiroyoshi

Microvasc. Res. 71 222-226 2006

Research paper (scientific journal), Joint Work, Accepted

Role of insulin-sensitizing property of telmisartan, a cooercially available angiotension II type 1 recepteor blocker in preventing the development of atrial fibrillation.

INOUE Hiroyoshi

Med Hypotheses 66 118-120 2006

Research paper (scientific journal), Joint Work, Accepted

強イオン性陰イオン交換濾紙膜を用いた放射性テクネチウム廃水処理.

INOUE Hiroyoshi

久留米大学医学部放射性同位元素施設紀要 4 1-6 2006

Research paper (bulletin of university, research institution), Single Work

Pigment epithelium-derived factor (PEDF) inhibits advanced glycation end product-induced retinal vascular permeability by blocking reactive oxygen species-mediated vascular endothelial growth factor (VEGF) expression.

INOUE Hiroyoshi

J Biol Chem. 281 20213-20220 2006

Research paper (scientific journal), Joint Work, Accepted

Azelnidipine, a new long-acting calcium-channel blocker, inhibits tumor necrosis factor-alpha-induced monocyte chemoattractant protein-1 expression in endothelial cells.

INOUE Hiroyoshi

J Int Med Res. 34 ( 6 ) 671-675 2006

Research paper (scientific journal), Joint Work, Accepted

Acarbose, an alpha-glucose inhibitor, decreases aortic gene expression and serum levels of monocyte chemoattractant protein-1 in fructose-fed rats.

INOUE Hiroyoshi

J Int Med Res. 34 ( 5 ) 525-530 2006

Research paper (scientific journal), Joint Work, Accepted

Pigment epithelium-derived factor (PEDF) blocks angiotensin II-induced T cell proliferation by suppressing autocrine production of interleukin-2.

INOUE Hiroyoshi

Med Chem. 2 ( 3 ) 265-269 2006

Research paper (scientific journal), Joint Work, Accepted

Pigment epithelium-derived factor (PEDF) blocks angiotensin II-induced T cell adhension to endothelial cells by suppressing intercellular adhesion molucule-1.

INOUE Hiroyoshi

Horm Metab Res. 38 ( 8 ) 546-548 2006

Research paper (scientific journal), Joint Work, Accepted

Pigment epithelium-derived factor (PEDF) blocks the interleukin-6 signaling to C-reactive protein expression in Hep3B cells by suppressing Rac-1 activation.

INOUE Hiroyoshi

Life Sci. 79 ( 21 ) 1981-1987 2006

Research paper (scientific journal), Joint Work, Accepted

原子力・放射線教育におけるインターネットの活用　－原子力図書館「げんしろう」へのコンテンツ提供－．

INOUE Hiroyoshi

広領域教育 62 6-15 2006

Research paper (scientific journal), Single Work, Accepted

原子力・放射線の記述に関する教科書調査．

INOUE Hiroyoshi

広領域教育 62 16-26 2006

Research paper (scientific journal), Single Work, Accepted

DNAアプタマーを用いた糖尿病血管合併症診断キット．

INOUE Hiroyoshi

バイオインダストリー 23 ( 5 ) 38-45 2006

Research paper (scientific journal), Single Work, Accepted

Renoprotective effects of azelnidipine, a dihydropyridine-based calcium antagonist in advanced glycation end product (AGE)-injected rats.

INOUE Hiroyoshi

Int J Tissue React. 27 ( 3 ) 137-143 2005

Research paper (scientific journal), Joint Work, Accepted

Azelnidipine, a dihydropyridine-based calcium antagonist, inhibits angiotensin II-induced oxidative stress generation and down-regulation of pigment epithelium-derived factor (PEDF) mRNA levels in microvascular endothelial cells.

INOUE Hiroyoshi

Drugs Exp Clin Res. 31 ( 5-6 ) 215-219 2005

Research paper (scientific journal), Joint Work, Accepted

Pigment epithelium-derived factor (PEDF) is a pericyte mitogen secreted by microvascular endothelial cells: A possible participation of angiotensin II-elicited PEDF down-regulation in diabetic retinopathy.

INOUE Hiroyoshi

Int J Tissue Reactions 27 ( 4 ) 197-202 2005

Research paper (scientific journal), Joint Work, Accepted

Acarbose, an α-glucosidase inhibitor, improves insulin resisitance in fructose-fed rat.

INOUE Hiroyoshi

Drugs Exp Clin Res. 31 ( 4 ) 155-159 2005

Research paper (scientific journal), Joint Work, Accepted

Inhibition by advanced glycation end products (AGEs) of pigment epithelium-derived factor (PEDF) gene expression in microvascular endothelial cells.

INOUE Hiroyoshi

Drugs Exp Clin Res. 31 ( 5-6 ) 227-232 2005

Research paper (scientific journal), Joint Work, Accepted

Possible partition of advanced glycation end products (AGEs) in the pathogenesis of osteoporosis in diabetic patients.

INOUE Hiroyoshi

Med Hypotheses 65 1013-1015 2005

Research paper (scientific journal), Joint Work, Accepted

Angiotensin II augments advanced glycation end-product-induced pericyte apoptosis through RAGE overexpression.

INOUE Hiroyoshi

FEBS Letter 579 4265-4270 2005

Research paper (scientific journal), Joint Work, Accepted

Therapeutic potentials of unicellular green alga chlorella in advanced glycation end product (AGE)-related disorders.

INOUE Hiroyoshi

Med Hypotheses 65 935-955 2005

Research paper (scientific journal), Joint Work, Accepted

Acarbose is promissing therapeutic strategy for the treatment of patients with nonalcholic steatohepatitis (NASH).

INOUE Hiroyoshi

Med Hypotheses 65 377-379 2005

Research paper (scientific journal), Joint Work, Accepted

Olmesartan medoxomil, a newly developed Angiotensin II Type 1 receptor antagonist, protects against renal damage in advanced glycation end product (AGE)-injected rats.

INOUE Hiroyoshi

Drug Exptl Clin Res. 31 ( 2 ) 45-51 2005

Research paper (scientific journal), Joint Work, Accepted

Unique athoroprotective property of azelnidipine, a dihydropyridine-based calcium antagonist.

INOUE Hiroyoshi

Med Hypotheses 65 155-157 2005

Research paper (scientific journal), Single Work

Possible participation of advanced glycation end products in the pathogenesis of colorectal cancer in diabetic patients.

INOUE Hiroyoshi

Med Hypotheses 64 1208-1210 2005

Research paper (scientific journal), Joint Work, Accepted

Pigment epithelium-derived factor (PEDF) inhibits oxidative stress-induced apoptosis and dysfunction of cultured retinal pericytes.

INOUE Hiroyoshi

Microvasc Res. 69 45-55 2005

Research paper (scientific journal), Joint Work, Accepted

Serum or cerebrospinal fluid levels of glyceraldehydde-derived advanced glycation end products (AGEs) may be a promising biomarker for early detection of Alzheimer’s disease.

INOUE Hiroyoshi

Med Hypotheses 64 1205-1207 2005

Research paper (scientific journal), Joint Work, Accepted

Met72Thr polymorphism of pigment epithelium-derived factor gene and susceptibility to age-related macular degeneration.

INOUE Hiroyoshi

Med Hypotheses 64 1202-1204 2005

Research paper (scientific journal), Joint Work, Accepted

放射線教育教材の開発と教育実践例.

INOUE Hiroyoshi

科教研報 20 ( 3 ) 49-54 2005

Research paper (scientific journal), Joint Work, Accepted

IT技術を用いたオンライン放射線教材.

INOUE Hiroyoshi

RADIOISOTOPES 54 67-72 2005

Research paper (scientific journal), Single Work, Accepted

電気浸透隔膜法を用いた廃棄ホエイからの新規ラクトフェリン抽出方法.

INOUE Hiroyoshi

Milk Science 53 ( 4 ) 242-243 2005

Research paper (scientific journal), Joint Work, Accepted

運動負荷時に放出されるラクトフェリンとその役割.

INOUE Hiroyoshi

Milk Science 53 ( 4 ) 323-324 2005

Research paper (scientific journal), Joint Work, Accepted

強イオン性陰イオン交換濾紙膜を用いた放射性ヨウ素廃水処理Ⅲ.

INOUE Hiroyoshi

久留米大学医学部放射性同位元素施設紀要 3 1-7 2005

Research paper (bulletin of university, research institution), Single Work

放射線教育:オフスクール学習からオンスクール学習への展開.

INOUE Hiroyoshi

広領域教育 59 56-58 2005

Research paper (scientific journal), Single Work, Accepted

電気浸透隔膜法によるラクトフェリンの抽出.

INOUE Hiroyoshi

ジャパンフードサイエンス 44 ( 3 ) 58-62 2005

Research paper (scientific journal), Single Work, Accepted

どこでも放射線教育-コラボレーション活動-.

INOUE Hiroyoshi

ISOTOPE NEWS 6 18-20 2005

Research paper (scientific journal), Joint Work, Accepted

インドにおける放射線教育事情と教育実践.

INOUE Hiroyoshi

Isotope News. 11 34-38 2005

Research paper (scientific journal), Single Work, Accepted

INOUE Hiroyoshi

Protein Pept Lett. 15 ( 8 ) 850-853 2005

Research paper (scientific journal), Single Work

脱！糖尿病宣言

INOUE Hiroyoshi

はぴねすくらぶ 27 13-16 2005

Research paper (scientific journal), Single Work, Accepted

放射線教育におけるコラボレーション

INOUE Hiroyoshi

久留米大学医学部放射性同位元素施設紀要 3 8-10 2005

Research paper (scientific journal), Single Work, Accepted

Effects of supersonic treatment on lactoferrin separation from whey using reversed micellar system.

INOUE Hiroyoshi

Environ Protection Eng. 31 ( 3-4 ) 5-12 2005

Research paper (scientific journal), Joint Work, Accepted

Design of New Phosphate Binder, Anion Exchange Resin, based on Microcalorimeter Measurements.

INOUE Hiroyoshi

Lett. Drug Design & Discovery 2 ( 3 ) 250-254 2005

Research paper (scientific journal), Joint Work, Accepted

Removal of pertechnatate ion, 99mTcO4-, from radioactive waste using exchange paper membrane.

INOUE Hiroyoshi

Environ Protection Eng. 31 ( 3-4 ) 119-126 2005

Research paper (scientific journal), Joint Work, Accepted

強イオン性陰イオン交換濾紙膜を用いた放射性ヨウ素排水処理Ⅱ.

INOUE Hiroyoshi

久留米大学医学部放射性同位元素施設紀要 2 1-9 2004

Research paper (bulletin of university, research institution), Joint Work

Radioactive Iodine Waste Treatment using Electrodialysis with an Anion Exchange Paper Membrane.

INOUE Hiroyoshi

Appl. Radiat. Isotopes 61 ( 6 ) 1189-1193 2004

Research paper (scientific journal), Joint Work, Accepted

Effects of Co-ions on Transport of Iodide Ions through a Non Conventional Anion Exchange Paper Membrane.

INOUE Hiroyoshi

J. Membrane Sci. 228 209-215 2004

Research paper (scientific journal), Single Work, Accepted

Blood Lactoferrin Release Induced by Running Exercise in Normal Volunteers: Antibacterial Activity.

INOUE Hiroyoshi

Clinica Chimica Acta 341 165-172 2004

Research paper (scientific journal), Joint Work, Accepted

科学技術体験活動「放射線を知っていますか？」.

INOUE Hiroyoshi

ISOTOPE　NEWS 12 14-17 2003

Research paper (scientific journal), Single Work, Accepted

Radioactive iodide and chloride transport across a paper membrane bearing trimethylhydroxypropyl ammonium anion exchange groups.

INOUE Hiroyoshi

J. Membrane Sci. 222 53-57 2003

Research paper (scientific journal), Single Work, Accepted

Removal of Sodium Ion from Bile Acid Solution using Diffusional Dialysis with Cation Exchange Membrane.

INOUE Hiroyoshi

Separation and Purif Technol. 33 189-197 2003

Research paper (scientific journal), Single Work, Accepted

Adsorption of Dietary Phosphate in Gut with Anion Exchange Resin.

INOUE Hiroyoshi

J Ion Exchange 14 57-60 2003

Research paper (scientific journal), Joint Work, Accepted

Pigment epithelium-derived factor inhibits leptin-induced angiogenesis by suppressing vascular endothelial growth factor gene expression through anti-oxidative properties.

INOUE Hiroyoshi

Microvasc. Res. 65 ( 3 ) 186-190 2003

Research paper (scientific journal), Joint Work, Accepted

Angiotensin II-type 1 receptor interaction upregulates vascular endothelial growth factor messenger RNA levels in retinal pericytes through intracellular reactive oxygen species generation.

INOUE Hiroyoshi

Drugs Exp. Clin. Res. 29 ( 2 ) 75-80 2003

Research paper (scientific journal), Joint Work, Accepted

強イオン性陰イオン交換濾紙膜を用いた放射性ヨウ素排水処理Ⅰ.

INOUE Hiroyoshi

久留米大学医学部放射性同位元素施設紀要 1 1-12 2003

Research paper (bulletin of university, research institution), Single Work

医学部放射性同位元素施設における放射性廃棄物.

INOUE Hiroyoshi

久留米大学医学部放射性同位元素施設紀要 1 16-18 2003

Research paper (bulletin of university, research institution), Joint Work

今後のリン排泄促進・吸収阻害薬.

INOUE Hiroyoshi

腎と透析 55 ( 6 ) 941-944 2003

Research paper (scientific journal), Single Work, Accepted

教育機関附属RI施設におけるISO14001.

INOUE Hiroyoshi

ISOTOPE　NEWS 1 16-17 2002

Research paper (scientific journal), Single Work, Accepted

Transport of 125I and 36Cl across an Anion-Exchange Paper Membrane.

INOUE Hiroyoshi

Appl. Radiat. Isotopes 56 ( 5 ) 659-665 2002

Research paper (scientific journal), Single Work, Accepted

トリメチルヒドロキシプロピルアミノ基を有する陰イオン交換濾紙膜による放射性廃液からの125Iの分離

INOUE Hiroyoshi

RADIOISOTOPES 51 ( 1 ) 19-25 2002

Research paper (scientific journal), Joint Work, Accepted

紫外線B波によるヒトリンパ球急性障害

INOUE Hiroyoshi

生物教育 42 ( 3 ) 136-140 2002

Research paper (scientific journal), Single Work, Accepted

中学生を対象とした科学技術体験活動「放射線を知っていますか？」.

INOUE Hiroyoshi

ISOTOPE　NEWS 5 16-18 2002

Research paper (scientific journal), Joint Work, Accepted

各国の放射性廃水管理事情.

INOUE Hiroyoshi

ISOTOPE　NEWS 3 31-33 2002

Research paper (scientific journal), Single Work, Accepted

Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitor.

INOUE Hiroyoshi

Bioorg. Med. Chem. Lett. 11 ( 7 ) 879-882 2001

Research paper (scientific journal), Joint Work, Accepted

Influence of Glucose and Urea on 125I Transport across Anion Exchange Paper Membrane.

INOUE Hiroyoshi

Appl. Radiat. Isotopes 54 ( 4 ) 595-602 2001

Research paper (scientific journal), Single Work, Accepted

Ethylene Glycol Dimethacrylate Cross-linking Anion Exchange Resin as phosphate binder: Effects on Rat Gut and Digestion by Small Intestine contents.

INOUE Hiroyoshi

Int. J. Artif. Organs 24 ( 6 ) 397-404 2001

Research paper (scientific journal), Single Work, Accepted

濾紙膜を用いた放射性実験廃液からの125Iの濾過型除去

INOUE Hiroyoshi

RADIOISOTOPES 49 ( 5 ) 266-270 2000

Research paper (scientific journal), Joint Work, Accepted

Removal of 125I from Radioactive Experimental Waste with an Anion Exchange Paper Membrane.

INOUE Hiroyoshi

Appl. Radiat. Isotopes 52 1407-1412 2000

Research paper (scientific journal), Joint Work, Accepted

Effects of Naltrexone on the Accumulation of L-3,4-dihydroxyphenylalanine and 5-hydroxy-L-tryprtophan and on the Firing Rate Induced by Acute Ethanol Administration.

INOUE Hiroyoshi

Eur. J. Pharmacol. 406 ( 3 ) 375-380 2000

Research paper (scientific journal), Single Work, Accepted

Effects of anion exchange resin as phosphate binder on serum phosphate and iPTH levels in normal rats.

INOUE Hiroyoshi

Int. J. Artif. Organs 23 ( 4 ) 243-249 2000

Research paper (scientific journal), Joint Work, Accepted

Understanding and Awareness of Irradiated Food in Japanese Young Students.

INOUE Hiroyoshi

Kurume Med. J. 47 ( 3 ) 253-256 2000

Research paper (scientific journal), Single Work, Accepted

陰イオン交換樹脂による消化管内食物性リン酸の吸着.

INOUE Hiroyoshi

日本化学会雑誌 1 19-23 2000

Research paper (scientific journal), Single Work, Accepted

Effects of Mg and Mn ions on the inhibitory action of cyclic nucleotides in the longitudinal myometrium of rats.

INOUE Hiroyoshi

Jpn. J. Physiol. 44 49-66 1994

Research paper (scientific journal), Joint Work, Accepted

Influence of Mn Ion the Action of Dibutyryl Cyclic AMP and Forskolin on Contraction, Membrane Response, and Cyclic AMP-Dependent Protein Kinase Activity in Rat Myometrium.

INOUE Hiroyoshi

Jpn. J. Physiol. 43 454-472 1993

Research paper (scientific journal), Joint Work, Accepted

Study of Ion across Amphoteric Ion-Exchange Membrane. VI. Multi-Ionic Potential, Membrane Permeability, and Ion-Sieve Effect.

INOUE Hiroyoshi

Bull. Chem. Soc. Jpn. 66 77-82 1993

Research paper (scientific journal), Joint Work, Accepted

子宮平滑筋に存在する過分極誘発内向き電流.

INOUE Hiroyoshi

J. Smooth Muscle Res. 28 ( 6 ) 333-334 1992

Research paper (scientific journal), Joint Work, Accepted

レラキシンと子宮筋弛緩.

INOUE Hiroyoshi

J. Smooth Muscle Res. 27 67-74 1991

Research paper (scientific journal), Joint Work, Accepted

Effects of porcine relaxin on contraction, membrane response and cyclic AMP content in rat myometrium in comparison with the effects of isoprenaline and forskolin.

INOUE Hiroyoshi

Br. J. Pharmacol. 104 950-960 1991

Research paper (scientific journal), Joint Work, Accepted

ラット子宮筋に及ぼすレラキシンの効果.

INOUE Hiroyoshi

日本平滑筋学会雑誌 26 ( 5 ) 316-318 1990

Research paper (scientific journal), Joint Work, Accepted

モルモット結腸紐におけるβ効果に及ぼす外液二価イオンの影響.

INOUE Hiroyoshi

日本平滑筋学会雑誌25(6) 25 ( 6 ) 282-283 1989

Research paper (scientific journal), Joint Work, Accepted

Comparison of Mg, Mn and Co ions affecting the β-adrenoceptor-mediated membrane response in the guinea-pig taenia caeci.

INOUE Hiroyoshi

Jpn. J. Physiol. 39 659-671 1989

Research paper (scientific journal), Joint Work, Accepted

Multi-ionic potential and membrane permeability matrix. III. Diffusion and concentration of ions within membrane phase as a controlling factor to ion permeability.

INOUE Hiroyoshi

Bull. Chem. Soc. Jpn. 62 2362-2368 1989

Research paper (scientific journal), Single Work, Accepted

Study of ion transport across amphoteric ion-exchange membrane. V. nonequilibrium thermodynamic analyses of ion selectivity.

INOUE Hiroyoshi

Bull. Chem. Soc. Jpn. 61 1517-1525 1988

Research paper (scientific journal), Joint Work, Accepted

Ion Transport across charged ultrafiltration membrane. Aqueous metal chloride solution – sulfonated polysulfone membrane system.

INOUE Hiroyoshi

Mem. Fac. Sci. Kyushu Univ., Ser. C. 16 ( 2 ) 137-148 1988

Research paper (bulletin of university, research institution), Joint Work, Accepted

Multi-ionic potential and membrane permeability matrix. II. Na-Ca bi-ionic system with a cation-exchange membrane and effects of Cl on cation transport.

INOUE Hiroyoshi

Bull. Chem. Soc. Jpn. 60 3175-3181 1987

Research paper (scientific journal), Joint Work, Accepted

　 Previous page - Next page 　